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The map label for this gene is srrA [H]

Identifier: 222524229

GI number: 222524229

Start: 1209487

End: 1210188

Strand: Reverse

Name: srrA [H]

Synonym: Chy400_0951

Alternate gene names: 222524229

Gene position: 1210188-1209487 (Counterclockwise)

Preceding gene: 222524230

Following gene: 222524228

Centisome position: 22.97

GC content: 57.69

Gene sequence:

>702_bases
ATGTCTCGCACCATCCTTGTGGTAGATGATGAACCGGGCATTGTCAAAATTGCCCGCGACTACCTTGAACGGGCCGGTTT
TCAGGTGATCAGTGCCGGCGATGGGCCGACAGCGTTACGGCTGGCGCGGCAGGAACATCCAGCCCTCATGGTACTCGATC
TGATGCTACCCGGTATGGATGGACTTGACGTAACCCGTGCCCTGCGCCAGGACCCGCTTACTGCGCGCTTACCGATCATC
ATGCTGACTGCCCGCGTCGAGGAGACCGACCGTCTGATTGGCCTGGAACTGGGTGCCGACGACTACATCACCAAACCCTT
CAGCCCCCGCGAACTGGTAGCGCGCGTGCGTGCCGTCTTGCGGCGCAGTGAAGGTTCAACCTCGCCAGGGAAGCAGATTC
AGATCGGCGGATTGGTTATCGACCTCGAATGCCGTAGTGTCCGCCGAGATGGTGAAACGATTGAACTGACCGCGACCGAA
TTCGATCTCCTTGCCGTTTTAGCCAGTGCGCCGGGTCGCCCCTTCACCCGTGCTCAATTGCTCGACCGTGTTTACAACAC
CGAATATACCGGCTTCGACCGGACTATCGACGCCCATATCAAAAATCTCCGCCGTAAGATTGAACCCGACTCGAATGGGC
CACCACGCCTGATCTTGACCGTCTACGGAGTTGGCTACAAGTTTGCCGAAACGTATCCATAA

Upstream 100 bases:

>100_bases
TGGCACAGGAGATATGGAAGACGCGGGACAGTCAGCCTGGCTGTCCCCATCACCTTCTTACCGCAGTTGAATCGGCTGAT
GGCAGGAGGAAGCAACGGCT

Downstream 100 bases:

>100_bases
TCCGATGCTCATTGAGGTGCGATATGCGCCCGCCTCGCCTCTTCAACCTGATGCTCACCGCCTTCGCCCTGGTCATCGTG
CTCGGTATCAGCGGGATGGC

Product: winged helix family two component transcriptional regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MSRTILVVDDEPGIVKIARDYLERAGFQVISAGDGPTALRLARQEHPALMVLDLMLPGMDGLDVTRALRQDPLTARLPII
MLTARVEETDRLIGLELGADDYITKPFSPRELVARVRAVLRRSEGSTSPGKQIQIGGLVIDLECRSVRRDGETIELTATE
FDLLAVLASAPGRPFTRAQLLDRVYNTEYTGFDRTIDAHIKNLRRKIEPDSNGPPRLILTVYGVGYKFAETYP

Sequences:

>Translated_233_residues
MSRTILVVDDEPGIVKIARDYLERAGFQVISAGDGPTALRLARQEHPALMVLDLMLPGMDGLDVTRALRQDPLTARLPII
MLTARVEETDRLIGLELGADDYITKPFSPRELVARVRAVLRRSEGSTSPGKQIQIGGLVIDLECRSVRRDGETIELTATE
FDLLAVLASAPGRPFTRAQLLDRVYNTEYTGFDRTIDAHIKNLRRKIEPDSNGPPRLILTVYGVGYKFAETYP
>Mature_232_residues
SRTILVVDDEPGIVKIARDYLERAGFQVISAGDGPTALRLARQEHPALMVLDLMLPGMDGLDVTRALRQDPLTARLPIIM
LTARVEETDRLIGLELGADDYITKPFSPRELVARVRAVLRRSEGSTSPGKQIQIGGLVIDLECRSVRRDGETIELTATEF
DLLAVLASAPGRPFTRAQLLDRVYNTEYTGFDRTIDAHIKNLRRKIEPDSNGPPRLILTVYGVGYKFAETYP

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=45.0892857142857, Blast_Score=184, Evalue=5e-48,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=43.1034482758621, Blast_Score=182, Evalue=1e-47,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=45.8515283842795, Blast_Score=180, Evalue=6e-47,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=44.7368421052632, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=41.2280701754386, Blast_Score=157, Evalue=5e-40,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=37.7777777777778, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=39.2857142857143, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=35.4700854700855, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=39.1891891891892, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1787229, Length=235, Percent_Identity=33.1914893617021, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=37.6106194690265, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1789402, Length=233, Percent_Identity=33.9055793991416, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=33.9285714285714, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=35.1851851851852, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=30.5825242718447, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788191, Length=119, Percent_Identity=30.2521008403361, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI145693157, Length=104, Percent_Identity=36.5384615384615, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788713, Length=105, Percent_Identity=34.2857142857143, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1790299, Length=139, Percent_Identity=28.7769784172662, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25885; Mature: 25754

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTILVVDDEPGIVKIARDYLERAGFQVISAGDGPTALRLARQEHPALMVLDLMLPGMD
CCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCEEEEEEECCCCCC
GLDVTRALRQDPLTARLPIIMLTARVEETDRLIGLELGADDYITKPFSPRELVARVRAVL
CHHHHHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
RRSEGSTSPGKQIQIGGLVIDLECRSVRRDGETIELTATEFDLLAVLASAPGRPFTRAQL
HHCCCCCCCCCEEEECCEEEEEEEHHHCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHH
LDRVYNTEYTGFDRTIDAHIKNLRRKIEPDSNGPPRLILTVYGVGYKFAETYP
HHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEEECCCCC
>Mature Secondary Structure 
SRTILVVDDEPGIVKIARDYLERAGFQVISAGDGPTALRLARQEHPALMVLDLMLPGMD
CCEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCEEEEEEECCCCCC
GLDVTRALRQDPLTARLPIIMLTARVEETDRLIGLELGADDYITKPFSPRELVARVRAVL
CHHHHHHHHHCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
RRSEGSTSPGKQIQIGGLVIDLECRSVRRDGETIELTATEFDLLAVLASAPGRPFTRAQL
HHCCCCCCCCCEEEECCEEEEEEEHHHCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHH
LDRVYNTEYTGFDRTIDAHIKNLRRKIEPDSNGPPRLILTVYGVGYKFAETYP
HHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA