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The map label for this gene is pyrE [H]

Identifier: 222094373

GI number: 222094373

Start: 684984

End: 685526

Strand: Direct

Name: pyrE [H]

Synonym: BCQ_0687

Alternate gene names: 222094373

Gene position: 684984-685526 (Clockwise)

Preceding gene: 222094372

Following gene: 222094374

Centisome position: 13.14

GC content: 36.65

Gene sequence:

>543_bases
ATGGAGAAATGGGAGTTAGCAAAGGAAATTTACAATACGTCACGTTTAACGGGAACATTTAAACTTCGATCAGGACAAGT
ATCAAATCAATACTTTGATAAGTACTTATTTGAATCTAATCCAGTATTGCTAGTAGAAATTGCTAAACAATTGAAAGAGC
TCATTCCTCCTGAGACAGAAGTGCTCGCAGGTTTAGAGATGGGAGGAATTCCAGTAGCAACAGCATTATCTTTACAAACA
GGTATACCAGTTGTATTTGTAAGAAAAGAAGCGAAGAAGTACGGTACATGCAAGTTAGCAGAAGGCGTTGATATTGCTGG
GAAAAATGTTTGTGTTGTTGAAGATGTTATTACGACAGGTGGTCAAATATTATTAAGCACGAAAGATTTAAGAGGATTAG
GTGCGAAAGTCCACCATGTTCTAGGCGTGATTGAACGAACGAAAGAGGGAAAAGAAAACTTATTAGAAGATGGTTTACAG
CTACATTCCTTATTTACAATGGATGAGTTAATTGAAGGAGAAAAGCAACATGCAAAGAGTTGA

Upstream 100 bases:

>100_bases
ATTCTTAGGAATCGACCTTTTTTGTTTGTATTTTAGGAATATACAAATAATTACAAGTGTGATAGAATGAGTTAATTTGT
GTGTAAAGGGGAGACAGGGA

Downstream 100 bases:

>100_bases
TGTCGTATATGCACTAATACATGACGAAGAAACAGATAAAATATTAATGGTACATAATGTAGAATAAAATGTTTGGTCAT
TGCCGGGTGGGGCTGTTGAA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MEKWELAKEIYNTSRLTGTFKLRSGQVSNQYFDKYLFESNPVLLVEIAKQLKELIPPETEVLAGLEMGGIPVATALSLQT
GIPVVFVRKEAKKYGTCKLAEGVDIAGKNVCVVEDVITTGGQILLSTKDLRGLGAKVHHVLGVIERTKEGKENLLEDGLQ
LHSLFTMDELIEGEKQHAKS

Sequences:

>Translated_180_residues
MEKWELAKEIYNTSRLTGTFKLRSGQVSNQYFDKYLFESNPVLLVEIAKQLKELIPPETEVLAGLEMGGIPVATALSLQT
GIPVVFVRKEAKKYGTCKLAEGVDIAGKNVCVVEDVITTGGQILLSTKDLRGLGAKVHHVLGVIERTKEGKENLLEDGLQ
LHSLFTMDELIEGEKQHAKS
>Mature_180_residues
MEKWELAKEIYNTSRLTGTFKLRSGQVSNQYFDKYLFESNPVLLVEIAKQLKELIPPETEVLAGLEMGGIPVATALSLQT
GIPVVFVRKEAKKYGTCKLAEGVDIAGKNVCVVEDVITTGGQILLSTKDLRGLGAKVHHVLGVIERTKEGKENLLEDGLQ
LHSLFTMDELIEGEKQHAKS

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=165, Percent_Identity=32.1212121212121, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17508631, Length=160, Percent_Identity=34.375, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17554964, Length=160, Percent_Identity=35, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17933654, Length=158, Percent_Identity=37.3417721518987, Blast_Score=97, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 19822; Mature: 19822

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKWELAKEIYNTSRLTGTFKLRSGQVSNQYFDKYLFESNPVLLVEIAKQLKELIPPETE
CCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHH
VLAGLEMGGIPVATALSLQTGIPVVFVRKEAKKYGTCKLAEGVDIAGKNVCVVEDVITTG
HHHCCCCCCCCHHHHHHHHCCCCEEEEECHHHHCCCEECCCCCCCCCCCEEEEHHHHHCC
GQILLSTKDLRGLGAKVHHVLGVIERTKEGKENLLEDGLQLHSLFTMDELIEGEKQHAKS
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCC
>Mature Secondary Structure
MEKWELAKEIYNTSRLTGTFKLRSGQVSNQYFDKYLFESNPVLLVEIAKQLKELIPPETE
CCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHH
VLAGLEMGGIPVATALSLQTGIPVVFVRKEAKKYGTCKLAEGVDIAGKNVCVVEDVITTG
HHHCCCCCCCCHHHHHHHHCCCCEEEEECHHHHCCCEECCCCCCCCCCCEEEEHHHHHCC
GQILLSTKDLRGLGAKVHHVLGVIERTKEGKENLLEDGLQLHSLFTMDELIEGEKQHAKS
CEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA