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The map label for this gene is adh [H]

Identifier: 222526660

GI number: 222526660

Start: 4272371

End: 4273414

Strand: Direct

Name: adh [H]

Synonym: Chy400_3429

Alternate gene names: 222526660

Gene position: 4272371-4273414 (Clockwise)

Preceding gene: 222526659

Following gene: 222526664

Centisome position: 81.09

GC content: 55.17

Gene sequence:

>1044_bases
ATGCGTGCTGCCCGTCTCCACGAGTACGATGAACATCTTAATGTCCAACTGCAACTCGAAGACGTGCCATTGCCGAAGAT
CACCAAACCCGGTGACGTTATCGTTCGCATCGGTGCAGCCGGCCTGTGTCGTACCGATCTGCACATCATCGAAGGGGTTT
GGAAAGATATTCAAGACCCCCAACGCACGCTGCTCCCCTACATCCTCGGCCACGAGAACGCAGGTTGGGTCGAAGAGGTT
GGGCCTGGCGTGACCTCAGTCAAGGTCGGTGATCCAGTTATTTGCCATCCGTTACGCTCGTGTGGCGTCTGCCTTGGTTG
TCGGCGCGGTGAGGACATGTACTGCGAGCACGGTAGTTTCCCCGGTCTCAACTGTGATGGTGGGTTCGCCGAGTACATGC
TCACCAACGAACGGGCGTTGATTAAGCTCAATCCCAACGTGGCTCCGGTTGATGTTGCACCCCTGGCCGATGCGGGCATT
ACCGCCTATCGGGTAGCCAAAAAGGCTGCCCGGAAATTAAATCCCGGCCAGTACTGTGTTATTCTCGGTGTTGGTGGATT
GGGACATATTGCACTGCAATCGGTACGCGAATTGTGCGGGGCACGCATTATCGCCATTGATCGTTCAGAGGCGGCTCGTC
AGTTAGCTCGTAATTTGGGGGCGCACTACGTGCTCGATGGCAGTGATACCATTGTGCAAGAGGTGAAGGAGCTAACGCAC
GGTGGCGCTCACGTGGTGATTGACTTCGTCGGTGAACTGGGTGCTGAACAGGTCTCGTGGCAAATGCTGCGACAGGGCGG
AACCCATTTTGTGGTTGGCTATGGTGGGGCGGTTCACGTGCCAACCGTGCACATGATCATTACCGAAATAGCCATTGAAG
GTAGCTTGGTCGGTAACTACGTCGAGCTGGTTGAACTGATGGAACTGAATGCCGAAGGTCGGGTTAAGCTTCACGGTCAG
CAATACCGGCTTGATCAGATCAACCAGGCGATTGACGATTTCAAGAACCGACGAATTGCCGGTAGAGCGGTGATTGTGCC
CTAG

Upstream 100 bases:

>100_bases
CTTTGTGAAGGACTGTTGCGTACACAGTTCTTTCCTGAACGTCAGTACGACTATTCCAGTGTGGGTGATCGCCTGATGAT
TGGATAGAGAGGACAAACCT

Downstream 100 bases:

>100_bases
GCGATAGGCTGAACCGTTGTCATTGGGATAATCGGGCACGTCACATTACCGGGCAGGTAGAGGCATGGCCTTGTCTGCCC
GGTAATGTTGACCCGGATGA

Product: alcohol dehydrogenase GroES domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRAARLHEYDEHLNVQLQLEDVPLPKITKPGDVIVRIGAAGLCRTDLHIIEGVWKDIQDPQRTLLPYILGHENAGWVEEV
GPGVTSVKVGDPVICHPLRSCGVCLGCRRGEDMYCEHGSFPGLNCDGGFAEYMLTNERALIKLNPNVAPVDVAPLADAGI
TAYRVAKKAARKLNPGQYCVILGVGGLGHIALQSVRELCGARIIAIDRSEAARQLARNLGAHYVLDGSDTIVQEVKELTH
GGAHVVIDFVGELGAEQVSWQMLRQGGTHFVVGYGGAVHVPTVHMIITEIAIEGSLVGNYVELVELMELNAEGRVKLHGQ
QYRLDQINQAIDDFKNRRIAGRAVIVP

Sequences:

>Translated_347_residues
MRAARLHEYDEHLNVQLQLEDVPLPKITKPGDVIVRIGAAGLCRTDLHIIEGVWKDIQDPQRTLLPYILGHENAGWVEEV
GPGVTSVKVGDPVICHPLRSCGVCLGCRRGEDMYCEHGSFPGLNCDGGFAEYMLTNERALIKLNPNVAPVDVAPLADAGI
TAYRVAKKAARKLNPGQYCVILGVGGLGHIALQSVRELCGARIIAIDRSEAARQLARNLGAHYVLDGSDTIVQEVKELTH
GGAHVVIDFVGELGAEQVSWQMLRQGGTHFVVGYGGAVHVPTVHMIITEIAIEGSLVGNYVELVELMELNAEGRVKLHGQ
QYRLDQINQAIDDFKNRRIAGRAVIVP
>Mature_347_residues
MRAARLHEYDEHLNVQLQLEDVPLPKITKPGDVIVRIGAAGLCRTDLHIIEGVWKDIQDPQRTLLPYILGHENAGWVEEV
GPGVTSVKVGDPVICHPLRSCGVCLGCRRGEDMYCEHGSFPGLNCDGGFAEYMLTNERALIKLNPNVAPVDVAPLADAGI
TAYRVAKKAARKLNPGQYCVILGVGGLGHIALQSVRELCGARIIAIDRSEAARQLARNLGAHYVLDGSDTIVQEVKELTH
GGAHVVIDFVGELGAEQVSWQMLRQGGTHFVVGYGGAVHVPTVHMIITEIAIEGSLVGNYVELVELMELNAEGRVKLHGQ
QYRLDQINQAIDDFKNRRIAGRAVIVP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=363, Percent_Identity=28.6501377410468, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4501929, Length=301, Percent_Identity=31.5614617940199, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI34577061, Length=354, Percent_Identity=29.3785310734463, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI71743840, Length=361, Percent_Identity=26.3157894736842, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI262073058, Length=361, Percent_Identity=26.3157894736842, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI156523966, Length=343, Percent_Identity=26.8221574344023, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4501939, Length=343, Percent_Identity=26.8221574344023, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI71565154, Length=289, Percent_Identity=28.3737024221453, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI71565152, Length=343, Percent_Identity=27.4052478134111, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI156627571, Length=338, Percent_Identity=25.7396449704142, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI87081918, Length=349, Percent_Identity=30.0859598853868, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786518, Length=335, Percent_Identity=29.8507462686567, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082125, Length=271, Percent_Identity=29.520295202952, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1788407, Length=219, Percent_Identity=29.6803652968037, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082401, Length=325, Percent_Identity=27.0769230769231, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI226510992, Length=298, Percent_Identity=27.5167785234899, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788073, Length=261, Percent_Identity=29.5019157088123, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787863, Length=219, Percent_Identity=30.1369863013699, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786552, Length=337, Percent_Identity=28.486646884273, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788075, Length=274, Percent_Identity=30.2919708029197, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790045, Length=205, Percent_Identity=28.2926829268293, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786825, Length=317, Percent_Identity=28.0757097791798, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790718, Length=271, Percent_Identity=25.830258302583, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=334, Percent_Identity=28.4431137724551, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17562582, Length=339, Percent_Identity=29.4985250737463, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71988145, Length=333, Percent_Identity=26.7267267267267, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562876, Length=330, Percent_Identity=26.969696969697, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562878, Length=339, Percent_Identity=26.8436578171091, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=341, Percent_Identity=23.7536656891496, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=337, Percent_Identity=23.4421364985163, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=267, Percent_Identity=25.0936329588015, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17544682, Length=356, Percent_Identity=25, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=338, Percent_Identity=31.9526627218935, Blast_Score=146, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6323729, Length=336, Percent_Identity=30.3571428571429, Blast_Score=145, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6319621, Length=336, Percent_Identity=31.8452380952381, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6324486, Length=343, Percent_Identity=31.1953352769679, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319258, Length=334, Percent_Identity=28.4431137724551, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=25.6064690026954, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=335, Percent_Identity=26.2686567164179, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=335, Percent_Identity=26.2686567164179, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=313, Percent_Identity=27.4760383386581, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=324, Percent_Identity=27.1604938271605, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323980, Length=326, Percent_Identity=25.7668711656442, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319949, Length=211, Percent_Identity=29.8578199052133, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737895, Length=352, Percent_Identity=26.7045454545455, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17737897, Length=345, Percent_Identity=28.4057971014493, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17137530, Length=331, Percent_Identity=26.5861027190332, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37726; Mature: 37726

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAARLHEYDEHLNVQLQLEDVPLPKITKPGDVIVRIGAAGLCRTDLHIIEGVWKDIQDP
CCCCCCCCHHCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCH
QRTLLPYILGHENAGWVEEVGPGVTSVKVGDPVICHPLRSCGVCLGCRRGEDMYCEHGSF
HHHHHHHHCCCCCCCCHHHHCCCCEEEECCCCCEEHHHHHCCEEEECCCCCCCCCCCCCC
PGLNCDGGFAEYMLTNERALIKLNPNVAPVDVAPLADAGITAYRVAKKAARKLNPGQYCV
CCCCCCCCCEEEEEECCEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCEEE
ILGVGGLGHIALQSVRELCGARIIAIDRSEAARQLARNLGAHYVLDGSDTIVQEVKELTH
EEECCCHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHC
GGAHVVIDFVGELGAEQVSWQMLRQGGTHFVVGYGGAVHVPTVHMIITEIAIEGSLVGNY
CCCEEEEEEHHHCCHHHHHHHHHHCCCCEEEEEECCEEECCHHHHHHHHHHHCCCHHHHH
VELVELMELNAEGRVKLHGQQYRLDQINQAIDDFKNRRIAGRAVIVP
HHHHHHHHCCCCCEEEECCCEECHHHHHHHHHHHHCCEECCEEEECC
>Mature Secondary Structure
MRAARLHEYDEHLNVQLQLEDVPLPKITKPGDVIVRIGAAGLCRTDLHIIEGVWKDIQDP
CCCCCCCCHHCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCH
QRTLLPYILGHENAGWVEEVGPGVTSVKVGDPVICHPLRSCGVCLGCRRGEDMYCEHGSF
HHHHHHHHCCCCCCCCHHHHCCCCEEEECCCCCEEHHHHHCCEEEECCCCCCCCCCCCCC
PGLNCDGGFAEYMLTNERALIKLNPNVAPVDVAPLADAGITAYRVAKKAARKLNPGQYCV
CCCCCCCCCEEEEEECCEEEEEECCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCEEE
ILGVGGLGHIALQSVRELCGARIIAIDRSEAARQLARNLGAHYVLDGSDTIVQEVKELTH
EEECCCHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHC
GGAHVVIDFVGELGAEQVSWQMLRQGGTHFVVGYGGAVHVPTVHMIITEIAIEGSLVGNY
CCCEEEEEEHHHCCHHHHHHHHHHCCCCEEEEEECCEEECCHHHHHHHHHHHCCCHHHHH
VELVELMELNAEGRVKLHGQQYRLDQINQAIDDFKNRRIAGRAVIVP
HHHHHHHHCCCCCEEEECCCEECHHHHHHHHHHHHCCEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]