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The map label for this gene is yisQ [H]

Identifier: 222094913

GI number: 222094913

Start: 1245127

End: 1246521

Strand: Reverse

Name: yisQ [H]

Synonym: BCQ_1251

Alternate gene names: 222094913

Gene position: 1246521-1245127 (Counterclockwise)

Preceding gene: 222094915

Following gene: 222094907

Centisome position: 23.91

GC content: 39.78

Gene sequence:

>1395_bases
ATGACAGCAATTCAGGCAAAAAACGGGCCTACTGAGAAATTAAGTTTATTCTTATTAACATGGCCTATTTTTCTAGAAGT
TTTTCTATTTATGTTAATGGGGATCGCTGATACTTTCATGTTAAGTGCATTATCAGATGATGCTGTATCTGGGGTTGGTG
CAGCGAATCAATATCTCCATATCGCTATTTTGGTACTAGAAGTCATCGGGAACGGCGCAGCTATCGTCGTATCTCAATAC
CTCGGTTCCAAACGTTTTATGGAAGCATCTAAAATATCAGCTTTAGCCGTCACATTAAATTTAGTGGTCGGACTCGTTAT
AAGTGCTGGTTTTCTTTTATTTTCAAAACATATGATGATGGCGATGAACTTACAAGGCGATGTACTTATGTATGCACAGA
GCTATTTATCTATCGTCGGAGGAGCTATTTTCCTTCAAGCTATTATTAATTCATTAGCCGCAATTATCCGCGTACATGGC
TTCACAAAGCAAGCGATGTTTATTTCACTTGGAATGAATATTATTCATATCGCTGGAAACTACGTACTCATTTTCGGGAA
ATTTGGTTTCCCAGAACTCGGTGTACAAGGGGCTGCCATTTCTTCTGCTGTCAGCAGGCTAATCGCGCTTATCGTTTTCT
TCTTGTTACTGTACCGCGTTATGGAGTACCGTGTAAAATTACAATACTACTTCACCTTATCAAAAGAATACATCGGGAAA
ATTTTAAAGATTGGGATTCCATCTGCATTTGAGCAGGTTATGTATCAAGCTTGCCAAATTGTCTTCTTATACTATGCAAC
ATATTTAGGAACGGAATCGTTAGCGGCTAGACAATACGCTACGAACATCTCTATGTTCACTTATTTATTCGCTATTGCAA
TCGGTATGGGAACTGCAATTATTATCGGACGCCTCGTTGGCGGTGGTGAAAAAGATGAAGCGTATGAACGTGTATGGAAA
AGTGTAAAGTGGGCGATTGGTGTCACTTTATGTATGGTTGCTCTCGTTATTACATTCCGCACACAATTAATGGGACTATT
TACAGATAATCCGCACATTATTGCGTTAGGTGCGTCAGTTCTTTTACTAAGTGTACTACTTGAAACAGGGCGTACGATGA
ACATCGTCATCATCAATTCACTTCGCGCAGCTGGTGATGCAAAATACCCAGTTTTAATCGGCGCATTCTCTATGGTGTTA
ATGAGTTTACCACTCGGTTACTTTTTCGCCTTCCATTTAGATATGGGACTCGTTGGTATTTGGCTAGCAATCGCTATTGA
TGAATGGACACGTGCTATTATTATGTTCTTCCGCTGGAAAAGTAGAGCATGGGAGCGTTATGCACTTGTTAAACCTGAAG
AACAAGAGGAGATTGTTTCTGTTCAGGTGCAATAA

Upstream 100 bases:

>100_bases
TTCATAATAAAGATATGTAGGTTAAAATGAGTGCAAAGGTTAAGAAAGTATGTTACGATACACTTTGCTAAAAATAGATA
TCGGTAAAGAGGGGACGGAC

Downstream 100 bases:

>100_bases
TACTCGTTTAATTAAGGCGTAGTCTTTAGTATAGGAAACTTATATCTGCGATTCTTTAAATATATCGACTTACCGAGAAA
TATTGACAACTCTTTTATAT

Product: efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MTAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLHIAILVLEVIGNGAAIVVSQY
LGSKRFMEASKISALAVTLNLVVGLVISAGFLLFSKHMMMAMNLQGDVLMYAQSYLSIVGGAIFLQAIINSLAAIIRVHG
FTKQAMFISLGMNIIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFLLLYRVMEYRVKLQYYFTLSKEYIGK
ILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAIIIGRLVGGGEKDEAYERVWK
SVKWAIGVTLCMVALVITFRTQLMGLFTDNPHIIALGASVLLLSVLLETGRTMNIVIINSLRAAGDAKYPVLIGAFSMVL
MSLPLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQVQ

Sequences:

>Translated_464_residues
MTAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLHIAILVLEVIGNGAAIVVSQY
LGSKRFMEASKISALAVTLNLVVGLVISAGFLLFSKHMMMAMNLQGDVLMYAQSYLSIVGGAIFLQAIINSLAAIIRVHG
FTKQAMFISLGMNIIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFLLLYRVMEYRVKLQYYFTLSKEYIGK
ILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAIIIGRLVGGGEKDEAYERVWK
SVKWAIGVTLCMVALVITFRTQLMGLFTDNPHIIALGASVLLLSVLLETGRTMNIVIINSLRAAGDAKYPVLIGAFSMVL
MSLPLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQVQ
>Mature_463_residues
TAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLHIAILVLEVIGNGAAIVVSQYL
GSKRFMEASKISALAVTLNLVVGLVISAGFLLFSKHMMMAMNLQGDVLMYAQSYLSIVGGAIFLQAIINSLAAIIRVHGF
TKQAMFISLGMNIIHIAGNYVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFLLLYRVMEYRVKLQYYFTLSKEYIGKI
LKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAIIIGRLVGGGEKDEAYERVWKS
VKWAIGVTLCMVALVITFRTQLMGLFTDNPHIIALGASVLLLSVLLETGRTMNIVIINSLRAAGDAKYPVLIGAFSMVLM
SLPLGYFFAFHLDMGLVGIWLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQVQ

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=419, Percent_Identity=22.4343675417661, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI38261960, Length=451, Percent_Identity=21.7294900221729, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI226510954, Length=443, Percent_Identity=25.5079006772009, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI48994890, Length=449, Percent_Identity=22.9398663697105, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51222; Mature: 51091

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLH
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHH
IAILVLEVIGNGAAIVVSQYLGSKRFMEASKISALAVTLNLVVGLVISAGFLLFSKHMMM
HHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMNLQGDVLMYAQSYLSIVGGAIFLQAIINSLAAIIRVHGFTKQAMFISLGMNIIHIAGN
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEECC
YVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFLLLYRVMEYRVKLQYYFTLSKEYIGK
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECHHHHHH
ILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGRLVGGGEKDEAYERVWKSVKWAIGVTLCMVALVITFRTQLMGLFTDNPHIIALGASV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHH
LLLSVLLETGRTMNIVIINSLRAAGDAKYPVLIGAFSMVLMSLPLGYFFAFHLDMGLVGI
HHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEC
>Mature Secondary Structure 
TAIQAKNGPTEKLSLFLLTWPIFLEVFLFMLMGIADTFMLSALSDDAVSGVGAANQYLH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHH
IAILVLEVIGNGAAIVVSQYLGSKRFMEASKISALAVTLNLVVGLVISAGFLLFSKHMMM
HHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMNLQGDVLMYAQSYLSIVGGAIFLQAIINSLAAIIRVHGFTKQAMFISLGMNIIHIAGN
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEEECC
YVLIFGKFGFPELGVQGAAISSAVSRLIALIVFFLLLYRVMEYRVKLQYYFTLSKEYIGK
EEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECHHHHHH
ILKIGIPSAFEQVMYQACQIVFLYYATYLGTESLAARQYATNISMFTYLFAIAIGMGTAI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIGRLVGGGEKDEAYERVWKSVKWAIGVTLCMVALVITFRTQLMGLFTDNPHIIALGASV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHH
LLLSVLLETGRTMNIVIINSLRAAGDAKYPVLIGAFSMVLMSLPLGYFFAFHLDMGLVGI
HHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLAIAIDEWTRAIIMFFRWKSRAWERYALVKPEEQEEIVSVQVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]