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The map label for this gene is gcvPA [H]

Identifier: 222526991

GI number: 222526991

Start: 4688775

End: 4690109

Strand: Direct

Name: gcvPA [H]

Synonym: Chy400_3769

Alternate gene names: 222526991

Gene position: 4688775-4690109 (Clockwise)

Preceding gene: 222526990

Following gene: 222526992

Centisome position: 88.99

GC content: 59.48

Gene sequence:

>1335_bases
ATGACCCACTACATTCCGATTACCGATGCCGACCGCCAGGCGATGCTACAGGCAATCGGTGTTGAAACAATTGAAGACCT
CTTCGTTGATGTTCCGGCCAGTCATCGCTTTCCGCCGCTCGAACTGCCACCACCGTTGTCGGAGCCGGAGCTGATGGCCG
AACTCAATCGGCTGAGTGAAGCCAATGCCCATAACCGCAAGTACAGTATCTTTCTTGGCGCCGGTGCGTACAACCACTTC
GTACCGGCAGCAGTCGATCAGATTATTCGCCGGGGTGAGTACTACACGGCCTACACCCCCTACCAGCCGGAGATCAGCCA
GGGAACGTTGCAGGCCATCTTTGAATATCAGAGCCTGATCTGTGCCCTGACCGGCATGGAGATTGCGAACGCTTCGCATT
ACGATGGCGCAACCGCACTCGCCGAATCGGCCATTATGGCGCTCAATGTGGTGCGTAACCGGCGCAAAATCGTGGTGGCA
CGTAGCGTCAATCCGCAGTACCGGGCAGTGCTGCGCACCTATATGCAAGGTCTGGATGTCGAGATTGTCGGTGATGAGAA
TCCGGGTGCCACTATCGCCGACGCCCTGGCCCAGGTTGACGATCACACGGCGCTGTTGATCGTGCAGAATCCCGATTTCC
TCGGTCGCATCCACGATCTACGCGGCCTGGGTGCCCAGGTGCAGGCACGAGGTGCCCTGCTCGCCGTGCATTTCGACCCC
ATCGCTCTGGGGCTGTTCCAGACCCCAGCCGAGGCCGGGGCCGATATTGCAACCGGTGAAGGCCAACCCCTGGGTCTCGG
CCTGGCCTTCGGTGGCCCGTACCTCGGTATCTTCACCACACGCCAGAAGTACGTCCACAAGATCGCCGGACGGATTGTTG
GAGTGACGAAAGATGTCGATGGGCGAATGGCCTACGTGCTGACCCTGCGCGCACGCGAGCAAGACATTCGCCGTGAGCGG
GCAACGAGCAATATCTGTACGAATCAGGGTCTGATGGCACTGGCCTCGGCGGTGTACATGTCGCTGATGGGGAAGCGCGG
GATGCGTGCGGTGGCCGAGATTACCTACCATCGGGCACACTACGCTGCGCAGCGGATCAGCGAACTGACCGGTTATCGGG
TACTTGCCGACCAACCCTTCTTCCGCGAGTTCGTGGTGCAATGCCCGCGACCGGTCGCCGAGATCAATGCTGCCCTGCGT
GAACAGGGAATCATTGGCGGCTATGATCTCAGCGCCGATGAACCACATCTGGGCCACGCCATGCTGGTTGCCGTGACCGA
GATGAATACACCGGCAGAGATTGATCGGTTTGTAGCCGCATTGGCTGCCATATAG

Upstream 100 bases:

>100_bases
TGCGCCCCAGTGGCGAATCGGCTGAATTGCTCGATGCCGAGGCGTATGCTGCGTTTGTTGCCGAAATCGATCATTAAACG
TTAGCTAGATGGAAGCTGGT

Downstream 100 bases:

>100_bases
CAGGTCAGGCTTTGGCCTGTGTGCGACTGAGTTGAAGCGTATGGTCACCGACCTGTCACTCCCCCAAATCGAACGCATTG
TCACCCGCATCCTGCCGGGA

Product: glycine dehydrogenase

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTHYIPITDADRQAMLQAIGVETIEDLFVDVPASHRFPPLELPPPLSEPELMAELNRLSEANAHNRKYSIFLGAGAYNHF
VPAAVDQIIRRGEYYTAYTPYQPEISQGTLQAIFEYQSLICALTGMEIANASHYDGATALAESAIMALNVVRNRRKIVVA
RSVNPQYRAVLRTYMQGLDVEIVGDENPGATIADALAQVDDHTALLIVQNPDFLGRIHDLRGLGAQVQARGALLAVHFDP
IALGLFQTPAEAGADIATGEGQPLGLGLAFGGPYLGIFTTRQKYVHKIAGRIVGVTKDVDGRMAYVLTLRAREQDIRRER
ATSNICTNQGLMALASAVYMSLMGKRGMRAVAEITYHRAHYAAQRISELTGYRVLADQPFFREFVVQCPRPVAEINAALR
EQGIIGGYDLSADEPHLGHAMLVAVTEMNTPAEIDRFVAALAAI

Sequences:

>Translated_444_residues
MTHYIPITDADRQAMLQAIGVETIEDLFVDVPASHRFPPLELPPPLSEPELMAELNRLSEANAHNRKYSIFLGAGAYNHF
VPAAVDQIIRRGEYYTAYTPYQPEISQGTLQAIFEYQSLICALTGMEIANASHYDGATALAESAIMALNVVRNRRKIVVA
RSVNPQYRAVLRTYMQGLDVEIVGDENPGATIADALAQVDDHTALLIVQNPDFLGRIHDLRGLGAQVQARGALLAVHFDP
IALGLFQTPAEAGADIATGEGQPLGLGLAFGGPYLGIFTTRQKYVHKIAGRIVGVTKDVDGRMAYVLTLRAREQDIRRER
ATSNICTNQGLMALASAVYMSLMGKRGMRAVAEITYHRAHYAAQRISELTGYRVLADQPFFREFVVQCPRPVAEINAALR
EQGIIGGYDLSADEPHLGHAMLVAVTEMNTPAEIDRFVAALAAI
>Mature_443_residues
THYIPITDADRQAMLQAIGVETIEDLFVDVPASHRFPPLELPPPLSEPELMAELNRLSEANAHNRKYSIFLGAGAYNHFV
PAAVDQIIRRGEYYTAYTPYQPEISQGTLQAIFEYQSLICALTGMEIANASHYDGATALAESAIMALNVVRNRRKIVVAR
SVNPQYRAVLRTYMQGLDVEIVGDENPGATIADALAQVDDHTALLIVQNPDFLGRIHDLRGLGAQVQARGALLAVHFDPI
ALGLFQTPAEAGADIATGEGQPLGLGLAFGGPYLGIFTTRQKYVHKIAGRIVGVTKDVDGRMAYVLTLRAREQDIRRERA
TSNICTNQGLMALASAVYMSLMGKRGMRAVAEITYHRAHYAAQRISELTGYRVLADQPFFREFVVQCPRPVAEINAALRE
QGIIGGYDLSADEPHLGHAMLVAVTEMNTPAEIDRFVAALAAI

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=423, Percent_Identity=34.7517730496454, Blast_Score=219, Evalue=3e-57,
Organism=Escherichia coli, GI1789269, Length=350, Percent_Identity=34, Blast_Score=182, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17535605, Length=363, Percent_Identity=36.6391184573003, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6323843, Length=409, Percent_Identity=31.2958435207824, Blast_Score=206, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24645648, Length=353, Percent_Identity=37.6770538243626, Blast_Score=224, Evalue=8e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 48508; Mature: 48377

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHYIPITDADRQAMLQAIGVETIEDLFVDVPASHRFPPLELPPPLSEPELMAELNRLSE
CCEEECCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ANAHNRKYSIFLGAGAYNHFVPAAVDQIIRRGEYYTAYTPYQPEISQGTLQAIFEYQSLI
CCCCCCEEEEEEECCCHHHCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
CALTGMEIANASHYDGATALAESAIMALNVVRNRRKIVVARSVNPQYRAVLRTYMQGLDV
HHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCE
EIVGDENPGATIADALAQVDDHTALLIVQNPDFLGRIHDLRGLGAQVQARGALLAVHFDP
EEEECCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEECCEEEEEEECC
IALGLFQTPAEAGADIATGEGQPLGLGLAFGGPYLGIFTTRQKYVHKIAGRIVGVTKDVD
HHHHHHCCCHHCCCCEECCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHEEEEEECCC
GRMAYVLTLRAREQDIRRERATSNICTNQGLMALASAVYMSLMGKRGMRAVAEITYHRAH
CCEEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
YAAQRISELTGYRVLADQPFFREFVVQCPRPVAEINAALREQGIIGGYDLSADEPHLGHA
HHHHHHHHHCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
MLVAVTEMNTPAEIDRFVAALAAI
EEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
THYIPITDADRQAMLQAIGVETIEDLFVDVPASHRFPPLELPPPLSEPELMAELNRLSE
CEEECCCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ANAHNRKYSIFLGAGAYNHFVPAAVDQIIRRGEYYTAYTPYQPEISQGTLQAIFEYQSLI
CCCCCCEEEEEEECCCHHHCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
CALTGMEIANASHYDGATALAESAIMALNVVRNRRKIVVARSVNPQYRAVLRTYMQGLDV
HHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCE
EIVGDENPGATIADALAQVDDHTALLIVQNPDFLGRIHDLRGLGAQVQARGALLAVHFDP
EEEECCCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEECCEEEEEEECC
IALGLFQTPAEAGADIATGEGQPLGLGLAFGGPYLGIFTTRQKYVHKIAGRIVGVTKDVD
HHHHHHCCCHHCCCCEECCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHEEEEEECCC
GRMAYVLTLRAREQDIRRERATSNICTNQGLMALASAVYMSLMGKRGMRAVAEITYHRAH
CCEEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
YAAQRISELTGYRVLADQPFFREFVVQCPRPVAEINAALREQGIIGGYDLSADEPHLGHA
HHHHHHHHHCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
MLVAVTEMNTPAEIDRFVAALAAI
EEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA