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The map label for this gene is tpl [H]

Identifier: 222523910

GI number: 222523910

Start: 755262

End: 756680

Strand: Direct

Name: tpl [H]

Synonym: Chy400_0619

Alternate gene names: 222523910

Gene position: 755262-756680 (Clockwise)

Preceding gene: 222523909

Following gene: 222523914

Centisome position: 14.33

GC content: 58.07

Gene sequence:

>1419_bases
ATGCAGGAACAAGACTACCCCCGTACAATGGGGCAACAATTCGGTCGGCGGTCGTGGGCCGAGCCGTGGAAGATCAAGAT
GGTTGAGCCGCTGCGCGTGACCAGCCGGGCCGAACGCGAGGCGGCGCTGAAGGCTGCCGGTTACAACACGTTTCTGCTGC
GTTCTGAAGATGTCTATATCGATCTGCTTACCGATAGTGGTACCAATGCCATGAGCGACCGGCAATGGGCAGCCCTGATG
ATGGGCGACGAGGCATACGCCGGGAGCCGCAGTTTTTATCGCCTGGAAGCAACTGTCCAACAGGTGTATGGCTACCGCCA
CATTATTCCCACCCATCAGGGGCGGGGCGCCGAGCATCTGATCAGTCAGGTCGCTATCCGCCGTGGGCAGTATGTTCCCG
GCAATATGTATTTCACAACCACCCGCCTGCACCAGGAGCTGGCCGGTGGCATCTTTGTTGATGTGATTATTGACGAAGCG
CACGATCCCCAAAGCCAGTATCCGTTTAAAGGCAACGTCGATCTCGACAAACTACAGGCGCTGATTGATAAGGTTGGCCC
GCAACAGATTGCCTATATCAGTCTGGCCGGTACCGTCAACATGGCTGGTGGGCAGCCGGTCAGTATGGCTAACGTCCGTG
CCTTACGCGCATTATGTGATCGGTACGGGTTGCGCATCTTTCTCGATTCCACACGCTTGGTTGAGAATGCCTTTTTCATC
AAAGAACGTGAACCCGGCTATGCCGAACAAAGAATCGCCGCGATTGTCCGCGAGTTTTGCAGTTACACCGATGGCGCATG
GATGAGCGCAAAGAAGGACGCGCTGGTGAACATCGGTGGCTGGTTAGCGCTCAACGATGATCAACTCGCCGATGAAGCCC
GCAATCTGGTGGTGGTGTACGAAGGGTTGCACACCTACGGCGGCATGGCCGGGCGTGATATGGAGGCGCTGGCGGTCGGG
ATTGAGGAGTCGCTGCAAGAGGATTACATCCGTGCCCGCATCGGTCAGGTGCGCTACCTCGGCGAACTGCTCCTCGACTG
GGACATCCCCATCGTAGTTCCGATTGGCGGTCACGCGATCTTTCTGGATGCACGCCGGTTCTATCCGCACCTGCCGCAAG
ACCTCTTCCCTGCCCAGACCCTGGCCGCCGAGTTGTACCTCGATTCAGGGGTGCGGGCTATGGAACGCGGTATTGCCAGC
GCCGGACGCGATCCCAAGACCGGGCAGAACTACTATCCCAAACTGGAATTAACCCGGCTGACCATCCCGCGCCGTGTTTA
TACTCAGGCCCACATGGATGTTGTGGCCGAGTCGGTGAAGGCAGTGTACGATCAACGTCATCAGGCCCGTGGCCTGCGGA
TGGTCTACGAACCACGGTACCTCCGCTTCTTCCAGGCCCGGTTTGAACCGGTGGAATGA

Upstream 100 bases:

>100_bases
ATCCACCATCCAGACCCACAACAAGCGTGCCCGGTTATCGGAGGTGTCGTACCGCTGAACCCACAACAATGGCGTTGGTA
GCAATTGCAGCGAGGCATCT

Downstream 100 bases:

>100_bases
CGACCGGACGGTAAATACTGGTAAATACTGGTGACGTATAGTCACCTTCCCTGTCGCCCAACATCAGGGGGCGCACGGCT
GTGCGCCCCCCTTATAAGAC

Product: tyrosine phenol-lyase

Products: NA

Alternate protein names: Beta-tyrosinase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MQEQDYPRTMGQQFGRRSWAEPWKIKMVEPLRVTSRAEREAALKAAGYNTFLLRSEDVYIDLLTDSGTNAMSDRQWAALM
MGDEAYAGSRSFYRLEATVQQVYGYRHIIPTHQGRGAEHLISQVAIRRGQYVPGNMYFTTTRLHQELAGGIFVDVIIDEA
HDPQSQYPFKGNVDLDKLQALIDKVGPQQIAYISLAGTVNMAGGQPVSMANVRALRALCDRYGLRIFLDSTRLVENAFFI
KEREPGYAEQRIAAIVREFCSYTDGAWMSAKKDALVNIGGWLALNDDQLADEARNLVVVYEGLHTYGGMAGRDMEALAVG
IEESLQEDYIRARIGQVRYLGELLLDWDIPIVVPIGGHAIFLDARRFYPHLPQDLFPAQTLAAELYLDSGVRAMERGIAS
AGRDPKTGQNYYPKLELTRLTIPRRVYTQAHMDVVAESVKAVYDQRHQARGLRMVYEPRYLRFFQARFEPVE

Sequences:

>Translated_472_residues
MQEQDYPRTMGQQFGRRSWAEPWKIKMVEPLRVTSRAEREAALKAAGYNTFLLRSEDVYIDLLTDSGTNAMSDRQWAALM
MGDEAYAGSRSFYRLEATVQQVYGYRHIIPTHQGRGAEHLISQVAIRRGQYVPGNMYFTTTRLHQELAGGIFVDVIIDEA
HDPQSQYPFKGNVDLDKLQALIDKVGPQQIAYISLAGTVNMAGGQPVSMANVRALRALCDRYGLRIFLDSTRLVENAFFI
KEREPGYAEQRIAAIVREFCSYTDGAWMSAKKDALVNIGGWLALNDDQLADEARNLVVVYEGLHTYGGMAGRDMEALAVG
IEESLQEDYIRARIGQVRYLGELLLDWDIPIVVPIGGHAIFLDARRFYPHLPQDLFPAQTLAAELYLDSGVRAMERGIAS
AGRDPKTGQNYYPKLELTRLTIPRRVYTQAHMDVVAESVKAVYDQRHQARGLRMVYEPRYLRFFQARFEPVE
>Mature_472_residues
MQEQDYPRTMGQQFGRRSWAEPWKIKMVEPLRVTSRAEREAALKAAGYNTFLLRSEDVYIDLLTDSGTNAMSDRQWAALM
MGDEAYAGSRSFYRLEATVQQVYGYRHIIPTHQGRGAEHLISQVAIRRGQYVPGNMYFTTTRLHQELAGGIFVDVIIDEA
HDPQSQYPFKGNVDLDKLQALIDKVGPQQIAYISLAGTVNMAGGQPVSMANVRALRALCDRYGLRIFLDSTRLVENAFFI
KEREPGYAEQRIAAIVREFCSYTDGAWMSAKKDALVNIGGWLALNDDQLADEARNLVVVYEGLHTYGGMAGRDMEALAVG
IEESLQEDYIRARIGQVRYLGELLLDWDIPIVVPIGGHAIFLDARRFYPHLPQDLFPAQTLAAELYLDSGVRAMERGIAS
AGRDPKTGQNYYPKLELTRLTIPRRVYTQAHMDVVAESVKAVYDQRHQARGLRMVYEPRYLRFFQARFEPVE

Specific function: Tryptophan catabolism. [C]

COG id: COG3033

COG function: function code E; Tryptophanase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-eliminating lyase family [H]

Homologues:

Organism=Escherichia coli, GI87082323, Length=468, Percent_Identity=45.9401709401709, Blast_Score=410, Evalue=1e-115,

Paralogues:

None

Copy number: 7160 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 460 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR011166
- InterPro:   IPR018176
- InterPro:   IPR013441 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.99.2 [H]

Molecular weight: Translated: 53507; Mature: 53507

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00853 BETA_ELIM_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEQDYPRTMGQQFGRRSWAEPWKIKMVEPLRVTSRAEREAALKAAGYNTFLLRSEDVYI
CCCCCCCHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCEEE
DLLTDSGTNAMSDRQWAALMMGDEAYAGSRSFYRLEATVQQVYGYRHIIPTHQGRGAEHL
EEEECCCCCCCCCCCEEEEEECCCCCCCCCCEEEHHHHHHHHCCCCEECCCCCCCCHHHH
ISQVAIRRGQYVPGNMYFTTTRLHQELAGGIFVDVIIDEAHDPQSQYPFKGNVDLDKLQA
HHHHHHHCCCCCCCCEEEEHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHH
LIDKVGPQQIAYISLAGTVNMAGGQPVSMANVRALRALCDRYGLRIFLDSTRLVENAFFI
HHHHCCCCCEEEEEEECEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHEEEE
KEREPGYAEQRIAAIVREFCSYTDGAWMSAKKDALVNIGGWLALNDDQLADEARNLVVVY
EECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCEEEECCHHHHHHHCCEEEEE
EGLHTYGGMAGRDMEALAVGIEESLQEDYIRARIGQVRYLGELLLDWDIPIVVPIGGHAI
ECHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEE
FLDARRFYPHLPQDLFPAQTLAAELYLDSGVRAMERGIASAGRDPKTGQNYYPKLELTRL
EEECHHHCCCCCHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
TIPRRVYTQAHMDVVAESVKAVYDQRHQARGLRMVYEPRYLRFFQARFEPVE
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCC
>Mature Secondary Structure
MQEQDYPRTMGQQFGRRSWAEPWKIKMVEPLRVTSRAEREAALKAAGYNTFLLRSEDVYI
CCCCCCCHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCEEE
DLLTDSGTNAMSDRQWAALMMGDEAYAGSRSFYRLEATVQQVYGYRHIIPTHQGRGAEHL
EEEECCCCCCCCCCCEEEEEECCCCCCCCCCEEEHHHHHHHHCCCCEECCCCCCCCHHHH
ISQVAIRRGQYVPGNMYFTTTRLHQELAGGIFVDVIIDEAHDPQSQYPFKGNVDLDKLQA
HHHHHHHCCCCCCCCEEEEHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHH
LIDKVGPQQIAYISLAGTVNMAGGQPVSMANVRALRALCDRYGLRIFLDSTRLVENAFFI
HHHHCCCCCEEEEEEECEEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCHHHHHHEEEE
KEREPGYAEQRIAAIVREFCSYTDGAWMSAKKDALVNIGGWLALNDDQLADEARNLVVVY
EECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCEEEECCHHHHHHHCCEEEEE
EGLHTYGGMAGRDMEALAVGIEESLQEDYIRARIGQVRYLGELLLDWDIPIVVPIGGHAI
ECHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEE
FLDARRFYPHLPQDLFPAQTLAAELYLDSGVRAMERGIASAGRDPKTGQNYYPKLELTRL
EEECHHHCCCCCHHHCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
TIPRRVYTQAHMDVVAESVKAVYDQRHQARGLRMVYEPRYLRFFQARFEPVE
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA