BacMap

Definition	Chloroflexus sp. Y-400-fl chromosome, complete genome.
Accession	NC_012032
Length	5,268,950

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The map label for this gene is fabG [C]

Identifier: 222526571

GI number: 222526571

Start: 4162052

End: 4162915

Strand: Reverse

Name: fabG [C]

Synonym: Chy400_3339

Alternate gene names: 222526571

Gene position: 4162915-4162052 (Counterclockwise)

Preceding gene: 222526572

Following gene: 222526570

Centisome position: 79.01

GC content: 56.94

Gene sequence:

>864_bases
ATGGAGCAGATAATGCAAGGCAAGACGGTGATTGTCACCGGTGCTAATTCGGGTATTGGTTACGTTACGGCACGCGAGCT
TGCCGCGATGGGAGCGCGCGTGATCATGGTTTGCCGTTCGCAGAGCAAGGGTGAAGCGGCCCGGCAACGGATCATGCAAG
AAGCTAAAGGAGCACCAGAACCAGAGCTAGTACTGGCCGATTTTGCCTCACTGGCATCAGTACGCCGTGCTGCCGGTGAC
ATTCTGGAGCGCTGCCCACGGATCGATGTCCTGGTTAACAATGCCGGTCTGTTTGTATCAGAACCCCTGGCCAGCGCCGA
CGGTTACGAAATGACCTTTGCCGTTAATCATCTGGCACCCTTCCTGCTCACCAACCTGTTGCTCGAACGGATTATCGCCA
GTGCGCCGGCCCGTATTATCAACGTTTCTTCTTTCGCGCATGTCGCCGGCAGAATCGCAATCCCACAGATCGCTTCTCCC
CAGCGCCCCAACATTGCCCAGGCTTACAGTGACTCCAAGCTGTGCAACATTCTGTTCACAAACGAACTGGCCCGTCGCTT
GCAGGGCAGTGGGGTGACTGCAAACAGCCTGCACCCCGGCGCAGTCGCTACCAATTTTGCCGCCGACTCCCGTGGCCTGT
TTGCCTTCTTCTTCCGCCTTGCTCGCCCCTTCATGCTCTCGCCGGAACATGGAGCAGCGACCTCGATTTACCTGGCTTCA
TCACCAGAAGTTGCTGAGATCAGTGGGCAGTATTTTGTGCGCAAGAAGCCTGTCAAACCATCAGCCGCAGCGCAAGGTGC
AGCCCTGGCGAAGAGGTTATGGGAGTTTAGCGAACAACTGGTGCGCGAGAAGGTAGCAGCCTGA

Upstream 100 bases:

>100_bases
AGTAGCGCCTGTACCTGTGGTATAGTACAAAAGGATGTACGTGACACGAGAAGACCCCGGTTGATGTACCGGGGTTTTTG
TATGAATGAGGCAAGTAACG

Downstream 100 bases:

>100_bases
TGGGATCGCATTAGACCGCACGATATTGCGCAGATTACCAGATCGCGGCAATAGCGCACAGAATAACGGGTGGGTGAAGG
ATTGCCTTCACTCATACGAA

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MEQIMQGKTVIVTGANSGIGYVTARELAAMGARVIMVCRSQSKGEAARQRIMQEAKGAPEPELVLADFASLASVRRAAGD
ILERCPRIDVLVNNAGLFVSEPLASADGYEMTFAVNHLAPFLLTNLLLERIIASAPARIINVSSFAHVAGRIAIPQIASP
QRPNIAQAYSDSKLCNILFTNELARRLQGSGVTANSLHPGAVATNFAADSRGLFAFFFRLARPFMLSPEHGAATSIYLAS
SPEVAEISGQYFVRKKPVKPSAAAQGAALAKRLWEFSEQLVREKVAA

Sequences:

>Translated_287_residues
MEQIMQGKTVIVTGANSGIGYVTARELAAMGARVIMVCRSQSKGEAARQRIMQEAKGAPEPELVLADFASLASVRRAAGD
ILERCPRIDVLVNNAGLFVSEPLASADGYEMTFAVNHLAPFLLTNLLLERIIASAPARIINVSSFAHVAGRIAIPQIASP
QRPNIAQAYSDSKLCNILFTNELARRLQGSGVTANSLHPGAVATNFAADSRGLFAFFFRLARPFMLSPEHGAATSIYLAS
SPEVAEISGQYFVRKKPVKPSAAAQGAALAKRLWEFSEQLVREKVAA
>Mature_287_residues
MEQIMQGKTVIVTGANSGIGYVTARELAAMGARVIMVCRSQSKGEAARQRIMQEAKGAPEPELVLADFASLASVRRAAGD
ILERCPRIDVLVNNAGLFVSEPLASADGYEMTFAVNHLAPFLLTNLLLERIIASAPARIINVSSFAHVAGRIAIPQIASP
QRPNIAQAYSDSKLCNILFTNELARRLQGSGVTANSLHPGAVATNFAADSRGLFAFFFRLARPFMLSPEHGAATSIYLAS
SPEVAEISGQYFVRKKPVKPSAAAQGAALAKRLWEFSEQLVREKVAA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI10190746, Length=293, Percent_Identity=46.7576791808874, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI225579078, Length=282, Percent_Identity=47.5177304964539, Blast_Score=204, Evalue=7e-53,
Organism=Homo sapiens, GI7706523, Length=289, Percent_Identity=40.4844290657439, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI166795268, Length=275, Percent_Identity=42.9090909090909, Blast_Score=192, Evalue=3e-49,
Organism=Homo sapiens, GI186928839, Length=277, Percent_Identity=42.5992779783394, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI146231950, Length=285, Percent_Identity=40.3508771929825, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI19923931, Length=222, Percent_Identity=47.2972972972973, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI193804850, Length=284, Percent_Identity=33.8028169014084, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI150247226, Length=256, Percent_Identity=29.296875, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7706318, Length=205, Percent_Identity=28.2926829268293, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI7705925, Length=210, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI20149619, Length=215, Percent_Identity=24.6511627906977, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=204, Percent_Identity=29.9019607843137, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786701, Length=212, Percent_Identity=29.7169811320755, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790717, Length=203, Percent_Identity=26.6009852216749, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI87082160, Length=211, Percent_Identity=28.436018957346, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17558006, Length=285, Percent_Identity=36.140350877193, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17532791, Length=291, Percent_Identity=35.0515463917526, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI193207620, Length=290, Percent_Identity=34.8275862068965, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17532805, Length=293, Percent_Identity=34.4709897610922, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71992402, Length=289, Percent_Identity=32.1799307958478, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17535059, Length=286, Percent_Identity=30.7692307692308, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI72001364, Length=299, Percent_Identity=31.1036789297659, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32565532, Length=227, Percent_Identity=31.7180616740088, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17505416, Length=314, Percent_Identity=28.343949044586, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI115533174, Length=288, Percent_Identity=29.8611111111111, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI115533172, Length=288, Percent_Identity=29.8611111111111, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=31.5789473684211, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=204, Percent_Identity=31.8627450980392, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=204, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=204, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=207, Percent_Identity=30.9178743961353, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=204, Percent_Identity=30.8823529411765, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=207, Percent_Identity=29.951690821256, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=209, Percent_Identity=29.6650717703349, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=265, Percent_Identity=27.5471698113208, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=213, Percent_Identity=27.2300469483568, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=209, Percent_Identity=30.622009569378, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=229, Percent_Identity=29.2576419213974, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=209, Percent_Identity=31.1004784688995, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=27.0676691729323, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=221, Percent_Identity=28.5067873303167, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324820, Length=313, Percent_Identity=29.073482428115, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI22024069, Length=280, Percent_Identity=43.9285714285714, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24586328, Length=282, Percent_Identity=42.5531914893617, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24647946, Length=283, Percent_Identity=40.2826855123675, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI45553409, Length=283, Percent_Identity=39.9293286219081, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24647948, Length=283, Percent_Identity=39.9293286219081, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI19921754, Length=289, Percent_Identity=41.1764705882353, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI20129347, Length=288, Percent_Identity=38.5416666666667, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI28573296, Length=283, Percent_Identity=38.86925795053, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI161076371, Length=284, Percent_Identity=40.1408450704225, Blast_Score=173, Evalue=9e-44,
Organism=Drosophila melanogaster, GI45554248, Length=281, Percent_Identity=40.5693950177936, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24640117, Length=281, Percent_Identity=40.5693950177936, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24647931, Length=296, Percent_Identity=34.4594594594595, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24656154, Length=282, Percent_Identity=34.7517730496454, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI19922628, Length=282, Percent_Identity=34.7517730496454, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI28571526, Length=203, Percent_Identity=32.0197044334975, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644339, Length=207, Percent_Identity=31.8840579710145, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24643142, Length=212, Percent_Identity=32.0754716981132, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21358495, Length=209, Percent_Identity=27.7511961722488, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21357041, Length=204, Percent_Identity=33.8235294117647, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI23397609, Length=205, Percent_Identity=33.6585365853659, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30739; Mature: 30739

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQIMQGKTVIVTGANSGIGYVTARELAAMGARVIMVCRSQSKGEAARQRIMQEAKGAPE
CCCHHCCCEEEEECCCCCCCHHHHHHHHHHCHHEEEEECCCCCCHHHHHHHHHHHCCCCC
PELVLADFASLASVRRAAGDILERCPRIDVLVNNAGLFVSEPLASADGYEMTFAVNHLAP
CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCEEEEEHHHHHH
FLLTNLLLERIIASAPARIINVSSFAHVAGRIAIPQIASPQRPNIAQAYSDSKLCNILFT
HHHHHHHHHHHHHHCCHHEEEHHHHHHHHHCEECCCCCCCCCCCHHHHHCCCHHHHHHHH
NELARRLQGSGVTANSLHPGAVATNFAADSRGLFAFFFRLARPFMLSPEHGAATSIYLAS
HHHHHHHCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHCCCCEECCCCCCCEEEEEEC
SPEVAEISGQYFVRKKPVKPSAAAQGAALAKRLWEFSEQLVREKVAA
CCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEQIMQGKTVIVTGANSGIGYVTARELAAMGARVIMVCRSQSKGEAARQRIMQEAKGAPE
CCCHHCCCEEEEECCCCCCCHHHHHHHHHHCHHEEEEECCCCCCHHHHHHHHHHHCCCCC
PELVLADFASLASVRRAAGDILERCPRIDVLVNNAGLFVSEPLASADGYEMTFAVNHLAP
CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEECCCCCCCCCEEEEEHHHHHH
FLLTNLLLERIIASAPARIINVSSFAHVAGRIAIPQIASPQRPNIAQAYSDSKLCNILFT
HHHHHHHHHHHHHHCCHHEEEHHHHHHHHHCEECCCCCCCCCCCHHHHHCCCHHHHHHHH
NELARRLQGSGVTANSLHPGAVATNFAADSRGLFAFFFRLARPFMLSPEHGAATSIYLAS
HHHHHHHCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHCCCCEECCCCCCCEEEEEEC
SPEVAEISGQYFVRKKPVKPSAAAQGAALAKRLWEFSEQLVREKVAA
CCCHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]