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The map label for this gene is mmuM [H]

Identifier: 222526567

GI number: 222526567

Start: 4157239

End: 4158198

Strand: Direct

Name: mmuM [H]

Synonym: Chy400_3335

Alternate gene names: 222526567

Gene position: 4157239-4158198 (Clockwise)

Preceding gene: 222526566

Following gene: 222526568

Centisome position: 78.9

GC content: 56.88

Gene sequence:

>960_bases
ATGAGTTCGCCAAATCCGATAACTGCTGCACTTGCCCAACGCCCACTTCTAATCCTCGACGGGGCATTGGCTACGGAGCT
GGAGCGGCGTGGTTGCGATCTCGCCGATCCGCTCTGGTCGGCGAAGGTGTTGATCGAAAATCCATCGTTGATCCAGGCTG
TGCACGCCGACTATTTTGCGGCTGGTGCTGATGTTGCCATTACTGCGAGTTATCAGGCAACGATTCCCGGTTTTATGGCG
CGTGGAATCGCTCCTGATCAGGCAATTCTGCTCTTACAGCGCTCGGTCGCATTGGCGCAGGCTGCGCGTGATCAATTTTG
GGCTGACCCGGCGAATCGCGAAGGGCGTCTACGACCACTGGTTGCAGCCTCGGTAGGCCCGTATGGTGCATTTTTGCACG
ACGGCTCGGAATATCGCGGCAACTACGGCTTATCCGTGGCTGAATTGATTGAGTTCCATCGACCTCGCATGGCTGCTCTG
GCGGCTGCCCGGCCTGATCTCTTTGCCTGTGAAACGATCCCCTGTCTCGACGAAGCACGGGCATTAGTTGCGCTCCTGCC
CGAATTTCCGCACCTGACCGCATGGATTAGTTTCAGTGCTCGCGATGGTGCTCACACCGCTCAGGGTGAACCAATTGCCG
AATGTGCTGCTGAGATTGCTGCTCATCCCCAGGTGGCCGCAATTGGAGTTAACTGTACAGCTCCTCGCTTCCTTCCCGAT
CTCATTCGCGCTGTACAGGCTGTTACCGACAAGCCGATTGTGGTCTACCCTAATTCGGGAGAAGTCTATGACCCGGTTGG
GCAATGTTGGATTGGTACGACTGAGATTGACGATTTTGTAGCCCAGGCCAGGCAATGGTACGCTATGGGGGCACGGCTGA
TCGGTGGTTGCTGCCGGACTACTCCTGACCACATTCGAGCGTTGGCTGCCTGGGCCGCTGCCGGGGTGAATCATGATTGA

Upstream 100 bases:

>100_bases
ATCTGGCTCAGGTTGGAGCCGGTACCACTCCTGCGACGAAGCCACGGAGGAGTTAGCGATTCGCAAAGCCTATTTCTCGC
CGAAAAGAGAGATGCTCAAG

Downstream 100 bases:

>100_bases
GGCATGGCCGTTCGATCCTTTCGTTATTCCCTCGCCGCAGGTATTACGAGTCGGTGCATACCCACTGCACGGCGCGCCGG
TTTTTCACGTCGATCCTGAT

Product: homocysteine methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSSPNPITAALAQRPLLILDGALATELERRGCDLADPLWSAKVLIENPSLIQAVHADYFAAGADVAITASYQATIPGFMA
RGIAPDQAILLLQRSVALAQAARDQFWADPANREGRLRPLVAASVGPYGAFLHDGSEYRGNYGLSVAELIEFHRPRMAAL
AAARPDLFACETIPCLDEARALVALLPEFPHLTAWISFSARDGAHTAQGEPIAECAAEIAAHPQVAAIGVNCTAPRFLPD
LIRAVQAVTDKPIVVYPNSGEVYDPVGQCWIGTTEIDDFVAQARQWYAMGARLIGGCCRTTPDHIRALAAWAAAGVNHD

Sequences:

>Translated_319_residues
MSSPNPITAALAQRPLLILDGALATELERRGCDLADPLWSAKVLIENPSLIQAVHADYFAAGADVAITASYQATIPGFMA
RGIAPDQAILLLQRSVALAQAARDQFWADPANREGRLRPLVAASVGPYGAFLHDGSEYRGNYGLSVAELIEFHRPRMAAL
AAARPDLFACETIPCLDEARALVALLPEFPHLTAWISFSARDGAHTAQGEPIAECAAEIAAHPQVAAIGVNCTAPRFLPD
LIRAVQAVTDKPIVVYPNSGEVYDPVGQCWIGTTEIDDFVAQARQWYAMGARLIGGCCRTTPDHIRALAAWAAAGVNHD
>Mature_318_residues
SSPNPITAALAQRPLLILDGALATELERRGCDLADPLWSAKVLIENPSLIQAVHADYFAAGADVAITASYQATIPGFMAR
GIAPDQAILLLQRSVALAQAARDQFWADPANREGRLRPLVAASVGPYGAFLHDGSEYRGNYGLSVAELIEFHRPRMAALA
AARPDLFACETIPCLDEARALVALLPEFPHLTAWISFSARDGAHTAQGEPIAECAAEIAAHPQVAAIGVNCTAPRFLPDL
IRAVQAVTDKPIVVYPNSGEVYDPVGQCWIGTTEIDDFVAQARQWYAMGARLIGGCCRTTPDHIRALAAWAAAGVNHD

Specific function: Catalyzes Methyl Transfer From S-Methylmethionine Or S- Adenosylmethionine (Less Efficient) To Homocysteine, Selenohomocysteine And Less Efficiently Selenocysteine. [C]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=327, Percent_Identity=25.0764525993884, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1786456, Length=314, Percent_Identity=51.9108280254777, Blast_Score=298, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI17569783, Length=271, Percent_Identity=26.1992619926199, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324982, Length=328, Percent_Identity=28.3536585365854, Blast_Score=136, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6322966, Length=326, Percent_Identity=27.9141104294479, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323983, Length=91, Percent_Identity=35.1648351648352, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24585077, Length=315, Percent_Identity=35.5555555555556, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI20129603, Length=314, Percent_Identity=36.9426751592357, Blast_Score=197, Evalue=7e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 34053; Mature: 33922

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPNPITAALAQRPLLILDGALATELERRGCDLADPLWSAKVLIENPSLIQAVHADYFA
CCCCCCHHHHHHHCCEEEECCHHHHHHHHCCCCCCCCHHCCEEEEECCHHHHHHHHHHHH
AGADVAITASYQATIPGFMARGIAPDQAILLLQRSVALAQAARDQFWADPANREGRLRPL
CCCCEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
VAASVGPYGAFLHDGSEYRGNYGLSVAELIEFHRPRMAALAAARPDLFACETIPCLDEAR
EEECCCCCHHHHCCCCHHCCCCCCCHHHHHHHCCCHHHHHHHCCCCCEEECCCCCHHHHH
ALVALLPEFPHLTAWISFSARDGAHTAQGEPIAECAAEIAAHPQVAAIGVNCTAPRFLPD
HHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHH
LIRAVQAVTDKPIVVYPNSGEVYDPVGQCWIGTTEIDDFVAQARQWYAMGARLIGGCCRT
HHHHHHHHCCCCEEEECCCCCEECCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCC
TPDHIRALAAWAAAGVNHD
CHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SSPNPITAALAQRPLLILDGALATELERRGCDLADPLWSAKVLIENPSLIQAVHADYFA
CCCCCHHHHHHHCCEEEECCHHHHHHHHCCCCCCCCHHCCEEEEECCHHHHHHHHHHHH
AGADVAITASYQATIPGFMARGIAPDQAILLLQRSVALAQAARDQFWADPANREGRLRPL
CCCCEEEEECCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
VAASVGPYGAFLHDGSEYRGNYGLSVAELIEFHRPRMAALAAARPDLFACETIPCLDEAR
EEECCCCCHHHHCCCCHHCCCCCCCHHHHHHHCCCHHHHHHHCCCCCEEECCCCCHHHHH
ALVALLPEFPHLTAWISFSARDGAHTAQGEPIAECAAEIAAHPQVAAIGVNCTAPRFLPD
HHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHH
LIRAVQAVTDKPIVVYPNSGEVYDPVGQCWIGTTEIDDFVAQARQWYAMGARLIGGCCRT
HHHHHHHHCCCCEEEECCCCCEECCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCC
TPDHIRALAAWAAAGVNHD
CHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]