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The map label for this gene is nuoH [H]

Identifier: 222526375

GI number: 222526375

Start: 3885937

End: 3887160

Strand: Direct

Name: nuoH [H]

Synonym: Chy400_3141

Alternate gene names: 222526375

Gene position: 3885937-3887160 (Clockwise)

Preceding gene: 222526374

Following gene: 222526376

Centisome position: 73.75

GC content: 53.35

Gene sequence:

>1224_bases
ATGGATTGGCTCACCATTCTGATTATCGTTATCCAATGTTTTATTATCACGCTGGCTGTAACCACTGCCTTTGCCTATCT
GACACTTTTTGAGCGGCGGATTCTGGCGCGCCTGCAAAATCGTGTTGGACCGAACCGGGCCGGGCCGGCCGGATTTCTGC
AACCGGCTGCCGATGCGGTCAAACTCTTCTTCAAAGAGGATATTGTGCCGGCAATGGCCGACAAGCCGGTTTATCTGCTC
GCGCCAGCACTGGCGGTTATTCCGGCGCTGATTATCTGGGCTGTCATCCCGTTTGGGTGTCTAAATCTGAACTGGGATTA
TCAGGCGTGTTACGATCCGGCACGTACCAATCTGTGGAATATCCTGCAAATTACCGATCTGAATATCGGTGTCCTGTATG
TGTTGGCCGTGACCAGTATCGGCGTTTACGGCATTACCCTGGCAGGTTGGGCTTCAAACAATAAATATTCAATGCTCGGC
GGGATCCGCTCGTCGGCGCAACTTATTTCATACGAACTGGCGTTGGGATGTGCTGTGCTCAGCGTAGTCATGACGTATGG
CACCTTCTCGACCCACGAGATCGTCGCTCAACAGCAGGGCTGGTTGTGGGGGATCATTCCGCAGTTGCTCGGCTTTGTAC
TGTATATGGTTGCGGCTACAGCGGAAGTAGTACGGGCTCCGTTTGATCTGGTTGAAGCAGAGCAAGAGCTAACCGGTGGT
TACAACACCGAGTATGGTTCGATGAAGTTTGCGCTCTTCTTCATGGCCGAATATATCAAGTTGATCGCCGTTTCTGCCCT
GGCCGTCACCTTCTTCTTTGGCGGCTGGCACTTCCCCGGACTCGACATTCTTGGTCGTGGAGTGACGGCACTGGCCGGGC
CGGTGGCGGGCAGCATCGTGTTTGGGATCGTCTCGCTCGGTGCTTTCCTGCTCAAAGTGGTCATCTTCCTGTTCATCTCG
GTTTGGATACGTGCGTCCTGGCCGCGCCTGCGTTACGACCGCTTGATGGATTTGGGCTGGAAGTGGCTCCTACCGGTTGG
TTTGCTCAATCTGGTCTACACTGCTGTGGTTATTGTGCTGATCCCGGATCGCGTTGTCCATTCGTGGGTACTGTTTGGGT
TAGGTGCATTGACAATTGCCATCGCCATTGGCTTCAATCGGACACCCAAGCCGGTTGATAATGTTACACTAGTCAACGAC
ATTCAGATACCACAGGGGAATTGA

Upstream 100 bases:

>100_bases
ACGGACACGGGTTAGTCTGGCTAAGGTGGTGATGGAATAACTGCACAGGCGTATCCGCCCGAAACATCCTGTTCGGCGGA
TACGCACACAGGGAGCGCTT

Downstream 100 bases:

>100_bases
TCACAGCAATCGAATGAGCCTGCTATGCTGTAGTACCGTTTGCCGGCAGCGATAGACAGGCACGATGGCTGCAAAGCAAT
CTCACAATAGCAACTGTTCG

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MDWLTILIIVIQCFIITLAVTTAFAYLTLFERRILARLQNRVGPNRAGPAGFLQPAADAVKLFFKEDIVPAMADKPVYLL
APALAVIPALIIWAVIPFGCLNLNWDYQACYDPARTNLWNILQITDLNIGVLYVLAVTSIGVYGITLAGWASNNKYSMLG
GIRSSAQLISYELALGCAVLSVVMTYGTFSTHEIVAQQQGWLWGIIPQLLGFVLYMVAATAEVVRAPFDLVEAEQELTGG
YNTEYGSMKFALFFMAEYIKLIAVSALAVTFFFGGWHFPGLDILGRGVTALAGPVAGSIVFGIVSLGAFLLKVVIFLFIS
VWIRASWPRLRYDRLMDLGWKWLLPVGLLNLVYTAVVIVLIPDRVVHSWVLFGLGALTIAIAIGFNRTPKPVDNVTLVND
IQIPQGN

Sequences:

>Translated_407_residues
MDWLTILIIVIQCFIITLAVTTAFAYLTLFERRILARLQNRVGPNRAGPAGFLQPAADAVKLFFKEDIVPAMADKPVYLL
APALAVIPALIIWAVIPFGCLNLNWDYQACYDPARTNLWNILQITDLNIGVLYVLAVTSIGVYGITLAGWASNNKYSMLG
GIRSSAQLISYELALGCAVLSVVMTYGTFSTHEIVAQQQGWLWGIIPQLLGFVLYMVAATAEVVRAPFDLVEAEQELTGG
YNTEYGSMKFALFFMAEYIKLIAVSALAVTFFFGGWHFPGLDILGRGVTALAGPVAGSIVFGIVSLGAFLLKVVIFLFIS
VWIRASWPRLRYDRLMDLGWKWLLPVGLLNLVYTAVVIVLIPDRVVHSWVLFGLGALTIAIAIGFNRTPKPVDNVTLVND
IQIPQGN
>Mature_407_residues
MDWLTILIIVIQCFIITLAVTTAFAYLTLFERRILARLQNRVGPNRAGPAGFLQPAADAVKLFFKEDIVPAMADKPVYLL
APALAVIPALIIWAVIPFGCLNLNWDYQACYDPARTNLWNILQITDLNIGVLYVLAVTSIGVYGITLAGWASNNKYSMLG
GIRSSAQLISYELALGCAVLSVVMTYGTFSTHEIVAQQQGWLWGIIPQLLGFVLYMVAATAEVVRAPFDLVEAEQELTGG
YNTEYGSMKFALFFMAEYIKLIAVSALAVTFFFGGWHFPGLDILGRGVTALAGPVAGSIVFGIVSLGAFLLKVVIFLFIS
VWIRASWPRLRYDRLMDLGWKWLLPVGLLNLVYTAVVIVLIPDRVVHSWVLFGLGALTIAIAIGFNRTPKPVDNVTLVND
IQIPQGN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=326, Percent_Identity=36.8098159509202, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1788618, Length=364, Percent_Identity=40.3846153846154, Blast_Score=267, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44681; Mature: 44681

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDWLTILIIVIQCFIITLAVTTAFAYLTLFERRILARLQNRVGPNRAGPAGFLQPAADAV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
KLFFKEDIVPAMADKPVYLLAPALAVIPALIIWAVIPFGCLNLNWDYQACYDPARTNLWN
HHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHCCCEE
ILQITDLNIGVLYVLAVTSIGVYGITLAGWASNNKYSMLGGIRSSAQLISYELALGCAVL
EEEEECCCHHHHHHHHHHHCCHHHEEEEEECCCCCCHHHHCHHHHHHHHHHHHHHHHHHH
SVVMTYGTFSTHEIVAQQQGWLWGIIPQLLGFVLYMVAATAEVVRAPFDLVEAEQELTGG
HHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
YNTEYGSMKFALFFMAEYIKLIAVSALAVTFFFGGWHFPGLDILGRGVTALAGPVAGSIV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHH
FGIVSLGAFLLKVVIFLFISVWIRASWPRLRYDRLMDLGWKWLLPVGLLNLVYTAVVIVL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
IPDRVVHSWVLFGLGALTIAIAIGFNRTPKPVDNVTLVNDIQIPQGN
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MDWLTILIIVIQCFIITLAVTTAFAYLTLFERRILARLQNRVGPNRAGPAGFLQPAADAV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
KLFFKEDIVPAMADKPVYLLAPALAVIPALIIWAVIPFGCLNLNWDYQACYDPARTNLWN
HHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHCCCEE
ILQITDLNIGVLYVLAVTSIGVYGITLAGWASNNKYSMLGGIRSSAQLISYELALGCAVL
EEEEECCCHHHHHHHHHHHCCHHHEEEEEECCCCCCHHHHCHHHHHHHHHHHHHHHHHHH
SVVMTYGTFSTHEIVAQQQGWLWGIIPQLLGFVLYMVAATAEVVRAPFDLVEAEQELTGG
HHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
YNTEYGSMKFALFFMAEYIKLIAVSALAVTFFFGGWHFPGLDILGRGVTALAGPVAGSIV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHH
FGIVSLGAFLLKVVIFLFISVWIRASWPRLRYDRLMDLGWKWLLPVGLLNLVYTAVVIVL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
IPDRVVHSWVLFGLGALTIAIAIGFNRTPKPVDNVTLVNDIQIPQGN
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA