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The map label for this gene is gcvPB [H]

Identifier: 222526993

GI number: 222526993

Start: 4691129

End: 4692604

Strand: Direct

Name: gcvPB [H]

Synonym: Chy400_3771

Alternate gene names: 222526993

Gene position: 4691129-4692604 (Clockwise)

Preceding gene: 222526992

Following gene: 222526994

Centisome position: 89.03

GC content: 60.09

Gene sequence:

>1476_bases
ATGAATAACGAGGAACCACCGATTTTTACCTATTCGCAGCCGGGCAAGATTGGCGTCAATCTACCGGCAGCCGGCGTGGC
ACCAACCCCGCTACCCGACGATCTGCTACGGCAAGACGATCTGGCCGGCTTTCCCGAACTCACCGAGCCGGAAGTGATTC
GTCACTTTACCCGGATCAGTCAGCGCAACTATGCCATCGACACCGGCTTCTACCCGCTCGGTTCGTGTACGATGAAGTAC
AACCCGAAGCTACACGAAGAAGCGGCCCGGCTACCGGGTTTTGCCGGTGCCCACCCCCTGCAAGATGAAGCGCTCAGCCA
GGGGGCGCTGCAACTGATGTACGAATTACAAAACTATCTTGGCGAAATCAGTGGCTTTGCGGCAGTGAGTCTGCAACCGG
CAGCCGGTGCCCAGGGTGAGCTGACCGGTATCCTGGTGTTCCGGGCGTGCCATCTCGACCGTGGCGACACCCAGCGCACC
GAAGTGCTGGTACCCGACTCGGCGCACGGCACCAATCCCGCCACTGCGGCCATGGCCGGCCTGAAGGTCGTTGAAGTGAA
GAGCGACGCACGCGGAAATGTCGATCTTGACGACCTGAAGGCGAAATTGTCGCCGCGCACAGCCGGCATGATGCTCACCA
ACCCGAACACCCTGGGCCTGTTTGAAGAGCACATCGTCGAAATCTGCCGTCTCGTTCATGATGCCGGTGGCCTGATGTAC
GGCGATGGCGCGAACTTCAACGCGATTCTGGGCATTGCCAAACCGGGAGAGCTGGGTTTCGACTTCATGCACTACAACCT
GCACAAGACCTTCACCACCCCGCACGGCGGTGGTGGCCCTGGTTCAGGTGCAGTGGGGTGTACAGCAGAACTGGCCCCCT
ACCTGCCCGGCCCGCGGGTACGGCAGCGGGAAGACGGCGGCTACGAATTCTTCACCCCTGAAAAGAGCATCGGGCGCATG
AAGGCATTCCACGGCAACTTCGGGATGCTGGTACGGGCGTGGACGTATATCCGCTCAATGGGGGCTGCCGGATTGCGAGA
GGTGAGTGAAACTGCGGTCTTGAATGCCAACTACGTGCGGGTGATGCTCAAAGACATCTACCCACAGGCGATTGATCGCA
TTTGCATGCACGAAGTGGTATTGCGTGGACAGATTGCCGGCGCTCCCAAAGATGTCCGCACCCTCGATATTGCCAAGCGG
CTCATTGACTACGGTTTCCACCCGCCGACGATCTACTTCCCGCTGATCGTACCGGAAGCGCTTATGATCGAGCCGACCGA
AACCGAGAGCAAGCAGACGCTCGATCACTTCATTGCCACCATGCGCCGAATCGCCGGCGAAGCCGTCGAAACGCCGGACG
TGCTGCATGCTGCACCAACCAAAGCGCCGGTACGTCGTCTCGACGAAGTACGGGCGGCGCGCCAGCCGATCCTGCGTTAC
GATCCCGCCGCAATTGCACGGTTGCAGGGTGAGTAG

Upstream 100 bases:

>100_bases
CGTGAATGTGTCGATCTGGCGCTCAACATCGCCACCGGTCTGGATACCGTACAGGCACCACCTATCGTAGCGACACCCGA
TACACCTGGAGAGAACAGCG

Downstream 100 bases:

>100_bases
GACGCATCATACTTATCCTTCGCTCTAAACACGTAGCACAGGCCCAGACCTGTGCTACAGCGTTTTGTCCTGTCAAAGTG
CGCACTGTTCCGGGTTTTTG

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNNEEPPIFTYSQPGKIGVNLPAAGVAPTPLPDDLLRQDDLAGFPELTEPEVIRHFTRISQRNYAIDTGFYPLGSCTMKY
NPKLHEEAARLPGFAGAHPLQDEALSQGALQLMYELQNYLGEISGFAAVSLQPAAGAQGELTGILVFRACHLDRGDTQRT
EVLVPDSAHGTNPATAAMAGLKVVEVKSDARGNVDLDDLKAKLSPRTAGMMLTNPNTLGLFEEHIVEICRLVHDAGGLMY
GDGANFNAILGIAKPGELGFDFMHYNLHKTFTTPHGGGGPGSGAVGCTAELAPYLPGPRVRQREDGGYEFFTPEKSIGRM
KAFHGNFGMLVRAWTYIRSMGAAGLREVSETAVLNANYVRVMLKDIYPQAIDRICMHEVVLRGQIAGAPKDVRTLDIAKR
LIDYGFHPPTIYFPLIVPEALMIEPTETESKQTLDHFIATMRRIAGEAVETPDVLHAAPTKAPVRRLDEVRAARQPILRY
DPAAIARLQGE

Sequences:

>Translated_491_residues
MNNEEPPIFTYSQPGKIGVNLPAAGVAPTPLPDDLLRQDDLAGFPELTEPEVIRHFTRISQRNYAIDTGFYPLGSCTMKY
NPKLHEEAARLPGFAGAHPLQDEALSQGALQLMYELQNYLGEISGFAAVSLQPAAGAQGELTGILVFRACHLDRGDTQRT
EVLVPDSAHGTNPATAAMAGLKVVEVKSDARGNVDLDDLKAKLSPRTAGMMLTNPNTLGLFEEHIVEICRLVHDAGGLMY
GDGANFNAILGIAKPGELGFDFMHYNLHKTFTTPHGGGGPGSGAVGCTAELAPYLPGPRVRQREDGGYEFFTPEKSIGRM
KAFHGNFGMLVRAWTYIRSMGAAGLREVSETAVLNANYVRVMLKDIYPQAIDRICMHEVVLRGQIAGAPKDVRTLDIAKR
LIDYGFHPPTIYFPLIVPEALMIEPTETESKQTLDHFIATMRRIAGEAVETPDVLHAAPTKAPVRRLDEVRAARQPILRY
DPAAIARLQGE
>Mature_491_residues
MNNEEPPIFTYSQPGKIGVNLPAAGVAPTPLPDDLLRQDDLAGFPELTEPEVIRHFTRISQRNYAIDTGFYPLGSCTMKY
NPKLHEEAARLPGFAGAHPLQDEALSQGALQLMYELQNYLGEISGFAAVSLQPAAGAQGELTGILVFRACHLDRGDTQRT
EVLVPDSAHGTNPATAAMAGLKVVEVKSDARGNVDLDDLKAKLSPRTAGMMLTNPNTLGLFEEHIVEICRLVHDAGGLMY
GDGANFNAILGIAKPGELGFDFMHYNLHKTFTTPHGGGGPGSGAVGCTAELAPYLPGPRVRQREDGGYEFFTPEKSIGRM
KAFHGNFGMLVRAWTYIRSMGAAGLREVSETAVLNANYVRVMLKDIYPQAIDRICMHEVVLRGQIAGAPKDVRTLDIAKR
LIDYGFHPPTIYFPLIVPEALMIEPTETESKQTLDHFIATMRRIAGEAVETPDVLHAAPTKAPVRRLDEVRAARQPILRY
DPAAIARLQGE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=414, Percent_Identity=40.8212560386473, Blast_Score=269, Evalue=4e-72,
Organism=Escherichia coli, GI1789269, Length=423, Percent_Identity=43.0260047281324, Blast_Score=299, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17535605, Length=407, Percent_Identity=40.5405405405405, Blast_Score=271, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI32564013, Length=364, Percent_Identity=42.032967032967, Blast_Score=247, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6323843, Length=410, Percent_Identity=42.6829268292683, Blast_Score=280, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24645648, Length=411, Percent_Identity=39.9026763990268, Blast_Score=277, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 53459; Mature: 53459

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNEEPPIFTYSQPGKIGVNLPAAGVAPTPLPDDLLRQDDLAGFPELTEPEVIRHFTRIS
CCCCCCCEEEECCCCCEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHH
QRNYAIDTGFYPLGSCTMKYNPKLHEEAARLPGFAGAHPLQDEALSQGALQLMYELQNYL
CCCEEEECCCCCCCCCEEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GEISGFAAVSLQPAAGAQGELTGILVFRACHLDRGDTQRTEVLVPDSAHGTNPATAAMAG
HHHCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCEEECCCCCCCCCHHHHHHHC
LKVVEVKSDARGNVDLDDLKAKLSPRTAGMMLTNPNTLGLFEEHIVEICRLVHDAGGLMY
CEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEEE
GDGANFNAILGIAKPGELGFDFMHYNLHKTFTTPHGGGGPGSGAVGCTAELAPYLPGPRV
CCCCCCEEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCC
RQREDGGYEFFTPEKSIGRMKAFHGNFGMLVRAWTYIRSMGAAGLREVSETAVLNANYVR
CCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHEECCHHHH
VMLKDIYPQAIDRICMHEVVLRGQIAGAPKDVRTLDIAKRLIDYGFHPPTIYFPLIVPEA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHEECCCE
LMIEPTETESKQTLDHFIATMRRIAGEAVETPDVLHAAPTKAPVRRLDEVRAARQPILRY
EEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCHHC
DPAAIARLQGE
CCHHHHHCCCC
>Mature Secondary Structure
MNNEEPPIFTYSQPGKIGVNLPAAGVAPTPLPDDLLRQDDLAGFPELTEPEVIRHFTRIS
CCCCCCCEEEECCCCCEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHH
QRNYAIDTGFYPLGSCTMKYNPKLHEEAARLPGFAGAHPLQDEALSQGALQLMYELQNYL
CCCEEEECCCCCCCCCEEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GEISGFAAVSLQPAAGAQGELTGILVFRACHLDRGDTQRTEVLVPDSAHGTNPATAAMAG
HHHCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCEEECCCCCCCCCHHHHHHHC
LKVVEVKSDARGNVDLDDLKAKLSPRTAGMMLTNPNTLGLFEEHIVEICRLVHDAGGLMY
CEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEEE
GDGANFNAILGIAKPGELGFDFMHYNLHKTFTTPHGGGGPGSGAVGCTAELAPYLPGPRV
CCCCCCEEEEEECCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCC
RQREDGGYEFFTPEKSIGRMKAFHGNFGMLVRAWTYIRSMGAAGLREVSETAVLNANYVR
CCCCCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHEECCHHHH
VMLKDIYPQAIDRICMHEVVLRGQIAGAPKDVRTLDIAKRLIDYGFHPPTIYFPLIVPEA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHEECCCE
LMIEPTETESKQTLDHFIATMRRIAGEAVETPDVLHAAPTKAPVRRLDEVRAARQPILRY
EEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCHHC
DPAAIARLQGE
CCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]