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The map label for this gene is trpC [H]

Identifier: 222524784

GI number: 222524784

Start: 1922854

End: 1923666

Strand: Direct

Name: trpC [H]

Synonym: Chy400_1511

Alternate gene names: 222524784

Gene position: 1922854-1923666 (Clockwise)

Preceding gene: 222524783

Following gene: 222524785

Centisome position: 36.49

GC content: 56.58

Gene sequence:

>813_bases
ATGAGCGAACCAACCATTCTGGAACAGATATTAGCCCACAAACGAGTGGAAGTACGTCGTCAACAAGCCAAAATTCCCCT
TGCTGCTCTGCATGACCGGATTCGGCATGCGCCACCGATTCGTGATTTCGCCGCTGCACTACGCCGGGGGCCGGCAACGG
CCCTCATTGCTGAGGTCAAGAAGGCCTCACCCAGTCGTGGTGTGTTGCTGGCCAACTTCGACCATCTGGCCCTGGCCCGT
ACCTACGTGGCCAACGGCGCGGCGGCATTGTCGGTATTGACCGATCAGCGATTCTTTCAGGGGAGCCTGACCTACCTGGC
CGGTATTCGTGCGCTGCCCGACATTCAGGCAGCAGGCACACCCTTGCTTCGGAAAGATTTCATCATCGATCCGTACCAGG
TCTATGAAGCGCGCGCCTACGGTGCTGACGCCATTTTGTTAATTGTGGCTGCACTCGATGATCAGACACTGGCTGAACTT
TTCACCCTAACCTATGAACTGGGAATGCATGCCCTGGTAGAGGTACACACTGTGGCTGAGTTGGAACGAGCACTACGCAT
CCAACCACCAATCATTGGGGTGAACAACCGTGATCTGCACCGATTCGTGACTGACCGCACGACAACCCGGAACATAGCAG
ATCATCTGCCATCAGGAACGCAACGACCACTGCTAGTCAGTGAGAGCGGTATTTTTACCCCCGACCACGTCGCCGAGGTG
CGGGGCTACGGTGCCGACGCGATCCTGGTCGGAGAGGCATTAGTAACAGCACCGGATATTGGGCTTCAGGTGCGAACGCT
AGCGACCGCATAA

Upstream 100 bases:

>100_bases
ATGGCGATTATCGGCTATCGTCTATCGGCAACAGGTATTGCCAGTCGCACCTCGGATGAGGGTCGAAGCAACCGACGGCA
CATGCTACCAGGGACAACTC

Downstream 100 bases:

>100_bases
CAGCAAGGAGTGTTTACTGTGCGACGATGTCCTGCCTGTGGGTACCCTGTTACCGGTACAGAACGATTTTGTCCGGCCTG
TGGTCACGGGTTGTCCTCAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MSEPTILEQILAHKRVEVRRQQAKIPLAALHDRIRHAPPIRDFAAALRRGPATALIAEVKKASPSRGVLLANFDHLALAR
TYVANGAAALSVLTDQRFFQGSLTYLAGIRALPDIQAAGTPLLRKDFIIDPYQVYEARAYGADAILLIVAALDDQTLAEL
FTLTYELGMHALVEVHTVAELERALRIQPPIIGVNNRDLHRFVTDRTTTRNIADHLPSGTQRPLLVSESGIFTPDHVAEV
RGYGADAILVGEALVTAPDIGLQVRTLATA

Sequences:

>Translated_270_residues
MSEPTILEQILAHKRVEVRRQQAKIPLAALHDRIRHAPPIRDFAAALRRGPATALIAEVKKASPSRGVLLANFDHLALAR
TYVANGAAALSVLTDQRFFQGSLTYLAGIRALPDIQAAGTPLLRKDFIIDPYQVYEARAYGADAILLIVAALDDQTLAEL
FTLTYELGMHALVEVHTVAELERALRIQPPIIGVNNRDLHRFVTDRTTTRNIADHLPSGTQRPLLVSESGIFTPDHVAEV
RGYGADAILVGEALVTAPDIGLQVRTLATA
>Mature_269_residues
SEPTILEQILAHKRVEVRRQQAKIPLAALHDRIRHAPPIRDFAAALRRGPATALIAEVKKASPSRGVLLANFDHLALART
YVANGAAALSVLTDQRFFQGSLTYLAGIRALPDIQAAGTPLLRKDFIIDPYQVYEARAYGADAILLIVAALDDQTLAELF
TLTYELGMHALVEVHTVAELERALRIQPPIIGVNNRDLHRFVTDRTTTRNIADHLPSGTQRPLLVSESGIFTPDHVAEVR
GYGADAILVGEALVTAPDIGLQVRTLATA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=261, Percent_Identity=40.2298850574713, Blast_Score=167, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=273, Percent_Identity=38.4615384615385, Blast_Score=172, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29406; Mature: 29275

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPTILEQILAHKRVEVRRQQAKIPLAALHDRIRHAPPIRDFAAALRRGPATALIAEVK
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHH
KASPSRGVLLANFDHLALARTYVANGAAALSVLTDQRFFQGSLTYLAGIRALPDIQAAGT
HCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCC
PLLRKDFIIDPYQVYEARAYGADAILLIVAALDDQTLAELFTLTYELGMHALVEVHTVAE
CCHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LERALRIQPPIIGVNNRDLHRFVTDRTTTRNIADHLPSGTQRPLLVSESGIFTPDHVAEV
HHHHHCCCCCEEECCCCHHHHHHHCCCHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHH
RGYGADAILVGEALVTAPDIGLQVRTLATA
HCCCCCEEEECCHHHCCCCCCEEEEEEECC
>Mature Secondary Structure 
SEPTILEQILAHKRVEVRRQQAKIPLAALHDRIRHAPPIRDFAAALRRGPATALIAEVK
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHH
KASPSRGVLLANFDHLALARTYVANGAAALSVLTDQRFFQGSLTYLAGIRALPDIQAAGT
HCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCC
PLLRKDFIIDPYQVYEARAYGADAILLIVAALDDQTLAELFTLTYELGMHALVEVHTVAE
CCHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LERALRIQPPIIGVNNRDLHRFVTDRTTTRNIADHLPSGTQRPLLVSESGIFTPDHVAEV
HHHHHCCCCCEEECCCCHHHHHHHCCCHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHH
RGYGADAILVGEALVTAPDIGLQVRTLATA
HCCCCCEEEECCHHHCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA