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The map label for this gene is nrdZ [H]

Identifier: 222109642

GI number: 222109642

Start: 428981

End: 431422

Strand: Direct

Name: nrdZ [H]

Synonym: Dtpsy_0422

Alternate gene names: 222109642

Gene position: 428981-431422 (Clockwise)

Preceding gene: 222109640

Following gene: 222109643

Centisome position: 11.3

GC content: 68.63

Gene sequence:

>2442_bases
ATGCAGCGTGAAATCACCGACCTTGCCCCCGCCCTGTCTACACAACCCATCAGCATGGATGTGCTGAAGGAGAAATACTT
CAAAGACGGCGAGAGCGATGTCGAGGATCTGTTCCGCCGCGTGGCGCGGGCGTTGGCCTCGGTCGAGCGCGAGGACATGC
GCCAGGCCCTGGAGGCGCGCTTCCTGGACAACCTGCGTGCCGGCGCCATCGGGGCGGGGCGCATCATGAGCGCCGCCGGC
ACCGACATCCAGGCCACCCTCATCAACTGCTTCGTGCAGCCCGTAGGCGACTGCATCCAGGGCGTGGACGACGCGGGCTA
CCCCGGCATCTACGAGGCCCTGCGCGAGGCCGCCGAGACCATGCGCCGCGGCGGCGGCGTGGGCTACGACTTCTCGCGCA
TCCGCCCGCGCGGCGCGCTGGTGAAGGGCACGGCCTCCATGGCCTCGGGCCCCTGCAGTTACATCAACGTCTTCGACCAG
TCCTGCTCCACGGTGGAGAGTGCGGGCGCGCGCCGCGGCGCGCAGATGGGCGTGCTGCGCATCGACCACCCGGACGTGCT
GGACTTCATCACCGCCAAGCGTACGCCGGGCCGCTGGAACAATTTCAATGTGTCCGTGGGCGTGCCCGATGCCTTCATGG
AGGCGGTGGAGCAGGACCGTGATTGGGAGCTGGTGCATGGCGCCGCGCCCGGTGCGGAGCTGCAGGCCCAGGGCGCACAC
CAGCGTGCCGACGGCCAGTGGGTGTACCGCACGGTGCGCGCGCGCGAATTGTGGGACACGATCATGAAGTCGGCTTACGA
CTTCGCTGAGCCCGGCATCCTGTTCCTGGACCAGATCAACACCGACAACAACCTGCACTACACCGAGACCATCCAGGCGA
CCAACCCGTGTGGCGAGCAGCCGCTGCCGCCCTACGGCTGCTGCGACCTGGGCCCGATCATCCTCACACGCTTCGTGCGC
AACCCGTTCGGGCTGCATGGCGAGGCGTCGTTCGACTTCGATGCCTTCGAGCAGGCCGTGGCCACCCAGGTACGCGCGCT
GGACAACGTGCTGGACGTGACCTTCTGGCCCCTGCCGCAGCAGCAGGCCGAGTCGGCGGCCAAGCGCCGCATCGGCGTGG
GCTTCACGGGCATGGGTAACACGCTGGCCATGCTGTGCAAGCGCTACGACCGCCGGGAAGGGCGCGACATGGCGGTACAG
ATCGCCGAGCGCATGCGCAACGCGGCCTACCGCGCGTCGGTGGAACTGGCCAAGGAAAAGGGCGCATTCCCCAAGTTCGA
CGCCGATGGCTACCTGGCCAAGGGCACCTTCGCCAGCCGCCTGCCCGCGGACATCCAGAAGGCCATCCGCAAGCACGGCA
TCCGCAACAGCCATCTGCTGTCCATCGCGCCCACGGGCACGGTGAGTCTGGCTTTCGCCGACAACGCCTCCAACGGCATC
GAGCCGCCGTTCTCCTGGAGCTACACGCGCCGCAAGCGCGAGGCCGACGGCAGCAAGAGCGAGTACGTGGTGGAGGACTA
CGCCTGGCGTCTGTACAAGACGCTGGGCGGCGACGTGAACCATCTGCCTGCGTATTTCGTGAGCGCCATGGACATGGCGG
CCGCCGACCACGTGGCCATGATGGAGGCCGTGCAGCCCTTCGTGGACACGGCGATCTCCAAGACCGTGAACGTGCCCGAG
GACTACCCCTACGCCGATTTCAAGGGCCTGTACATGCAGGCCTGGCACTCGGGCCTGAAGGGCCTGGCCACCTACCGGCC
CAACAGCATCCTGGGCGCTGTGCTGGAAGTCACGCCCGCCGCAGCGCCAGCCCCCGCCGCCGCACCCGAGGCTGTGCCCG
CCCCGGTGGTGGTGGACCCCATGCGCACCATGATCGAGAGCCGTCCCACGGGCGGCCTGTCGGCCGTGGCGGAGAAGCTG
GAGTACTGGACGCAGGAAGGCCACAAGACGCTGTACCTGATCGTCTCCTTCCTGCCCGTGCCTGACGGGCGCGGCGGCAC
GGTGGACCGCGCCATCGAGTTCTTCATGCCCGTGGGGCAGAGCGGCGAATCGCAGCAGTGGATCACCTCCAGCATGCGCC
TGCTGTCGCTGGCCGCGCGCGGCGGCTTCCTGGAGCGCGCGTTGTCCGACATGCGCAAGGTCGCCTGGGACCGTGGCCCC
GTGCGCCTGGGCACGCACCAGAAGGCCGACGGCACCCACGTGCCGCTGTGGCACGACTCCGAGGTGGCCGCCATCGCGTA
TGCCGTGCAGAACATCCTGGCCCAGCGTGCCATGCCGCAGCAGCAGGTGCTGCCGCTGGACGAGCCCGCCGCAGCGCCCG
CGACCGGCATGCCTCCGGCCATGGCCGGCAAGAAGTGCAATGAGTGCGGTGCCCACGCCGTGATCCGCAAGGACGGCTGC
GACTACTGCACCCAGTGCGGCGCCCTGGGCAGCTGCGGCTGA

Upstream 100 bases:

>100_bases
CGCAGGTTCGCGGCGCGGGCTCCCGAGCAGTGTAAAAATCTAGGATCGCCGCCGCGGCTGCCCGCGGCGTGCCCGTCAGA
ATCCCTTTCGGAGCCCCTCC

Downstream 100 bases:

>100_bases
GCAGACCGGAATGCCCTGGCAACGCCAGGGCGTTTACTATCAGTATGATAGCTATCCGCGCTTGATGGGAGCGCGCGAAA
TCATGTTTTCGCTTGTATGC

Product: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 813; Mature: 813

Protein sequence:

>813_residues
MQREITDLAPALSTQPISMDVLKEKYFKDGESDVEDLFRRVARALASVEREDMRQALEARFLDNLRAGAIGAGRIMSAAG
TDIQATLINCFVQPVGDCIQGVDDAGYPGIYEALREAAETMRRGGGVGYDFSRIRPRGALVKGTASMASGPCSYINVFDQ
SCSTVESAGARRGAQMGVLRIDHPDVLDFITAKRTPGRWNNFNVSVGVPDAFMEAVEQDRDWELVHGAAPGAELQAQGAH
QRADGQWVYRTVRARELWDTIMKSAYDFAEPGILFLDQINTDNNLHYTETIQATNPCGEQPLPPYGCCDLGPIILTRFVR
NPFGLHGEASFDFDAFEQAVATQVRALDNVLDVTFWPLPQQQAESAAKRRIGVGFTGMGNTLAMLCKRYDRREGRDMAVQ
IAERMRNAAYRASVELAKEKGAFPKFDADGYLAKGTFASRLPADIQKAIRKHGIRNSHLLSIAPTGTVSLAFADNASNGI
EPPFSWSYTRRKREADGSKSEYVVEDYAWRLYKTLGGDVNHLPAYFVSAMDMAAADHVAMMEAVQPFVDTAISKTVNVPE
DYPYADFKGLYMQAWHSGLKGLATYRPNSILGAVLEVTPAAAPAPAAAPEAVPAPVVVDPMRTMIESRPTGGLSAVAEKL
EYWTQEGHKTLYLIVSFLPVPDGRGGTVDRAIEFFMPVGQSGESQQWITSSMRLLSLAARGGFLERALSDMRKVAWDRGP
VRLGTHQKADGTHVPLWHDSEVAAIAYAVQNILAQRAMPQQQVLPLDEPAAAPATGMPPAMAGKKCNECGAHAVIRKDGC
DYCTQCGALGSCG

Sequences:

>Translated_813_residues
MQREITDLAPALSTQPISMDVLKEKYFKDGESDVEDLFRRVARALASVEREDMRQALEARFLDNLRAGAIGAGRIMSAAG
TDIQATLINCFVQPVGDCIQGVDDAGYPGIYEALREAAETMRRGGGVGYDFSRIRPRGALVKGTASMASGPCSYINVFDQ
SCSTVESAGARRGAQMGVLRIDHPDVLDFITAKRTPGRWNNFNVSVGVPDAFMEAVEQDRDWELVHGAAPGAELQAQGAH
QRADGQWVYRTVRARELWDTIMKSAYDFAEPGILFLDQINTDNNLHYTETIQATNPCGEQPLPPYGCCDLGPIILTRFVR
NPFGLHGEASFDFDAFEQAVATQVRALDNVLDVTFWPLPQQQAESAAKRRIGVGFTGMGNTLAMLCKRYDRREGRDMAVQ
IAERMRNAAYRASVELAKEKGAFPKFDADGYLAKGTFASRLPADIQKAIRKHGIRNSHLLSIAPTGTVSLAFADNASNGI
EPPFSWSYTRRKREADGSKSEYVVEDYAWRLYKTLGGDVNHLPAYFVSAMDMAAADHVAMMEAVQPFVDTAISKTVNVPE
DYPYADFKGLYMQAWHSGLKGLATYRPNSILGAVLEVTPAAAPAPAAAPEAVPAPVVVDPMRTMIESRPTGGLSAVAEKL
EYWTQEGHKTLYLIVSFLPVPDGRGGTVDRAIEFFMPVGQSGESQQWITSSMRLLSLAARGGFLERALSDMRKVAWDRGP
VRLGTHQKADGTHVPLWHDSEVAAIAYAVQNILAQRAMPQQQVLPLDEPAAAPATGMPPAMAGKKCNECGAHAVIRKDGC
DYCTQCGALGSCG
>Mature_813_residues
MQREITDLAPALSTQPISMDVLKEKYFKDGESDVEDLFRRVARALASVEREDMRQALEARFLDNLRAGAIGAGRIMSAAG
TDIQATLINCFVQPVGDCIQGVDDAGYPGIYEALREAAETMRRGGGVGYDFSRIRPRGALVKGTASMASGPCSYINVFDQ
SCSTVESAGARRGAQMGVLRIDHPDVLDFITAKRTPGRWNNFNVSVGVPDAFMEAVEQDRDWELVHGAAPGAELQAQGAH
QRADGQWVYRTVRARELWDTIMKSAYDFAEPGILFLDQINTDNNLHYTETIQATNPCGEQPLPPYGCCDLGPIILTRFVR
NPFGLHGEASFDFDAFEQAVATQVRALDNVLDVTFWPLPQQQAESAAKRRIGVGFTGMGNTLAMLCKRYDRREGRDMAVQ
IAERMRNAAYRASVELAKEKGAFPKFDADGYLAKGTFASRLPADIQKAIRKHGIRNSHLLSIAPTGTVSLAFADNASNGI
EPPFSWSYTRRKREADGSKSEYVVEDYAWRLYKTLGGDVNHLPAYFVSAMDMAAADHVAMMEAVQPFVDTAISKTVNVPE
DYPYADFKGLYMQAWHSGLKGLATYRPNSILGAVLEVTPAAAPAPAAAPEAVPAPVVVDPMRTMIESRPTGGLSAVAEKL
EYWTQEGHKTLYLIVSFLPVPDGRGGTVDRAIEFFMPVGQSGESQQWITSSMRLLSLAARGGFLERALSDMRKVAWDRGP
VRLGTHQKADGTHVPLWHDSEVAAIAYAVQNILAQRAMPQQQVLPLDEPAAAPATGMPPAMAGKKCNECGAHAVIRKDGC
DYCTQCGALGSCG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=606, Percent_Identity=24.5874587458746, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI2367133, Length=569, Percent_Identity=24.780316344464, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1789030, Length=618, Percent_Identity=22.3300970873786, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17555242, Length=533, Percent_Identity=26.6416510318949, Blast_Score=179, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6322123, Length=478, Percent_Identity=26.7782426778243, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6320914, Length=479, Percent_Identity=25.678496868476, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI17352481, Length=586, Percent_Identity=24.061433447099, Blast_Score=164, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 88606; Mature: 88606

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQREITDLAPALSTQPISMDVLKEKYFKDGESDVEDLFRRVARALASVEREDMRQALEAR
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLDNLRAGAIGAGRIMSAAGTDIQATLINCFVQPVGDCIQGVDDAGYPGIYEALREAAET
HHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MRRGGGVGYDFSRIRPRGALVKGTASMASGPCSYINVFDQSCSTVESAGARRGAQMGVLR
HHHCCCCCCCHHHCCCCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
IDHPDVLDFITAKRTPGRWNNFNVSVGVPDAFMEAVEQDRDWELVHGAAPGAELQAQGAH
CCCCHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHCCCCCEEEECCCCCCCHHCCCCC
QRADGQWVYRTVRARELWDTIMKSAYDFAEPGILFLDQINTDNNLHYTETIQATNPCGEQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCCCCC
PLPPYGCCDLGPIILTRFVRNPFGLHGEASFDFDAFEQAVATQVRALDNVLDVTFWPLPQ
CCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEECCCCH
QQAESAAKRRIGVGFTGMGNTLAMLCKRYDRREGRDMAVQIAERMRNAAYRASVELAKEK
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GAFPKFDADGYLAKGTFASRLPADIQKAIRKHGIRNSHLLSIAPTGTVSLAFADNASNGI
CCCCCCCCCCCEECCCHHHCCCHHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCCCCCC
EPPFSWSYTRRKREADGSKSEYVVEDYAWRLYKTLGGDVNHLPAYFVSAMDMAAADHVAM
CCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
MEAVQPFVDTAISKTVNVPEDYPYADFKGLYMQAWHSGLKGLATYRPNSILGAVLEVTPA
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
AAPAPAAAPEAVPAPVVVDPMRTMIESRPTGGLSAVAEKLEYWTQEGHKTLYLIVSFLPV
CCCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHCCC
PDGRGGTVDRAIEFFMPVGQSGESQQWITSSMRLLSLAARGGFLERALSDMRKVAWDRGP
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
VRLGTHQKADGTHVPLWHDSEVAAIAYAVQNILAQRAMPQQQVLPLDEPAAAPATGMPPA
EEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCC
MAGKKCNECGAHAVIRKDGCDYCTQCGALGSCG
CCCCCHHHCCCCEEEECCCCHHHHHCCCCCCCC
>Mature Secondary Structure
MQREITDLAPALSTQPISMDVLKEKYFKDGESDVEDLFRRVARALASVEREDMRQALEAR
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLDNLRAGAIGAGRIMSAAGTDIQATLINCFVQPVGDCIQGVDDAGYPGIYEALREAAET
HHHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MRRGGGVGYDFSRIRPRGALVKGTASMASGPCSYINVFDQSCSTVESAGARRGAQMGVLR
HHHCCCCCCCHHHCCCCCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
IDHPDVLDFITAKRTPGRWNNFNVSVGVPDAFMEAVEQDRDWELVHGAAPGAELQAQGAH
CCCCHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHCCCCCEEEECCCCCCCHHCCCCC
QRADGQWVYRTVRARELWDTIMKSAYDFAEPGILFLDQINTDNNLHYTETIQATNPCGEQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCCCCC
PLPPYGCCDLGPIILTRFVRNPFGLHGEASFDFDAFEQAVATQVRALDNVLDVTFWPLPQ
CCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEECCCCH
QQAESAAKRRIGVGFTGMGNTLAMLCKRYDRREGRDMAVQIAERMRNAAYRASVELAKEK
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GAFPKFDADGYLAKGTFASRLPADIQKAIRKHGIRNSHLLSIAPTGTVSLAFADNASNGI
CCCCCCCCCCCEECCCHHHCCCHHHHHHHHHCCCCCCCEEEEECCCEEEEEEECCCCCCC
EPPFSWSYTRRKREADGSKSEYVVEDYAWRLYKTLGGDVNHLPAYFVSAMDMAAADHVAM
CCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
MEAVQPFVDTAISKTVNVPEDYPYADFKGLYMQAWHSGLKGLATYRPNSILGAVLEVTPA
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
AAPAPAAAPEAVPAPVVVDPMRTMIESRPTGGLSAVAEKLEYWTQEGHKTLYLIVSFLPV
CCCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEHCCC
PDGRGGTVDRAIEFFMPVGQSGESQQWITSSMRLLSLAARGGFLERALSDMRKVAWDRGP
CCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
VRLGTHQKADGTHVPLWHDSEVAAIAYAVQNILAQRAMPQQQVLPLDEPAAAPATGMPPA
EEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCC
MAGKKCNECGAHAVIRKDGCDYCTQCGALGSCG
CCCCCHHHCCCCEEEECCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]