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The map label for this gene is serA [H]

Identifier: 222523594

GI number: 222523594

Start: 363809

End: 365386

Strand: Direct

Name: serA [H]

Synonym: Chy400_0300

Alternate gene names: 222523594

Gene position: 363809-365386 (Clockwise)

Preceding gene: 222523593

Following gene: 222523608

Centisome position: 6.9

GC content: 59.44

Gene sequence:

>1578_bases
ATGAACCGGATTCTTGTTACTGAAAAGATCGCTGCCGAAGGACTTGCGGTGTTGCGTCAGGCCGGGACAGTGGATGTTCG
GCTTGATCTCGACAAACCGACGCTGATCTCGATCATTGGTGAATACGATGCCCTGGTTGTCCGTTCGGCGACGAAGGTCA
CCGCTGAAGTGATTGCTGCCGGCGAACGATTGCGCGTGATCGGGCGCGCCGGCACCGGGGTTGACAATATCGACGTTGAA
GCGGCCACCCGACGCGGGATCATCGTGGTCAATGCTCCGGCCTCAAACAACGTTGCGGTTGCCGAACTGACGATTGGCCT
GTTGATCAGTCTGGCCCGTCGCATCCCCCAGGCTCATGCATCGTTGCAGAGCGGACGCTGGGCGCGGAACGATTTCGTCG
GTTGGGAAGTTCGCGGCAAGACGCTCGGCCTGGTCGGGCTGGGGCGAATTGGCTCGGAGGTGGCACGACGGGCACGGTCG
TTAGAGATGGAGGTGCTGGCGTATGATCCGGTTGTCTCGTTTGACCGCGCCGAACAACTGGGGGTTTCGCTGGTTACCCT
CGACGAACTGGTGCAACGGAGCGATGTGATCTCACTCCACGTCCCATTGATCGAAAGCACACGCAATCTGTTCGATCAGC
AGCGGATTATGCAGATGAAGCGGGGCGCTTACCTGATCAATGCCAGTCGCGGGGGGATCGTTGATGAAGTCGCGCTGGTT
GAGGCGTTGAACAGTGGTCATCTGGGTGGCGCGGCGCTCGATGTATACAACCAGGAACCGCTACCGGCGGATAGCCCGCT
GCTTGGTCACCCGAAGATCATCACTGTGCCCCATATTGGTGCATCAACCACCGAAGCGCAATTGAGCGCCGGGACTGAGA
TGGCGGAAGGCGTGGTAACTGCGCTGAACGGTGGCACACCACGCTATGCAGTGAATGCGCCCTTCGTGGCACCAGAGGCA
TGGAACGTGCTGCAACCGTACCTCAATCTGGGCCGCTTACTCGGCACACTGGTCATGCAACTGGTGCAGGAGCCGGTGCG
CAGCTACGATCTCGAATTGGGTGGTGAACTGGCTGACATGGACACCCAACCGGTGCGCCTCGCCGTCTTGCAGGGCTTAC
TGGCCGCCAGCAGCTCAGAGCGGATTACCCCAGTGAATGCACCGATTATCGCCCGCGAGCGTGGCGTGCGCATGACCGAA
CGAGTCTCGCCGGAAGCGGAAAACTACGCCGGTCTGATCACCCTACACGTGCAAACAGCGGAACGCACTCGCACATTCAG
CGGTACTGTGTTGCGTGGCGAACCACATATCGTGCAGATGGACGGCTATTTTGTCGATTTTGTCCCGCAGGGATCACTCT
TGATCACCTACCACCACGACCAGCCGGGCATGATCGGTAAAGTCGGGCAACTACTCGGCGCAGCCGATGTAAACATTTCG
GGGATGTACGTGGGGCGGCGTGCGCCCCGCGAGCGGGCGGTGATGGTCTTAACGCTCGACGAACCGGCACCACCGCAGGT
GATGGAGCAGATAGCGACGATTCCAGGTATTCAGGCTGCGTTTAGTGTAGAGTTGTAA

Upstream 100 bases:

>100_bases
GCGTATTCAGGAAGTTCACACCCTCTTTCTGCATGCCATCTGCGAGCAGGTCGAACAACGTCTTGCCAGTGCTAGCGAGC
CATACGTTTGAGAGGAGTCT

Downstream 100 bases:

>100_bases
GTGACGAACGAATGACGAAGGGGGCGGATGGTTCCGCCCCCTTTTGGTTATGGCTCTCAGGCCACCCTCTCGGCTTCAGC
CGGTGATCGCGCCGGCTGCG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MNRILVTEKIAAEGLAVLRQAGTVDVRLDLDKPTLISIIGEYDALVVRSATKVTAEVIAAGERLRVIGRAGTGVDNIDVE
AATRRGIIVVNAPASNNVAVAELTIGLLISLARRIPQAHASLQSGRWARNDFVGWEVRGKTLGLVGLGRIGSEVARRARS
LEMEVLAYDPVVSFDRAEQLGVSLVTLDELVQRSDVISLHVPLIESTRNLFDQQRIMQMKRGAYLINASRGGIVDEVALV
EALNSGHLGGAALDVYNQEPLPADSPLLGHPKIITVPHIGASTTEAQLSAGTEMAEGVVTALNGGTPRYAVNAPFVAPEA
WNVLQPYLNLGRLLGTLVMQLVQEPVRSYDLELGGELADMDTQPVRLAVLQGLLAASSSERITPVNAPIIARERGVRMTE
RVSPEAENYAGLITLHVQTAERTRTFSGTVLRGEPHIVQMDGYFVDFVPQGSLLITYHHDQPGMIGKVGQLLGAADVNIS
GMYVGRRAPRERAVMVLTLDEPAPPQVMEQIATIPGIQAAFSVEL

Sequences:

>Translated_525_residues
MNRILVTEKIAAEGLAVLRQAGTVDVRLDLDKPTLISIIGEYDALVVRSATKVTAEVIAAGERLRVIGRAGTGVDNIDVE
AATRRGIIVVNAPASNNVAVAELTIGLLISLARRIPQAHASLQSGRWARNDFVGWEVRGKTLGLVGLGRIGSEVARRARS
LEMEVLAYDPVVSFDRAEQLGVSLVTLDELVQRSDVISLHVPLIESTRNLFDQQRIMQMKRGAYLINASRGGIVDEVALV
EALNSGHLGGAALDVYNQEPLPADSPLLGHPKIITVPHIGASTTEAQLSAGTEMAEGVVTALNGGTPRYAVNAPFVAPEA
WNVLQPYLNLGRLLGTLVMQLVQEPVRSYDLELGGELADMDTQPVRLAVLQGLLAASSSERITPVNAPIIARERGVRMTE
RVSPEAENYAGLITLHVQTAERTRTFSGTVLRGEPHIVQMDGYFVDFVPQGSLLITYHHDQPGMIGKVGQLLGAADVNIS
GMYVGRRAPRERAVMVLTLDEPAPPQVMEQIATIPGIQAAFSVEL
>Mature_525_residues
MNRILVTEKIAAEGLAVLRQAGTVDVRLDLDKPTLISIIGEYDALVVRSATKVTAEVIAAGERLRVIGRAGTGVDNIDVE
AATRRGIIVVNAPASNNVAVAELTIGLLISLARRIPQAHASLQSGRWARNDFVGWEVRGKTLGLVGLGRIGSEVARRARS
LEMEVLAYDPVVSFDRAEQLGVSLVTLDELVQRSDVISLHVPLIESTRNLFDQQRIMQMKRGAYLINASRGGIVDEVALV
EALNSGHLGGAALDVYNQEPLPADSPLLGHPKIITVPHIGASTTEAQLSAGTEMAEGVVTALNGGTPRYAVNAPFVAPEA
WNVLQPYLNLGRLLGTLVMQLVQEPVRSYDLELGGELADMDTQPVRLAVLQGLLAASSSERITPVNAPIIARERGVRMTE
RVSPEAENYAGLITLHVQTAERTRTFSGTVLRGEPHIVQMDGYFVDFVPQGSLLITYHHDQPGMIGKVGQLLGAADVNIS
GMYVGRRAPRERAVMVLTLDEPAPPQVMEQIATIPGIQAAFSVEL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=414, Percent_Identity=41.0628019323672, Blast_Score=309, Evalue=5e-84,
Organism=Homo sapiens, GI145580578, Length=295, Percent_Identity=37.9661016949153, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI4557499, Length=295, Percent_Identity=37.9661016949153, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI61743967, Length=296, Percent_Identity=36.1486486486487, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI4557497, Length=296, Percent_Identity=36.1486486486487, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI145580575, Length=285, Percent_Identity=38.2456140350877, Blast_Score=164, Evalue=3e-40,
Organism=Homo sapiens, GI6912396, Length=316, Percent_Identity=30.379746835443, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1789279, Length=324, Percent_Identity=40.1234567901235, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI87082289, Length=286, Percent_Identity=36.3636363636364, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=37.2448979591837, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788660, Length=292, Percent_Identity=32.5342465753425, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87081824, Length=244, Percent_Identity=28.2786885245902, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=315, Percent_Identity=46.6666666666667, Blast_Score=295, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI25147481, Length=281, Percent_Identity=35.5871886120996, Blast_Score=162, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6320925, Length=331, Percent_Identity=37.7643504531722, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6322116, Length=341, Percent_Identity=36.950146627566, Blast_Score=204, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6324055, Length=226, Percent_Identity=32.7433628318584, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324964, Length=270, Percent_Identity=31.1111111111111, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6324980, Length=196, Percent_Identity=30.1020408163265, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=122, Percent_Identity=28.6885245901639, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI19921140, Length=324, Percent_Identity=42.5925925925926, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24646446, Length=284, Percent_Identity=38.0281690140845, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24646448, Length=284, Percent_Identity=38.0281690140845, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24646452, Length=284, Percent_Identity=38.0281690140845, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24646450, Length=284, Percent_Identity=38.0281690140845, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI62472511, Length=264, Percent_Identity=39.0151515151515, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI28574286, Length=280, Percent_Identity=32.5, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24585516, Length=310, Percent_Identity=28.3870967741935, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28574284, Length=311, Percent_Identity=29.903536977492, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24585514, Length=311, Percent_Identity=29.903536977492, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI28574282, Length=311, Percent_Identity=29.903536977492, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI45552429, Length=311, Percent_Identity=29.903536977492, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI45551003, Length=311, Percent_Identity=29.903536977492, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI28571528, Length=299, Percent_Identity=33.7792642140468, Blast_Score=138, Evalue=8e-33,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56387; Mature: 56387

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRILVTEKIAAEGLAVLRQAGTVDVRLDLDKPTLISIIGEYDALVVRSATKVTAEVIAA
CCCEEEEHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCEEEEECHHHHHHHHHHC
GERLRVIGRAGTGVDNIDVEAATRRGIIVVNAPASNNVAVAELTIGLLISLARRIPQAHA
CCEEEEEECCCCCCCCCEEEEECCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHCCHHHH
SLQSGRWARNDFVGWEVRGKTLGLVGLGRIGSEVARRARSLEMEVLAYDPVVSFDRAEQL
HHHCCCCCCCCCCCEEECCCEEEEEECCHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHH
GVSLVTLDELVQRSDVISLHVPLIESTRNLFDQQRIMQMKRGAYLINASRGGIVDEVALV
CEEEEEHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHH
EALNSGHLGGAALDVYNQEPLPADSPLLGHPKIITVPHIGASTTEAQLSAGTEMAEGVVT
HHHCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHCCCHHHCCCEE
ALNGGTPRYAVNAPFVAPEAWNVLQPYLNLGRLLGTLVMQLVQEPVRSYDLELGGELADM
EECCCCCCEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCEEECC
DTQPVRLAVLQGLLAASSSERITPVNAPIIARERGVRMTERVSPEAENYAGLITLHVQTA
CCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCHHHHCCCCCCCCEEEEEEEEEEH
ERTRTFSGTVLRGEPHIVQMDGYFVDFVPQGSLLITYHHDQPGMIGKVGQLLGAADVNIS
HHCEECCCEEEECCCCEEEECCEEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCEE
GMYVGRRAPRERAVMVLTLDEPAPPQVMEQIATIPGIQAAFSVEL
EEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure
MNRILVTEKIAAEGLAVLRQAGTVDVRLDLDKPTLISIIGEYDALVVRSATKVTAEVIAA
CCCEEEEHHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCEEEEECHHHHHHHHHHC
GERLRVIGRAGTGVDNIDVEAATRRGIIVVNAPASNNVAVAELTIGLLISLARRIPQAHA
CCEEEEEECCCCCCCCCEEEEECCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHCCHHHH
SLQSGRWARNDFVGWEVRGKTLGLVGLGRIGSEVARRARSLEMEVLAYDPVVSFDRAEQL
HHHCCCCCCCCCCCEEECCCEEEEEECCHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHH
GVSLVTLDELVQRSDVISLHVPLIESTRNLFDQQRIMQMKRGAYLINASRGGIVDEVALV
CEEEEEHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHH
EALNSGHLGGAALDVYNQEPLPADSPLLGHPKIITVPHIGASTTEAQLSAGTEMAEGVVT
HHHCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHCCCHHHCCCEE
ALNGGTPRYAVNAPFVAPEAWNVLQPYLNLGRLLGTLVMQLVQEPVRSYDLELGGELADM
EECCCCCCEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCEEECC
DTQPVRLAVLQGLLAASSSERITPVNAPIIARERGVRMTERVSPEAENYAGLITLHVQTA
CCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCHHHHCCCCCCCCEEEEEEEEEEH
ERTRTFSGTVLRGEPHIVQMDGYFVDFVPQGSLLITYHHDQPGMIGKVGQLLGAADVNIS
HHCEECCCEEEECCCCEEEECCEEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCCCCEE
GMYVGRRAPRERAVMVLTLDEPAPPQVMEQIATIPGIQAAFSVEL
EEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]