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The map label for this gene is relA [H]

Identifier: 222526573

GI number: 222526573

Start: 4163523

End: 4164074

Strand: Reverse

Name: relA [H]

Synonym: Chy400_3341

Alternate gene names: 222526573

Gene position: 4164074-4163523 (Counterclockwise)

Preceding gene: 222526574

Following gene: 222526572

Centisome position: 79.03

GC content: 58.33

Gene sequence:

>552_bases
ATGCAAACACCTGATCTGGTACAGGCTGCACTCTTCTTTGCTGCCCAGGCTCACAATGGCCAGGTGCGCCCTGGCAGTAC
CTGGCCGTACCTCGTGCATCTATGCGACGTTGCCCTGGAAGTGGCGACAACGCTGATGATTGAGCCAGGGCACGACACAA
CGCTGGCGCTTTGTTGTGCGCTTTTGCACGATGTGCTTGAGGATACTGATACTGACGAGGCGCAGTTGTCTCAGCTCTTC
GGTTCGGCAATCACGGCAGGAGTGCGGGCGCTTACAAAAGACCTGACTCTCCCCCAGGCCGAACGGATGGCCGACAGCCT
GCGCCGTATCAAGCAACAACCGCACGAAGTCTGGCTGGTGAAGCTGGCCGACCGGATCAGTAATCTATCAACACCACCTC
CTGACCATTGGTCGGCGGAACGGATCGCTGCGTATCGTGCTGAAGCTGAACTCATTCTCGCCGCCCTCGGTTCGGCCAGT
CCACATCTGGCTGCACGACTCCGAAACAGGATTGAACAGTATGGAGCATCCTCCCCAATGCCGGGACGGTGA

Upstream 100 bases:

>100_bases
CGTTGCGCGATATTACGAAGGAGCGTGACGCACAACCGGTTGACCAGGCTCCGTAGCCATGGTAGTGCGTCACGTGACAT
CTGGCCTGATCTGAACCGGT

Downstream 100 bases:

>100_bases
GAGCCATACAGTTGGAAAGGATGTCGTATGCGGATTGCTGTAGGGAGTGATGAACGGACTTACATGACCGATGCGCTTAT
CACCGAACTCAAACAGCGTG

Product: metal dependent phosphohydrolase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MQTPDLVQAALFFAAQAHNGQVRPGSTWPYLVHLCDVALEVATTLMIEPGHDTTLALCCALLHDVLEDTDTDEAQLSQLF
GSAITAGVRALTKDLTLPQAERMADSLRRIKQQPHEVWLVKLADRISNLSTPPPDHWSAERIAAYRAEAELILAALGSAS
PHLAARLRNRIEQYGASSPMPGR

Sequences:

>Translated_183_residues
MQTPDLVQAALFFAAQAHNGQVRPGSTWPYLVHLCDVALEVATTLMIEPGHDTTLALCCALLHDVLEDTDTDEAQLSQLF
GSAITAGVRALTKDLTLPQAERMADSLRRIKQQPHEVWLVKLADRISNLSTPPPDHWSAERIAAYRAEAELILAALGSAS
PHLAARLRNRIEQYGASSPMPGR
>Mature_183_residues
MQTPDLVQAALFFAAQAHNGQVRPGSTWPYLVHLCDVALEVATTLMIEPGHDTTLALCCALLHDVLEDTDTDEAQLSQLF
GSAITAGVRALTKDLTLPQAERMADSLRRIKQQPHEVWLVKLADRISNLSTPPPDHWSAERIAAYRAEAELILAALGSAS
PHLAARLRNRIEQYGASSPMPGR

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI25143118, Length=175, Percent_Identity=29.1428571428571, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650996, Length=171, Percent_Identity=31.5789473684211, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 19967; Mature: 19967

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPDLVQAALFFAAQAHNGQVRPGSTWPYLVHLCDVALEVATTLMIEPGHDTTLALCCA
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LLHDVLEDTDTDEAQLSQLFGSAITAGVRALTKDLTLPQAERMADSLRRIKQQPHEVWLV
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHH
KLADRISNLSTPPPDHWSAERIAAYRAEAELILAALGSASPHLAARLRNRIEQYGASSPM
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
PGR
CCC
>Mature Secondary Structure
MQTPDLVQAALFFAAQAHNGQVRPGSTWPYLVHLCDVALEVATTLMIEPGHDTTLALCCA
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LLHDVLEDTDTDEAQLSQLFGSAITAGVRALTKDLTLPQAERMADSLRRIKQQPHEVWLV
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHH
KLADRISNLSTPPPDHWSAERIAAYRAEAELILAALGSASPHLAARLRNRIEQYGASSPM
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
PGR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA