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The map label for this gene is pgl [H]

Identifier: 222525997

GI number: 222525997

Start: 3397476

End: 3398225

Strand: Direct

Name: pgl [H]

Synonym: Chy400_2753

Alternate gene names: 222525997

Gene position: 3397476-3398225 (Clockwise)

Preceding gene: 222525996

Following gene: 222525999

Centisome position: 64.48

GC content: 56.93

Gene sequence:

>750_bases
ATGAATGAACAGCAATCGATTCGGGTCTACGAGCACGCCGATGAGCTGTACCGGATGGCAGCGACATTTGTTGCTGAGCA
GATTCGATCCGCAATTGATAATCGTGGGCAGGCGTTAATTGCGCTTTCGGGAGGAAGCCTGACCTCGCGCCTGTATCCAT
TGCTCGCGAATGCACCGTTGCGCGAACAGATTGACTGGAGCAGGGTGAGTATCGTATTTGCCGATGAACGGTATGTACCG
TTCGACGACAGCGAGAACAATTATCGTGCGACACGACAGACGTTTCTCGATCACGTACCGGTACATGCCGATCAGGTTTT
TCCGGTGCCGACCTACTATCGTGATCCGCAACAGGCAGCCACCATTTATCAGCAGCAGTTAACAGCGTTGCTGACAGCGC
ATGGCGGCCAGATTGACGTAGCATTGCTCGGCATGGGGCCGGATGGCCACACTGCATCGCTGTTTCCCCGGCATCCGGTT
CTGACGGCAATTCCTGCCGGCGCATTGACTGTGGTTGTGGCCGATGCACCGAAACCACCACCACTGCGTCTGAGTTTAAC
GCCAGCCGCATTGAATACGGCACGCGCAGTGGTATTTGTGGTCAGCGGTGCCGACAAGGCAGCAGCCGTGGCAGCCGCGC
TGGCCGATACCGGTGACGCAATGGCACAACCAACGCGCCTGATTAATCCGGTAGCAGGGACGGTCTATTGGATGCTGGAT
CGGGCAGCGGCAGAGAGGGTGACGCAGTAA

Upstream 100 bases:

>100_bases
CCAGATCGGAGCGCAGTGGACGCGCAGGGAATATCTGGTTTCTCATTGCTACGCTTTCAACACCTGTTGATAGCGTACAG
TACCAGTTCAGGACACATCC

Downstream 100 bases:

>100_bases
CCACGTGCGTCAACTATTCACGATGCCCATGCTCCGTGCTTTGCAGTGGTGCGAACGCGGCAAAGTGATATGTCAGCAGC
CACGCAGCGTATCTGTTCAC

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MNEQQSIRVYEHADELYRMAATFVAEQIRSAIDNRGQALIALSGGSLTSRLYPLLANAPLREQIDWSRVSIVFADERYVP
FDDSENNYRATRQTFLDHVPVHADQVFPVPTYYRDPQQAATIYQQQLTALLTAHGGQIDVALLGMGPDGHTASLFPRHPV
LTAIPAGALTVVVADAPKPPPLRLSLTPAALNTARAVVFVVSGADKAAAVAAALADTGDAMAQPTRLINPVAGTVYWMLD
RAAAERVTQ

Sequences:

>Translated_249_residues
MNEQQSIRVYEHADELYRMAATFVAEQIRSAIDNRGQALIALSGGSLTSRLYPLLANAPLREQIDWSRVSIVFADERYVP
FDDSENNYRATRQTFLDHVPVHADQVFPVPTYYRDPQQAATIYQQQLTALLTAHGGQIDVALLGMGPDGHTASLFPRHPV
LTAIPAGALTVVVADAPKPPPLRLSLTPAALNTARAVVFVVSGADKAAAVAAALADTGDAMAQPTRLINPVAGTVYWMLD
RAAAERVTQ
>Mature_249_residues
MNEQQSIRVYEHADELYRMAATFVAEQIRSAIDNRGQALIALSGGSLTSRLYPLLANAPLREQIDWSRVSIVFADERYVP
FDDSENNYRATRQTFLDHVPVHADQVFPVPTYYRDPQQAATIYQQQLTALLTAHGGQIDVALLGMGPDGHTASLFPRHPV
LTAIPAGALTVVVADAPKPPPLRLSLTPAALNTARAVVFVVSGADKAAAVAAALADTGDAMAQPTRLINPVAGTVYWMLD
RAAAERVTQ

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912586, Length=249, Percent_Identity=35.3413654618474, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI52145310, Length=233, Percent_Identity=30.9012875536481, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI115533058, Length=213, Percent_Identity=31.924882629108, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI115533060, Length=209, Percent_Identity=32.0574162679426, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6321957, Length=251, Percent_Identity=29.0836653386454, Blast_Score=108, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6321687, Length=247, Percent_Identity=31.5789473684211, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324362, Length=226, Percent_Identity=33.1858407079646, Blast_Score=102, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6319918, Length=222, Percent_Identity=32.4324324324324, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24641119, Length=208, Percent_Identity=34.1346153846154, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26927; Mature: 26927

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQQSIRVYEHADELYRMAATFVAEQIRSAIDNRGQALIALSGGSLTSRLYPLLANAPL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCC
REQIDWSRVSIVFADERYVPFDDSENNYRATRQTFLDHVPVHADQVFPVPTYYRDPQQAA
HHCCCCEEEEEEEECCEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
TIYQQQLTALLTAHGGQIDVALLGMGPDGHTASLFPRHPVLTAIPAGALTVVVADAPKPP
HHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCCC
PLRLSLTPAALNTARAVVFVVSGADKAAAVAAALADTGDAMAQPTRLINPVAGTVYWMLD
CEEEEECHHHHCCCEEEEEEEECCCHHHHHHHHHHCCCHHHHCCHHHHCHHHHHHHHHHH
RAAAERVTQ
HHHHHHCCC
>Mature Secondary Structure
MNEQQSIRVYEHADELYRMAATFVAEQIRSAIDNRGQALIALSGGSLTSRLYPLLANAPL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCC
REQIDWSRVSIVFADERYVPFDDSENNYRATRQTFLDHVPVHADQVFPVPTYYRDPQQAA
HHCCCCEEEEEEEECCEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
TIYQQQLTALLTAHGGQIDVALLGMGPDGHTASLFPRHPVLTAIPAGALTVVVADAPKPP
HHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEECCCEEEEEEECCCCCC
PLRLSLTPAALNTARAVVFVVSGADKAAAVAAALADTGDAMAQPTRLINPVAGTVYWMLD
CEEEEECHHHHCCCEEEEEEEECCCHHHHHHHHHHCCCHHHHCCHHHHCHHHHHHHHHHH
RAAAERVTQ
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231; 9298645 [H]