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The map label for this gene is yfnC [H]

Identifier: 222526054

GI number: 222526054

Start: 3463835

End: 3465043

Strand: Reverse

Name: yfnC [H]

Synonym: Chy400_2811

Alternate gene names: 222526054

Gene position: 3465043-3463835 (Counterclockwise)

Preceding gene: 222526055

Following gene: 222526053

Centisome position: 65.76

GC content: 60.05

Gene sequence:

>1209_bases
ATGCTGCGTAATCGCGTCTTCACAGCCGTTGTCGGTGGTCATTTTATGGTCGATCTGCTGAACAGCCTGGGAGCAGTTCT
GCTGGCGGTACTGGCGGTACCGCTCGGTTTAAGCAATCAGCAGATCGGGTTAGCGCTGACGATCTATACGCTCCTTGGGG
CGCTATCACAACCACTCTTTGGCTGGATCGCCGACCGACTACCCGGACGCACCCTTCAACTCGCAGCAATTGGCGTGATC
TGGATGGCAACCTGCTACACAGGCGTTGCCCTTGCCCCTAACTGGACTATCCTGCTGCCGTGTTTTCTCCTGGCCGCGCT
CGGCAGTGGTCTCTTTCACCCGATTGGCACCGCCAGCGCCGCGGCTGCCGTGCCCGACAAACCGGCCAGTGCAACATCGA
TCTTCTTCTTCGGTGGGCAGATCGGTCTGGCCACCGGCCCAATCCTGGCCGGTATTGTGTTGACCATGGCCGGGACACCC
GGCATCGTGCCAATTGCGCTCGCAGCCGCCATACCGGCAGGTGTATTACTCCTGGCGCAACAAACCGCACGCAGTCGCCG
TCTGAACCGCGCTGCTCCTACACCCAACACCCACCCCTGGACAAAGCTGGCTGTCGTTCTGTTGATTGCCTTTATTGTGC
TGGTAGTTGTGCGATCATCGATCCAAACCGTCTATCAATCATTCCTGCCCAAACTATTCAGTGATCGCGGATGGGAACCG
GCGATCTATGGTGCGCTGGCCGGCACCTTCATGGCGAGTGGCGCAATTGGCAATGTGATTAACGGTTGGATGGCCGACCG
CTTCGGCATGCGGGCTGCAACCGTCTGGCCGCTCATCCTCAGCGTCCCTGCCGGTCTGGCCTGCTTCATAGCTACCCCCT
TGTGGGCAATCTTTATCGGCTGCGGCCTGGCAGGTATGCTCGTCGGCGGCCAGCACAGCATCCTGGTCTTACATGCCCAA
CGCATTTTACCGGTACGACAGGGGTTGGCATCGGGACTCATCCTCGGCTTCACCTTTGCCAGCGGCGCCATCGGCACCTG
GTTTAGCGGCATCATTGCCGATGTGATTGGGCTTGAAACCGTGATGATCGGCGTTACCCTGCTCGGTTTACCGGCAGCCG
CTCTGGCGCTCACCCTGCCGGGCCGCCCTAAAGCAACCGTCACCCGCGACATACCTGCGGGGATGCAAGCGGAAGTGCGG
GGGTCGTAA

Upstream 100 bases:

>100_bases
ATGCCGGTAACCCACCTTCATACATTGCACGCCGAACTAACGATGGTTGGGGGCAAGATCGTTTTTAATCGCACATCTCG
TTGAGAAAGGGATTGCCATC

Downstream 100 bases:

>100_bases
ATAATTCAAGTTGCCACCTTTATCACCACAGAGGCACGGAGGACGCAGAGGATGGGCATAACCTGGTTTGCTCCTATGAG
GCGTGGCTCCGTAAAAACTG

Product: major facilitator superfamily protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MLRNRVFTAVVGGHFMVDLLNSLGAVLLAVLAVPLGLSNQQIGLALTIYTLLGALSQPLFGWIADRLPGRTLQLAAIGVI
WMATCYTGVALAPNWTILLPCFLLAALGSGLFHPIGTASAAAAVPDKPASATSIFFFGGQIGLATGPILAGIVLTMAGTP
GIVPIALAAAIPAGVLLLAQQTARSRRLNRAAPTPNTHPWTKLAVVLLIAFIVLVVVRSSIQTVYQSFLPKLFSDRGWEP
AIYGALAGTFMASGAIGNVINGWMADRFGMRAATVWPLILSVPAGLACFIATPLWAIFIGCGLAGMLVGGQHSILVLHAQ
RILPVRQGLASGLILGFTFASGAIGTWFSGIIADVIGLETVMIGVTLLGLPAAALALTLPGRPKATVTRDIPAGMQAEVR
GS

Sequences:

>Translated_402_residues
MLRNRVFTAVVGGHFMVDLLNSLGAVLLAVLAVPLGLSNQQIGLALTIYTLLGALSQPLFGWIADRLPGRTLQLAAIGVI
WMATCYTGVALAPNWTILLPCFLLAALGSGLFHPIGTASAAAAVPDKPASATSIFFFGGQIGLATGPILAGIVLTMAGTP
GIVPIALAAAIPAGVLLLAQQTARSRRLNRAAPTPNTHPWTKLAVVLLIAFIVLVVVRSSIQTVYQSFLPKLFSDRGWEP
AIYGALAGTFMASGAIGNVINGWMADRFGMRAATVWPLILSVPAGLACFIATPLWAIFIGCGLAGMLVGGQHSILVLHAQ
RILPVRQGLASGLILGFTFASGAIGTWFSGIIADVIGLETVMIGVTLLGLPAAALALTLPGRPKATVTRDIPAGMQAEVR
GS
>Mature_402_residues
MLRNRVFTAVVGGHFMVDLLNSLGAVLLAVLAVPLGLSNQQIGLALTIYTLLGALSQPLFGWIADRLPGRTLQLAAIGVI
WMATCYTGVALAPNWTILLPCFLLAALGSGLFHPIGTASAAAAVPDKPASATSIFFFGGQIGLATGPILAGIVLTMAGTP
GIVPIALAAAIPAGVLLLAQQTARSRRLNRAAPTPNTHPWTKLAVVLLIAFIVLVVVRSSIQTVYQSFLPKLFSDRGWEP
AIYGALAGTFMASGAIGNVINGWMADRFGMRAATVWPLILSVPAGLACFIATPLWAIFIGCGLAGMLVGGQHSILVLHAQ
RILPVRQGLASGLILGFTFASGAIGTWFSGIIADVIGLETVMIGVTLLGLPAAALALTLPGRPKATVTRDIPAGMQAEVR
GS

Specific function: Confers The Resistance Against Fosmidomycin. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=367, Percent_Identity=27.2479564032698, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41531; Mature: 41531

Theoretical pI: Translated: 10.88; Mature: 10.88

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRNRVFTAVVGGHFMVDLLNSLGAVLLAVLAVPLGLSNQQIGLALTIYTLLGALSQPLF
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
GWIADRLPGRTLQLAAIGVIWMATCYTGVALAPNWTILLPCFLLAALGSGLFHPIGTASA
HHHHHHCCCCEEHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCHH
AAAVPDKPASATSIFFFGGQIGLATGPILAGIVLTMAGTPGIVPIALAAAIPAGVLLLAQ
HCCCCCCCCCCCEEEEECCEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
QTARSRRLNRAAPTPNTHPWTKLAVVLLIAFIVLVVVRSSIQTVYQSFLPKLFSDRGWEP
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AIYGALAGTFMASGAIGNVINGWMADRFGMRAATVWPLILSVPAGLACFIATPLWAIFIG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
CGLAGMLVGGQHSILVLHAQRILPVRQGLASGLILGFTFASGAIGTWFSGIIADVIGLET
HHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VMIGVTLLGLPAAALALTLPGRPKATVTRDIPAGMQAEVRGS
HHHHHHHHHCCHHHHEEECCCCCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure
MLRNRVFTAVVGGHFMVDLLNSLGAVLLAVLAVPLGLSNQQIGLALTIYTLLGALSQPLF
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
GWIADRLPGRTLQLAAIGVIWMATCYTGVALAPNWTILLPCFLLAALGSGLFHPIGTASA
HHHHHHCCCCEEHHHHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCHH
AAAVPDKPASATSIFFFGGQIGLATGPILAGIVLTMAGTPGIVPIALAAAIPAGVLLLAQ
HCCCCCCCCCCCEEEEECCEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
QTARSRRLNRAAPTPNTHPWTKLAVVLLIAFIVLVVVRSSIQTVYQSFLPKLFSDRGWEP
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AIYGALAGTFMASGAIGNVINGWMADRFGMRAATVWPLILSVPAGLACFIATPLWAIFIG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
CGLAGMLVGGQHSILVLHAQRILPVRQGLASGLILGFTFASGAIGTWFSGIIADVIGLET
HHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VMIGVTLLGLPAAALALTLPGRPKATVTRDIPAGMQAEVRGS
HHHHHHHHHCCHHHHEEECCCCCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]