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The map label for this gene is ndh [H]

Identifier: 222094523

GI number: 222094523

Start: 846580

End: 848244

Strand: Direct

Name: ndh [H]

Synonym: BCQ_0861

Alternate gene names: 222094523

Gene position: 846580-848244 (Clockwise)

Preceding gene: 222094522

Following gene: 222094524

Centisome position: 16.24

GC content: 37.36

Gene sequence:

>1665_bases
ATGTCCAGAAAAATAGTTGTAGTAGGCGGAGTTGCTGGCGGCGCATCAGTAGCTGCAAGGCTTCGTCGTTTAAGTGAGGA
AGATGAAATTATTATGGTTGAACGCGGTGAATACATTTCATTCGCAAACTGTGGATTGCCATATTATATTGGCGGTGTCA
TTACAGAAAGACAAAAATTATTAGTACAAACTGTTGAAAGAATGTCGAAGCGTTTTAATTTAGATATACGTGTATTGAGT
GAAGTAGTACAGATTAATAAAGAAGAGAAAACAATTACGATAAAGAATGTAACGACAAATGAAACATATAGCGAGGAATA
TGATATTTTAATTCTTTCACCAGGGGCGAAACCAATTGTTCCATCTATCCCGGGTATTGAAGAAGCGAAGGCGTTGTTTA
CGTTACGGAATGTACCTGATACAGATCGTATTAAAGCATACGTTGATGAGCAGAAACCACGTCATGCGACGGTTATTGGT
GGCGGATTTATTGGTGTGGAGATGGTTGAAAATTTAAGAGAACGTGGAATTGATGTTACTCTTGTAGAGATGGCAAATCA
AGTGATGCCACCAATCGATTATGAAATGGCGGCATATGTGCATGAGCATCTTCAAAAACACGATGTTGAGCTCGTTTTTG
AAGATGGTGTAGATGCGTTAGAAGAGAATGGGACTGTTGTACGTTTAAAAAGTGGCTCAATTATAGAGACAGATATGATT
ATTTTAGCAATTGGTGTACAATCAGAGAGTAGTTTAGCGAAGGATGCAGGATTAGCATTAGGAGTTAGAGGGACGATAAA
AGTAAATGAGAAATTTCAAACGTCGGACCCACATATATATGCAATTGGTGATGCGATTGAAGTAAAAGATTTTGTTACTG
AAACAGAAACGATGATTCCTTTAGCGTGGCCAGCTAATCGTCAAGGTCGTATGTTAGCAGATATTATTCATGGTAATACA
GATTCTGTATATAAAGGTACACTCGGAACTTCTGTAGCTAAAGTTTTTGATTTAACGGTTGCTTCGACGGGAGTAAATGA
GAAAATATTAAAACGATTAAATATACCCTATGAGGTAGTGCATGTACAGGCAAATTCGCATGCGGGATACTACCCGAATG
CTACGCCAGTGCTAATAAAATTAATTTTTAATAAAGATAGTGGGAAAATTTACGGAGCACAGGCTCTAGGACGTGACGGT
GTAGATAAGCGTATGGATGTTATCGCAACGGCAATAAAAGCAAATTTAACTGTACTTGATTTGCCAGATTTAGAATTATC
ATATGCCCCGCCATATTCTTCTGCAAAAGACCCTGTAAACATGGTAGGGTATGCAGCAAGTAATATAGTAGATGGTTTTG
TGGACACAGTACAATGGCATGAAATAGATCGTATTGTTGAAAATGGTGGATATCTTATTGATGTTCGAGAGCCTAATGAA
TTAAAACAAGGAATGATTAAAGGCTCTATTAATATTCCGTTAGATGAATTACGTGATCGTTTGGATGAGGTGCCGGTAGA
TAAAGAAATATATATTACTTGTCAACTTGGTATGAGAGGGTATGTTGCAGCACGCATGTTAATGGAAAAAGGATATAAGG
TAAAGAATGTAGATGGTGGTTTTAAATTGTATGGAACAGTATTACCAGAACGTATTGTATATTGA

Upstream 100 bases:

>100_bases
TATTGATTGAAATTAACTTTTTTATAATTTATTATATACCCATACAGGTATAGGTTTTATGTGGGGGTTGAGAAAATTAA
ATACTATGGAGGTTTAAAAT

Downstream 100 bases:

>100_bases
TATTTTTTCATCTTCCACTTCAAAATTTGGTGGAAGATGAAAGCCTATAGATGAAGGTTTCGCTTTGTGTTTTGTGAATG
TATAAGGTAAAAGTTTAAAA

Product: NADH dehydrogenase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MSRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKLLVQTVERMSKRFNLDIRVLS
EVVQINKEEKTITIKNVTTNETYSEEYDILILSPGAKPIVPSIPGIEEAKALFTLRNVPDTDRIKAYVDEQKPRHATVIG
GGFIGVEMVENLRERGIDVTLVEMANQVMPPIDYEMAAYVHEHLQKHDVELVFEDGVDALEENGTVVRLKSGSIIETDMI
ILAIGVQSESSLAKDAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGNT
DSVYKGTLGTSVAKVFDLTVASTGVNEKILKRLNIPYEVVHVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQALGRDG
VDKRMDVIATAIKANLTVLDLPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDRIVENGGYLIDVREPNE
LKQGMIKGSINIPLDELRDRLDEVPVDKEIYITCQLGMRGYVAARMLMEKGYKVKNVDGGFKLYGTVLPERIVY

Sequences:

>Translated_554_residues
MSRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKLLVQTVERMSKRFNLDIRVLS
EVVQINKEEKTITIKNVTTNETYSEEYDILILSPGAKPIVPSIPGIEEAKALFTLRNVPDTDRIKAYVDEQKPRHATVIG
GGFIGVEMVENLRERGIDVTLVEMANQVMPPIDYEMAAYVHEHLQKHDVELVFEDGVDALEENGTVVRLKSGSIIETDMI
ILAIGVQSESSLAKDAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGNT
DSVYKGTLGTSVAKVFDLTVASTGVNEKILKRLNIPYEVVHVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQALGRDG
VDKRMDVIATAIKANLTVLDLPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDRIVENGGYLIDVREPNE
LKQGMIKGSINIPLDELRDRLDEVPVDKEIYITCQLGMRGYVAARMLMEKGYKVKNVDGGFKLYGTVLPERIVY
>Mature_553_residues
SRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKLLVQTVERMSKRFNLDIRVLSE
VVQINKEEKTITIKNVTTNETYSEEYDILILSPGAKPIVPSIPGIEEAKALFTLRNVPDTDRIKAYVDEQKPRHATVIGG
GFIGVEMVENLRERGIDVTLVEMANQVMPPIDYEMAAYVHEHLQKHDVELVFEDGVDALEENGTVVRLKSGSIIETDMII
LAIGVQSESSLAKDAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGNTD
SVYKGTLGTSVAKVFDLTVASTGVNEKILKRLNIPYEVVHVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQALGRDGV
DKRMDVIATAIKANLTVLDLPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDRIVENGGYLIDVREPNEL
KQGMIKGSINIPLDELRDRLDEVPVDKEIYITCQLGMRGYVAARMLMEKGYKVKNVDGGFKLYGTVLPERIVY

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=314, Percent_Identity=25.796178343949, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI65787454, Length=314, Percent_Identity=25.796178343949, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI226437568, Length=314, Percent_Identity=25.796178343949, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1789065, Length=328, Percent_Identity=26.5243902439024, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI87082354, Length=294, Percent_Identity=26.1904761904762, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786307, Length=304, Percent_Identity=28.6184210526316, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1789765, Length=289, Percent_Identity=26.2975778546713, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788892, Length=196, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787352, Length=240, Percent_Identity=27.9166666666667, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559934, Length=218, Percent_Identity=25.2293577981651, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585130, Length=293, Percent_Identity=25.2559726962457, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 61202; Mature: 61071

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKL
CCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHH
LVQTVERMSKRFNLDIRVLSEVVQINKEEKTITIKNVTTNETYSEEYDILILSPGAKPIV
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCCC
PSIPGIEEAKALFTLRNVPDTDRIKAYVDEQKPRHATVIGGGFIGVEMVENLRERGIDVT
CCCCCHHHHHHHEEECCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEE
LVEMANQVMPPIDYEMAAYVHEHLQKHDVELVFEDGVDALEENGTVVRLKSGSIIETDMI
EHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEECCCHHHHCCCCEEEECCCCEEEECEE
ILAIGVQSESSLAKDAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIP
EEEEECCCCHHHHHHCCEEEEEEEEEEECCCCCCCCCEEEEECCCEEHHHHHCCCCCEEE
LAWPANRQGRMLADIIHGNTDSVYKGTLGTSVAKVFDLTVASTGVNEKILKRLNIPYEVV
EECCCCCCCCEEEEECCCCCCCEEECCHHHHHHHHHEEEEECCCCCHHHHHHHCCCEEEE
HVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQALGRDGVDKRMDVIATAIKANLTVLD
EEEECCCCCCCCCCCCEEEEEEEECCCCEEEEEHHCCCCCCHHHHHHHHHHHHCCEEEEE
LPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDRIVENGGYLIDVREPNE
CCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
LKQGMIKGSINIPLDELRDRLDEVPVDKEIYITCQLGMRGYVAARMLMEKGYKVKNVDGG
HHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCC
FKLYGTVLPERIVY
EEEEEECCCHHHCC
>Mature Secondary Structure 
SRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKL
CCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHH
LVQTVERMSKRFNLDIRVLSEVVQINKEEKTITIKNVTTNETYSEEYDILILSPGAKPIV
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCCC
PSIPGIEEAKALFTLRNVPDTDRIKAYVDEQKPRHATVIGGGFIGVEMVENLRERGIDVT
CCCCCHHHHHHHEEECCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEE
LVEMANQVMPPIDYEMAAYVHEHLQKHDVELVFEDGVDALEENGTVVRLKSGSIIETDMI
EHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEECCCHHHHCCCCEEEECCCCEEEECEE
ILAIGVQSESSLAKDAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIP
EEEEECCCCHHHHHHCCEEEEEEEEEEECCCCCCCCCEEEEECCCEEHHHHHCCCCCEEE
LAWPANRQGRMLADIIHGNTDSVYKGTLGTSVAKVFDLTVASTGVNEKILKRLNIPYEVV
EECCCCCCCCEEEEECCCCCCCEEECCHHHHHHHHHEEEEECCCCCHHHHHHHCCCEEEE
HVQANSHAGYYPNATPVLIKLIFNKDSGKIYGAQALGRDGVDKRMDVIATAIKANLTVLD
EEEECCCCCCCCCCCCEEEEEEEECCCCEEEEEHHCCCCCCHHHHHHHHHHHHCCEEEEE
LPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVDTVQWHEIDRIVENGGYLIDVREPNE
CCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
LKQGMIKGSINIPLDELRDRLDEVPVDKEIYITCQLGMRGYVAARMLMEKGYKVKNVDGG
HHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCC
FKLYGTVLPERIVY
EEEEEECCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA