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The map label for this gene is mmgC [H]

Identifier: 222527059

GI number: 222527059

Start: 4782222

End: 4783406

Strand: Direct

Name: mmgC [H]

Synonym: Chy400_3838

Alternate gene names: 222527059

Gene position: 4782222-4783406 (Clockwise)

Preceding gene: 222527058

Following gene: 222527063

Centisome position: 90.76

GC content: 58.65

Gene sequence:

>1185_bases
ATGACGATCGCAAGCGAGCGCGGTATCGATCTCTTCCACTTCGACGAACTCCTCACCCCGCGCGAGCGCGCACTTCGCGA
TAAGGTGCGCGCATTTTGTAACGAGCACGTGTTGCCGATCATCAACGATTACTGGGAGCGAGCCGAATTTCCCTTCGAGC
TGATTCCCCGGATCGCCGAATTAGGGATCGTCGGTGGCACCATCCAGGGCTACGGTTGTCCGGGATTCTCCAGTGTTGAA
GTTGGGCTGATCGCTGCCGAGCTGGCCCGCGGTGATGGCAGTGTCGGCACATTTGTCGGCGTAACCAGTGGTCTGGCAAT
GGGTGCCATCGCTGCCTGCGGTTCAGAGGAGCAGAAGCAACGCTGGCTACCGGCGATGGCCCGGCTAGAAAAGATTGGTG
CGTTTGCCCTCACCGAGCCTTACGTCGGTTCCGATGCGGCTCACATTCGCACCACTGCCAAACGTGTGAGTGGCGGCTAC
CTGCTCAACGGCGCCAAGCGTTGGATCGGGAACGCTACCTTTGCCGACGTGATCGTGGTGTGGGCCCAGGATGAAGAGAC
TGGTCGGATTGGCGGATTTTTGGTCGAGAAGGGCACCCCCGGCTATCGGGCAACCAAGATCGAAGGCAAGATTGCCAAGC
GTTCGGTCATCAATGCCGACATTACCCTGGAGAACGTCTTCGTGCCGGAAGAGAATCGCCTGCCGTTGGCCCGCTCGTTC
CGTGATACGGCGAATATCTTGAAGAACACCCGCTATGGGGTCGCCTGGGAAGCAGTTGGTCACGCTCAGGCTGCCTACGA
ACTGGCACTTGAGTACACCCTCCAGCGCGAGCAGTTTGGCCGTCCGATTGCCGGCTTCCAGTTGGTGCAGCAGAAGCTGG
TTCATATGCTCGGTGATCTCACTGCGATCCAGTTGATGGCCTGGCGGCTGAGCAAGCTCCGCGACGAGGACGAAAGCCAG
ATCACCGAGGGTATGGCGTCGCTTGCCAAGCAATACTGTGCAGCCAAGGCACGCCAGATTGTTGCCCTGGGCCGTGAAGT
ACTCGGCGGCAACGGGATTCTGCTCGACCGGCATATTGCACGCCACTTTGCCGATATTGAAGCTGTCTATACCTACGAGG
GCACCAACGAGATTAATACCCTGGTTGTCGGGCGCGAGATTACCGGGATTGCCGCATTTGTATAA

Upstream 100 bases:

>100_bases
TACCAGAATTGCGCCCGGCCAGACTTGATCACGATGATGATATTCTGTGTTATAATTATTACGCAGTGCGTCATACACGT
ATTATCTCAGGAGGCGAACA

Downstream 100 bases:

>100_bases
CGTCCTCTAATTAACCCTCAACCTCGCTCCTCGTCTTTGAAGAGAGGAGCGAGGTGGCACTCGCTACCACCGGAGCGTTA
CATCAAATCTGATTTCATAG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTIASERGIDLFHFDELLTPRERALRDKVRAFCNEHVLPIINDYWERAEFPFELIPRIAELGIVGGTIQGYGCPGFSSVE
VGLIAAELARGDGSVGTFVGVTSGLAMGAIAACGSEEQKQRWLPAMARLEKIGAFALTEPYVGSDAAHIRTTAKRVSGGY
LLNGAKRWIGNATFADVIVVWAQDEETGRIGGFLVEKGTPGYRATKIEGKIAKRSVINADITLENVFVPEENRLPLARSF
RDTANILKNTRYGVAWEAVGHAQAAYELALEYTLQREQFGRPIAGFQLVQQKLVHMLGDLTAIQLMAWRLSKLRDEDESQ
ITEGMASLAKQYCAAKARQIVALGREVLGGNGILLDRHIARHFADIEAVYTYEGTNEINTLVVGREITGIAAFV

Sequences:

>Translated_394_residues
MTIASERGIDLFHFDELLTPRERALRDKVRAFCNEHVLPIINDYWERAEFPFELIPRIAELGIVGGTIQGYGCPGFSSVE
VGLIAAELARGDGSVGTFVGVTSGLAMGAIAACGSEEQKQRWLPAMARLEKIGAFALTEPYVGSDAAHIRTTAKRVSGGY
LLNGAKRWIGNATFADVIVVWAQDEETGRIGGFLVEKGTPGYRATKIEGKIAKRSVINADITLENVFVPEENRLPLARSF
RDTANILKNTRYGVAWEAVGHAQAAYELALEYTLQREQFGRPIAGFQLVQQKLVHMLGDLTAIQLMAWRLSKLRDEDESQ
ITEGMASLAKQYCAAKARQIVALGREVLGGNGILLDRHIARHFADIEAVYTYEGTNEINTLVVGREITGIAAFV
>Mature_393_residues
TIASERGIDLFHFDELLTPRERALRDKVRAFCNEHVLPIINDYWERAEFPFELIPRIAELGIVGGTIQGYGCPGFSSVEV
GLIAAELARGDGSVGTFVGVTSGLAMGAIAACGSEEQKQRWLPAMARLEKIGAFALTEPYVGSDAAHIRTTAKRVSGGYL
LNGAKRWIGNATFADVIVVWAQDEETGRIGGFLVEKGTPGYRATKIEGKIAKRSVINADITLENVFVPEENRLPLARSFR
DTANILKNTRYGVAWEAVGHAQAAYELALEYTLQREQFGRPIAGFQLVQQKLVHMLGDLTAIQLMAWRLSKLRDEDESQI
TEGMASLAKQYCAAKARQIVALGREVLGGNGILLDRHIARHFADIEAVYTYEGTNEINTLVVGREITGIAAFV

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=387, Percent_Identity=43.4108527131783, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=42.6229508196721, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=32.0754716981132, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI4501859, Length=382, Percent_Identity=30.8900523560209, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI226958412, Length=394, Percent_Identity=30.4568527918782, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI187960098, Length=386, Percent_Identity=30.5699481865285, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4557231, Length=386, Percent_Identity=30.5699481865285, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=31.0850439882698, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI21361497, Length=344, Percent_Identity=29.9418604651163, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI7656849, Length=360, Percent_Identity=29.4444444444444, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI4557235, Length=403, Percent_Identity=28.5359801488834, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI76496475, Length=403, Percent_Identity=28.5359801488834, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI4501857, Length=385, Percent_Identity=28.051948051948, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI38505218, Length=376, Percent_Identity=23.4042553191489, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI218563752, Length=288, Percent_Identity=28.125, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1786223, Length=282, Percent_Identity=30.8510638297872, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87081958, Length=347, Percent_Identity=27.6657060518732, Blast_Score=98, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=40.2061855670103, Blast_Score=300, Evalue=7e-82,
Organism=Caenorhabditis elegans, GI17569725, Length=386, Percent_Identity=29.7927461139896, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=29.2225201072386, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17538396, Length=381, Percent_Identity=28.8713910761155, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17534899, Length=379, Percent_Identity=28.7598944591029, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17570075, Length=382, Percent_Identity=28.0104712041885, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=29.3333333333333, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71985184, Length=365, Percent_Identity=29.3150684931507, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=27.1276595744681, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71990804, Length=282, Percent_Identity=31.2056737588652, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI71985192, Length=318, Percent_Identity=30.188679245283, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32563615, Length=223, Percent_Identity=30.9417040358744, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=28.4671532846715, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17551932, Length=373, Percent_Identity=24.1286863270777, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17505929, Length=362, Percent_Identity=23.7569060773481, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19920834, Length=388, Percent_Identity=44.0721649484536, Blast_Score=294, Evalue=7e-80,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=31.2, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24646207, Length=380, Percent_Identity=32.6315789473684, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24666513, Length=379, Percent_Identity=29.8153034300792, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=31.2169312169312, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI281363737, Length=343, Percent_Identity=31.1953352769679, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI21355753, Length=389, Percent_Identity=27.2493573264781, Blast_Score=138, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 43183; Mature: 43052

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIASERGIDLFHFDELLTPRERALRDKVRAFCNEHVLPIINDYWERAEFPFELIPRIAE
CCCCCCCCCCEEEHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHH
LGIVGGTIQGYGCPGFSSVEVGLIAAELARGDGSVGTFVGVTSGLAMGAIAACGSEEQKQ
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
RWLPAMARLEKIGAFALTEPYVGSDAAHIRTTAKRVSGGYLLNGAKRWIGNATFADVIVV
HHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHCCCEEECCHHHHHCCCCEEEEEEE
WAQDEETGRIGGFLVEKGTPGYRATKIEGKIAKRSVINADITLENVFVPEENRLPLARSF
EECCCCCCCCCCEEEECCCCCCEEEEECCHHHHHHHEECCEEEEEEECCCCCCCCHHHHH
RDTANILKNTRYGVAWEAVGHAQAAYELALEYTLQREQFGRPIAGFQLVQQKLVHMLGDL
HHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
TAIQLMAWRLSKLRDEDESQITEGMASLAKQYCAAKARQIVALGREVLGGNGILLDRHIA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHH
RHFADIEAVYTYEGTNEINTLVVGREITGIAAFV
HHHHCCEEEEEECCCCCCEEEEECCCCCCHHHCC
>Mature Secondary Structure 
TIASERGIDLFHFDELLTPRERALRDKVRAFCNEHVLPIINDYWERAEFPFELIPRIAE
CCCCCCCCCEEEHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHH
LGIVGGTIQGYGCPGFSSVEVGLIAAELARGDGSVGTFVGVTSGLAMGAIAACGSEEQKQ
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
RWLPAMARLEKIGAFALTEPYVGSDAAHIRTTAKRVSGGYLLNGAKRWIGNATFADVIVV
HHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHCCCEEECCHHHHHCCCCEEEEEEE
WAQDEETGRIGGFLVEKGTPGYRATKIEGKIAKRSVINADITLENVFVPEENRLPLARSF
EECCCCCCCCCCEEEECCCCCCEEEEECCHHHHHHHEECCEEEEEEECCCCCCCCHHHHH
RDTANILKNTRYGVAWEAVGHAQAAYELALEYTLQREQFGRPIAGFQLVQQKLVHMLGDL
HHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
TAIQLMAWRLSKLRDEDESQITEGMASLAKQYCAAKARQIVALGREVLGGNGILLDRHIA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHH
RHFADIEAVYTYEGTNEINTLVVGREITGIAAFV
HHHHCCEEEEEECCCCCCEEEEECCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]