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The map label for this gene is hmeD [H]

Identifier: 222523487

GI number: 222523487

Start: 228753

End: 230288

Strand: Direct

Name: hmeD [H]

Synonym: Chy400_0193

Alternate gene names: 222523487

Gene position: 228753-230288 (Clockwise)

Preceding gene: 222523486

Following gene: 222523488

Centisome position: 4.34

GC content: 53.12

Gene sequence:

>1536_bases
ATGGAACCGGAGATGCAAGCGTTCGTCGATTCGTTGCGCCACAACCTGACTGCCGAGGATGTGGTCAACCTCGAAGCCTG
CATGGATTGCAAGATGTGCGGCGAGGCATGTGCATGGTATCTGGTGACCGGTGATGAGAAACTTCATCCCACGTATAAGA
CCGGTCTGATTCGCCAGATCTATCATCGCTATATGACGGTGGAGGGGCGCATTGGGGGTGCATTGGGGTTAGTGCCAACT
CCCACAGTCGCCGATTTGCGGGAACATATGCAATACTTCTGGGCATGTACTGCCTGTGGACGTTGTACCCTGGCCTGTCC
ATCCGGGATTAGTATTCGCCGGATTGTTCGCCTGGCCCGCGCCGCATACGCCGATTCCGGTCTGAGCCTCGCCAATCCCA
CCATTCGGTCAATTATCGAAAATACTGATCGACATCGACATAGTTTTGGGTTAACCATGCCCCAGGTCATCGGTCGCGTC
GGCCTGTTTTTGCGTAGTGAGGATTTGGAGGTGCCGGTTGATGTGCCTGGGGCTGACATGCTCTTTGTGTGCCCGGCAGC
CGGTAATACGAAAATTCCTGATTACGGCATTAAACTTATCAAAATTCTGAATGCGGCTGGTGTCAGCTACACTATTTCGC
CTTATGTGATTGATACCGGCACTGAGATTGACCATATTGCTGTGCATCATAACCTTTCAAAGCAAATGTTAGAAGATTGG
GAACAGGAAGCGGATCGGCTGGGCGTGAAGAACATTCTGCTCGTAGAGTGTGGCTGCGATACCCGCACCCTTTACGCCGA
AGCCTCTGAAACCCTGGGCCGGCCTTTCCGCTATCCGATTGTTAGTGTTGATGCGCTGATGCTTGATTTGATCAAGCAGG
GACGGCTACCGGTTGAAAAGACTCATCTGAAGGTGACGCTGCACGATCCCTGTTATGCGACCCGTCTTTCTGGCCTGGGC
GATCTGTTCCGCGAATTACTGAATCTCGTCACCGACAATTTTATCGAGATGACACCCAACCGCGAGCATAATTATTGCTG
CAATGGTGGTGCCGGTGGGATGCGGTTACCGGAAAACACTGCGACTCGTCGCAAGATTTCGGTGCTGAAGGCCAACCAGA
TTCGCGCCACCAATGCCACATACGTGACATCACCGTGCGTGGTGTGTACGCTGTCACTGGAAGATACCTGTCAGACCTAC
GGCCTGGCCCCGCAAGGCGAACGTATGGCACTGGTGTTGTTTGAGGTTGTGTATGCCGCAATGGAGCAGGCGCTTGCCAA
ACGCGGTGAACTGGATCGGATGCGCATTCCGGCCGAATTACAGAATCGTGATCACGAGTTTTTCGTTGCGCACAGTATTG
AGGGTCGCCTGTCAATGTTGATGCAGCTTCCCGAATTTCCAGCCCTCCTTGATTGGCTTGAGCAGGATGATATTGTCAGA
CGATTCAGCAAGGATCATCCTCACGTGTACGACCTGTTACGGGCCTGGCGTGAAGTCGTGACCGCACCAAAACAACGCTC
AATTACCGCCGATTAG

Upstream 100 bases:

>100_bases
GGGAGTGCGTTACCCATGTTCGTCCTGTTACCAATTCCCATCTTCAATCAATCGCATTTGACACATTTGGATATCAAAAC
CATCGTGAGGAGGGCTTTGC

Downstream 100 bases:

>100_bases
TATGTTCGCTATTCGTAAGTAGAGGTGTCCTATGCTTATCACGTTACTGAATATTGTTGCACCAATTGCAATGACCATTT
TTGTAGTCGGTGTTGGCTTG

Product: hypothetical protein

Products: FADH2; dihydroxy-acetone-phosphate [C]

Alternate protein names: Hme subunit D [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MEPEMQAFVDSLRHNLTAEDVVNLEACMDCKMCGEACAWYLVTGDEKLHPTYKTGLIRQIYHRYMTVEGRIGGALGLVPT
PTVADLREHMQYFWACTACGRCTLACPSGISIRRIVRLARAAYADSGLSLANPTIRSIIENTDRHRHSFGLTMPQVIGRV
GLFLRSEDLEVPVDVPGADMLFVCPAAGNTKIPDYGIKLIKILNAAGVSYTISPYVIDTGTEIDHIAVHHNLSKQMLEDW
EQEADRLGVKNILLVECGCDTRTLYAEASETLGRPFRYPIVSVDALMLDLIKQGRLPVEKTHLKVTLHDPCYATRLSGLG
DLFRELLNLVTDNFIEMTPNREHNYCCNGGAGGMRLPENTATRRKISVLKANQIRATNATYVTSPCVVCTLSLEDTCQTY
GLAPQGERMALVLFEVVYAAMEQALAKRGELDRMRIPAELQNRDHEFFVAHSIEGRLSMLMQLPEFPALLDWLEQDDIVR
RFSKDHPHVYDLLRAWREVVTAPKQRSITAD

Sequences:

>Translated_511_residues
MEPEMQAFVDSLRHNLTAEDVVNLEACMDCKMCGEACAWYLVTGDEKLHPTYKTGLIRQIYHRYMTVEGRIGGALGLVPT
PTVADLREHMQYFWACTACGRCTLACPSGISIRRIVRLARAAYADSGLSLANPTIRSIIENTDRHRHSFGLTMPQVIGRV
GLFLRSEDLEVPVDVPGADMLFVCPAAGNTKIPDYGIKLIKILNAAGVSYTISPYVIDTGTEIDHIAVHHNLSKQMLEDW
EQEADRLGVKNILLVECGCDTRTLYAEASETLGRPFRYPIVSVDALMLDLIKQGRLPVEKTHLKVTLHDPCYATRLSGLG
DLFRELLNLVTDNFIEMTPNREHNYCCNGGAGGMRLPENTATRRKISVLKANQIRATNATYVTSPCVVCTLSLEDTCQTY
GLAPQGERMALVLFEVVYAAMEQALAKRGELDRMRIPAELQNRDHEFFVAHSIEGRLSMLMQLPEFPALLDWLEQDDIVR
RFSKDHPHVYDLLRAWREVVTAPKQRSITAD
>Mature_511_residues
MEPEMQAFVDSLRHNLTAEDVVNLEACMDCKMCGEACAWYLVTGDEKLHPTYKTGLIRQIYHRYMTVEGRIGGALGLVPT
PTVADLREHMQYFWACTACGRCTLACPSGISIRRIVRLARAAYADSGLSLANPTIRSIIENTDRHRHSFGLTMPQVIGRV
GLFLRSEDLEVPVDVPGADMLFVCPAAGNTKIPDYGIKLIKILNAAGVSYTISPYVIDTGTEIDHIAVHHNLSKQMLEDW
EQEADRLGVKNILLVECGCDTRTLYAEASETLGRPFRYPIVSVDALMLDLIKQGRLPVEKTHLKVTLHDPCYATRLSGLG
DLFRELLNLVTDNFIEMTPNREHNYCCNGGAGGMRLPENTATRRKISVLKANQIRATNATYVTSPCVVCTLSLEDTCQTY
GLAPQGERMALVLFEVVYAAMEQALAKRGELDRMRIPAELQNRDHEFFVAHSIEGRLSMLMQLPEFPALLDWLEQDDIVR
RFSKDHPHVYDLLRAWREVVTAPKQRSITAD

Specific function: Has menaquinol-oxidizing activity. The hmeC and hmeD subunits may together mediate electron transfer from menaquinol to an unidentified electron acceptor on the cytoplasmic side of the membrane [H]

COG id: COG0247

COG function: function code C; Fe-S oxidoreductase

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR009051 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 57269; Mature: 57269

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPEMQAFVDSLRHNLTAEDVVNLEACMDCKMCGEACAWYLVTGDEKLHPTYKTGLIRQI
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHH
YHRYMTVEGRIGGALGLVPTPTVADLREHMQYFWACTACGRCTLACPSGISIRRIVRLAR
HHHHEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHH
AAYADSGLSLANPTIRSIIENTDRHRHSFGLTMPQVIGRVGLFLRSEDLEVPVDVPGADM
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCE
LFVCPAAGNTKIPDYGIKLIKILNAAGVSYTISPYVIDTGTEIDHIAVHHNLSKQMLEDW
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCEEEECCCCCCEEEEHHCHHHHHHHHH
EQEADRLGVKNILLVECGCDTRTLYAEASETLGRPFRYPIVSVDALMLDLIKQGRLPVEK
HHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEE
THLKVTLHDPCYATRLSGLGDLFRELLNLVTDNFIEMTPNREHNYCCNGGAGGMRLPENT
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEECCCCCCCCCCCCH
ATRRKISVLKANQIRATNATYVTSPCVVCTLSLEDTCQTYGLAPQGERMALVLFEVVYAA
HHHHHHHEEECCCEEECCCEEEECCEEEEEEEHHHHHHHCCCCCCCCHHHHHHHHHHHHH
MEQALAKRGELDRMRIPAELQNRDHEFFVAHSIEGRLSMLMQLPEFPALLDWLEQDDIVR
HHHHHHHCCCCCCEECCHHHCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHH
RFSKDHPHVYDLLRAWREVVTAPKQRSITAD
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEPEMQAFVDSLRHNLTAEDVVNLEACMDCKMCGEACAWYLVTGDEKLHPTYKTGLIRQI
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHH
YHRYMTVEGRIGGALGLVPTPTVADLREHMQYFWACTACGRCTLACPSGISIRRIVRLAR
HHHHEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHH
AAYADSGLSLANPTIRSIIENTDRHRHSFGLTMPQVIGRVGLFLRSEDLEVPVDVPGADM
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCE
LFVCPAAGNTKIPDYGIKLIKILNAAGVSYTISPYVIDTGTEIDHIAVHHNLSKQMLEDW
EEEECCCCCCCCCHHHHHHHHHHHHCCCEEEECCEEEECCCCCCEEEEHHCHHHHHHHHH
EQEADRLGVKNILLVECGCDTRTLYAEASETLGRPFRYPIVSVDALMLDLIKQGRLPVEK
HHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEE
THLKVTLHDPCYATRLSGLGDLFRELLNLVTDNFIEMTPNREHNYCCNGGAGGMRLPENT
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEECCCCCCCCCCCCH
ATRRKISVLKANQIRATNATYVTSPCVVCTLSLEDTCQTYGLAPQGERMALVLFEVVYAA
HHHHHHHEEECCCEEECCCEEEECCEEEEEEEHHHHHHHCCCCCCCCHHHHHHHHHHHHH
MEQALAKRGELDRMRIPAELQNRDHEFFVAHSIEGRLSMLMQLPEFPALLDWLEQDDIVR
HHHHHHHCCCCCCEECCHHHCCCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHH
RFSKDHPHVYDLLRAWREVVTAPKQRSITAD
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: FAD; glycerol-3-phosphate [C]

Specific reaction: FAD + glycerol-3-phosphate = FADH2 + dihydroxy-acetone-phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA