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The map label for this gene is mprF [H]

Identifier: 222095195

GI number: 222095195

Start: 1509980

End: 1512565

Strand: Reverse

Name: mprF [H]

Synonym: BCQ_1535

Alternate gene names: 222095195

Gene position: 1512565-1509980 (Counterclockwise)

Preceding gene: 222095210

Following gene: 222095193

Centisome position: 29.01

GC content: 36.16

Gene sequence:

>2586_bases
ATGTCGTTTTCATGGAAACGTTTCTTACAAATCGGGAAAATTATCTTCCCATTTGTTGTATTAACCATTGTATTCTTTCA
AGCAAAAAAAGAATTAGCAGGCATTTCTTTTTTAGAAGCAATCAATACAATTAAAAACATTCCAACCGGAGGAGTCTTTT
TAGCCATTACACTTGGTGCATTTGCCGTATCAACAATGTTCTTTTACGACTATGTTATGCTTCGTTATTTAAAAGCTGAT
ATACCTGTCCAAAAGATTTTTCGTATCTCATGGATTGCTAATACCTTAAATGGATTTATTGGATTTGGTGGTCTCGTTGG
AGCGGGTGTACGTACGATGCTTTATCGTCCATACATAAAAGAAAATGGCAAGCTGATTAAAAGTATCGCCTGGATGACAA
CTGCTTTTATTAACGGACTCGCTATTCTTTCATTCCTCGGCCTTATTGGAATATTAGACACAAGTTTTATTTTGCATGAA
AAACCGTGGCTATGGCCTGTTTTGATCTTCTTCGCCCTTTTCGTCCCTATATACATTGGCTTTTCTAAACTAAAAAATAG
AAAACCAAAGCAAACCGAAGGACAAGATGAACGAGAAGAAGAGAAAAATCCAACTGTTTTATACTCATTAGTTTCATTAG
TTGAGTGGGTATCTGCTGGTATTGTTATGTACGTCATACTAATATTATTTGGCATTGATATCGAATTTCAAAAGTTTTTA
GGTGTGTATGTAATTGCTGCTTTAGCTGGTGTTGTTAGTCTTGTACCTGGTGGACTTGGTTCATTTGACCTTGTCTTTTT
AACTGGGCTCGGACAATATGGCATTGATACAGGCGTATTACTACCTGCTATGTTATTATATCGCCTCGTCTATTACATTT
TACCATTCTGCCTTGGTCTTATTTTTGCAGCTTTTGAAATGACAGGCGTGGCCATTAAAAAGTTTGAAGACAAACCTTTT
ATTGCGCCTGCATTAGAAACAACTGGTGTTATATGGACTTTGCAGCGTGATTTTCTAGGAAAACTAGGTTCGTGGGCCTC
TGCTGCTTTAACAGTATTTGCTGGATTAATGGTTATTTTATCGACCATTCTACCGACAAGTATAAACAGAGCACACGCCT
TACATATTCTAGCTCCAAAACATCTTATTCAATTTTCTTTTAGCTTATCACTAACATTCGGTATTCTCCTCCTGATCCTT
TCACGAGGCATATATTATGGAACAAAGCGTTCTTACTATATGACGATTATTTCTTTAATCGGAGCAGCTATCTTTAATAC
GCTAAAAGGGATTGATATTGAAGAAACGTTTATTTTATTAATTGTACTCGCTGTATTATATATGCTTCGTAAAAGATTTG
TACGCGAGAAAATGGAAGTCTCACTTTCTGATATCGTAAAAGTTTTTATATTCTTACTTATAACTTTATATTTATATAAA
AACTTAGGTATTTTATTTGCAGGTGCAAAAGAAGCTTTTAAACCTGATTTTGTCGTTCGTAATATTACGCAAGTAAAACG
AAGTGCATTAGCAGCTGCCTTTTTCGTTCCTACATTTTTACTGATTGGCTCACTCATTGCTAATCGTTATCGAAATGAAT
TTCCCGGGCAACCAGCTAATGATAAAAGATTACAAAACTTTTTAGATGAACATGGCGGAAATGTACTTAGTCATTTAGGT
TTCTTAGGCGATAAACAATTCTTCTTTAGTAGTGATGGGAAAGCGCTCCTTCTCTTCTCTATAACTGGAAAACGTCTTGT
TGTACTAGGTGATCCAATTGGAGATCCTTCCTCCTACCGTACTGTGTTACAAGAGTTTTTAGCTGAAGCTGACCGATTTG
GGTACATTTGTGTATTCTACCAAATCGAAAGTAAATGGATGAGTTTATATCATGATTTTGGTTACAACTTCTTTAAGCTT
GGTGAAGAAGCTGTCGTTGATTTGAATACATTTACAATAACAGGAAAAAAACGCGCCGGTATGCGAGCGACTTTCAACCG
TTTTGAACGAGAAGGCTATACATTCTCTATTCACCAGCCGCCGTTCTCAGATGAACTATTTGAAGAATTAAAAAAAGTTT
CAGATGCGTGGCTCGGTGGAAAAAAAGAGAAAAGTTTCTCACTCGGATACTTTGATCGTGAATATATTAGCCGTGCTCCT
ATCGCTACATTATCTGATGCAGATGGAAAAATCATTGCATTCACGACATTTATGCCCGTATATCAAGACGGATCATTGTC
TGTTGATTTAATGCGGTATTATCCAGATGCACCTAGCGGCATTATGGATGCCATTTTCATCCACCTATTCCAGTGGGCAA
AAGAAAATGAATACCACTCCTTTAATATTGGCATGGCGCCACTTTCGAATGTAGGTTTATCGACACAATCTTTCTGGTCT
GAACGAGTTGCCGCTGCCATCTTTAATAATGTTCGTTACACATATAGTTTCAGCGGGTTACGACATTTTAAAGAAAAATA
TAAACCAACATGGAGCGGTAAATATTTAGCATTTAGAAAGAATCATTCTTTACCAATTACAATGCTCTCTGTAACAAAAT
TAATAGGAAAAAGAAAAAACAGCTAA

Upstream 100 bases:

>100_bases
AAATAGCTTCCTTATACAGGAATTTACCTTTTTATTTTTCTTGAAGTTTGTCATAATAATATTATTGTCTCAGTTTTCTT
ATACAAGGAGAGTTGTATTT

Downstream 100 bases:

>100_bases
ATAGTTAGCTGTTTTTTCTTTTTTGAACTTGTACAATAAATTCTTTTTCATATTTCTTACCATTTATATAGAAATCTCCC
CATATTTTGTACGTTCCTTC

Product: virulence factor mprf

Products: NA

Alternate protein names: Lysylphosphatidylglycerol synthase; LPG synthase [H]

Number of amino acids: Translated: 861; Mature: 860

Protein sequence:

>861_residues
MSFSWKRFLQIGKIIFPFVVLTIVFFQAKKELAGISFLEAINTIKNIPTGGVFLAITLGAFAVSTMFFYDYVMLRYLKAD
IPVQKIFRISWIANTLNGFIGFGGLVGAGVRTMLYRPYIKENGKLIKSIAWMTTAFINGLAILSFLGLIGILDTSFILHE
KPWLWPVLIFFALFVPIYIGFSKLKNRKPKQTEGQDEREEEKNPTVLYSLVSLVEWVSAGIVMYVILILFGIDIEFQKFL
GVYVIAALAGVVSLVPGGLGSFDLVFLTGLGQYGIDTGVLLPAMLLYRLVYYILPFCLGLIFAAFEMTGVAIKKFEDKPF
IAPALETTGVIWTLQRDFLGKLGSWASAALTVFAGLMVILSTILPTSINRAHALHILAPKHLIQFSFSLSLTFGILLLIL
SRGIYYGTKRSYYMTIISLIGAAIFNTLKGIDIEETFILLIVLAVLYMLRKRFVREKMEVSLSDIVKVFIFLLITLYLYK
NLGILFAGAKEAFKPDFVVRNITQVKRSALAAAFFVPTFLLIGSLIANRYRNEFPGQPANDKRLQNFLDEHGGNVLSHLG
FLGDKQFFFSSDGKALLLFSITGKRLVVLGDPIGDPSSYRTVLQEFLAEADRFGYICVFYQIESKWMSLYHDFGYNFFKL
GEEAVVDLNTFTITGKKRAGMRATFNRFEREGYTFSIHQPPFSDELFEELKKVSDAWLGGKKEKSFSLGYFDREYISRAP
IATLSDADGKIIAFTTFMPVYQDGSLSVDLMRYYPDAPSGIMDAIFIHLFQWAKENEYHSFNIGMAPLSNVGLSTQSFWS
ERVAAAIFNNVRYTYSFSGLRHFKEKYKPTWSGKYLAFRKNHSLPITMLSVTKLIGKRKNS

Sequences:

>Translated_861_residues
MSFSWKRFLQIGKIIFPFVVLTIVFFQAKKELAGISFLEAINTIKNIPTGGVFLAITLGAFAVSTMFFYDYVMLRYLKAD
IPVQKIFRISWIANTLNGFIGFGGLVGAGVRTMLYRPYIKENGKLIKSIAWMTTAFINGLAILSFLGLIGILDTSFILHE
KPWLWPVLIFFALFVPIYIGFSKLKNRKPKQTEGQDEREEEKNPTVLYSLVSLVEWVSAGIVMYVILILFGIDIEFQKFL
GVYVIAALAGVVSLVPGGLGSFDLVFLTGLGQYGIDTGVLLPAMLLYRLVYYILPFCLGLIFAAFEMTGVAIKKFEDKPF
IAPALETTGVIWTLQRDFLGKLGSWASAALTVFAGLMVILSTILPTSINRAHALHILAPKHLIQFSFSLSLTFGILLLIL
SRGIYYGTKRSYYMTIISLIGAAIFNTLKGIDIEETFILLIVLAVLYMLRKRFVREKMEVSLSDIVKVFIFLLITLYLYK
NLGILFAGAKEAFKPDFVVRNITQVKRSALAAAFFVPTFLLIGSLIANRYRNEFPGQPANDKRLQNFLDEHGGNVLSHLG
FLGDKQFFFSSDGKALLLFSITGKRLVVLGDPIGDPSSYRTVLQEFLAEADRFGYICVFYQIESKWMSLYHDFGYNFFKL
GEEAVVDLNTFTITGKKRAGMRATFNRFEREGYTFSIHQPPFSDELFEELKKVSDAWLGGKKEKSFSLGYFDREYISRAP
IATLSDADGKIIAFTTFMPVYQDGSLSVDLMRYYPDAPSGIMDAIFIHLFQWAKENEYHSFNIGMAPLSNVGLSTQSFWS
ERVAAAIFNNVRYTYSFSGLRHFKEKYKPTWSGKYLAFRKNHSLPITMLSVTKLIGKRKNS
>Mature_860_residues
SFSWKRFLQIGKIIFPFVVLTIVFFQAKKELAGISFLEAINTIKNIPTGGVFLAITLGAFAVSTMFFYDYVMLRYLKADI
PVQKIFRISWIANTLNGFIGFGGLVGAGVRTMLYRPYIKENGKLIKSIAWMTTAFINGLAILSFLGLIGILDTSFILHEK
PWLWPVLIFFALFVPIYIGFSKLKNRKPKQTEGQDEREEEKNPTVLYSLVSLVEWVSAGIVMYVILILFGIDIEFQKFLG
VYVIAALAGVVSLVPGGLGSFDLVFLTGLGQYGIDTGVLLPAMLLYRLVYYILPFCLGLIFAAFEMTGVAIKKFEDKPFI
APALETTGVIWTLQRDFLGKLGSWASAALTVFAGLMVILSTILPTSINRAHALHILAPKHLIQFSFSLSLTFGILLLILS
RGIYYGTKRSYYMTIISLIGAAIFNTLKGIDIEETFILLIVLAVLYMLRKRFVREKMEVSLSDIVKVFIFLLITLYLYKN
LGILFAGAKEAFKPDFVVRNITQVKRSALAAAFFVPTFLLIGSLIANRYRNEFPGQPANDKRLQNFLDEHGGNVLSHLGF
LGDKQFFFSSDGKALLLFSITGKRLVVLGDPIGDPSSYRTVLQEFLAEADRFGYICVFYQIESKWMSLYHDFGYNFFKLG
EEAVVDLNTFTITGKKRAGMRATFNRFEREGYTFSIHQPPFSDELFEELKKVSDAWLGGKKEKSFSLGYFDREYISRAPI
ATLSDADGKIIAFTTFMPVYQDGSLSVDLMRYYPDAPSGIMDAIFIHLFQWAKENEYHSFNIGMAPLSNVGLSTQSFWSE
RVAAAIFNNVRYTYSFSGLRHFKEKYKPTWSGKYLAFRKNHSLPITMLSVTKLIGKRKNS

Specific function: Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contribu

COG id: COG2898

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LPG synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016181
- InterPro:   IPR022791 [H]

Pfam domain/function: PF03706 UPF0104 [H]

EC number: =2.3.2.3 [H]

Molecular weight: Translated: 97148; Mature: 97017

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS01039 SBP_BACTERIAL_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSWKRFLQIGKIIFPFVVLTIVFFQAKKELAGISFLEAINTIKNIPTGGVFLAITLGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FAVSTMFFYDYVMLRYLKADIPVQKIFRISWIANTLNGFIGFGGLVGAGVRTMLYRPYIK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ENGKLIKSIAWMTTAFINGLAILSFLGLIGILDTSFILHEKPWLWPVLIFFALFVPIYIG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FSKLKNRKPKQTEGQDEREEEKNPTVLYSLVSLVEWVSAGIVMYVILILFGIDIEFQKFL
HHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GVYVIAALAGVVSLVPGGLGSFDLVFLTGLGQYGIDTGVLLPAMLLYRLVYYILPFCLGL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IFAAFEMTGVAIKKFEDKPFIAPALETTGVIWTLQRDFLGKLGSWASAALTVFAGLMVIL
HHHHHHHHHHHHHHCCCCCCCCCCHHCCCEEEEECHHHHHHHCCHHHHHHHHHHHHHHHH
STILPTSINRAHALHILAPKHLIQFSFSLSLTFGILLLILSRGIYYGTKRSYYMTIISLI
HHHHCCCCCCHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHH
GAAIFNTLKGIDIEETFILLIVLAVLYMLRKRFVREKMEVSLSDIVKVFIFLLITLYLYK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
NLGILFAGAKEAFKPDFVVRNITQVKRSALAAAFFVPTFLLIGSLIANRYRNEFPGQPAN
CCCEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DKRLQNFLDEHGGNVLSHLGFLGDKQFFFSSDGKALLLFSITGKRLVVLGDPIGDPSSYR
HHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCCCEEEEEEECCCEEEEEECCCCCCHHHH
TVLQEFLAEADRFGYICVFYQIESKWMSLYHDFGYNFFKLGEEAVVDLNTFTITGKKRAG
HHHHHHHHHHHCCCEEEEEEEEHHHHHHHHHHHCCHHHHCCCHHEEEEEEEEEECCCCCC
MRATFNRFEREGYTFSIHQPPFSDELFEELKKVSDAWLGGKKEKSFSLGYFDREYISRAP
HHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCC
IATLSDADGKIIAFTTFMPVYQDGSLSVDLMRYYPDAPSGIMDAIFIHLFQWAKENEYHS
CCEECCCCCCEEEEEEECCEECCCCCEEHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCE
FNIGMAPLSNVGLSTQSFWSERVAAAIFNNVRYTYSFSGLRHFKEKYKPTWSGKYLAFRK
EECCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHCCCCCCCCEEEEEC
NHSLPITMLSVTKLIGKRKNS
CCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SFSWKRFLQIGKIIFPFVVLTIVFFQAKKELAGISFLEAINTIKNIPTGGVFLAITLGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH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CCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]