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The map label for this gene is copA [H]

Identifier: 222523915

GI number: 222523915

Start: 762681

End: 765233

Strand: Reverse

Name: copA [H]

Synonym: Chy400_0625

Alternate gene names: 222523915

Gene position: 765233-762681 (Counterclockwise)

Preceding gene: 222523916

Following gene: 222523913

Centisome position: 14.52

GC content: 61.3

Gene sequence:

>2553_bases
ATGGCCGAGCGTGAAGTGATATTGCCAATCACCGGGATGACCTGTGCAAGCTGCTCGGCGCGGGTCGAGAAGGCGTTGCG
TAAGGCACCGGGTGTGCTGGCTGCCGAGGTGAATCTGGCCGGTGAGCAGGCGCTGGTGCGCTACGATCCGGGGCTGGTTC
AGCCCGAAGCGTTGCAGGCGGCGGTGGAGCAGGCCGGGTATGGGGTGGTTGTCGATGAGATCACGCTGGCGATCACCGGG
ATGACCTGTGCCAGTTGTTCGGCACGGGTCGAGAAGGCGTTGCGTAAGCTGCCGGGGGTGTTGGCGGCGGAAGTGAATCT
GGCCAGTGAGCAGGCGCTGGTGCGTTATGTGCCGGGGATGGTTGAGCGCACCGATCTGGTGGCGGCGGTGGAGCAGGCCG
GGTATGGGGTGATTTTGCCGTCTGCTACCGATGAGGCCGCTGAAGATGTGGAGGCGCGGGCACGTGAAGCAGAGATGACG
GTGCGGCGGCGGCGATTGCTGGTTGGTGTGGTCTTTGGGCTGCCGCTCTTCGTGTTGTCGATGGCGCGTGATTTTGGTCT
GATTGCCCCCTGGTTAATCGGTGAGGGGGCGGCGATGATGGCGACAATGCGTGATGCGGCTATGGGTGAGATTATGGCCA
TGGTCGCTGCCCGCGATGACCTGCTCAACTGGCTCTTTCTGGCGCTGGCGACACCGGTGCAGTTTTACTCCGGTCGCGAT
TTCTACCGGCATGCGTGGCGGGCATTGCGTGCCCGTACCGCCACTATGGATACGCTCATTGCCCTCGGTTCGTCGGCTGC
CTATTTCTACAGTCTGGCAATGTTGCTCAGCGGTGCGCCCGGCCATGTCTATTTCGAGACGGCGGCATTGATCATTACGC
TGATTCTGGTTGGGAAGTATCTGGAGGCGCGTGCGAAGGGGCAGACGAGTGCCGCGATTAAGGCGTTGATCGGGCTTCAG
CCGAAGACCGCACGAGTGGTGCGGGGCGGTCAAGAAGTTGATGTGCCGCTCACCGAGGTGCGGGTAGGTGAGATGATTAT
TGTGCGACCGGGGGAGAAGATTCCGGTCGATGGGGTGATTGTCTCCGGTGAGTCGACGATTGATGAGAGTATGCTCACCG
GTGAGAGTTTGCCGGTTGAGAAGCGCAGTGGCGATCCGGTCTTCGGGGCGACGATTAATCGCAGCGGTAGTTTTCAGATG
CGGGCGACACGGATCGGTAAGGATTCGGCGCTGGCGCAGATTATTCGTCTCGTGCAAGAGGCGCAAGGCTCGAAAGCACC
GGTACAGGCGCTGGTTGATCGGGTTTCTGCTGTCTTTGTGCCGATAGTGATTGTGATTGCGTTGATTACCTTTCTCGGCT
GGTTGTGGGCCGGGGTGGGGTTGACCCAGGCGCTCATTTTTGCGGTGGCGGTGCTGGTGATTGCCTGTCCGTGTGCGTTG
GGATTGGCCACGCCGACTGCAATTATGGTTGGCACCGGTACCGGTGCGTCACACGGTATTTTGATCCGCAATGCCGAGGC
TCTGGAACGTGCGGCAAGTCTGCACGCGGTGGTGTTCGATAAGACCGGTACCATTACGCATGGTCGCCCCGCAGTGACCG
ATGTTGTGATGGTGGCCAGGCCGGTGCTGGCGCAGGGAACCCAGTCCGACGGCACGGGAGATCAGGTGTTGCTACAGATT
GCGGCGGCGGCTGAGAGTCGCAGCGAGCATCCATTAGGGGTGGCAATTGTGAAGGCGGCGCAGGAGCGTGGTCTGGCTGT
CGAGCGACCGACGCGCTTTCAGGCTGTCAGTGGTGCCGGGGTGGAAGCTGAGGTCGGTGGGCAGACTGTGCTGGTGGGAA
CGCTGCGCTGGTTGCGTGAGCGAGGGGTTGAGATACACGCTTTAGAGGCTATCGTCGATCAGTTGCAGAATGAAGGGAAA
ACCGCGATTGCGGTGGCCGTTGATAGTGAGGCGTGGGGTGTGATCGCGCTGGCCGATACGGTCAAACCAACCGCTGCGGA
GGCGGTAGCAAAGCTGCATCAGGCCGGGATTGAGGTTGCGTTGCTGACCGGTGATAATCAGCGCACGGCAGCAGCGATAG
CGGCGGCGGTCGGTATTCCGGCAACAGCCGTGTATGCTGAAGTGAAGCCGGATGAAAAGGCGGCGATTGTGGCTCGCTTG
CAGCAGAGTGGGCCGCATGGCAAACCACGCCGGGTAGCGATGGTGGGTGATGGGATTAATGATGCGCCGGCGCTGGCCCA
GGCTGACGTGGGGATTGCGATGGGGAGCGGTACCGATGTGGCGATGGAGACGGCGGATATTACGTTGATGCGCAGCGATC
CGCGGGGCGTGGTGCAGGCAATTGCCCTCAGTCGCGCCACAGTACGCACCATTCGCTGGAATCTCTTCTGGGCGTTTGCC
TACAATGTGTTGTTGATCCCGGTGGCGGCGGGTGTCTTCTACCCGTTGACCGGCTGGCAGTTAAGCCCGGTGCTGGCCGC
GGCTGCAATGGCCTTCTCGTCGGTCTTTGTGGTGACTAATTCGCTCCGTCTGCGGCGTGTGCGGATGGGGTGA

Upstream 100 bases:

>100_bases
TTCGCAACGATGTTCAGAGGCGCACATCAGTGCGCCTCTTTCACTCAGATGGTGGAGATAGGCTGTACAATCGCAGTCTG
TCGAGGAAGGAGTTGTTACC

Downstream 100 bases:

>100_bases
TGATAGGAGCAAGTCTTGACGGAAGGTTAAACAGCCGGACCGGTCTACAGGCGTGTTGCCTCCGTGAATTGTGGGGGAAC
CGCTGATACACGCACGTGAT

Product: copper-translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: Protein CopA [H]

Number of amino acids: Translated: 850; Mature: 849

Protein sequence:

>850_residues
MAEREVILPITGMTCASCSARVEKALRKAPGVLAAEVNLAGEQALVRYDPGLVQPEALQAAVEQAGYGVVVDEITLAITG
MTCASCSARVEKALRKLPGVLAAEVNLASEQALVRYVPGMVERTDLVAAVEQAGYGVILPSATDEAAEDVEARAREAEMT
VRRRRLLVGVVFGLPLFVLSMARDFGLIAPWLIGEGAAMMATMRDAAMGEIMAMVAARDDLLNWLFLALATPVQFYSGRD
FYRHAWRALRARTATMDTLIALGSSAAYFYSLAMLLSGAPGHVYFETAALIITLILVGKYLEARAKGQTSAAIKALIGLQ
PKTARVVRGGQEVDVPLTEVRVGEMIIVRPGEKIPVDGVIVSGESTIDESMLTGESLPVEKRSGDPVFGATINRSGSFQM
RATRIGKDSALAQIIRLVQEAQGSKAPVQALVDRVSAVFVPIVIVIALITFLGWLWAGVGLTQALIFAVAVLVIACPCAL
GLATPTAIMVGTGTGASHGILIRNAEALERAASLHAVVFDKTGTITHGRPAVTDVVMVARPVLAQGTQSDGTGDQVLLQI
AAAAESRSEHPLGVAIVKAAQERGLAVERPTRFQAVSGAGVEAEVGGQTVLVGTLRWLRERGVEIHALEAIVDQLQNEGK
TAIAVAVDSEAWGVIALADTVKPTAAEAVAKLHQAGIEVALLTGDNQRTAAAIAAAVGIPATAVYAEVKPDEKAAIVARL
QQSGPHGKPRRVAMVGDGINDAPALAQADVGIAMGSGTDVAMETADITLMRSDPRGVVQAIALSRATVRTIRWNLFWAFA
YNVLLIPVAAGVFYPLTGWQLSPVLAAAAMAFSSVFVVTNSLRLRRVRMG

Sequences:

>Translated_850_residues
MAEREVILPITGMTCASCSARVEKALRKAPGVLAAEVNLAGEQALVRYDPGLVQPEALQAAVEQAGYGVVVDEITLAITG
MTCASCSARVEKALRKLPGVLAAEVNLASEQALVRYVPGMVERTDLVAAVEQAGYGVILPSATDEAAEDVEARAREAEMT
VRRRRLLVGVVFGLPLFVLSMARDFGLIAPWLIGEGAAMMATMRDAAMGEIMAMVAARDDLLNWLFLALATPVQFYSGRD
FYRHAWRALRARTATMDTLIALGSSAAYFYSLAMLLSGAPGHVYFETAALIITLILVGKYLEARAKGQTSAAIKALIGLQ
PKTARVVRGGQEVDVPLTEVRVGEMIIVRPGEKIPVDGVIVSGESTIDESMLTGESLPVEKRSGDPVFGATINRSGSFQM
RATRIGKDSALAQIIRLVQEAQGSKAPVQALVDRVSAVFVPIVIVIALITFLGWLWAGVGLTQALIFAVAVLVIACPCAL
GLATPTAIMVGTGTGASHGILIRNAEALERAASLHAVVFDKTGTITHGRPAVTDVVMVARPVLAQGTQSDGTGDQVLLQI
AAAAESRSEHPLGVAIVKAAQERGLAVERPTRFQAVSGAGVEAEVGGQTVLVGTLRWLRERGVEIHALEAIVDQLQNEGK
TAIAVAVDSEAWGVIALADTVKPTAAEAVAKLHQAGIEVALLTGDNQRTAAAIAAAVGIPATAVYAEVKPDEKAAIVARL
QQSGPHGKPRRVAMVGDGINDAPALAQADVGIAMGSGTDVAMETADITLMRSDPRGVVQAIALSRATVRTIRWNLFWAFA
YNVLLIPVAAGVFYPLTGWQLSPVLAAAAMAFSSVFVVTNSLRLRRVRMG
>Mature_849_residues
AEREVILPITGMTCASCSARVEKALRKAPGVLAAEVNLAGEQALVRYDPGLVQPEALQAAVEQAGYGVVVDEITLAITGM
TCASCSARVEKALRKLPGVLAAEVNLASEQALVRYVPGMVERTDLVAAVEQAGYGVILPSATDEAAEDVEARAREAEMTV
RRRRLLVGVVFGLPLFVLSMARDFGLIAPWLIGEGAAMMATMRDAAMGEIMAMVAARDDLLNWLFLALATPVQFYSGRDF
YRHAWRALRARTATMDTLIALGSSAAYFYSLAMLLSGAPGHVYFETAALIITLILVGKYLEARAKGQTSAAIKALIGLQP
KTARVVRGGQEVDVPLTEVRVGEMIIVRPGEKIPVDGVIVSGESTIDESMLTGESLPVEKRSGDPVFGATINRSGSFQMR
ATRIGKDSALAQIIRLVQEAQGSKAPVQALVDRVSAVFVPIVIVIALITFLGWLWAGVGLTQALIFAVAVLVIACPCALG
LATPTAIMVGTGTGASHGILIRNAEALERAASLHAVVFDKTGTITHGRPAVTDVVMVARPVLAQGTQSDGTGDQVLLQIA
AAAESRSEHPLGVAIVKAAQERGLAVERPTRFQAVSGAGVEAEVGGQTVLVGTLRWLRERGVEIHALEAIVDQLQNEGKT
AIAVAVDSEAWGVIALADTVKPTAAEAVAKLHQAGIEVALLTGDNQRTAAAIAAAVGIPATAVYAEVKPDEKAAIVARLQ
QSGPHGKPRRVAMVGDGINDAPALAQADVGIAMGSGTDVAMETADITLMRSDPRGVVQAIALSRATVRTIRWNLFWAFAY
NVLLIPVAAGVFYPLTGWQLSPVLAAAAMAFSSVFVVTNSLRLRRVRMG

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=928, Percent_Identity=37.6077586206897, Blast_Score=566, Evalue=1e-161,
Organism=Homo sapiens, GI55743071, Length=914, Percent_Identity=38.6214442013129, Blast_Score=557, Evalue=1e-158,
Organism=Homo sapiens, GI55743073, Length=571, Percent_Identity=41.8563922942207, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI48762687, Length=166, Percent_Identity=33.1325301204819, Blast_Score=88, Evalue=4e-17,
Organism=Homo sapiens, GI48762685, Length=166, Percent_Identity=33.1325301204819, Blast_Score=88, Evalue=4e-17,
Organism=Homo sapiens, GI48762689, Length=166, Percent_Identity=33.1325301204819, Blast_Score=88, Evalue=4e-17,
Organism=Homo sapiens, GI48762691, Length=166, Percent_Identity=33.1325301204819, Blast_Score=88, Evalue=4e-17,
Organism=Homo sapiens, GI28373103, Length=180, Percent_Identity=31.6666666666667, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI28373113, Length=180, Percent_Identity=31.6666666666667, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI28373105, Length=180, Percent_Identity=31.6666666666667, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI28373107, Length=180, Percent_Identity=31.6666666666667, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI28373115, Length=180, Percent_Identity=31.6666666666667, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI28373111, Length=180, Percent_Identity=31.6666666666667, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI28373109, Length=180, Percent_Identity=31.6666666666667, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI237681111, Length=357, Percent_Identity=26.6106442577031, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI237681109, Length=357, Percent_Identity=26.6106442577031, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI153946397, Length=250, Percent_Identity=28.4, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI21361181, Length=357, Percent_Identity=26.6106442577031, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI51944966, Length=282, Percent_Identity=25.886524822695, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI22748667, Length=258, Percent_Identity=27.1317829457364, Blast_Score=81, Evalue=5e-15,
Organism=Homo sapiens, GI4502271, Length=352, Percent_Identity=25.5681818181818, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI118498343, Length=166, Percent_Identity=31.3253012048193, Blast_Score=78, Evalue=4e-14,
Organism=Homo sapiens, GI83700225, Length=271, Percent_Identity=25.830258302583, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI297374799, Length=277, Percent_Identity=24.9097472924188, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786691, Length=888, Percent_Identity=40.5405405405405, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1789879, Length=789, Percent_Identity=32.0659062103929, Blast_Score=319, Evalue=4e-88,
Organism=Escherichia coli, GI1786914, Length=561, Percent_Identity=31.1942959001783, Blast_Score=178, Evalue=1e-45,
Organism=Escherichia coli, GI2367363, Length=568, Percent_Identity=24.4718309859155, Blast_Score=122, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17556548, Length=912, Percent_Identity=34.4298245614035, Blast_Score=462, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI17541776, Length=208, Percent_Identity=32.6923076923077, Blast_Score=91, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71988506, Length=180, Percent_Identity=29.4444444444444, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17554158, Length=180, Percent_Identity=29.4444444444444, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI193210130, Length=180, Percent_Identity=29.4444444444444, Blast_Score=84, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25152707, Length=180, Percent_Identity=32.7777777777778, Blast_Score=83, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71999438, Length=180, Percent_Identity=32.7777777777778, Blast_Score=83, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71999440, Length=180, Percent_Identity=32.7777777777778, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI193203356, Length=226, Percent_Identity=28.7610619469027, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193203354, Length=230, Percent_Identity=28.695652173913, Blast_Score=82, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71997262, Length=165, Percent_Identity=33.9393939393939, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71997269, Length=165, Percent_Identity=33.9393939393939, Blast_Score=81, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71997275, Length=165, Percent_Identity=33.9393939393939, Blast_Score=81, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17559224, Length=293, Percent_Identity=26.6211604095563, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17557486, Length=214, Percent_Identity=28.5046728971963, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320475, Length=897, Percent_Identity=32.2185061315496, Blast_Score=442, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319772, Length=796, Percent_Identity=27.2613065326633, Blast_Score=311, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6325221, Length=553, Percent_Identity=25.8589511754069, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6321430, Length=521, Percent_Identity=26.4875239923225, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6321271, Length=645, Percent_Identity=23.1007751937985, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320243, Length=240, Percent_Identity=31.25, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320244, Length=240, Percent_Identity=31.25, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320245, Length=240, Percent_Identity=30.8333333333333, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321432, Length=166, Percent_Identity=34.9397590361446, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221329854, Length=652, Percent_Identity=34.2024539877301, Blast_Score=350, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24668704, Length=611, Percent_Identity=24.2225859247136, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24668708, Length=611, Percent_Identity=24.2225859247136, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281366617, Length=611, Percent_Identity=24.2225859247136, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24668696, Length=611, Percent_Identity=24.2225859247136, Blast_Score=125, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161085803, Length=611, Percent_Identity=24.2225859247136, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17136664, Length=175, Percent_Identity=31.4285714285714, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762455, Length=175, Percent_Identity=31.4285714285714, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762453, Length=175, Percent_Identity=31.4285714285714, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762447, Length=175, Percent_Identity=31.4285714285714, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762457, Length=175, Percent_Identity=31.4285714285714, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762449, Length=175, Percent_Identity=31.4285714285714, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762445, Length=175, Percent_Identity=31.4285714285714, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762451, Length=175, Percent_Identity=31.4285714285714, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24648576, Length=303, Percent_Identity=24.0924092409241, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45553437, Length=303, Percent_Identity=24.0924092409241, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281362164, Length=303, Percent_Identity=24.0924092409241, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45553435, Length=303, Percent_Identity=24.0924092409241, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45553439, Length=303, Percent_Identity=24.0924092409241, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45553441, Length=303, Percent_Identity=24.0924092409241, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648580, Length=303, Percent_Identity=24.0924092409241, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648578, Length=303, Percent_Identity=24.0924092409241, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648582, Length=280, Percent_Identity=24.6428571428571, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366676, Length=259, Percent_Identity=24.7104247104247, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR006122
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 89371; Mature: 89240

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEREVILPITGMTCASCSARVEKALRKAPGVLAAEVNLAGEQALVRYDPGLVQPEALQA
CCCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCHHHHHH
AVEQAGYGVVVDEITLAITGMTCASCSARVEKALRKLPGVLAAEVNLASEQALVRYVPGM
HHHHCCCCEEEECEEEEEECCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCH
VERTDLVAAVEQAGYGVILPSATDEAAEDVEARAREAEMTVRRRRLLVGVVFGLPLFVLS
HHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MARDFGLIAPWLIGEGAAMMATMRDAAMGEIMAMVAARDDLLNWLFLALATPVQFYSGRD
HHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCH
FYRHAWRALRARTATMDTLIALGSSAAYFYSLAMLLSGAPGHVYFETAALIITLILVGKY
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
LEARAKGQTSAAIKALIGLQPKTARVVRGGQEVDVPLTEVRVGEMIIVRPGEKIPVDGVI
HHHHCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHEEECCEEEECCCCCCCCCCEE
VSGESTIDESMLTGESLPVEKRSGDPVFGATINRSGSFQMRATRIGKDSALAQIIRLVQE
ECCCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHH
AQGSKAPVQALVDRVSAVFVPIVIVIALITFLGWLWAGVGLTQALIFAVAVLVIACPCAL
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLATPTAIMVGTGTGASHGILIRNAEALERAASLHAVVFDKTGTITHGRPAVTDVVMVAR
CCCCCCEEEEECCCCCCCCEEEECHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHH
PVLAQGTQSDGTGDQVLLQIAAAAESRSEHPLGVAIVKAAQERGLAVERPTRFQAVSGAG
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEECCCCCEEEECCCC
VEAEVGGQTVLVGTLRWLRERGVEIHALEAIVDQLQNEGKTAIAVAVDSEAWGVIALADT
CEEECCCCEEEHHHHHHHHHCCCEEEHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECC
VKPTAAEAVAKLHQAGIEVALLTGDNQRTAAAIAAAVGIPATAVYAEVKPDEKAAIVARL
CCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHH
QQSGPHGKPRRVAMVGDGINDAPALAQADVGIAMGSGTDVAMETADITLMRSDPRGVVQA
HHCCCCCCCCEEEEECCCCCCCCCHHHCCCCEEECCCCCEEEEEEEEEEEECCCHHHHHH
IALSRATVRTIRWNLFWAFAYNVLLIPVAAGVFYPLTGWQLSPVLAAAAMAFSSVFVVTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEECC
SLRLRRVRMG
CHHEEEECCC
>Mature Secondary Structure 
AEREVILPITGMTCASCSARVEKALRKAPGVLAAEVNLAGEQALVRYDPGLVQPEALQA
CCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCHHHHHH
AVEQAGYGVVVDEITLAITGMTCASCSARVEKALRKLPGVLAAEVNLASEQALVRYVPGM
HHHHCCCCEEEECEEEEEECCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHCCCH
VERTDLVAAVEQAGYGVILPSATDEAAEDVEARAREAEMTVRRRRLLVGVVFGLPLFVLS
HHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MARDFGLIAPWLIGEGAAMMATMRDAAMGEIMAMVAARDDLLNWLFLALATPVQFYSGRD
HHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCH
FYRHAWRALRARTATMDTLIALGSSAAYFYSLAMLLSGAPGHVYFETAALIITLILVGKY
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHH
LEARAKGQTSAAIKALIGLQPKTARVVRGGQEVDVPLTEVRVGEMIIVRPGEKIPVDGVI
HHHHCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHEEECCEEEECCCCCCCCCCEE
VSGESTIDESMLTGESLPVEKRSGDPVFGATINRSGSFQMRATRIGKDSALAQIIRLVQE
ECCCCHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHH
AQGSKAPVQALVDRVSAVFVPIVIVIALITFLGWLWAGVGLTQALIFAVAVLVIACPCAL
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLATPTAIMVGTGTGASHGILIRNAEALERAASLHAVVFDKTGTITHGRPAVTDVVMVAR
CCCCCCEEEEECCCCCCCCEEEECHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHH
PVLAQGTQSDGTGDQVLLQIAAAAESRSEHPLGVAIVKAAQERGLAVERPTRFQAVSGAG
HHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEECCCCCEEEECCCC
VEAEVGGQTVLVGTLRWLRERGVEIHALEAIVDQLQNEGKTAIAVAVDSEAWGVIALADT
CEEECCCCEEEHHHHHHHHHCCCEEEHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECC
VKPTAAEAVAKLHQAGIEVALLTGDNQRTAAAIAAAVGIPATAVYAEVKPDEKAAIVARL
CCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHH
QQSGPHGKPRRVAMVGDGINDAPALAQADVGIAMGSGTDVAMETADITLMRSDPRGVVQA
HHCCCCCCCCEEEEECCCCCCCCCHHHCCCCEEECCCCCEEEEEEEEEEEECCCHHHHHH
IALSRATVRTIRWNLFWAFAYNVLLIPVAAGVFYPLTGWQLSPVLAAAAMAFSSVFVVTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEECC
SLRLRRVRMG
CHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 12644235; 11922674; 12590580 [H]