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The map label for this gene is nuoM [H]

Identifier: 222527100

GI number: 222527100

Start: 4828125

End: 4829723

Strand: Direct

Name: nuoM [H]

Synonym: Chy400_3880

Alternate gene names: 222527100

Gene position: 4828125-4829723 (Clockwise)

Preceding gene: 222527097

Following gene: 222527105

Centisome position: 91.63

GC content: 57.66

Gene sequence:

>1599_bases
ATGAACCTGCTCGGCCTACCCATCCTGTCACTGTTGCTCTGGTTACCGGCGTTTGGCGCTCTTATCATCCTGTTGCAGCC
GGCTGGTCGCCCTGCGCTTTATCGCTGGACAGCGATGAGTGCAGCTCTGGCGACATTCGTTGTTGCGGGAATTGTTATTG
GTCTCTTCTATACCGGCCCATACGGCCCGGTCTCCGGTGTCGTCGTTGGCCCACCACTACAATTCGTCGACTCAATCGCA
TGGTTACCGGCATTTGGCGCCAGCTATTTCATTGGCGTTGATGGGATCAATTTGTGGCTGGTCGGTCTGACTGCATTTCT
GGCGCCATTCGCGATTGCAGCGACCTGGCAACGACAAACGCGCAGCCTGCGCTTGCTTCTGGCACTATTGCTCCTGGCCG
AGACTGCGTTTCTGGGTGTGTTTCTTGCCCAGGACATGCTGCTCTTCTACGTCTTCTACGAGCTGGCCCTGATCCCGATG
GTATTTCTGGTTGGGATGTGGGGTGGTCACGGTCGAGCCGCAGCGGCTTTGAAGCTGTTCCTTTACACCTTCAGCGGTTC
ACTGCTGATGCTGCTGGCGATTATCGGTCTGCACATCCTGCATCGCAACGCGATAGCAGCGGTTGAACCGGGTTACACCG
GTACGTTCGCGCTGAACCAGATTGTGGCCGATCTGCGGGCCGGTCTCTTCACGCTTGACCCGCTGGTTGCCCGTTTGCTG
TTCGGGGCATTCTTTGTGGCATTTGCGATCAAACTGGCGCTCTGGCCATTCCACACCTGGCTGCCTGACGCATACAGCGT
GGCCCCGACGCCGGTCGCAATTATTCTGGCCGGTTTGATGGCAAAATTCGGCGTCTACGGTTTGATCCGCTTCAATGCCA
CCCTGTTCCCCGAAGTGATGTCCTGGGTAGCCCCGGTTGTCGCTGTACTGGCCGTGATCGGGATCATTTACGGCGCACTG
ATCGCCTTCACGCAGCGCGACATGCAGCGAATGATCGCGTATGCCTCGATCAGCCACATGAACTTTGTAGCCCTCGGCGT
TATGGCACTGAATACCATTGGTATCAACGGAGCGTTGTTCCAGATGGTTGCCCACGGTGTTATGATGGCTGCGCTCTTGC
TGATTGTGGCTGTGATTGAGGAACGCCGCGATAGCCGCGATTTCAGCACCCTTGGCGGTTTGTGGCAGGTGACCCCTGTC
TACGCCGGTTTGACATTACTGACCCTGCTGGCGATGGCCGGTCTGCCCGGTCTGAGCGGGTTTGTCGGTGAGTTCACGAT
GCTTCAGGGCATCTTTACCTCGCCTCTGTTGGGATGGCCGTTTGCCATCGGGGCGGCAATTGGGATCATTCTGGCTGCGG
TTTACGCGCTGCGGGTGTTCCACATGGGCTTTATGGGTGAAGTCCGCAATACCGCTCATCTCGATCTGCCGGATTTGCAG
CGCTGTGAATTGCTGACGCTGGGTGTGTTGGCGGCGGCAATGGTTGTTCTGGGCCTGTTCCCCAACCTGCTGCTGAGTGG
TACAACCGGTTCTGTTCAGGGTCTGGTTGACGCTTTGACGCCGGCAGTGCAGGCCGCAGCCCAGTTGAATGGGTGGTAG

Upstream 100 bases:

>100_bases
AAGAGGTAACGAAGCTGCGTTAGCTGTTGACTTGCGACATCGTACTTTGGTCGCAGCGTAGGTTTACTTTGTTTATGTAA
AAGAAAGAAGGTCTGGCGTC

Downstream 100 bases:

>100_bases
AGGTACGTTACGCCCCCACCCCTGCCCTCTCCCGCTGGGGGAGGGTGTTTTTTATGTAGCGATACCCCACTGGGAGAGGG
TGGTTTTTTTATGGAGTGTT

Product: proton-translocating NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MNLLGLPILSLLLWLPAFGALIILLQPAGRPALYRWTAMSAALATFVVAGIVIGLFYTGPYGPVSGVVVGPPLQFVDSIA
WLPAFGASYFIGVDGINLWLVGLTAFLAPFAIAATWQRQTRSLRLLLALLLLAETAFLGVFLAQDMLLFYVFYELALIPM
VFLVGMWGGHGRAAAALKLFLYTFSGSLLMLLAIIGLHILHRNAIAAVEPGYTGTFALNQIVADLRAGLFTLDPLVARLL
FGAFFVAFAIKLALWPFHTWLPDAYSVAPTPVAIILAGLMAKFGVYGLIRFNATLFPEVMSWVAPVVAVLAVIGIIYGAL
IAFTQRDMQRMIAYASISHMNFVALGVMALNTIGINGALFQMVAHGVMMAALLLIVAVIEERRDSRDFSTLGGLWQVTPV
YAGLTLLTLLAMAGLPGLSGFVGEFTMLQGIFTSPLLGWPFAIGAAIGIILAAVYALRVFHMGFMGEVRNTAHLDLPDLQ
RCELLTLGVLAAAMVVLGLFPNLLLSGTTGSVQGLVDALTPAVQAAAQLNGW

Sequences:

>Translated_532_residues
MNLLGLPILSLLLWLPAFGALIILLQPAGRPALYRWTAMSAALATFVVAGIVIGLFYTGPYGPVSGVVVGPPLQFVDSIA
WLPAFGASYFIGVDGINLWLVGLTAFLAPFAIAATWQRQTRSLRLLLALLLLAETAFLGVFLAQDMLLFYVFYELALIPM
VFLVGMWGGHGRAAAALKLFLYTFSGSLLMLLAIIGLHILHRNAIAAVEPGYTGTFALNQIVADLRAGLFTLDPLVARLL
FGAFFVAFAIKLALWPFHTWLPDAYSVAPTPVAIILAGLMAKFGVYGLIRFNATLFPEVMSWVAPVVAVLAVIGIIYGAL
IAFTQRDMQRMIAYASISHMNFVALGVMALNTIGINGALFQMVAHGVMMAALLLIVAVIEERRDSRDFSTLGGLWQVTPV
YAGLTLLTLLAMAGLPGLSGFVGEFTMLQGIFTSPLLGWPFAIGAAIGIILAAVYALRVFHMGFMGEVRNTAHLDLPDLQ
RCELLTLGVLAAAMVVLGLFPNLLLSGTTGSVQGLVDALTPAVQAAAQLNGW
>Mature_532_residues
MNLLGLPILSLLLWLPAFGALIILLQPAGRPALYRWTAMSAALATFVVAGIVIGLFYTGPYGPVSGVVVGPPLQFVDSIA
WLPAFGASYFIGVDGINLWLVGLTAFLAPFAIAATWQRQTRSLRLLLALLLLAETAFLGVFLAQDMLLFYVFYELALIPM
VFLVGMWGGHGRAAAALKLFLYTFSGSLLMLLAIIGLHILHRNAIAAVEPGYTGTFALNQIVADLRAGLFTLDPLVARLL
FGAFFVAFAIKLALWPFHTWLPDAYSVAPTPVAIILAGLMAKFGVYGLIRFNATLFPEVMSWVAPVVAVLAVIGIIYGAL
IAFTQRDMQRMIAYASISHMNFVALGVMALNTIGINGALFQMVAHGVMMAALLLIVAVIEERRDSRDFSTLGGLWQVTPV
YAGLTLLTLLAMAGLPGLSGFVGEFTMLQGIFTSPLLGWPFAIGAAIGIILAAVYALRVFHMGFMGEVRNTAHLDLPDLQ
RCELLTLGVLAAAMVVLGLFPNLLLSGTTGSVQGLVDALTPAVQAAAQLNGW

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=384, Percent_Identity=27.8645833333333, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI251831117, Length=217, Percent_Identity=28.110599078341, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1788613, Length=464, Percent_Identity=35.5603448275862, Blast_Score=261, Evalue=9e-71,
Organism=Escherichia coli, GI1788827, Length=290, Percent_Identity=24.4827586206897, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1788831, Length=287, Percent_Identity=25.4355400696864, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI145693160, Length=388, Percent_Identity=28.8659793814433, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI2367154, Length=182, Percent_Identity=30.7692307692308, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1788829, Length=442, Percent_Identity=26.0180995475113, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788614, Length=344, Percent_Identity=27.0348837209302, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 56826; Mature: 56826

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLGLPILSLLLWLPAFGALIILLQPAGRPALYRWTAMSAALATFVVAGIVIGLFYTGP
CCCCHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YGPVSGVVVGPPLQFVDSIAWLPAFGASYFIGVDGINLWLVGLTAFLAPFAIAATWQRQT
CCCCCCEEECCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
RSLRLLLALLLLAETAFLGVFLAQDMLLFYVFYELALIPMVFLVGMWGGHGRAAAALKLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LYTFSGSLLMLLAIIGLHILHRNAIAAVEPGYTGTFALNQIVADLRAGLFTLDPLVARLL
HHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGAFFVAFAIKLALWPFHTWLPDAYSVAPTPVAIILAGLMAKFGVYGLIRFNATLFPEVM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
SWVAPVVAVLAVIGIIYGALIAFTQRDMQRMIAYASISHMNFVALGVMALNTIGINGALF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
QMVAHGVMMAALLLIVAVIEERRDSRDFSTLGGLWQVTPVYAGLTLLTLLAMAGLPGLSG
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
FVGEFTMLQGIFTSPLLGWPFAIGAAIGIILAAVYALRVFHMGFMGEVRNTAHLDLPDLQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
RCELLTLGVLAAAMVVLGLFPNLLLSGTTGSVQGLVDALTPAVQAAAQLNGW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLLGLPILSLLLWLPAFGALIILLQPAGRPALYRWTAMSAALATFVVAGIVIGLFYTGP
CCCCHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YGPVSGVVVGPPLQFVDSIAWLPAFGASYFIGVDGINLWLVGLTAFLAPFAIAATWQRQT
CCCCCCEEECCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
RSLRLLLALLLLAETAFLGVFLAQDMLLFYVFYELALIPMVFLVGMWGGHGRAAAALKLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LYTFSGSLLMLLAIIGLHILHRNAIAAVEPGYTGTFALNQIVADLRAGLFTLDPLVARLL
HHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGAFFVAFAIKLALWPFHTWLPDAYSVAPTPVAIILAGLMAKFGVYGLIRFNATLFPEVM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
SWVAPVVAVLAVIGIIYGALIAFTQRDMQRMIAYASISHMNFVALGVMALNTIGINGALF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
QMVAHGVMMAALLLIVAVIEERRDSRDFSTLGGLWQVTPVYAGLTLLTLLAMAGLPGLSG
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
FVGEFTMLQGIFTSPLLGWPFAIGAAIGIILAAVYALRVFHMGFMGEVRNTAHLDLPDLQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
RCELLTLGVLAAAMVVLGLFPNLLLSGTTGSVQGLVDALTPAVQAAAQLNGW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA