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The map label for this gene is wecB [H]

Identifier: 222527294

GI number: 222527294

Start: 5049801

End: 5050886

Strand: Direct

Name: wecB [H]

Synonym: Chy400_4079

Alternate gene names: 222527294

Gene position: 5049801-5050886 (Clockwise)

Preceding gene: 222527293

Following gene: 222527295

Centisome position: 95.84

GC content: 59.85

Gene sequence:

>1086_bases
ATGGCGCGCGTCCTCACCGTCCTCGGCACCCGACCAGAGATTATTAAACTCTCACCGGTGATTCCACTGCTCGAAGAACG
CTTTGATCATATCCTGGTGCATTCTGGTCAGCACTATTCGTATGAGGTTGACGCTATCTTTTTTGAGGAACTGAGTCTGC
CATCGCCCCGCTACACCCTCGGCGTAGGTTCGGCGCAGCACGGCGAGCAGACGGCCCGCATTCTGGCCCGGCTTGAGCCA
ATCTTGCTGCAAGAGCGCCCCGATCTCGTGCTGGTGCAGGGTGACACCAACACCACAATGGCCGGTGCGCTCTGCGCCGC
CAAACTCGGCTTTCCGGTAGTGCATCTGGAAGCGGGTGGGCGGTCGTTCAACCGCGCTATGCCCGAAGAACTCAACCGCA
TTATTGTCGATCATATTGCCGAAATACTGCTAGCCGCCGATGAAATTGCCGCGGCCAACCTGCGCGCAGAGGGGCTGCCA
GACGAACGGATTCACGTGATCGGTTCTACCGCCATCGACGCTGCCTTGCGCCATCGCGAGCGTGCCGCCACCAGTACCAT
CCTGCAACAACTGGAACTGACACCGGGGAGCTATCTGGCGCTGACGCTACACCGCGCCGAAAACACGGAACCGACGACCC
TACCGGGCATTGTGCGGGCGCTAAACGAACTGGCCGAGAGCTACCGAATCGTCTTCCCGGTACATCCACGCACTGCGGCT
GCGCTTGAGCGCCAGGGATTACAACTTTCGCCACACATCCTGGCGATCCGCCCGCTCGGCTACCTCGACACCCTCTGCCT
GGTGCAGTCGGCCCAGGCTCTGCTCACCGACTCTGGTGGCCTGCAAGAAGAGGCCGCCGTGTTGGGTACGCCCATTCTGC
TGGTACGTAATGAAACCGAATGGCGCTACCTGGTCGATGCCGGTGTTGCGGTATTGATCGGGAACTCTTACGAAGACATT
CTCGCCGGTGCTGCAACGTGGCTCAGTCCAACCGGTTTAAGCCGTCTCCGCAATGCCCGCTCACCAATTGTCAGTGGTGC
CGCCGAACGCGCGGTGGCAATTATGGAAGCTGCCGTCAATACATAA

Upstream 100 bases:

>100_bases
CTATCGGCGCAGCCCTGCGCGCGCAGTCATTCTTGATGCACTGTGCACATTTTTACAGCGCTACTACGGTATTCAACTCG
AATATGAAGAGAGGTAACTT

Downstream 100 bases:

>100_bases
TTATTTTGTCACATATACACCTATCAATAGTTAGTCAATATTCAGACCTGGTAACTATCCTACAAGCGTCCAGCAGCAGA
AGCGTTCAGGGGTCATATGA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MARVLTVLGTRPEIIKLSPVIPLLEERFDHILVHSGQHYSYEVDAIFFEELSLPSPRYTLGVGSAQHGEQTARILARLEP
ILLQERPDLVLVQGDTNTTMAGALCAAKLGFPVVHLEAGGRSFNRAMPEELNRIIVDHIAEILLAADEIAAANLRAEGLP
DERIHVIGSTAIDAALRHRERAATSTILQQLELTPGSYLALTLHRAENTEPTTLPGIVRALNELAESYRIVFPVHPRTAA
ALERQGLQLSPHILAIRPLGYLDTLCLVQSAQALLTDSGGLQEEAAVLGTPILLVRNETEWRYLVDAGVAVLIGNSYEDI
LAGAATWLSPTGLSRLRNARSPIVSGAAERAVAIMEAAVNT

Sequences:

>Translated_361_residues
MARVLTVLGTRPEIIKLSPVIPLLEERFDHILVHSGQHYSYEVDAIFFEELSLPSPRYTLGVGSAQHGEQTARILARLEP
ILLQERPDLVLVQGDTNTTMAGALCAAKLGFPVVHLEAGGRSFNRAMPEELNRIIVDHIAEILLAADEIAAANLRAEGLP
DERIHVIGSTAIDAALRHRERAATSTILQQLELTPGSYLALTLHRAENTEPTTLPGIVRALNELAESYRIVFPVHPRTAA
ALERQGLQLSPHILAIRPLGYLDTLCLVQSAQALLTDSGGLQEEAAVLGTPILLVRNETEWRYLVDAGVAVLIGNSYEDI
LAGAATWLSPTGLSRLRNARSPIVSGAAERAVAIMEAAVNT
>Mature_360_residues
ARVLTVLGTRPEIIKLSPVIPLLEERFDHILVHSGQHYSYEVDAIFFEELSLPSPRYTLGVGSAQHGEQTARILARLEPI
LLQERPDLVLVQGDTNTTMAGALCAAKLGFPVVHLEAGGRSFNRAMPEELNRIIVDHIAEILLAADEIAAANLRAEGLPD
ERIHVIGSTAIDAALRHRERAATSTILQQLELTPGSYLALTLHRAENTEPTTLPGIVRALNELAESYRIVFPVHPRTAAA
LERQGLQLSPHILAIRPLGYLDTLCLVQSAQALLTDSGGLQEEAAVLGTPILLVRNETEWRYLVDAGVAVLIGNSYEDIL
AGAATWLSPTGLSRLRNARSPIVSGAAERAVAIMEAAVNT

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) to produce UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=379, Percent_Identity=34.8284960422164, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 39063; Mature: 38932

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARVLTVLGTRPEIIKLSPVIPLLEERFDHILVHSGQHYSYEVDAIFFEELSLPSPRYTL
CCCEEEEECCCCCEEEECCCHHHHHHHHHEEEEECCCCCEEEEEEEEEEHHCCCCCCEEE
GVGSAQHGEQTARILARLEPILLQERPDLVLVQGDTNTTMAGALCAAKLGFPVVHLEAGG
ECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCC
RSFNRAMPEELNRIIVDHIAEILLAADEIAAANLRAEGLPDERIHVIGSTAIDAALRHRE
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHH
RAATSTILQQLELTPGSYLALTLHRAENTEPTTLPGIVRALNELAESYRIVFPVHPRTAA
HHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCHHH
ALERQGLQLSPHILAIRPLGYLDTLCLVQSAQALLTDSGGLQEEAAVLGTPILLVRNETE
HHHHCCCEECCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEECCCC
WRYLVDAGVAVLIGNSYEDILAGAATWLSPTGLSRLRNARSPIVSGAAERAVAIMEAAVN
EEEEEECCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHC
T
C
>Mature Secondary Structure 
ARVLTVLGTRPEIIKLSPVIPLLEERFDHILVHSGQHYSYEVDAIFFEELSLPSPRYTL
CCEEEEECCCCCEEEECCCHHHHHHHHHEEEEECCCCCEEEEEEEEEEHHCCCCCCEEE
GVGSAQHGEQTARILARLEPILLQERPDLVLVQGDTNTTMAGALCAAKLGFPVVHLEAGG
ECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCC
RSFNRAMPEELNRIIVDHIAEILLAADEIAAANLRAEGLPDERIHVIGSTAIDAALRHRE
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHH
RAATSTILQQLELTPGSYLALTLHRAENTEPTTLPGIVRALNELAESYRIVFPVHPRTAA
HHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCHHH
ALERQGLQLSPHILAIRPLGYLDTLCLVQSAQALLTDSGGLQEEAAVLGTPILLVRNETE
HHHHCCCEECCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEECCCC
WRYLVDAGVAVLIGNSYEDILAGAATWLSPTGLSRLRNARSPIVSGAAERAVAIMEAAVN
EEEEEECCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHC
T
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]