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The map label for this gene is vraR [H]

Identifier: 222526864

GI number: 222526864

Start: 4528907

End: 4529572

Strand: Reverse

Name: vraR [H]

Synonym: Chy400_3640

Alternate gene names: 222526864

Gene position: 4529572-4528907 (Counterclockwise)

Preceding gene: 222526865

Following gene: 222526863

Centisome position: 85.97

GC content: 53.9

Gene sequence:

>666_bases
ATGGGAGCAACCATCCGCGTCTTGATTGCCGACGACATCTTGCCTTTCGTCAAAGGTCTGAAGGAGATGCTCGCCGAATT
GCCGACGATTGACTTGATCGGGGAGGCGTTTACCTCTACCGAGGCAGTAACGAAAGCCATCTCATTACGCCCGGATGTGA
TCATGATCGATCTGCACTGGAAAGAGGAACGTACCGGTGGCTTAAGTATGCGCCAGCATTACGAACGTGGCCTGGAAGCG
ATCCGGCGCATCAAGCAGCAAGCGCCGGAGGTTGCAGTACTGGCGATGACTGCTCACGCCGAATTGGTTGAGCAGGCCCG
TCGGCATGGAGCGGATGTGGCAGTGATGAAGGAGCAGCTTAACGATTTCGATCAGCTTGAACAACTCTTACACCATGCGA
TTGAGACGGTACGTTCGCCTCAGATTCGGCGTGATGCGTTCGAGCAATTGTCTGTGCGTGAACAGCAGATTCTGGAATTG
ATGGCAAAAGGATTAACCGATCAGGAGATTAGCACCCGGCTGGCCTGGGGCATTGGCGTCATCAAGCGTGACGTGCAGGC
AATCTTCGAGAAACTGCGCGTTCGCAGTCGAGCACACGCCGTTGCCAGAGGGTATGACCTCGGTCTCTTGCAGAAGGATA
GTAGTTTCGATAGCAATGAGTCATAA

Upstream 100 bases:

>100_bases
AAGAACGGGCAAAGCGCATTGGCGCTACTGTCAACATTGGTAATCGTCCAGATGGAGGGGTTATGATTGTTGTGGAAGGT
GTGCTGAAGTAGGAGTTGTT

Downstream 100 bases:

>100_bases
CCATCACGGGTTGCCACATCGTCAGATTCCTCGCGGCGCAGCGGATGCGCCGCTTTTTCTTTGCCCCGAACTGGTAGGAA
CATTGGCATTATCTTGAAGG

Product: LuxR family two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MGATIRVLIADDILPFVKGLKEMLAELPTIDLIGEAFTSTEAVTKAISLRPDVIMIDLHWKEERTGGLSMRQHYERGLEA
IRRIKQQAPEVAVLAMTAHAELVEQARRHGADVAVMKEQLNDFDQLEQLLHHAIETVRSPQIRRDAFEQLSVREQQILEL
MAKGLTDQEISTRLAWGIGVIKRDVQAIFEKLRVRSRAHAVARGYDLGLLQKDSSFDSNES

Sequences:

>Translated_221_residues
MGATIRVLIADDILPFVKGLKEMLAELPTIDLIGEAFTSTEAVTKAISLRPDVIMIDLHWKEERTGGLSMRQHYERGLEA
IRRIKQQAPEVAVLAMTAHAELVEQARRHGADVAVMKEQLNDFDQLEQLLHHAIETVRSPQIRRDAFEQLSVREQQILEL
MAKGLTDQEISTRLAWGIGVIKRDVQAIFEKLRVRSRAHAVARGYDLGLLQKDSSFDSNES
>Mature_220_residues
GATIRVLIADDILPFVKGLKEMLAELPTIDLIGEAFTSTEAVTKAISLRPDVIMIDLHWKEERTGGLSMRQHYERGLEAI
RRIKQQAPEVAVLAMTAHAELVEQARRHGADVAVMKEQLNDFDQLEQLLHHAIETVRSPQIRRDAFEQLSVREQQILELM
AKGLTDQEISTRLAWGIGVIKRDVQAIFEKLRVRSRAHAVARGYDLGLLQKDSSFDSNES

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu3, which leads to vancomycin resistance [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24957; Mature: 24826

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGATIRVLIADDILPFVKGLKEMLAELPTIDLIGEAFTSTEAVTKAISLRPDVIMIDLHW
CCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
KEERTGGLSMRQHYERGLEAIRRIKQQAPEVAVLAMTAHAELVEQARRHGADVAVMKEQL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHH
NDFDQLEQLLHHAIETVRSPQIRRDAFEQLSVREQQILELMAKGLTDQEISTRLAWGIGV
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IKRDVQAIFEKLRVRSRAHAVARGYDLGLLQKDSSFDSNES
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GATIRVLIADDILPFVKGLKEMLAELPTIDLIGEAFTSTEAVTKAISLRPDVIMIDLHW
CCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
KEERTGGLSMRQHYERGLEAIRRIKQQAPEVAVLAMTAHAELVEQARRHGADVAVMKEQL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCHHHHHHHHH
NDFDQLEQLLHHAIETVRSPQIRRDAFEQLSVREQQILELMAKGLTDQEISTRLAWGIGV
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IKRDVQAIFEKLRVRSRAHAVARGYDLGLLQKDSSFDSNES
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]