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The map label for this gene is pncB [H]

Identifier: 222523499

GI number: 222523499

Start: 244890

End: 246434

Strand: Reverse

Name: pncB [H]

Synonym: Chy400_0205

Alternate gene names: 222523499

Gene position: 246434-244890 (Counterclockwise)

Preceding gene: 222523500

Following gene: 222523497

Centisome position: 4.68

GC content: 57.41

Gene sequence:

>1545_bases
ATGAACAACGTCCAACAGCGTACTGCTACCGGCATCCTCTTCACCGATCAGTATCAATTGACAATGGCCCAACTCTATTT
TCGGATGGGCATTCACGAACGCATGGCGCAATTCGATCATTTCTTCCGCCAGCCACCCAACTACGGCTTGCACGCTGCCG
GGTACTGCATTGCTGCCGGTCTGGAATGGCTCCTCGACTGGATGGAGACGGCATGCTTTGGCCCTGCCGAGCTTGAAGTG
TTGCGCAACCAGCGGAATCGGGTCGGTAACCCGATCTTCGCCGAAGATTTTCTGACCTACCTGAGTCGGCATGGTCATTT
CGGTGGGATGACGCTGTGGGCCGTCCCAGAGGGTCGAGTAGTTCATGCCCAGGCGCCGATGACGATTGTGCGTGGGCCGT
TGCTCATGGCGCAGATTTTGGAAACAGCGCTGCTCAATCATCTCAATTACCAGACACTGGTTGCTACCAAAGCCAGCCGT
ATTCGCGAGGCGAGTGGTGCCAGCACGGTGCTGGAATTCGGCCTGCGTCGCGGCCAGGGGATGGGAGCCAATGCCGGCAC
CCGTGCCGCGCTGATCGGTGGCGCCGATTTTACCTCGAATGTCGGTCTGGCCCATACTGTCGGGCAGACCGCCAAAGGGA
CACATGCCCACGCCATGGTGCAGGCATTTCTGGCCCTCGGCATGAGTGAACTTGACGCCTTCCGTGCTTACGCCGAGGTC
TATCCCGACGATTGTCTGTTACTGGTCGATACGATTGACACGCTGAACAGCGGTCTGCCCAATGCGATTCGCGTCTTTGA
AGAGTTGCGGGCGAAAGGCCACAAACCAGTTGGTGTGCGTCTTGATTCGGGTGATCTGGCGTATCTGGCAATTCAAACGG
CCTTGATGCTTGATCGGTCCGGTTTTCCCGATACCGTTATTGTGCTTTCCAATGACCTCGATGAACTGGTGATCTGGCAG
ATTCAAAGCCAGATCGTTCAGGAAGCGCCGCGCTACAATGCCGATGCCAATGCTATTATTCGCCGTCTGGTGTACGGTGT
TGGTACACGGTTGGTGACCTCACATGGTGAAGGGGCGTTGGGGGGAGTCTACAAGCTGGTAGCGTTGCACGATGGACGCG
AATGGCAACCCGCAATTAAGATCGCCGAAAGTGCGGCCAAACTGACCAATCCCGGCCTGAAGCGGGTCTGGCGATTGTAC
GATAGTCGGGGCAAGGCCACCGCCGATCTGATTGCACTTGAGGACGAAGACCCGACCCAGGAAGAACTGATTCGGCTACG
CCACCCTAGCGATCATGCCCGTCAGCGGGTGGTCGTCCGTGCCGAACTGACCGGGATTGAGCCGTTGCTTGAGCCGGCAA
TGCTGGCAGGCCGGCGTCTGATCGAGCCACAACCAATCGAGCAGATGCGGGCGCGGCGGTACGCCGATGTTGAGCGGCTC
GATCTTGGGGTGCGACGCATCATGAATCCGCACATCTATCACGTCTCGCTCAGTCAACGGCTGTGGGATATGAAACAAGA
GTTGCTCAACCGCTTTCAAATGTAG

Upstream 100 bases:

>100_bases
ATAGGTTCTAGCACGCTCACCCGCTATCCTCACAACTATTGACAGCACTGCCCTGCGCTGGTATATTAGTGTATAATTTA
CACTATACAGTGAGGCTTGT

Downstream 100 bases:

>100_bases
CACCGGTTGTGAGCATTGACGTGAAGGTGATGCACAGATACTCATCGTGTGGAAGCATGGCGTTCGTCCTGTTATCCAAT
CAGAGCGTATACCCTTTACC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MNNVQQRTATGILFTDQYQLTMAQLYFRMGIHERMAQFDHFFRQPPNYGLHAAGYCIAAGLEWLLDWMETACFGPAELEV
LRNQRNRVGNPIFAEDFLTYLSRHGHFGGMTLWAVPEGRVVHAQAPMTIVRGPLLMAQILETALLNHLNYQTLVATKASR
IREASGASTVLEFGLRRGQGMGANAGTRAALIGGADFTSNVGLAHTVGQTAKGTHAHAMVQAFLALGMSELDAFRAYAEV
YPDDCLLLVDTIDTLNSGLPNAIRVFEELRAKGHKPVGVRLDSGDLAYLAIQTALMLDRSGFPDTVIVLSNDLDELVIWQ
IQSQIVQEAPRYNADANAIIRRLVYGVGTRLVTSHGEGALGGVYKLVALHDGREWQPAIKIAESAAKLTNPGLKRVWRLY
DSRGKATADLIALEDEDPTQEELIRLRHPSDHARQRVVVRAELTGIEPLLEPAMLAGRRLIEPQPIEQMRARRYADVERL
DLGVRRIMNPHIYHVSLSQRLWDMKQELLNRFQM

Sequences:

>Translated_514_residues
MNNVQQRTATGILFTDQYQLTMAQLYFRMGIHERMAQFDHFFRQPPNYGLHAAGYCIAAGLEWLLDWMETACFGPAELEV
LRNQRNRVGNPIFAEDFLTYLSRHGHFGGMTLWAVPEGRVVHAQAPMTIVRGPLLMAQILETALLNHLNYQTLVATKASR
IREASGASTVLEFGLRRGQGMGANAGTRAALIGGADFTSNVGLAHTVGQTAKGTHAHAMVQAFLALGMSELDAFRAYAEV
YPDDCLLLVDTIDTLNSGLPNAIRVFEELRAKGHKPVGVRLDSGDLAYLAIQTALMLDRSGFPDTVIVLSNDLDELVIWQ
IQSQIVQEAPRYNADANAIIRRLVYGVGTRLVTSHGEGALGGVYKLVALHDGREWQPAIKIAESAAKLTNPGLKRVWRLY
DSRGKATADLIALEDEDPTQEELIRLRHPSDHARQRVVVRAELTGIEPLLEPAMLAGRRLIEPQPIEQMRARRYADVERL
DLGVRRIMNPHIYHVSLSQRLWDMKQELLNRFQM
>Mature_514_residues
MNNVQQRTATGILFTDQYQLTMAQLYFRMGIHERMAQFDHFFRQPPNYGLHAAGYCIAAGLEWLLDWMETACFGPAELEV
LRNQRNRVGNPIFAEDFLTYLSRHGHFGGMTLWAVPEGRVVHAQAPMTIVRGPLLMAQILETALLNHLNYQTLVATKASR
IREASGASTVLEFGLRRGQGMGANAGTRAALIGGADFTSNVGLAHTVGQTAKGTHAHAMVQAFLALGMSELDAFRAYAEV
YPDDCLLLVDTIDTLNSGLPNAIRVFEELRAKGHKPVGVRLDSGDLAYLAIQTALMLDRSGFPDTVIVLSNDLDELVIWQ
IQSQIVQEAPRYNADANAIIRRLVYGVGTRLVTSHGEGALGGVYKLVALHDGREWQPAIKIAESAAKLTNPGLKRVWRLY
DSRGKATADLIALEDEDPTQEELIRLRHPSDHARQRVVVRAELTGIEPLLEPAMLAGRRLIEPQPIEQMRARRYADVERL
DLGVRRIMNPHIYHVSLSQRLWDMKQELLNRFQM

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=559, Percent_Identity=32.2003577817531, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71997952, Length=552, Percent_Identity=33.3333333333333, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71997947, Length=552, Percent_Identity=33.3333333333333, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71997955, Length=213, Percent_Identity=39.4366197183099, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24581587, Length=549, Percent_Identity=30.7832422586521, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI161076680, Length=286, Percent_Identity=32.1678321678322, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24581595, Length=286, Percent_Identity=32.1678321678322, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI28574709, Length=286, Percent_Identity=32.1678321678322, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24581593, Length=286, Percent_Identity=32.1678321678322, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24581591, Length=286, Percent_Identity=32.1678321678322, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 57356; Mature: 57356

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVQQRTATGILFTDQYQLTMAQLYFRMGIHERMAQFDHFFRQPPNYGLHAAGYCIAAG
CCCHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LEWLLDWMETACFGPAELEVLRNQRNRVGNPIFAEDFLTYLSRHGHFGGMTLWAVPEGRV
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCE
VHAQAPMTIVRGPLLMAQILETALLNHLNYQTLVATKASRIREASGASTVLEFGLRRGQG
EEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
MGANAGTRAALIGGADFTSNVGLAHTVGQTAKGTHAHAMVQAFLALGMSELDAFRAYAEV
CCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
YPDDCLLLVDTIDTLNSGLPNAIRVFEELRAKGHKPVGVRLDSGDLAYLAIQTALMLDRS
CCCCEEEEEECHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHHCC
GFPDTVIVLSNDLDELVIWQIQSQIVQEAPRYNADANAIIRRLVYGVGTRLVTSHGEGAL
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHEEECCCCCCH
GGVYKLVALHDGREWQPAIKIAESAAKLTNPGLKRVWRLYDSRGKATADLIALEDEDPTQ
HHHEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCH
EELIRLRHPSDHARQRVVVRAELTGIEPLLEPAMLAGRRLIEPQPIEQMRARRYADVERL
HHHHHHCCCCHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHH
DLGVRRIMNPHIYHVSLSQRLWDMKQELLNRFQM
HHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNNVQQRTATGILFTDQYQLTMAQLYFRMGIHERMAQFDHFFRQPPNYGLHAAGYCIAAG
CCCHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LEWLLDWMETACFGPAELEVLRNQRNRVGNPIFAEDFLTYLSRHGHFGGMTLWAVPEGRV
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCE
VHAQAPMTIVRGPLLMAQILETALLNHLNYQTLVATKASRIREASGASTVLEFGLRRGQG
EEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
MGANAGTRAALIGGADFTSNVGLAHTVGQTAKGTHAHAMVQAFLALGMSELDAFRAYAEV
CCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
YPDDCLLLVDTIDTLNSGLPNAIRVFEELRAKGHKPVGVRLDSGDLAYLAIQTALMLDRS
CCCCEEEEEECHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHHCC
GFPDTVIVLSNDLDELVIWQIQSQIVQEAPRYNADANAIIRRLVYGVGTRLVTSHGEGAL
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCHHEEECCCCCCH
GGVYKLVALHDGREWQPAIKIAESAAKLTNPGLKRVWRLYDSRGKATADLIALEDEDPTQ
HHHEEEEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCH
EELIRLRHPSDHARQRVVVRAELTGIEPLLEPAMLAGRRLIEPQPIEQMRARRYADVERL
HHHHHHCCCCHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHH
DLGVRRIMNPHIYHVSLSQRLWDMKQELLNRFQM
HHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]