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The map label for this gene is pbp [H]

Identifier: 222526632

GI number: 222526632

Start: 4229017

End: 4230066

Strand: Direct

Name: pbp [H]

Synonym: Chy400_3400

Alternate gene names: 222526632

Gene position: 4229017-4230066 (Clockwise)

Preceding gene: 222526631

Following gene: 222526634

Centisome position: 80.26

GC content: 54.76

Gene sequence:

>1050_bases
ATGAACCTGCGCGCCCATCTGGAACAACTGCGAACCGAAATGAACGTACCCGCCCTCGCTGCCTTTGTTGTCAGCCATGA
GTCCACCCTCGCTGCGGATGTGGTTGGGTTGCGCCACGCTGATCACCCAAACGACCCGCTTACCCTGGTAGATTACTTCC
AAATCGGCTCCAACGCCAAAGCGTTTATCGCCACTACCTGCGCTGCATTGGTCGAAAAAGGGCTTATCACGTGGAATACT
CCCGTCGCCAGCCTGTTTCCCGAACTGTCAGGGGCAATCCTTCCCCCTTACCGCACCATCACGCTGCGACATCTGTTGCA
ACATCGTTCCGGTTTGCCCGCTTACACCGACACAGACAGCCCCGATTTCATCCTGCCCGATTTCGATAACGTACCTGATA
GCGCACACGTTAATCACTTTGCGATCTGGCTGATGCAAACCTGCCCGCCACGCGATCCGCCAGGCAGTCAATTCACCTAT
TCCAATGCCGGTTACAGCCTGGCGGCTGCCATACTGGAACGCGCAGCCGAAAGCCCATGGAATCTTCTCTTGGACAATCT
TGTGCTCAGGCCGCTCAACATCCAGGCGTATCCTGGCATACAACATCCAGCGCGCATAAATGCAGCGCAACCCTGGGGTC
ATTGGTTTGAAAACGGCATATATCACCCCTGCGCTGTCGATCAAGAGATTGTTCCACCTTGTTTTGCACCTGCTGGGGAT
ATGTGCATCTCCCTGCCAGACTATGCCCGCTTTTTGCAATTCCACCTGAAGGGGCTGCAAGGCAAAGACGATCTTCTGCC
TGCTGCGCTTATCCAGACTCTTCACAACGACGGAGCATTGGGACAGGGCATGGGCTGGGGAATCAATGCGCTGCGCGGCA
TGGAGTCGCTTGGGCGCTGGAGCCTGCACGCCGGTTCAACCGGCACATTTTATGCTATTGCTGCCCTCTCACATGACTAT
AACCTGGGCTTTGCTTTATTCACAAATGCTGGTGTGCCTGAGTTAACCTTTGCGCTCAAAAGCCTGATTTCCAATTGGTT
TCGCCTGTAA

Upstream 100 bases:

>100_bases
TTGCGTAGTGGGGCGCTCAACGGTAGAAAGGGTGTCGTCCGCTATCACCCTGCGTTCAATGGAGTTGAATAATCACTATT
GGTAGGATGTAATTGAAACT

Downstream 100 bases:

>100_bases
ATATCTCTATCAGACGCGCTCCTTCACGCCTTACGGTAGTAACTCAGGTTATGCCCATCCTCTGTGTCCTCTGTGTCTCT
GCGGTGATAAAGGTAGCGAC

Product: beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: PBP-4 [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MNLRAHLEQLRTEMNVPALAAFVVSHESTLAADVVGLRHADHPNDPLTLVDYFQIGSNAKAFIATTCAALVEKGLITWNT
PVASLFPELSGAILPPYRTITLRHLLQHRSGLPAYTDTDSPDFILPDFDNVPDSAHVNHFAIWLMQTCPPRDPPGSQFTY
SNAGYSLAAAILERAAESPWNLLLDNLVLRPLNIQAYPGIQHPARINAAQPWGHWFENGIYHPCAVDQEIVPPCFAPAGD
MCISLPDYARFLQFHLKGLQGKDDLLPAALIQTLHNDGALGQGMGWGINALRGMESLGRWSLHAGSTGTFYAIAALSHDY
NLGFALFTNAGVPELTFALKSLISNWFRL

Sequences:

>Translated_349_residues
MNLRAHLEQLRTEMNVPALAAFVVSHESTLAADVVGLRHADHPNDPLTLVDYFQIGSNAKAFIATTCAALVEKGLITWNT
PVASLFPELSGAILPPYRTITLRHLLQHRSGLPAYTDTDSPDFILPDFDNVPDSAHVNHFAIWLMQTCPPRDPPGSQFTY
SNAGYSLAAAILERAAESPWNLLLDNLVLRPLNIQAYPGIQHPARINAAQPWGHWFENGIYHPCAVDQEIVPPCFAPAGD
MCISLPDYARFLQFHLKGLQGKDDLLPAALIQTLHNDGALGQGMGWGINALRGMESLGRWSLHAGSTGTFYAIAALSHDY
NLGFALFTNAGVPELTFALKSLISNWFRL
>Mature_349_residues
MNLRAHLEQLRTEMNVPALAAFVVSHESTLAADVVGLRHADHPNDPLTLVDYFQIGSNAKAFIATTCAALVEKGLITWNT
PVASLFPELSGAILPPYRTITLRHLLQHRSGLPAYTDTDSPDFILPDFDNVPDSAHVNHFAIWLMQTCPPRDPPGSQFTY
SNAGYSLAAAILERAAESPWNLLLDNLVLRPLNIQAYPGIQHPARINAAQPWGHWFENGIYHPCAVDQEIVPPCFAPAGD
MCISLPDYARFLQFHLKGLQGKDDLLPAALIQTLHNDGALGQGMGWGINALRGMESLGRWSLHAGSTGTFYAIAALSHDY
NLGFALFTNAGVPELTFALKSLISNWFRL

Specific function: Involved in cell wall biosynthesis and may also act as a sensor of external penicillins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 38237; Mature: 38237

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRAHLEQLRTEMNVPALAAFVVSHESTLAADVVGLRHADHPNDPLTLVDYFQIGSNAK
CCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCH
AFIATTCAALVEKGLITWNTPVASLFPELSGAILPPYRTITLRHLLQHRSGLPAYTDTDS
HHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
PDFILPDFDNVPDSAHVNHFAIWLMQTCPPRDPPGSQFTYSNAGYSLAAAILERAAESPW
CCEECCCCCCCCCCCCCCHHEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCH
NLLLDNLVLRPLNIQAYPGIQHPARINAAQPWGHWFENGIYHPCAVDQEIVPPCFAPAGD
HHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
MCISLPDYARFLQFHLKGLQGKDDLLPAALIQTLHNDGALGQGMGWGINALRGMESLGRW
EEEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCE
SLHAGSTGTFYAIAALSHDYNLGFALFTNAGVPELTFALKSLISNWFRL
EECCCCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLRAHLEQLRTEMNVPALAAFVVSHESTLAADVVGLRHADHPNDPLTLVDYFQIGSNAK
CCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCH
AFIATTCAALVEKGLITWNTPVASLFPELSGAILPPYRTITLRHLLQHRSGLPAYTDTDS
HHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
PDFILPDFDNVPDSAHVNHFAIWLMQTCPPRDPPGSQFTYSNAGYSLAAAILERAAESPW
CCEECCCCCCCCCCCCCCHHEEEEECCCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCH
NLLLDNLVLRPLNIQAYPGIQHPARINAAQPWGHWFENGIYHPCAVDQEIVPPCFAPAGD
HHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
MCISLPDYARFLQFHLKGLQGKDDLLPAALIQTLHNDGALGQGMGWGINALRGMESLGRW
EEEECHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCE
SLHAGSTGTFYAIAALSHDYNLGFALFTNAGVPELTFALKSLISNWFRL
EECCCCCCCEEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]