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The map label for this gene is norM [H]

Identifier: 222095117

GI number: 222095117

Start: 1433195

End: 1434556

Strand: Reverse

Name: norM [H]

Synonym: BCQ_1457

Alternate gene names: 222095117

Gene position: 1434556-1433195 (Counterclockwise)

Preceding gene: 222095119

Following gene: 222095116

Centisome position: 27.51

GC content: 36.05

Gene sequence:

>1362_bases
ATGAAAGAAACTAGTACATTCTCACAAAAATTAAAGCAATTTGTATTACTATTTTTCCCGATTTTTGTTACGCAAATGTC
ATTATTTGCAATGAGCTTTTTTGATACAACAATGTCAGGACATGCAAGCCCTATTGATTTAGCAGGGGTTGCTATCGGAA
CGAGTATATGGATTCCAGTTAGTACGGGATTAACAGGTATTTTGATGGCTACAACTCCAATTGTTGCGCAACTCGTTGGA
TCCAAGAAAAAAGAAGATGTTCCTCACGTTGTCATACAGGCAGTATATTTAGCCATTTTCGCTAGCCTCGTTGTTATCCT
TATCGGTTTCTTTACTGTTACACCTATTTTAAATGGCATGCGATTAGAAGAACCGGTAGAACGTATTGCAGCACAATTTT
TAAGTATTATTGCAATTGGAATTATCCCTTTATTTACTTACACAGTTTTACGCGGATTTATTGATGCATTAGGAAAAACT
CGTACAACGATGATCATTACATTACTATCATTACCAATTAATGTAGTATTAAATTATGTATTAATTTTCGGTAACTTCGG
TTTTCCAAAACTCGGTGGTGTCGGAGCAGCAATTGCTTCTGCAGCAACCTATTGGTGCATTTTAATTATTACCGTTATGA
TTATTCGTACGAAAGAGCCTTTTGCATCTTTCCATATTTTTAAACAGTTATATCACCCTTCTCTTTCTAGTTGGAAAGAA
TTCTTAAAACTTGGCGTCCCTATCGGATTTGCTATCTTTTTTGAAACGAGTATTTTCGCTGCAGTAACACTTATGATGAG
TAATTTTAGTACGACAACAATCGCAGCTCATCAAGCAGCTATGAACTTCGCTTCCTTGCTATATATGACTCCTTTAAGTT
TAGCAATGGCCATGACCATCTCTGTTGGATTTGAAGTTGGAGCGAAACGATATAATAATGCAAAACAATATGGATTTATC
GGGATTGGCTTAGCACTTGCATTCGCCCTATTATATTCCATTCTTCTTTACTTCTTTGATGATGAAATTGCTTCTATTTA
TACGACAGATATACAAGTTCATCATTTAGCAAAAGAATTTCTTATATTTGCGATTTTATTTCAAATCTCAGATGCAATTG
CAACTCCTGTACAAGGGGCACTACGTGGTTATAAAGATGTAAATGTCGCCTTAATTATGACATTAATCGCCTATTGGGTA
ATTGGTCTCCCTCTCGGTTACATATTAGCAACCTATACTGATTGGGCAGCAAAAGGATATTGGATCGGTCTTATTATCGG
TCTAGCATTTGGAGCAACCTTCCTCCTTATCCGTCTCTTTCAAGTTCAGAGAAAATATACAACGCAAAACAGCCGCTCAT
AA

Upstream 100 bases:

>100_bases
TATAGTCAAACCGTAGTTTTAATAAGCTTATTCCTTTTCTATTTTTTGATTAAATTGTATGATAGTAAGAGTTTTCTTTT
TTACGTAGAAAGGGGATTTT

Downstream 100 bases:

>100_bases
TATAGCGGTTGTTTTCTTTATGCATATTTTTTCTTGTAACGTATAACATAATGAAAAAGAAAGGTGGATACATATGGACG
AAAAAGAAAAAAAGCAATCA

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKETSTFSQKLKQFVLLFFPIFVTQMSLFAMSFFDTTMSGHASPIDLAGVAIGTSIWIPVSTGLTGILMATTPIVAQLVG
SKKKEDVPHVVIQAVYLAIFASLVVILIGFFTVTPILNGMRLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKT
RTTMIITLLSLPINVVLNYVLIFGNFGFPKLGGVGAAIASAATYWCILIITVMIIRTKEPFASFHIFKQLYHPSLSSWKE
FLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTISVGFEVGAKRYNNAKQYGFI
GIGLALAFALLYSILLYFFDDEIASIYTTDIQVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWV
IGLPLGYILATYTDWAAKGYWIGLIIGLAFGATFLLIRLFQVQRKYTTQNSRS

Sequences:

>Translated_453_residues
MKETSTFSQKLKQFVLLFFPIFVTQMSLFAMSFFDTTMSGHASPIDLAGVAIGTSIWIPVSTGLTGILMATTPIVAQLVG
SKKKEDVPHVVIQAVYLAIFASLVVILIGFFTVTPILNGMRLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKT
RTTMIITLLSLPINVVLNYVLIFGNFGFPKLGGVGAAIASAATYWCILIITVMIIRTKEPFASFHIFKQLYHPSLSSWKE
FLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTISVGFEVGAKRYNNAKQYGFI
GIGLALAFALLYSILLYFFDDEIASIYTTDIQVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWV
IGLPLGYILATYTDWAAKGYWIGLIIGLAFGATFLLIRLFQVQRKYTTQNSRS
>Mature_453_residues
MKETSTFSQKLKQFVLLFFPIFVTQMSLFAMSFFDTTMSGHASPIDLAGVAIGTSIWIPVSTGLTGILMATTPIVAQLVG
SKKKEDVPHVVIQAVYLAIFASLVVILIGFFTVTPILNGMRLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKT
RTTMIITLLSLPINVVLNYVLIFGNFGFPKLGGVGAAIASAATYWCILIITVMIIRTKEPFASFHIFKQLYHPSLSSWKE
FLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTISVGFEVGAKRYNNAKQYGFI
GIGLALAFALLYSILLYFFDDEIASIYTTDIQVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWV
IGLPLGYILATYTDWAAKGYWIGLIIGLAFGATFLLIRLFQVQRKYTTQNSRS

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=450, Percent_Identity=22.8888888888889, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI153792564, Length=408, Percent_Identity=24.0196078431373, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI38261960, Length=438, Percent_Identity=22.6027397260274, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI48994890, Length=434, Percent_Identity=36.6359447004608, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI226510954, Length=459, Percent_Identity=22.6579520697168, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321821, Length=394, Percent_Identity=23.0964467005076, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320545, Length=330, Percent_Identity=23.6363636363636, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49848; Mature: 49848

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA