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The map label for this gene is prs [H]

Identifier: 222527107

GI number: 222527107

Start: 4837450

End: 4838448

Strand: Reverse

Name: prs [H]

Synonym: Chy400_3888

Alternate gene names: 222527107

Gene position: 4838448-4837450 (Counterclockwise)

Preceding gene: 222527108

Following gene: 222527104

Centisome position: 91.83

GC content: 54.15

Gene sequence:

>999_bases
ATGGGAAGCCGCTTCGACGAGATGCGGATTTTTGCCGGCAATGGTAATCTACCACTGGCCAGGGCCATCAGTGAGCGCCT
CGGCGTTCCGCTGGGTGATGTTACCATTGTGAAGTTTAGCAATGAGAATATCTTTGTCAGGCTTAATGAAAGTGTACGTG
AAAAGGATGTCTTCGTTATTCAATCACTGTCAATGCCCGATCTCAGTGATCGGATTATGGAATTGCTGATTTTACTCGAT
GCCTGTAAGCGTGCCTCTGCCGGGCGGATTACCGCTGTCATTCCTTATTACGCTTACGGGCGTACTGATAAGAAAGACCA
GCCCCGTGTACCGATTACCGCCCGCTTGCTGGCCGATATGATCCAGGTTGCCGGCGCGCATCAGGTGATGACGATTGACC
TGCACGCCGGGCAGATTCAGGGCTTTTTCTCGATCCCGATGGATGAACTGACAGCCATGAATCTGCTGGTGCGCTATTTT
GCCGATAAGGGCTGGAACGATCTGATTGTCGTCTCGCCCGATGTTGGCTTTGCCAAACGTGCCCGCAACTTCGCCGAAGC
CCTGAATGCGCCGCTGGCGATTGCTGAAAAGCGCCGGCTGCAACACTTTGATCGGAAAGACGGTTCACTCACCGTTCCGG
AAATTCTGAATCTGATCGGTGATGTACGCGGCAAGCGTTGTCTGATTGTAGACGACGAGATTGCCACCGGTAGCTCGATC
CTCGAAGTCGTGCAGTTGCTCGAAAAGGAGGGCGCGAGCGAGATTTATGCCTGCTGCGTCCACCCGGTGTTCGCCGGGAA
TGCTATCGAGCGCCTGCGGGCAAGTCCGATCCGCGAGCTTGTGGTGACCGATACATTACCGGTTGCTCCGGAACGACGCT
GGCCCGGCCTGACAATCCTCTCGGTCAGTACGTTGATTGCTGAAGTCATCCAGCGCATCCATAGCGGTGTGAGTGTCGAT
ACGATATTTCAACATCGTCGCCATCCAGCATTAAGCTAG

Upstream 100 bases:

>100_bases
TACCGGTAGGCTGGCGGTTGTCGCGGACTGAGCTGTTGGCGATGTTTGCAATCGACTCAGGCGTTGTTTGAACGGTACCT
CGCAGGCTAAGGAGGAAGGA

Downstream 100 bases:

>100_bases
ATTACAGGGTGCGACCTCATATACCGGTGTCGCACCCCTGTGCCTACTCGAACCCCAGACCTCGTTCGCGCAAACTGACG
TAGCGGCCATTGCCGATAAT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MGSRFDEMRIFAGNGNLPLARAISERLGVPLGDVTIVKFSNENIFVRLNESVREKDVFVIQSLSMPDLSDRIMELLILLD
ACKRASAGRITAVIPYYAYGRTDKKDQPRVPITARLLADMIQVAGAHQVMTIDLHAGQIQGFFSIPMDELTAMNLLVRYF
ADKGWNDLIVVSPDVGFAKRARNFAEALNAPLAIAEKRRLQHFDRKDGSLTVPEILNLIGDVRGKRCLIVDDEIATGSSI
LEVVQLLEKEGASEIYACCVHPVFAGNAIERLRASPIRELVVTDTLPVAPERRWPGLTILSVSTLIAEVIQRIHSGVSVD
TIFQHRRHPALS

Sequences:

>Translated_332_residues
MGSRFDEMRIFAGNGNLPLARAISERLGVPLGDVTIVKFSNENIFVRLNESVREKDVFVIQSLSMPDLSDRIMELLILLD
ACKRASAGRITAVIPYYAYGRTDKKDQPRVPITARLLADMIQVAGAHQVMTIDLHAGQIQGFFSIPMDELTAMNLLVRYF
ADKGWNDLIVVSPDVGFAKRARNFAEALNAPLAIAEKRRLQHFDRKDGSLTVPEILNLIGDVRGKRCLIVDDEIATGSSI
LEVVQLLEKEGASEIYACCVHPVFAGNAIERLRASPIRELVVTDTLPVAPERRWPGLTILSVSTLIAEVIQRIHSGVSVD
TIFQHRRHPALS
>Mature_331_residues
GSRFDEMRIFAGNGNLPLARAISERLGVPLGDVTIVKFSNENIFVRLNESVREKDVFVIQSLSMPDLSDRIMELLILLDA
CKRASAGRITAVIPYYAYGRTDKKDQPRVPITARLLADMIQVAGAHQVMTIDLHAGQIQGFFSIPMDELTAMNLLVRYFA
DKGWNDLIVVSPDVGFAKRARNFAEALNAPLAIAEKRRLQHFDRKDGSLTVPEILNLIGDVRGKRCLIVDDEIATGSSIL
EVVQLLEKEGASEIYACCVHPVFAGNAIERLRASPIRELVVTDTLPVAPERRWPGLTILSVSTLIAEVIQRIHSGVSVDT
IFQHRRHPALS

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=323, Percent_Identity=39.3188854489164, Blast_Score=244, Evalue=7e-65,
Organism=Homo sapiens, GI28557709, Length=321, Percent_Identity=39.5638629283489, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4506129, Length=321, Percent_Identity=39.2523364485981, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI84875539, Length=324, Percent_Identity=38.8888888888889, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI4506133, Length=345, Percent_Identity=34.4927536231884, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=32.463768115942, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI310128524, Length=141, Percent_Identity=31.9148936170213, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI310115209, Length=141, Percent_Identity=31.9148936170213, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI310118259, Length=141, Percent_Identity=31.9148936170213, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI310119946, Length=141, Percent_Identity=31.9148936170213, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1787458, Length=322, Percent_Identity=41.9254658385093, Blast_Score=259, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17554702, Length=327, Percent_Identity=39.1437308868502, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71989924, Length=327, Percent_Identity=39.1437308868502, Blast_Score=244, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI25149168, Length=323, Percent_Identity=39.3188854489164, Blast_Score=243, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI17554704, Length=321, Percent_Identity=39.5638629283489, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17570245, Length=339, Percent_Identity=31.2684365781711, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320946, Length=322, Percent_Identity=41.304347826087, Blast_Score=241, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6319403, Length=324, Percent_Identity=40.1234567901235, Blast_Score=239, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6321776, Length=322, Percent_Identity=36.6459627329193, Blast_Score=220, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6322667, Length=200, Percent_Identity=40, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324511, Length=270, Percent_Identity=30.7407407407407, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21355239, Length=326, Percent_Identity=41.1042944785276, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI45551540, Length=349, Percent_Identity=38.3954154727794, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI281362873, Length=354, Percent_Identity=32.4858757062147, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24651454, Length=354, Percent_Identity=32.4858757062147, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24651458, Length=354, Percent_Identity=32.4858757062147, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24651456, Length=354, Percent_Identity=32.4858757062147, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24651462, Length=373, Percent_Identity=30.8310991957105, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24651464, Length=373, Percent_Identity=30.8310991957105, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI45552010, Length=373, Percent_Identity=30.8310991957105, Blast_Score=172, Evalue=2e-43,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 36803; Mature: 36672

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSRFDEMRIFAGNGNLPLARAISERLGVPLGDVTIVKFSNENIFVRLNESVREKDVFVI
CCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCCCCCEEEE
QSLSMPDLSDRIMELLILLDACKRASAGRITAVIPYYAYGRTDKKDQPRVPITARLLADM
EECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHCCCCCCCCCCCCCCHHHHHHHHH
IQVAGAHQVMTIDLHAGQIQGFFSIPMDELTAMNLLVRYFADKGWNDLIVVSPDVGFAKR
HHHCCCCEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHH
ARNFAEALNAPLAIAEKRRLQHFDRKDGSLTVPEILNLIGDVRGKRCLIVDDEIATGSSI
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCEEEEECCCCCCCHHH
LEVVQLLEKEGASEIYACCVHPVFAGNAIERLRASPIRELVVTDTLPVAPERRWPGLTIL
HHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCEEHH
SVSTLIAEVIQRIHSGVSVDTIFQHRRHPALS
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
GSRFDEMRIFAGNGNLPLARAISERLGVPLGDVTIVKFSNENIFVRLNESVREKDVFVI
CCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCCCCCEEEE
QSLSMPDLSDRIMELLILLDACKRASAGRITAVIPYYAYGRTDKKDQPRVPITARLLADM
EECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHCCCCCCCCCCCCCCHHHHHHHHH
IQVAGAHQVMTIDLHAGQIQGFFSIPMDELTAMNLLVRYFADKGWNDLIVVSPDVGFAKR
HHHCCCCEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHH
ARNFAEALNAPLAIAEKRRLQHFDRKDGSLTVPEILNLIGDVRGKRCLIVDDEIATGSSI
HHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCEEEEECCCCCCCHHH
LEVVQLLEKEGASEIYACCVHPVFAGNAIERLRASPIRELVVTDTLPVAPERRWPGLTIL
HHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCEEHH
SVSTLIAEVIQRIHSGVSVDTIFQHRRHPALS
HHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]