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The map label for this gene is rsmA [H]

Identifier: 222524255

GI number: 222524255

Start: 1251654

End: 1252526

Strand: Reverse

Name: rsmA [H]

Synonym: Chy400_0978

Alternate gene names: 222524255

Gene position: 1252526-1251654 (Counterclockwise)

Preceding gene: 222524256

Following gene: 222524254

Centisome position: 23.77

GC content: 61.74

Gene sequence:

>873_bases
GTGAATCCATATCTGAATCCACAACGCATTCGTGCTGCCCTGCGGGCGCTCAATCTGCGCCCGACCCGTGGCATGGGGCA
GAACTTTCTCCTCGATGGTCAGGTACTGGCAACGATTGTGGATGAGGCGAAACTCAATGCTTCTGATGCTGTCGTCGAAG
TCGGGCCGGGCCTCGGTGTGTTGACGTGGGAGCTGGTGCAGCGTGCCGGGCGGGTGATCTGTGTTGAACTGGATCGCCGG
CTTGCCGACCGGCTGGCCGCTGAGTTCCGCGATCAGTCTCATCTCTATCTGATCCAGGGTGATGTTTTGAAGGTTGCGCC
TTCCGATCTGCTGGCGCGGGCTGCTGCTACGCCACCGTACAAACTGGTTGCGAATATCCCATACGCCATCACCGCCCCGC
TGCTGCGCCATTTTCTTGAGGCGACCACCCCACCCGACCTGAGCATCTTGCTGGTGCAGTGGGAGGTTGCCGAACGTATC
TGCGCCGGCCCCGGCGATTACAGCGTCCTGGCGCACGCGGTGCAACTGTACGCCGAACCGACGATTGTGGCCCGCGTTCC
GGCTGCCAGCTTTTTCCCGGCACCGGCGGTCGACTCGGCAATCCTGCGCCTCGTTCGCCGTCCGCAACTGGCGGTGGCAG
TAGACGATGTGAATGCGCTGTTCCGGCTGATCAAAGCCGGGTTTCTTCATGCCCGCAAGCAGTTAGGGAATGCCCTGCCC
GGTGGTCTGGCCGCACTTGGGGTAACGGTTAGCCGTGAACACGTCGTGCAGGCGCTTCACGCCGCCGGTATCGATCCGCA
ACGCCGTGCCGAAACGGTAACCCTGGCGGAATGGGCAAAATTGCTCGCTGTGTTGTCCGAATCGGGGGTATAG

Upstream 100 bases:

>100_bases
TGAATATCGATGAGCGTGCCCGTCTGGTGGGTGGCCGGGCTGAGATTGATTCGACCCCTGGCAAAGGCACACAGATTACC
ATTTTTGTTCCGATTGAGTC

Downstream 100 bases:

>100_bases
TTATAAAGAGAGACCTTTCTGATCTGATCGTGACAACAGCAGCGGAGGCACGTGTGGCTGAGCAAACAGTACCATATTTC
GCAAATCTTTACCGGCACGA

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MNPYLNPQRIRAALRALNLRPTRGMGQNFLLDGQVLATIVDEAKLNASDAVVEVGPGLGVLTWELVQRAGRVICVELDRR
LADRLAAEFRDQSHLYLIQGDVLKVAPSDLLARAAATPPYKLVANIPYAITAPLLRHFLEATTPPDLSILLVQWEVAERI
CAGPGDYSVLAHAVQLYAEPTIVARVPAASFFPAPAVDSAILRLVRRPQLAVAVDDVNALFRLIKAGFLHARKQLGNALP
GGLAALGVTVSREHVVQALHAAGIDPQRRAETVTLAEWAKLLAVLSESGV

Sequences:

>Translated_290_residues
MNPYLNPQRIRAALRALNLRPTRGMGQNFLLDGQVLATIVDEAKLNASDAVVEVGPGLGVLTWELVQRAGRVICVELDRR
LADRLAAEFRDQSHLYLIQGDVLKVAPSDLLARAAATPPYKLVANIPYAITAPLLRHFLEATTPPDLSILLVQWEVAERI
CAGPGDYSVLAHAVQLYAEPTIVARVPAASFFPAPAVDSAILRLVRRPQLAVAVDDVNALFRLIKAGFLHARKQLGNALP
GGLAALGVTVSREHVVQALHAAGIDPQRRAETVTLAEWAKLLAVLSESGV
>Mature_290_residues
MNPYLNPQRIRAALRALNLRPTRGMGQNFLLDGQVLATIVDEAKLNASDAVVEVGPGLGVLTWELVQRAGRVICVELDRR
LADRLAAEFRDQSHLYLIQGDVLKVAPSDLLARAAATPPYKLVANIPYAITAPLLRHFLEATTPPDLSILLVQWEVAERI
CAGPGDYSVLAHAVQLYAEPTIVARVPAASFFPAPAVDSAILRLVRRPQLAVAVDDVNALFRLIKAGFLHARKQLGNALP
GGLAALGVTVSREHVVQALHAAGIDPQRRAETVTLAEWAKLLAVLSESGV

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=224, Percent_Identity=32.5892857142857, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI156415992, Length=295, Percent_Identity=26.4406779661017, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786236, Length=268, Percent_Identity=32.8358208955224, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI25146882, Length=217, Percent_Identity=33.6405529953917, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI25141369, Length=227, Percent_Identity=27.7533039647577, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324989, Length=207, Percent_Identity=33.8164251207729, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21358017, Length=222, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI21357273, Length=303, Percent_Identity=27.3927392739274, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 31245; Mature: 31245

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPYLNPQRIRAALRALNLRPTRGMGQNFLLDGQVLATIVDEAKLNASDAVVEVGPGLGV
CCCCCCHHHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCCEEEECCCCCH
LTWELVQRAGRVICVELDRRLADRLAAEFRDQSHLYLIQGDVLKVAPSDLLARAAATPPY
HHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEECCEEEECHHHHHHHHCCCCCH
KLVANIPYAITAPLLRHFLEATTPPDLSILLVQWEVAERICAGPGDYSVLAHAVQLYAEP
HHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHCCCCCHHHHHHHHHHHCCC
TIVARVPAASFFPAPAVDSAILRLVRRPQLAVAVDDVNALFRLIKAGFLHARKQLGNALP
EEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCC
GGLAALGVTVSREHVVQALHAAGIDPQRRAETVTLAEWAKLLAVLSESGV
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPYLNPQRIRAALRALNLRPTRGMGQNFLLDGQVLATIVDEAKLNASDAVVEVGPGLGV
CCCCCCHHHHHHHHHHHCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCCCEEEECCCCCH
LTWELVQRAGRVICVELDRRLADRLAAEFRDQSHLYLIQGDVLKVAPSDLLARAAATPPY
HHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEECCEEEECHHHHHHHHCCCCCH
KLVANIPYAITAPLLRHFLEATTPPDLSILLVQWEVAERICAGPGDYSVLAHAVQLYAEP
HHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHCCCCCHHHHHHHHHHHCCC
TIVARVPAASFFPAPAVDSAILRLVRRPQLAVAVDDVNALFRLIKAGFLHARKQLGNALP
EEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCC
GGLAALGVTVSREHVVQALHAAGIDPQRRAETVTLAEWAKLLAVLSESGV
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA