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The map label for this gene is gmhA [H]

Identifier: 222527305

GI number: 222527305

Start: 5062240

End: 5062848

Strand: Direct

Name: gmhA [H]

Synonym: Chy400_4090

Alternate gene names: 222527305

Gene position: 5062240-5062848 (Clockwise)

Preceding gene: 222527304

Following gene: 222527306

Centisome position: 96.08

GC content: 54.52

Gene sequence:

>609_bases
ATGAACAATCTGACATCGTATGTTGTCCAGACATGCCAAACGCTTGAGCAGTTGCCACTCTGGGAACTCCAACGAGTAGC
TGACGCCATCTGGGAAGCCTACCAGCGCGATGCAACCATCTTTGTCTGTGGCAATGGGGGTAGTGCGGCAACCGCCTCGC
ACTTCGCCTGCGATCTCTCGAAATGGACGATCAATCCCCAGGCTCGCCGGGTGCGCGCTATTGCGCTCACCGACAACGTT
CCACTGATTACTGCCTGGTCAAACGATCAAGAGTATGCCGATGTGTTTGTCGAGCAGTTGCAGGCGCTCTACCGCGATGG
CGACATCATCATTGCGATTTCCGGGAGTGGCAACTCGGCCAATGTGGTACGGGCCATCGAATGGGGCAATCGCGTTGGTG
CCGTCACCATCGGCATTACCGGACGTGATGGTGGCCGCCTGTATCGGATTGCCAAAATTGGCCTGCACGTCAAAAACAAC
TTTATGCCTTTGATTGAAGACATCCATAGCATTGTCTGCCATGCTCTGGCGGTCAATTTAGGTCGGCAAATCGAAGCCTC
GCTCCAACCGGTAATTTTGCAGGCAAAGGCGGTAGGAGGTCAGCAATGA

Upstream 100 bases:

>100_bases
CAGGTCAATCCACTGCGCGCAGCCGGTGTGATTGTGATTTGTGCCGGCATGTTAATGGTTGCGCGCTCGTAAATACATCA
GAAACCACTGGGAGGGGGTC

Downstream 100 bases:

>100_bases
TCCCCATCTCCCGACCACTGATCGGCCCCGAAGAGGAAGAGGCGGTGCTGGCTGTGTTACGTTCGGGCATGATTGCGCAG
GGGCCAGAAGTTGAACGCTT

Product: sugar isomerase (SIS)

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MNNLTSYVVQTCQTLEQLPLWELQRVADAIWEAYQRDATIFVCGNGGSAATASHFACDLSKWTINPQARRVRAIALTDNV
PLITAWSNDQEYADVFVEQLQALYRDGDIIIAISGSGNSANVVRAIEWGNRVGAVTIGITGRDGGRLYRIAKIGLHVKNN
FMPLIEDIHSIVCHALAVNLGRQIEASLQPVILQAKAVGGQQ

Sequences:

>Translated_202_residues
MNNLTSYVVQTCQTLEQLPLWELQRVADAIWEAYQRDATIFVCGNGGSAATASHFACDLSKWTINPQARRVRAIALTDNV
PLITAWSNDQEYADVFVEQLQALYRDGDIIIAISGSGNSANVVRAIEWGNRVGAVTIGITGRDGGRLYRIAKIGLHVKNN
FMPLIEDIHSIVCHALAVNLGRQIEASLQPVILQAKAVGGQQ
>Mature_202_residues
MNNLTSYVVQTCQTLEQLPLWELQRVADAIWEAYQRDATIFVCGNGGSAATASHFACDLSKWTINPQARRVRAIALTDNV
PLITAWSNDQEYADVFVEQLQALYRDGDIIIAISGSGNSANVVRAIEWGNRVGAVTIGITGRDGGRLYRIAKIGLHVKNN
FMPLIEDIHSIVCHALAVNLGRQIEASLQPVILQAKAVGGQQ

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate [H]

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1786416, Length=159, Percent_Identity=35.2201257861635, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1789539, Length=133, Percent_Identity=37.593984962406, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004515
- InterPro:   IPR020620
- InterPro:   IPR001347 [H]

Pfam domain/function: PF01380 SIS [H]

EC number: =5.3.1.28 [H]

Molecular weight: Translated: 22056; Mature: 22056

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLTSYVVQTCQTLEQLPLWELQRVADAIWEAYQRDATIFVCGNGGSAATASHFACDLS
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHEEECE
KWTINPQARRVRAIALTDNVPLITAWSNDQEYADVFVEQLQALYRDGDIIIAISGSGNSA
EEECCHHHHEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
NVVRAIEWGNRVGAVTIGITGRDGGRLYRIAKIGLHVKNNFMPLIEDIHSIVCHALAVNL
EEEEEEECCCCEEEEEEEEECCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
GRQIEASLQPVILQAKAVGGQQ
CCHHHCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MNNLTSYVVQTCQTLEQLPLWELQRVADAIWEAYQRDATIFVCGNGGSAATASHFACDLS
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHEEECE
KWTINPQARRVRAIALTDNVPLITAWSNDQEYADVFVEQLQALYRDGDIIIAISGSGNSA
EEECCHHHHEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
NVVRAIEWGNRVGAVTIGITGRDGGRLYRIAKIGLHVKNNFMPLIEDIHSIVCHALAVNL
EEEEEEECCCCEEEEEEEEECCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
GRQIEASLQPVILQAKAVGGQQ
CCHHHCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500908 [H]