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The map label for this gene is nat [H]

Identifier: 222525892

GI number: 222525892

Start: 3277158

End: 3277970

Strand: Direct

Name: nat [H]

Synonym: Chy400_2645

Alternate gene names: 222525892

Gene position: 3277158-3277970 (Clockwise)

Preceding gene: 222525891

Following gene: 222525893

Centisome position: 62.2

GC content: 59.16

Gene sequence:

>813_bases
ATGGATATAACTGCTTATCTCAACCGCATCAATTATGCTGGCCCGCTGGCACCCACCGCCGAGACCTTGCGGCGGTTGCA
CCTAGCGCACCTGCTCTCAGTGCCTTTCGAGAACCTTAGCATCCACTGGCATGAGCCTATCGTCCTCACAGATGAAGCCC
TTTTCCAGAAGATTGTATTGCGCCAGCGCGGCGGCTTCTGTTACGAGCTGAACGGGCTGTTCGCTTCCTTGCTGCGGACC
TTAGGCTTCCAGGTTGAGATGCTCTCGGCAGGCGTGATGAATAAGCGCGGTGAGTTCGGGCCGGAGTTCGACCACATGAC
CTTGATGGTCACACTTGCGGAGCGCTGGCTGGTAGACGTTGGCTTCGGTGACTCTTTCCGTGAGCCGCTGCTTCTGGATG
CGCGTACGGAGCAGGTGCAGGGTCGGCGCGCTTACCGCATTGAGGAGGTCGGCGACGGGCGTTTAATCCTGATGGAGCGC
CGAGAGGGCGACGAGTGGCAGGCGCAATACCGCTTCAGCCTGGAGCCGCACGTCTACGCTGATTATGCAGGGATGTGCCG
CTATCATCAGACCTCACCTGAGTCACACTTCACGCAGCGACGAATCTGTTCTTTGGCGACAGCGGATGGGCGGGTGACAT
TGAGTGAGCGGCGGCTGATTATCACGCGAGGGGGTGAGCGGCAGGAGCGGGAGTTGGGGAGTGCGGAGGAGTATGGGGAG
GTGTTGCGCACACACTTTGGTATCGAAGCCGCGCCGAACCAGGGGATGCAGCCGACCGCAATGAGGAGGTCTGTTATTCT
CGAAACATACTAG

Upstream 100 bases:

>100_bases
CGAGTTTTTCCTGCTCCCAAGCAGAGTCCACGCCCGCCCACACGCAGGTAACGCACACCGTTCGGCGCTTACGAGTCGTG
AAACAGGAGATATGTCTCGC

Downstream 100 bases:

>100_bases
CGGCGGCTGATCTCCGGCGTTCGTATATTCTCGCATGATTAGCAAAGCATCCAATACGACCTGGTGTCGCTATGAATAAA
ACGCCTTCGATGAAAAGTGA

Product: N-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MDITAYLNRINYAGPLAPTAETLRRLHLAHLLSVPFENLSIHWHEPIVLTDEALFQKIVLRQRGGFCYELNGLFASLLRT
LGFQVEMLSAGVMNKRGEFGPEFDHMTLMVTLAERWLVDVGFGDSFREPLLLDARTEQVQGRRAYRIEEVGDGRLILMER
REGDEWQAQYRFSLEPHVYADYAGMCRYHQTSPESHFTQRRICSLATADGRVTLSERRLIITRGGERQERELGSAEEYGE
VLRTHFGIEAAPNQGMQPTAMRRSVILETY

Sequences:

>Translated_270_residues
MDITAYLNRINYAGPLAPTAETLRRLHLAHLLSVPFENLSIHWHEPIVLTDEALFQKIVLRQRGGFCYELNGLFASLLRT
LGFQVEMLSAGVMNKRGEFGPEFDHMTLMVTLAERWLVDVGFGDSFREPLLLDARTEQVQGRRAYRIEEVGDGRLILMER
REGDEWQAQYRFSLEPHVYADYAGMCRYHQTSPESHFTQRRICSLATADGRVTLSERRLIITRGGERQERELGSAEEYGE
VLRTHFGIEAAPNQGMQPTAMRRSVILETY
>Mature_270_residues
MDITAYLNRINYAGPLAPTAETLRRLHLAHLLSVPFENLSIHWHEPIVLTDEALFQKIVLRQRGGFCYELNGLFASLLRT
LGFQVEMLSAGVMNKRGEFGPEFDHMTLMVTLAERWLVDVGFGDSFREPLLLDARTEQVQGRRAYRIEEVGDGRLILMER
REGDEWQAQYRFSLEPHVYADYAGMCRYHQTSPESHFTQRRICSLATADGRVTLSERRLIITRGGERQERELGSAEEYGE
VLRTHFGIEAAPNQGMQPTAMRRSVILETY

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649132, Length=273, Percent_Identity=32.967032967033, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI237649130, Length=273, Percent_Identity=32.967032967033, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI237649128, Length=273, Percent_Identity=32.967032967033, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI237649126, Length=273, Percent_Identity=32.967032967033, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI237649124, Length=273, Percent_Identity=32.967032967033, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI237649122, Length=273, Percent_Identity=32.967032967033, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI237649119, Length=273, Percent_Identity=32.967032967033, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI42741671, Length=273, Percent_Identity=32.967032967033, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI237649009, Length=273, Percent_Identity=32.967032967033, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI116295260, Length=234, Percent_Identity=33.7606837606838, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1787736, Length=250, Percent_Identity=30.4, Blast_Score=115, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 31022; Mature: 31022

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDITAYLNRINYAGPLAPTAETLRRLHLAHLLSVPFENLSIHWHEPIVLTDEALFQKIVL
CCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEHHHHHHHHHH
RQRGGFCYELNGLFASLLRTLGFQVEMLSAGVMNKRGEFGPEFDHMTLMVTLAERWLVDV
HHCCCCEEEHHHHHHHHHHHHCCEEEEHHHHHHCCCCCCCCCCCHHHHHEEEHHHHEEEC
GFGDSFREPLLLDARTEQVQGRRAYRIEEVGDGRLILMERREGDEWQAQYRFSLEPHVYA
CCCCCCCCCEEECCCHHHHCCCCCEEEEECCCCEEEEEECCCCCCEEEEEEEECCCCEEE
DYAGMCRYHQTSPESHFTQRRICSLATADGRVTLSERRLIITRGGERQERELGSAEEYGE
CHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCHHHHHCCCHHHHHH
VLRTHFGIEAAPNQGMQPTAMRRSVILETY
HHHHHCCCCCCCCCCCCHHHHHHHEEEECC
>Mature Secondary Structure
MDITAYLNRINYAGPLAPTAETLRRLHLAHLLSVPFENLSIHWHEPIVLTDEALFQKIVL
CCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEHHHHHHHHHH
RQRGGFCYELNGLFASLLRTLGFQVEMLSAGVMNKRGEFGPEFDHMTLMVTLAERWLVDV
HHCCCCEEEHHHHHHHHHHHHCCEEEEHHHHHHCCCCCCCCCCCHHHHHEEEHHHHEEEC
GFGDSFREPLLLDARTEQVQGRRAYRIEEVGDGRLILMERREGDEWQAQYRFSLEPHVYA
CCCCCCCCCEEECCCHHHHCCCCCEEEEECCCCEEEEEECCCCCCEEEEEEEECCCCEEE
DYAGMCRYHQTSPESHFTQRRICSLATADGRVTLSERRLIITRGGERQERELGSAEEYGE
CHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCHHHHHCCCHHHHHH
VLRTHFGIEAAPNQGMQPTAMRRSVILETY
HHHHHCCCCCCCCCCCCHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]