Click here to switch to the map view.

The map label for this gene is prsA [H]

Identifier: 222094890

GI number: 222094890

Start: 1223397

End: 1224254

Strand: Reverse

Name: prsA [H]

Synonym: BCQ_1228

Alternate gene names: 222094890

Gene position: 1224254-1223397 (Counterclockwise)

Preceding gene: 222094891

Following gene: 222094882

Centisome position: 23.48

GC content: 33.57

Gene sequence:

>858_bases
ATGAGAGGGAAACACATTTTCATTATTACTGCACTACTAAGTATATTAATGCTATCTGCTTGTGGACAAAAAAACGACTC
AGATACAGTCGCTACGGCAACAGACTCAACCATTACGAAGAGCGACTTCGAAAAACAGTTGAAAGATCGTTACGGAAAAG
ACATGCTGTACGAAATGATGGCGCAAGACGTTATCACGAAAAAATATAAAGTATCTGACGATGATGTAGATAAAGAATTA
CAAAAAGCGAAAAATCAATACGGAGACCAATTTAAAAACGTATTGAAAAACAATGGTTTAAAAGATGAAGCTGATTTCAA
AAATCAAATTAAGTTCAAACTTGCTATGAATGAAGCGATTAAGAAAAGTATTACAGAAAAAGACGTGAAAGACCACTATA
AACCTGAAATTAAAGCAAGCCATATTTTAGTAAGTGACGAAAATGAAGCGAAAGAAATAAAGAAAAAATTAGATGCTGGT
GCTTCATTTGAAGAACTAGCAAAACAAGAATCGCAAGACCTACTATCAAAAGAGAAAGGCGGAGACCTTGGATACTTCAA
TTCAGGTAGAATGGCACCTGAATTTGAAACTGCTGCCTATAAACTAAAGGTCGGACAAATTAGCAATCCCGTTGCATCAC
CAAACGGTTATCATATTATTAAATTAACTGATAAAAAAGAATTAAAACCCTATGATGAAGTGAAAGACTCTATTCGCAAA
AACTTAGAAGAAGAACGTATCTCTGACCCTATATTCGGCAAAAAACTATTGCAAAATGAATTAAAAAAAGCAAATATTAA
AATAAATGATAGTGAGTTGGAAGATACATTTGCACTTGTATATGAGCCAGCGAACTAA

Upstream 100 bases:

>100_bases
TACTTTTTTTACAGTTTACAGGGAAAAAACATTAAAAATTCACTTCATGTTCACTTCTATATTCTACAATAGCGATAACA
TATTCGGATGAGGTGTTAGC

Downstream 100 bases:

>100_bases
AAGAAAGAGGTTGTCTCATAAGTCTCTTTCGAAGTAAAATCACATGAAATTGAAAAGGAAGAAACGTTATTAAATCAACG
TTTCTTCCTTTCACTTTCTA

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MRGKHIFIITALLSILMLSACGQKNDSDTVATATDSTITKSDFEKQLKDRYGKDMLYEMMAQDVITKKYKVSDDDVDKEL
QKAKNQYGDQFKNVLKNNGLKDEADFKNQIKFKLAMNEAIKKSITEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDAG
ASFEELAKQESQDLLSKEKGGDLGYFNSGRMAPEFETAAYKLKVGQISNPVASPNGYHIIKLTDKKELKPYDEVKDSIRK
NLEEERISDPIFGKKLLQNELKKANIKINDSELEDTFALVYEPAN

Sequences:

>Translated_285_residues
MRGKHIFIITALLSILMLSACGQKNDSDTVATATDSTITKSDFEKQLKDRYGKDMLYEMMAQDVITKKYKVSDDDVDKEL
QKAKNQYGDQFKNVLKNNGLKDEADFKNQIKFKLAMNEAIKKSITEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDAG
ASFEELAKQESQDLLSKEKGGDLGYFNSGRMAPEFETAAYKLKVGQISNPVASPNGYHIIKLTDKKELKPYDEVKDSIRK
NLEEERISDPIFGKKLLQNELKKANIKINDSELEDTFALVYEPAN
>Mature_285_residues
MRGKHIFIITALLSILMLSACGQKNDSDTVATATDSTITKSDFEKQLKDRYGKDMLYEMMAQDVITKKYKVSDDDVDKEL
QKAKNQYGDQFKNVLKNNGLKDEADFKNQIKFKLAMNEAIKKSITEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDAG
ASFEELAKQESQDLLSKEKGGDLGYFNSGRMAPEFETAAYKLKVGQISNPVASPNGYHIIKLTDKKELKPYDEVKDSIRK
NLEEERISDPIFGKKLLQNELKKANIKINDSELEDTFALVYEPAN

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. Important for the secretion of the protective antigen. The three psrA proteins in this organism show different but overlapping

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=168, Percent_Identity=29.1666666666667, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790211, Length=84, Percent_Identity=39.2857142857143, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322478, Length=102, Percent_Identity=44.1176470588235, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32344; Mature: 32344

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKHIFIITALLSILMLSACGQKNDSDTVATATDSTITKSDFEKQLKDRYGKDMLYEMM
CCCCEEEHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCHHHHHHHH
AQDVITKKYKVSDDDVDKELQKAKNQYGDQFKNVLKNNGLKDEADFKNQIKFKLAMNEAI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KKSITEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDAGASFEELAKQESQDLLSKEKG
HHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
GDLGYFNSGRMAPEFETAAYKLKVGQISNPVASPNGYHIIKLTDKKELKPYDEVKDSIRK
CCCCCCCCCCCCCCHHHHEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
NLEEERISDPIFGKKLLQNELKKANIKINDSELEDTFALVYEPAN
HHHHHHCCCCHHHHHHHHHHHHHCCCEECHHHHCCEEEEEEECCC
>Mature Secondary Structure
MRGKHIFIITALLSILMLSACGQKNDSDTVATATDSTITKSDFEKQLKDRYGKDMLYEMM
CCCCEEEHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCHHHHHHHH
AQDVITKKYKVSDDDVDKELQKAKNQYGDQFKNVLKNNGLKDEADFKNQIKFKLAMNEAI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KKSITEKDVKDHYKPEIKASHILVSDENEAKEIKKKLDAGASFEELAKQESQDLLSKEKG
HHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
GDLGYFNSGRMAPEFETAAYKLKVGQISNPVASPNGYHIIKLTDKKELKPYDEVKDSIRK
CCCCCCCCCCCCCCHHHHEEEEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
NLEEERISDPIFGKKLLQNELKKANIKINDSELEDTFALVYEPAN
HHHHHHCCCCHHHHHHHHHHHHHCCCEECHHHHCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721629; 12606539 [H]