Click here to switch to the map view.

The map label for this gene is vraR [H]

Identifier: 222524791

GI number: 222524791

Start: 1930006

End: 1930662

Strand: Direct

Name: vraR [H]

Synonym: Chy400_1518

Alternate gene names: 222524791

Gene position: 1930006-1930662 (Clockwise)

Preceding gene: 222524790

Following gene: 222524794

Centisome position: 36.63

GC content: 55.4

Gene sequence:

>657_bases
ATGACGATCCGCGTTCTGATAGTCGATGATCAGGCTCTCATTCGCACCGGTATCGCGACCTTGCTGTCGCGCAAAGCTGA
TATCGAAGTTGTTGGTCAGGCCGGGAATGGGCGCGAGGCGCTTGAGCTGGTTGCATCACTCGATCCCGATGTGGTGCTTA
TGGATGTGATGATGCCGGTCATGGATGGGGTAGAAGCGACGCGGAAACTTGCCGAACGCGGCCCACGCCCAGCAGTAATT
ATGTTAACTACCTTCCACGATGATGAACGGGTCCTGCAATCAATCGCTGCCGGCGCTCGTGGTTACCTGCTGAAAGATGT
CGATCATCGAGTATTGGCCGATAGCATTCGCACTGTTGCTGGAGGCGGTGCGCTGATTCACCCGCAGATCATTGCGCAAT
TATTGCCACGCCTGGCCAGTCTGGCTCCCACACCAGTCACCGCTTCCTCATCGCCATCCGATGTTACCAGCATCCTCACA
CCACGCGAACGCGACATTTTGCGACTACTGGCCCAAGGCTACACCAATCAAGAGATCGGCGAACAACTTGCGCTGAGTGT
AGGAACCGTTAAGAATCATTTAAGCGTGATTTTCGCCAAGCTGGCAGTACGCGACCGCACTCAGGCTGCACTCTGGGCGC
GAGAGCATTTGTTGTAG

Upstream 100 bases:

>100_bases
AACGGGCAGAGTTGCTGGGAGGCGGGATCGAAGCCGGTGCATTACCGGAAGGAGGCTGGCGATTACGGCTGGTGCTTCCG
ATTGACCACGAGGAATAACG

Downstream 100 bases:

>100_bases
GCAATGGGGATCGGGATCGCTCCCATATCGTCAGGGTAGAACTTGCTTCATATCCAGTTTCCGGTATTGCTCAAGATTTG
ATAATACAGCGAGAGAACGT

Product: LuxR family two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MTIRVLIVDDQALIRTGIATLLSRKADIEVVGQAGNGREALELVASLDPDVVLMDVMMPVMDGVEATRKLAERGPRPAVI
MLTTFHDDERVLQSIAAGARGYLLKDVDHRVLADSIRTVAGGGALIHPQIIAQLLPRLASLAPTPVTASSSPSDVTSILT
PRERDILRLLAQGYTNQEIGEQLALSVGTVKNHLSVIFAKLAVRDRTQAALWAREHLL

Sequences:

>Translated_218_residues
MTIRVLIVDDQALIRTGIATLLSRKADIEVVGQAGNGREALELVASLDPDVVLMDVMMPVMDGVEATRKLAERGPRPAVI
MLTTFHDDERVLQSIAAGARGYLLKDVDHRVLADSIRTVAGGGALIHPQIIAQLLPRLASLAPTPVTASSSPSDVTSILT
PRERDILRLLAQGYTNQEIGEQLALSVGTVKNHLSVIFAKLAVRDRTQAALWAREHLL
>Mature_217_residues
TIRVLIVDDQALIRTGIATLLSRKADIEVVGQAGNGREALELVASLDPDVVLMDVMMPVMDGVEATRKLAERGPRPAVIM
LTTFHDDERVLQSIAAGARGYLLKDVDHRVLADSIRTVAGGGALIHPQIIAQLLPRLASLAPTPVTASSSPSDVTSILTP
RERDILRLLAQGYTNQEIGEQLALSVGTVKNHLSVIFAKLAVRDRTQAALWAREHLL

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu3, which leads to vancomycin resistance [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=209, Percent_Identity=37.3205741626794, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787473, Length=219, Percent_Identity=36.5296803652968, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1788222, Length=201, Percent_Identity=35.8208955223881, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790102, Length=209, Percent_Identity=33.0143540669856, Blast_Score=94, Evalue=5e-21,
Organism=Escherichia coli, GI1786747, Length=210, Percent_Identity=24.2857142857143, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082052, Length=106, Percent_Identity=38.6792452830189, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788550, Length=105, Percent_Identity=38.0952380952381, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788712, Length=202, Percent_Identity=24.7524752475248, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23516; Mature: 23385

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRVLIVDDQALIRTGIATLLSRKADIEVVGQAGNGREALELVASLDPDVVLMDVMMPV
CEEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHH
MDGVEATRKLAERGPRPAVIMLTTFHDDERVLQSIAAGARGYLLKDVDHRVLADSIRTVA
HCCHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
GGGALIHPQIIAQLLPRLASLAPTPVTASSSPSDVTSILTPRERDILRLLAQGYTNQEIG
CCCCEECHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCHHHH
EQLALSVGTVKNHLSVIFAKLAVRDRTQAALWAREHLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TIRVLIVDDQALIRTGIATLLSRKADIEVVGQAGNGREALELVASLDPDVVLMDVMMPV
EEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHH
MDGVEATRKLAERGPRPAVIMLTTFHDDERVLQSIAAGARGYLLKDVDHRVLADSIRTVA
HCCHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
GGGALIHPQIIAQLLPRLASLAPTPVTASSSPSDVTSILTPRERDILRLLAQGYTNQEIG
CCCCEECHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCHHHH
EQLALSVGTVKNHLSVIFAKLAVRDRTQAALWAREHLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]