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The map label for this gene is dnaX [H]

Identifier: 222523851

GI number: 222523851

Start: 665172

End: 666968

Strand: Reverse

Name: dnaX [H]

Synonym: Chy400_0559

Alternate gene names: 222523851

Gene position: 666968-665172 (Counterclockwise)

Preceding gene: 222523854

Following gene: 222523850

Centisome position: 12.66

GC content: 57.21

Gene sequence:

>1797_bases
ATGGCAGTTCAGTCGCTCTATCGAAAATGGCGTTCACAGACCTTTGCTGAGCTGGTCGGGCAGGAGCATGTCGTACAGAC
GCTCCGCAATGCGATTGCCGAAGATCGGGTTGGCCATGCCTACCTGTTTACCGGCCCCCGTGGTGTTGGGAAGACGACCA
TGGCTCGCCTGCTTGCCAAAGCAGTGAATTGTCTTAACCCCGATCCCACCGCTCGACCGTGCGGCGTGTGCGAGATGTGT
GCTGCCATTGCTGAAGGGCGTGCAGTTGATGTGATCGAGATGGATGCCGCTTCCCACACCAGTGTGGAAGATGCGCGCGA
GATTATCGAGCGGGTGCAGTTTCGACCAGCCGAAGCTCGCATGAAGGTCTACATTATCGACGAGACCCACATGCTCTCGA
CAGCAGCGTTCAATGCCTTGCTGAAAACGCTGGAAGAGCCACCCGATCATGCCCTCTTTATCCTTGCAACCACCGAAGTT
CATAAGGTTCCCGCCACGATTCTGTCACGCTGCCAGCGCTTTACCTTCGTTCGCCATAGTGTTTCGGCAATGGCCGCTCA
TCTCCGCCGGATTGCAGCGGCAGAAGGAATTGTGCTGGCCGATGGTGTGCCTGAAGCAATTGCGCGCGCTGCCACCGGCA
GTATGCGTGATGCGCTCGGTATTCTCGAGCAACTGGCTTCGTTTGTCGAAGGCCCGATCACGCTACCACAGGTGCAAAGC
CTGCTTGGGATGACGGCAGCGGCTGAAGTTGATGCGTTGATCACGGCTCTTGTCAATCACGATCTGACAGCAGCGCTGCG
CGCAGTGCATGGGGTTGCCAATCAGGGGGCTGATGTGCGTCAGTTTACCCGCGATCTGGTGGAACGTCTGCGCGCAGTGA
TGGTGCTGAAGGCGACCGGTGATCGCACACTGCTTGATTTGAGCGATGACGAAGTGGCGCTCTTGGGGCAATGGGTGCAG
CAGGCCGATATGGCTGCGTTGGTACATTGGGTGAAGCTGTTTAGCAATCTCGATGCACAGTTACGTACAACACCCTATGG
TCAGTTACCGCTCGAAGTGGCAGTCGTTGAAGCGTTGCTGGTGCCACCACCGGTTGCGCAACCTGCCTCTTCATCTGCGT
CACGTTCCGCTTCATTGGCAGGACGTACCCCTACCAGCCGTCCCAGTGCTGCTGTACCGGCAATCGTTCCGCAAACCGAA
CCCGTTCGCGCCCCGGCACATCCCGAACCAGTGCCGCCCAGCGTTGTTGCGCCGCCGCCACCTCCAGTACCCGAACCGGT
ATCTGCATCCGGCAGTGAAGTACCGTCGGATGTCACACCTGTCTCCGATCCACCACCGCCACCGCCAGAGGCATGGGCAG
CGACCCGCCAGATGCGTCCGCCTGCCGATCCTGCTGTTGCTCGTGCTGCCGATGCTGATATGTCGGTGCTTGAACAGCTT
GAGGCGATCTGGGAAGATTTCAAGCGTGATGTTCGTCCGCGCAGTCCGACGGTGCAGGCGTTGCTCAATAGTGCGCGTCC
GTATGATGTCGAAGGCAATACTATCGTGCTGCTGGTGACATCCTCGTTCCATAAAGAACGCCTGGAAGAACCGAAGAATC
GGTCGCTTCTCGAAGATTTATTGCGTCGTCGTTTGGGGAAGACCTACGCGGTACGCTGTACCATCGAGGAAAAATCGGTT
GAACCCACCGATCTGCGTGGGAAAATTCGCGAAGCTCGTAAAGATGAACTGGTTCGTGCTGCATTGAATATCTTCGATGC
CCATATTGTAGATATCGAACCGCTCGATCCTGAATAA

Upstream 100 bases:

>100_bases
AATACCTGTATCTCGATTATACCACTCTCGGCGCGGAAGTGGGGTACCTCCTCTGGTATAATACGAGATGCTGTGCGGGT
CAAGATCATCGGAAAGCGTA

Downstream 100 bases:

>100_bases
TGTTTGCGGGATAGCTGTACAATTGTGTAGCAGTGTGGTACTCTACCCATATCTACGCTCACATGTCTTCGCCGGCTTCA
CGTGTTCTGGTACAGGCAAT

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MAVQSLYRKWRSQTFAELVGQEHVVQTLRNAIAEDRVGHAYLFTGPRGVGKTTMARLLAKAVNCLNPDPTARPCGVCEMC
AAIAEGRAVDVIEMDAASHTSVEDAREIIERVQFRPAEARMKVYIIDETHMLSTAAFNALLKTLEEPPDHALFILATTEV
HKVPATILSRCQRFTFVRHSVSAMAAHLRRIAAAEGIVLADGVPEAIARAATGSMRDALGILEQLASFVEGPITLPQVQS
LLGMTAAAEVDALITALVNHDLTAALRAVHGVANQGADVRQFTRDLVERLRAVMVLKATGDRTLLDLSDDEVALLGQWVQ
QADMAALVHWVKLFSNLDAQLRTTPYGQLPLEVAVVEALLVPPPVAQPASSSASRSASLAGRTPTSRPSAAVPAIVPQTE
PVRAPAHPEPVPPSVVAPPPPPVPEPVSASGSEVPSDVTPVSDPPPPPPEAWAATRQMRPPADPAVARAADADMSVLEQL
EAIWEDFKRDVRPRSPTVQALLNSARPYDVEGNTIVLLVTSSFHKERLEEPKNRSLLEDLLRRRLGKTYAVRCTIEEKSV
EPTDLRGKIREARKDELVRAALNIFDAHIVDIEPLDPE

Sequences:

>Translated_598_residues
MAVQSLYRKWRSQTFAELVGQEHVVQTLRNAIAEDRVGHAYLFTGPRGVGKTTMARLLAKAVNCLNPDPTARPCGVCEMC
AAIAEGRAVDVIEMDAASHTSVEDAREIIERVQFRPAEARMKVYIIDETHMLSTAAFNALLKTLEEPPDHALFILATTEV
HKVPATILSRCQRFTFVRHSVSAMAAHLRRIAAAEGIVLADGVPEAIARAATGSMRDALGILEQLASFVEGPITLPQVQS
LLGMTAAAEVDALITALVNHDLTAALRAVHGVANQGADVRQFTRDLVERLRAVMVLKATGDRTLLDLSDDEVALLGQWVQ
QADMAALVHWVKLFSNLDAQLRTTPYGQLPLEVAVVEALLVPPPVAQPASSSASRSASLAGRTPTSRPSAAVPAIVPQTE
PVRAPAHPEPVPPSVVAPPPPPVPEPVSASGSEVPSDVTPVSDPPPPPPEAWAATRQMRPPADPAVARAADADMSVLEQL
EAIWEDFKRDVRPRSPTVQALLNSARPYDVEGNTIVLLVTSSFHKERLEEPKNRSLLEDLLRRRLGKTYAVRCTIEEKSV
EPTDLRGKIREARKDELVRAALNIFDAHIVDIEPLDPE
>Mature_597_residues
AVQSLYRKWRSQTFAELVGQEHVVQTLRNAIAEDRVGHAYLFTGPRGVGKTTMARLLAKAVNCLNPDPTARPCGVCEMCA
AIAEGRAVDVIEMDAASHTSVEDAREIIERVQFRPAEARMKVYIIDETHMLSTAAFNALLKTLEEPPDHALFILATTEVH
KVPATILSRCQRFTFVRHSVSAMAAHLRRIAAAEGIVLADGVPEAIARAATGSMRDALGILEQLASFVEGPITLPQVQSL
LGMTAAAEVDALITALVNHDLTAALRAVHGVANQGADVRQFTRDLVERLRAVMVLKATGDRTLLDLSDDEVALLGQWVQQ
ADMAALVHWVKLFSNLDAQLRTTPYGQLPLEVAVVEALLVPPPVAQPASSSASRSASLAGRTPTSRPSAAVPAIVPQTEP
VRAPAHPEPVPPSVVAPPPPPVPEPVSASGSEVPSDVTPVSDPPPPPPEAWAATRQMRPPADPAVARAADADMSVLEQLE
AIWEDFKRDVRPRSPTVQALLNSARPYDVEGNTIVLLVTSSFHKERLEEPKNRSLLEDLLRRRLGKTYAVRCTIEEKSVE
PTDLRGKIREARKDELVRAALNIFDAHIVDIEPLDPE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=261, Percent_Identity=26.4367816091954, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI194306571, Length=261, Percent_Identity=27.2030651340996, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI194306567, Length=261, Percent_Identity=27.2030651340996, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI4506491, Length=328, Percent_Identity=24.0853658536585, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI31881687, Length=328, Percent_Identity=24.0853658536585, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1786676, Length=278, Percent_Identity=47.1223021582734, Blast_Score=257, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17541988, Length=218, Percent_Identity=27.9816513761468, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71986063, Length=252, Percent_Identity=25.3968253968254, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=224, Percent_Identity=27.2321428571429, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322528, Length=261, Percent_Identity=24.5210727969349, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921076, Length=217, Percent_Identity=25.8064516129032, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 64776; Mature: 64645

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVQSLYRKWRSQTFAELVGQEHVVQTLRNAIAEDRVGHAYLFTGPRGVGKTTMARLLAK
CCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
AVNCLNPDPTARPCGVCEMCAAIAEGRAVDVIEMDAASHTSVEDAREIIERVQFRPAEAR
HHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
MKVYIIDETHMLSTAAFNALLKTLEEPPDHALFILATTEVHKVPATILSRCQRFTFVRHS
EEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHH
VSAMAAHLRRIAAAEGIVLADGVPEAIARAATGSMRDALGILEQLASFVEGPITLPQVQS
HHHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
LLGMTAAAEVDALITALVNHDLTAALRAVHGVANQGADVRQFTRDLVERLRAVMVLKATG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECC
DRTLLDLSDDEVALLGQWVQQADMAALVHWVKLFSNLDAQLRTTPYGQLPLEVAVVEALL
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHH
VPPPVAQPASSSASRSASLAGRTPTSRPSAAVPAIVPQTEPVRAPAHPEPVPPSVVAPPP
CCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPVPEPVSASGSEVPSDVTPVSDPPPPPPEAWAATRQMRPPADPAVARAADADMSVLEQL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHH
EAIWEDFKRDVRPRSPTVQALLNSARPYDVEGNTIVLLVTSSFHKERLEEPKNRSLLEDL
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHCCCCCHHHHHHH
LRRRLGKTYAVRCTIEEKSVEPTDLRGKIREARKDELVRAALNIFDAHIVDIEPLDPE
HHHHHCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC
>Mature Secondary Structure 
AVQSLYRKWRSQTFAELVGQEHVVQTLRNAIAEDRVGHAYLFTGPRGVGKTTMARLLAK
CHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
AVNCLNPDPTARPCGVCEMCAAIAEGRAVDVIEMDAASHTSVEDAREIIERVQFRPAEAR
HHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCC
MKVYIIDETHMLSTAAFNALLKTLEEPPDHALFILATTEVHKVPATILSRCQRFTFVRHS
EEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHH
VSAMAAHLRRIAAAEGIVLADGVPEAIARAATGSMRDALGILEQLASFVEGPITLPQVQS
HHHHHHHHHHHHHHCCEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHH
LLGMTAAAEVDALITALVNHDLTAALRAVHGVANQGADVRQFTRDLVERLRAVMVLKATG
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEECC
DRTLLDLSDDEVALLGQWVQQADMAALVHWVKLFSNLDAQLRTTPYGQLPLEVAVVEALL
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHH
VPPPVAQPASSSASRSASLAGRTPTSRPSAAVPAIVPQTEPVRAPAHPEPVPPSVVAPPP
CCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PPVPEPVSASGSEVPSDVTPVSDPPPPPPEAWAATRQMRPPADPAVARAADADMSVLEQL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHCCCHHHHHHHH
EAIWEDFKRDVRPRSPTVQALLNSARPYDVEGNTIVLLVTSSFHKERLEEPKNRSLLEDL
HHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHCCCCCHHHHHHH
LRRRLGKTYAVRCTIEEKSVEPTDLRGKIREARKDELVRAALNIFDAHIVDIEPLDPE
HHHHHCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]