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The map label for this gene is nuoL [H]

Identifier: 222526379

GI number: 222526379

Start: 3888733

End: 3890658

Strand: Direct

Name: nuoL [H]

Synonym: Chy400_3145

Alternate gene names: 222526379

Gene position: 3888733-3890658 (Clockwise)

Preceding gene: 222526378

Following gene: 222526380

Centisome position: 73.8

GC content: 56.33

Gene sequence:

>1926_bases
ATGGAACTGTTGATCTGGCTTATTCCGCTGTTACCATTTATTGGTTTTCTGCTCAATGTCTTTGTTATTCGTCAGGAACG
ACAGGCCGGACTGGTAGCGAGTGGCATGGTGGCGGCAGCCTTCGTGATCACGTTGATCGCGGTGGGATTTCTGGCCGGTA
TGCCACCAGAAGAGCGCCGGATTGTCAGCACTGCCTGGGAGTGGATCAATACCGGCAGCTTTCGGGTGCCGTTTGCAATC
ATGTTTGATCCGCTGACGGCGGTGATGGCGTTGCTGATTACCGGTGTCGGAGCGCTCATTCATGTTTATTCAATCGGCTA
TATGCATGGTGATCCGCGGGTGGTGCGCTATTTTGCGTACCTCAATCTGTTTGTCACCATGATGCTTTTCCTGGTGATGG
CGAACAACCTCCTGCTGCTCTTCCTCGGTTGGGAGGGAGTCGGTCTCTGTTCGTTCCTCTTGATCGGGTTCTGGTTCGAG
CGCAAGACGTCCGGTGAGGCAGCGGTGAAGGCATTTGTCGTTAACCGCATTGGCGATGCTGCCTTCATTCTGGCGATGCT
GGCAATCTTTACATACTTCGGCACACTCAACTTCTACAGTGACGAAGGTGGGGGGCTGGGTTTTCTCGAACGGGTTGGCG
ACATTGCCGGTTTGCGGATTGGCCCCGACTGGCAACCGATCTTTGTCAGTACGGCCATCTCATTCCTGCTCCTGATCGGC
GCGACCGGTAAGAGTGCGCAGTTTCCCCTCTTTGTCTGGTTGCCTGATGCGATGGCTGGCCCAACGCCGGTATCGGCCCT
GATCCACGCTGCCACTATGGTGACCGGCGGTGTCTATCTAATGGCGCGTACCGAGCCACTCTTCGTCGCTTCCTTTACGA
CGCAAGGTTGGGTGGCCTGGATCGGTGCGCTGACGGCATTGATTGCCGGTACAGCAGCTATGGCGCAGTGGGATATTAAG
CGCGTTCTGGCTTACAGCACAGTCTCGCAATTGGGGTTTATGGTGGCTGCCTGCGGCATGGGTGCCTATGTCGCCGCTAT
TTTTCACCTGTTGACCCACGGCATCTTCAAGGCCCTGCTCTTCCTGGCAGCCGGTTCGGTTATTCACGGCACGCACGACA
CTCAGGATATGCGACGCATGGGTGGTTTGAAGGATGCCATGCCGACCACCTTCCGCACCTATCTGATTGGTGCGCTGGCG
CTGGCCGGTATCTTCCCGTTGGCCGGCTTCTGGAGTAAAGATGAGATTCTGGCCCACGCAGTTGCCCACGGTCATACGCC
GATCTTTATCATCCTGTTTATCACCTCGCTGCTCACCGCTTTCTATATGGGGCGTCAGGTTGCGCTCATCTTCTTCGGCA
AACAGCGTGATCCCGGCTACCACCCACACGAGAGTCCCCAGGTGATGACGGTGCCCCTGATTGTACTGGCGGTAGGTGCT
GTTATCGGTGGGGCAATGAACCTGCCGGTCTTGCACTGGCTCACCGACTGGCTCGAACCGGTGTTGCACGAGGAGGCCGG
TGAATTCAATCTCTGGCTGGCGTTGATCGCGACGCTGGGAGCAGTCGGGATGGGCTATCTGGGCTGGTGGATTTACACGA
CCAATGCAGCCAAAATCAAGATTGGTGGCAAAGACCCGGCGTATCGCTACAGTGGCGATATTTGGGAAGGCATGGAAGAG
GCGTGGTACCTCGACCGGCTGTACCAGCGCACAGTGGTTGCCGGTTTTGAGCGATTGGCCGATTTTCTGGCCCGTGTGTT
TGATCCCCAGGGTGTTGATGGTCTGGTGATGGGAGTTGGACGCTTCTTTGGTGGCCTGGCCAATGCGATGCGTACCTTCC
AAACCGGCTATGTTCGCACCTATGCACTGGTCTTTACGGTTGGTGTGCTGATCGTGCTTGGATTTATGCTCTGGATTGCT
CGCTAG

Upstream 100 bases:

>100_bases
TGCTGAGGTGGCGGTTGGTCTGGCGTTGCTGGTATCCATCTTCCGCACCAAACGCACGGCAGACGTGGATGAAGTCAGTA
CATTGAAGGGCTAGCCAACC

Downstream 100 bases:

>100_bases
GGACGCGGGGCAGGCTGAAGTCGGGGATAGTGTGGAATCCGGTATCGGTGTGATCGCCTGGTGCCGGTACACAATGCAGA
GTAACGGTGGGTTGTGAACT

Product: proton-translocating NADH-quinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 641; Mature: 641

Protein sequence:

>641_residues
MELLIWLIPLLPFIGFLLNVFVIRQERQAGLVASGMVAAAFVITLIAVGFLAGMPPEERRIVSTAWEWINTGSFRVPFAI
MFDPLTAVMALLITGVGALIHVYSIGYMHGDPRVVRYFAYLNLFVTMMLFLVMANNLLLLFLGWEGVGLCSFLLIGFWFE
RKTSGEAAVKAFVVNRIGDAAFILAMLAIFTYFGTLNFYSDEGGGLGFLERVGDIAGLRIGPDWQPIFVSTAISFLLLIG
ATGKSAQFPLFVWLPDAMAGPTPVSALIHAATMVTGGVYLMARTEPLFVASFTTQGWVAWIGALTALIAGTAAMAQWDIK
RVLAYSTVSQLGFMVAACGMGAYVAAIFHLLTHGIFKALLFLAAGSVIHGTHDTQDMRRMGGLKDAMPTTFRTYLIGALA
LAGIFPLAGFWSKDEILAHAVAHGHTPIFIILFITSLLTAFYMGRQVALIFFGKQRDPGYHPHESPQVMTVPLIVLAVGA
VIGGAMNLPVLHWLTDWLEPVLHEEAGEFNLWLALIATLGAVGMGYLGWWIYTTNAAKIKIGGKDPAYRYSGDIWEGMEE
AWYLDRLYQRTVVAGFERLADFLARVFDPQGVDGLVMGVGRFFGGLANAMRTFQTGYVRTYALVFTVGVLIVLGFMLWIA
R

Sequences:

>Translated_641_residues
MELLIWLIPLLPFIGFLLNVFVIRQERQAGLVASGMVAAAFVITLIAVGFLAGMPPEERRIVSTAWEWINTGSFRVPFAI
MFDPLTAVMALLITGVGALIHVYSIGYMHGDPRVVRYFAYLNLFVTMMLFLVMANNLLLLFLGWEGVGLCSFLLIGFWFE
RKTSGEAAVKAFVVNRIGDAAFILAMLAIFTYFGTLNFYSDEGGGLGFLERVGDIAGLRIGPDWQPIFVSTAISFLLLIG
ATGKSAQFPLFVWLPDAMAGPTPVSALIHAATMVTGGVYLMARTEPLFVASFTTQGWVAWIGALTALIAGTAAMAQWDIK
RVLAYSTVSQLGFMVAACGMGAYVAAIFHLLTHGIFKALLFLAAGSVIHGTHDTQDMRRMGGLKDAMPTTFRTYLIGALA
LAGIFPLAGFWSKDEILAHAVAHGHTPIFIILFITSLLTAFYMGRQVALIFFGKQRDPGYHPHESPQVMTVPLIVLAVGA
VIGGAMNLPVLHWLTDWLEPVLHEEAGEFNLWLALIATLGAVGMGYLGWWIYTTNAAKIKIGGKDPAYRYSGDIWEGMEE
AWYLDRLYQRTVVAGFERLADFLARVFDPQGVDGLVMGVGRFFGGLANAMRTFQTGYVRTYALVFTVGVLIVLGFMLWIA
R
>Mature_641_residues
MELLIWLIPLLPFIGFLLNVFVIRQERQAGLVASGMVAAAFVITLIAVGFLAGMPPEERRIVSTAWEWINTGSFRVPFAI
MFDPLTAVMALLITGVGALIHVYSIGYMHGDPRVVRYFAYLNLFVTMMLFLVMANNLLLLFLGWEGVGLCSFLLIGFWFE
RKTSGEAAVKAFVVNRIGDAAFILAMLAIFTYFGTLNFYSDEGGGLGFLERVGDIAGLRIGPDWQPIFVSTAISFLLLIG
ATGKSAQFPLFVWLPDAMAGPTPVSALIHAATMVTGGVYLMARTEPLFVASFTTQGWVAWIGALTALIAGTAAMAQWDIK
RVLAYSTVSQLGFMVAACGMGAYVAAIFHLLTHGIFKALLFLAAGSVIHGTHDTQDMRRMGGLKDAMPTTFRTYLIGALA
LAGIFPLAGFWSKDEILAHAVAHGHTPIFIILFITSLLTAFYMGRQVALIFFGKQRDPGYHPHESPQVMTVPLIVLAVGA
VIGGAMNLPVLHWLTDWLEPVLHEEAGEFNLWLALIATLGAVGMGYLGWWIYTTNAAKIKIGGKDPAYRYSGDIWEGMEE
AWYLDRLYQRTVVAGFERLADFLARVFDPQGVDGLVMGVGRFFGGLANAMRTFQTGYVRTYALVFTVGVLIVLGFMLWIA
R

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton transloca

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=521, Percent_Identity=36.084452975048, Blast_Score=274, Evalue=2e-73,
Organism=Escherichia coli, GI1788614, Length=629, Percent_Identity=39.7456279809221, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1788829, Length=510, Percent_Identity=29.2156862745098, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1788831, Length=348, Percent_Identity=31.0344827586207, Blast_Score=123, Evalue=4e-29,
Organism=Escherichia coli, GI1788827, Length=433, Percent_Identity=29.0993071593533, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1788613, Length=414, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI2367154, Length=463, Percent_Identity=25.2699784017279, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693160, Length=214, Percent_Identity=29.9065420560748, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 70119; Mature: 70119

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLIWLIPLLPFIGFLLNVFVIRQERQAGLVASGMVAAAFVITLIAVGFLAGMPPEERR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
IVSTAWEWINTGSFRVPFAIMFDPLTAVMALLITGVGALIHVYSIGYMHGDPRVVRYFAY
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LNLFVTMMLFLVMANNLLLLFLGWEGVGLCSFLLIGFWFERKTSGEAAVKAFVVNRIGDA
HHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHH
AFILAMLAIFTYFGTLNFYSDEGGGLGFLERVGDIAGLRIGPDWQPIFVSTAISFLLLIG
HHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHC
ATGKSAQFPLFVWLPDAMAGPTPVSALIHAATMVTGGVYLMARTEPLFVASFTTQGWVAW
CCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCHHHHH
IGALTALIAGTAAMAQWDIKRVLAYSTVSQLGFMVAACGMGAYVAAIFHLLTHGIFKALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
FLAAGSVIHGTHDTQDMRRMGGLKDAMPTTFRTYLIGALALAGIFPLAGFWSKDEILAHA
HHHCCCCEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VAHGHTPIFIILFITSLLTAFYMGRQVALIFFGKQRDPGYHPHESPQVMTVPLIVLAVGA
HHCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHH
VIGGAMNLPVLHWLTDWLEPVLHEEAGEFNLWLALIATLGAVGMGYLGWWIYTTNAAKIK
HHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEE
IGGKDPAYRYSGDIWEGMEEAWYLDRLYQRTVVAGFERLADFLARVFDPQGVDGLVMGVG
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
RFFGGLANAMRTFQTGYVRTYALVFTVGVLIVLGFMLWIAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELLIWLIPLLPFIGFLLNVFVIRQERQAGLVASGMVAAAFVITLIAVGFLAGMPPEERR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
IVSTAWEWINTGSFRVPFAIMFDPLTAVMALLITGVGALIHVYSIGYMHGDPRVVRYFAY
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LNLFVTMMLFLVMANNLLLLFLGWEGVGLCSFLLIGFWFERKTSGEAAVKAFVVNRIGDA
HHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHH
AFILAMLAIFTYFGTLNFYSDEGGGLGFLERVGDIAGLRIGPDWQPIFVSTAISFLLLIG
HHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHC
ATGKSAQFPLFVWLPDAMAGPTPVSALIHAATMVTGGVYLMARTEPLFVASFTTQGWVAW
CCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCHHHHH
IGALTALIAGTAAMAQWDIKRVLAYSTVSQLGFMVAACGMGAYVAAIFHLLTHGIFKALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
FLAAGSVIHGTHDTQDMRRMGGLKDAMPTTFRTYLIGALALAGIFPLAGFWSKDEILAHA
HHHCCCCEECCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
VAHGHTPIFIILFITSLLTAFYMGRQVALIFFGKQRDPGYHPHESPQVMTVPLIVLAVGA
HHCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHH
VIGGAMNLPVLHWLTDWLEPVLHEEAGEFNLWLALIATLGAVGMGYLGWWIYTTNAAKIK
HHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEE
IGGKDPAYRYSGDIWEGMEEAWYLDRLYQRTVVAGFERLADFLARVFDPQGVDGLVMGVG
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
RFFGGLANAMRTFQTGYVRTYALVFTVGVLIVLGFMLWIAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]