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The map label for this gene is hyi [H]

Identifier: 222527146

GI number: 222527146

Start: 4877108

End: 4877944

Strand: Reverse

Name: hyi [H]

Synonym: Chy400_3928

Alternate gene names: 222527146

Gene position: 4877944-4877108 (Counterclockwise)

Preceding gene: 222527147

Following gene: 222527145

Centisome position: 92.58

GC content: 56.99

Gene sequence:

>837_bases
ATGCTCCACATTGCGCTTAATGTATCACTTACCATGCGCGAACTGGCGTGGTCTGAACGCTTCGACACGGCGGCACGGCT
CGGTTTCGGTACAGTCGAGTTCTGGTGGCCGGATGGGGTTGATCTCAAGGCAATCAGCCGCCAGTTGCGTGATCTCGATC
TGCAAGTAGCACTGGTCAATTTTGCCGCCGGTGTGCTGGCCCATGGTGAACGAGGGTTATTGAACCATCCGGAACGGCAA
CATGAGTTTCGCGCCAATGTTCCGGTGGCGCTGGAGTTTGCCCAACAGATTGGGTGTCGGCGACTGAATGCCCTGGTTGG
TAAGCTCCTGCCCGGAGAAGATCGCGCTTCACAGATGTCACGGGTACGCGAGAATCTGGCCTGGGCTTGCGAGCAGGCAG
CCGCAGCCGGGATTGAGGTGGTCGTCGAGTCGCTCAATGCCTGGGAAAACAGTGGCTATCTACTGACCAACACCGCCGAG
ACGCTGGCATTTCTGGCGAGTGTTGGTGCACCGAATCTGCGCTATCAGTACGACTGTTACCACATGCAGTTGATGGAAGG
AAATATCACTCGCACGATTCGCGAACACGTTGCTCGGATTGGTCATATTCAGGTCGCCGATGCTCCCCATCGCCACCAGC
CCGGTACCGGCGAACTGCATTTTCCGTACATCTTCCGGGCAATTGTTGAGAGTGGCTACACCGGTTTTGTCGGTCTGGAG
TTCATCCCTGACCGTGAACTGGCCGCTTGCCTGGAATGGCTACCCCCAGATCGTCGGCAACCGATAGCGCTTGAAGCTAT
GCGCTGGTCGGCAGTGGGTGAAGAACAGGAGCGTTAA

Upstream 100 bases:

>100_bases
GTCAGCAGATTGAAGGCGATGAAAGCGTCCTGGTTGGTGATATTACGCGAGAGGTGGCATTGTTACAGTGATGGCATTAT
ACAGACGTTGAGGCGGTAAT

Downstream 100 bases:

>100_bases
TCGCTCTAGTCATGACGCCGCGATGTTTGCCCCAAACCTGGCGTTGTGGGGATTGCATAGTGTGTCTCGTTGTTATCCAT
CATCGACAGAAAGTTACACA

Product: Hydroxypyruvate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MLHIALNVSLTMRELAWSERFDTAARLGFGTVEFWWPDGVDLKAISRQLRDLDLQVALVNFAAGVLAHGERGLLNHPERQ
HEFRANVPVALEFAQQIGCRRLNALVGKLLPGEDRASQMSRVRENLAWACEQAAAAGIEVVVESLNAWENSGYLLTNTAE
TLAFLASVGAPNLRYQYDCYHMQLMEGNITRTIREHVARIGHIQVADAPHRHQPGTGELHFPYIFRAIVESGYTGFVGLE
FIPDRELAACLEWLPPDRRQPIALEAMRWSAVGEEQER

Sequences:

>Translated_278_residues
MLHIALNVSLTMRELAWSERFDTAARLGFGTVEFWWPDGVDLKAISRQLRDLDLQVALVNFAAGVLAHGERGLLNHPERQ
HEFRANVPVALEFAQQIGCRRLNALVGKLLPGEDRASQMSRVRENLAWACEQAAAAGIEVVVESLNAWENSGYLLTNTAE
TLAFLASVGAPNLRYQYDCYHMQLMEGNITRTIREHVARIGHIQVADAPHRHQPGTGELHFPYIFRAIVESGYTGFVGLE
FIPDRELAACLEWLPPDRRQPIALEAMRWSAVGEEQER
>Mature_278_residues
MLHIALNVSLTMRELAWSERFDTAARLGFGTVEFWWPDGVDLKAISRQLRDLDLQVALVNFAAGVLAHGERGLLNHPERQ
HEFRANVPVALEFAQQIGCRRLNALVGKLLPGEDRASQMSRVRENLAWACEQAAAAGIEVVVESLNAWENSGYLLTNTAE
TLAFLASVGAPNLRYQYDCYHMQLMEGNITRTIREHVARIGHIQVADAPHRHQPGTGELHFPYIFRAIVESGYTGFVGLE
FIPDRELAACLEWLPPDRRQPIALEAMRWSAVGEEQER

Specific function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) [H]

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=260, Percent_Identity=35, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI300068964, Length=244, Percent_Identity=35.2459016393443, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1786718, Length=258, Percent_Identity=38.3720930232558, Blast_Score=190, Evalue=7e-50,
Organism=Escherichia coli, GI1789095, Length=254, Percent_Identity=33.4645669291339, Blast_Score=161, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17552022, Length=240, Percent_Identity=27.5, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17530883, Length=251, Percent_Identity=31.0756972111554, Blast_Score=136, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017643
- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: =5.3.1.22 [H]

Molecular weight: Translated: 31263; Mature: 31263

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHIALNVSLTMRELAWSERFDTAARLGFGTVEFWWPDGVDLKAISRQLRDLDLQVALVN
CEEEEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
FAAGVLAHGERGLLNHPERQHEFRANVPVALEFAQQIGCRRLNALVGKLLPGEDRASQMS
HHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
RVRENLAWACEQAAAAGIEVVVESLNAWENSGYLLTNTAETLAFLASVGAPNLRYQYDCY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHCCCCCCEEEECCE
HMQLMEGNITRTIREHVARIGHIQVADAPHRHQPGTGELHFPYIFRAIVESGYTGFVGLE
EEEEECCCHHHHHHHHHHHHCCEEECCCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEE
FIPDRELAACLEWLPPDRRQPIALEAMRWSAVGEEQER
ECCCHHHHHHHHHCCCCCCCCEEHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLHIALNVSLTMRELAWSERFDTAARLGFGTVEFWWPDGVDLKAISRQLRDLDLQVALVN
CEEEEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
FAAGVLAHGERGLLNHPERQHEFRANVPVALEFAQQIGCRRLNALVGKLLPGEDRASQMS
HHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
RVRENLAWACEQAAAAGIEVVVESLNAWENSGYLLTNTAETLAFLASVGAPNLRYQYDCY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHCCCCCCEEEECCE
HMQLMEGNITRTIREHVARIGHIQVADAPHRHQPGTGELHFPYIFRAIVESGYTGFVGLE
EEEEECCCHHHHHHHHHHHHCCEEECCCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEE
FIPDRELAACLEWLPPDRRQPIALEAMRWSAVGEEQER
ECCCHHHHHHHHHCCCCCCCCEEHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8440684; 10561547; 9278503 [H]