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The map label for this gene is phoP [H]

Identifier: 222523414

GI number: 222523414

Start: 144870

End: 145556

Strand: Direct

Name: phoP [H]

Synonym: Chy400_0116

Alternate gene names: 222523414

Gene position: 144870-145556 (Clockwise)

Preceding gene: 222523413

Following gene: 222523416

Centisome position: 2.75

GC content: 56.48

Gene sequence:

>687_bases
ATGCAACCAACCATTCTCGTTGTCGATGACGAAGCCAGTATTCGCAATGTCGCCAAAGCCTACCTCGAACACGCCGGGTA
CCGCGTCTTGTGTGCAACGACCGGCCCGGAAGGGTTGCAGATGGCGCTTGAAGAGCAACCTGATTTGATCGTTCTCGATC
TGATGCTGCCCGGTATGGACGGCATGGAGATCACTGCCCGCCTGCGCGAGCGTTCAGATGTCTACATCCTGATGCTGACT
GCACGGAGCGACGAGATGGATCGGGTTGCCGGCTTGCGCGTGGGCGCTGATGACTACCTTACCAAACCCTTCAGCCCACG
CGAACTGGTGGCACGGGTAGAAGCTATTTTGCGCCGGCAACGCAACAAAACGGCCAAAAGCTCGCTGATGCGCTTTACGC
ATGTCGAAATTGACCCGGAAGCGCGCGAAGCCCGGGCCAATGGTCAACTGTTGGAGCTAACACCGACTGAATTCGATCTC
TTGCTGGCCCTGGCCCGCAACCACAATCGTGTGCTCAGTCGCGAAGACCTGATTGAAAAGGTATGGGGTGCTGATTTCTT
TGGCACCGACCGGGTTGTCGATGTGTATGTCAGTCAGCTTCGGCGCAAAATCGAGGCCATTACCGGCGAAAATGTTATTC
GGACGGCACGCGGCGTTGGCTATCGCTTTGTTGATACACCGGCATAG

Upstream 100 bases:

>100_bases
TCGGCGTTGTGCTTAGCAATGCTCGCCTGTGAGGTGTATCGCGACAGAAACATCGATACCGTCTCTACCGCGTGAACAGT
CAGTATTCGTGCGAGGATGT

Downstream 100 bases:

>100_bases
CGGGGGTCAATGCGATAATGGTGAAGGTGGCAAGCCATGCGCTTCTGGCGGCAACTACGCTGGCAAATGATTGGCGCCCA
AATGCTGGTGGTGGTGGTCG

Product: winged helix family two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MQPTILVVDDEASIRNVAKAYLEHAGYRVLCATTGPEGLQMALEEQPDLIVLDLMLPGMDGMEITARLRERSDVYILMLT
ARSDEMDRVAGLRVGADDYLTKPFSPRELVARVEAILRRQRNKTAKSSLMRFTHVEIDPEAREARANGQLLELTPTEFDL
LLALARNHNRVLSREDLIEKVWGADFFGTDRVVDVYVSQLRRKIEAITGENVIRTARGVGYRFVDTPA

Sequences:

>Translated_228_residues
MQPTILVVDDEASIRNVAKAYLEHAGYRVLCATTGPEGLQMALEEQPDLIVLDLMLPGMDGMEITARLRERSDVYILMLT
ARSDEMDRVAGLRVGADDYLTKPFSPRELVARVEAILRRQRNKTAKSSLMRFTHVEIDPEAREARANGQLLELTPTEFDL
LLALARNHNRVLSREDLIEKVWGADFFGTDRVVDVYVSQLRRKIEAITGENVIRTARGVGYRFVDTPA
>Mature_228_residues
MQPTILVVDDEASIRNVAKAYLEHAGYRVLCATTGPEGLQMALEEQPDLIVLDLMLPGMDGMEITARLRERSDVYILMLT
ARSDEMDRVAGLRVGADDYLTKPFSPRELVARVEAILRRQRNKTAKSSLMRFTHVEIDPEAREARANGQLLELTPTEFDL
LLALARNHNRVLSREDLIEKVWGADFFGTDRVVDVYVSQLRRKIEAITGENVIRTARGVGYRFVDTPA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=42.3423423423423, Blast_Score=175, Evalue=2e-45,
Organism=Escherichia coli, GI1788394, Length=222, Percent_Identity=40.990990990991, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=40.5405405405405, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=38.3259911894273, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=36.5217391304348, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=41.8502202643172, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=41.743119266055, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=38.1818181818182, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=37.2727272727273, Blast_Score=138, Evalue=2e-34,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=35, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786784, Length=218, Percent_Identity=37.1559633027523, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=35.5263157894737, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=35.2941176470588, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=32.9004329004329, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790299, Length=139, Percent_Identity=33.8129496402878, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788550, Length=120, Percent_Identity=31.6666666666667, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25742; Mature: 25742

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPTILVVDDEASIRNVAKAYLEHAGYRVLCATTGPEGLQMALEEQPDLIVLDLMLPGMD
CCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCC
GMEITARLRERSDVYILMLTARSDEMDRVAGLRVGADDYLTKPFSPRELVARVEAILRRQ
CHHHHHHHHCCCCEEEEEEEECCCCHHHHHCEEECCHHHHCCCCCHHHHHHHHHHHHHHH
RNKTAKSSLMRFTHVEIDPEAREARANGQLLELTPTEFDLLLALARNHNRVLSREDLIEK
HCHHHHHHHHHHHEEEECCHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCHHHHHHH
VWGADFFGTDRVVDVYVSQLRRKIEAITGENVIRTARGVGYRFVDTPA
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEECCCC
>Mature Secondary Structure
MQPTILVVDDEASIRNVAKAYLEHAGYRVLCATTGPEGLQMALEEQPDLIVLDLMLPGMD
CCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCC
GMEITARLRERSDVYILMLTARSDEMDRVAGLRVGADDYLTKPFSPRELVARVEAILRRQ
CHHHHHHHHCCCCEEEEEEEECCCCHHHHHCEEECCHHHHCCCCCHHHHHHHHHHHHHHH
RNKTAKSSLMRFTHVEIDPEAREARANGQLLELTPTEFDLLLALARNHNRVLSREDLIEK
HCHHHHHHHHHHHEEEECCHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCHHHHHHH
VWGADFFGTDRVVDVYVSQLRRKIEAITGENVIRTARGVGYRFVDTPA
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]