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The map label for this gene is yrkA [H]

Identifier: 222094359

GI number: 222094359

Start: 669298

End: 670575

Strand: Direct

Name: yrkA [H]

Synonym: BCQ_0673

Alternate gene names: 222094359

Gene position: 669298-670575 (Clockwise)

Preceding gene: 222094358

Following gene: 222094360

Centisome position: 12.84

GC content: 35.45

Gene sequence:

>1278_bases
ATGGTAGTCATTCTTATTGCATTAACAGGTTTTTTTGTAGCTGTTGAGTTTGCAATTATTAAGGTGCGTAGCAGTCGTAT
TGACCAACTCGTTAGTGAGAAACGACGAGGAGCATTGGCAGCAAAAAAAGTAACTTCAAATTTAGATGAATATTTATCAG
CATGTCAGTTAGGTATTACAATTACCGCTTTAGGGCTTGGGTGGTTAGGAGAGCCGACCATAAAACATTTACTCGAGCCG
TTGTTTTTAAAACTGCATTTATCTCCTGCAATTTCCAGCACAGTTTCATTTATTATTGCCTTTGCAGTGATTACGTTTTT
ACATGTTGTCATTGGTGAACTTGCTCCTAAGACGTTCGCCATACAAAGGGCAGAGCAAGTTAGCTTATTATTATCGAAGC
CACTTATTTATTTTTACCGAATAATGTATCCGTTTATTTGGGCTTTAAATGGTTCAGCAAGGCTTGTAACAGGGTTATTC
GGATTACATCCGGCTTCTGAACATGAAGTTGCTCATTCGGAAGAAGAATTACGGTTAATCTTATCTGAGAGTTATGAGAG
CGGAGAGATTAATCAAAGGGAATTTAAATATGTAAATAATATTTTTGAATTTGATAATAGAGTGGCAAAGGAAATTATGG
TACCTCGTACGGAAGTTGTAGGTTTATATGAGGACGAACCATTTGAAACACATATTAAAATAATCGCACAAGAAAAATAT
ACGAGGTATCCTGTATTTGGTGAAGATAAAGATGAAATCATTGGGATGGTTAATGTAAAGGATTTATTTATTCGTTATAT
GGATGGTAATCGGGACGAGGATTGCTCGATTATGCCATATACAAGGCCGGTCATTGAAGTACTAGAAAATATTCCAATTC
ATGATTTACTATTACAAATGCAAAGAAAACACATTCCATTAGCTGTGTTGTATGATGAATATGGTGGTACAGCTGGGATT
GTTACATTAGAAGATATTTTAGAAGAAATTGTTGGGGAAATTCGAGATGAATACGATGAAGATGAACACCCGCCTATAGA
GCATATAAGTGAAGGGTGTAAAATCGTAGAGGGGAAAGTGCTTATTAGTGAAGTAAATGATTTATTTGGCATACACTTAA
TCGCTGATGATGTAGATACAATTGGTGGATGGATTATGGTACAAAAGCAAATCGTTGCTGAAGGAGATATTATTGAAAAA
CACGGCTTTTCTTTTAAAGTTCTGGAAAAAGATATGCATCAAATTAAACGAGTGGAAATAAAGAAGGGAGAAGAATGA

Upstream 100 bases:

>100_bases
TTGAGTAAATGAAGAAACTAAAGTGAAACTTCTTTTTTAAAGGAGGTGTCACTTTAGCTAAGAAGGCTAAAGGATATATG
TGGATATTTTAAAATTACTG

Downstream 100 bases:

>100_bases
TTTTCTATAAAAGGTATATATAGAAAATTAAATGTTTGCGCTTTCAAAAAAGGTGCTATATAGTGAAGGTGGACACTGAA
AAATTCTTCTGAATGATACT

Product: cbs domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MVVILIALTGFFVAVEFAIIKVRSSRIDQLVSEKRRGALAAKKVTSNLDEYLSACQLGITITALGLGWLGEPTIKHLLEP
LFLKLHLSPAISSTVSFIIAFAVITFLHVVIGELAPKTFAIQRAEQVSLLLSKPLIYFYRIMYPFIWALNGSARLVTGLF
GLHPASEHEVAHSEEELRLILSESYESGEINQREFKYVNNIFEFDNRVAKEIMVPRTEVVGLYEDEPFETHIKIIAQEKY
TRYPVFGEDKDEIIGMVNVKDLFIRYMDGNRDEDCSIMPYTRPVIEVLENIPIHDLLLQMQRKHIPLAVLYDEYGGTAGI
VTLEDILEEIVGEIRDEYDEDEHPPIEHISEGCKIVEGKVLISEVNDLFGIHLIADDVDTIGGWIMVQKQIVAEGDIIEK
HGFSFKVLEKDMHQIKRVEIKKGEE

Sequences:

>Translated_425_residues
MVVILIALTGFFVAVEFAIIKVRSSRIDQLVSEKRRGALAAKKVTSNLDEYLSACQLGITITALGLGWLGEPTIKHLLEP
LFLKLHLSPAISSTVSFIIAFAVITFLHVVIGELAPKTFAIQRAEQVSLLLSKPLIYFYRIMYPFIWALNGSARLVTGLF
GLHPASEHEVAHSEEELRLILSESYESGEINQREFKYVNNIFEFDNRVAKEIMVPRTEVVGLYEDEPFETHIKIIAQEKY
TRYPVFGEDKDEIIGMVNVKDLFIRYMDGNRDEDCSIMPYTRPVIEVLENIPIHDLLLQMQRKHIPLAVLYDEYGGTAGI
VTLEDILEEIVGEIRDEYDEDEHPPIEHISEGCKIVEGKVLISEVNDLFGIHLIADDVDTIGGWIMVQKQIVAEGDIIEK
HGFSFKVLEKDMHQIKRVEIKKGEE
>Mature_425_residues
MVVILIALTGFFVAVEFAIIKVRSSRIDQLVSEKRRGALAAKKVTSNLDEYLSACQLGITITALGLGWLGEPTIKHLLEP
LFLKLHLSPAISSTVSFIIAFAVITFLHVVIGELAPKTFAIQRAEQVSLLLSKPLIYFYRIMYPFIWALNGSARLVTGLF
GLHPASEHEVAHSEEELRLILSESYESGEINQREFKYVNNIFEFDNRVAKEIMVPRTEVVGLYEDEPFETHIKIIAQEKY
TRYPVFGEDKDEIIGMVNVKDLFIRYMDGNRDEDCSIMPYTRPVIEVLENIPIHDLLLQMQRKHIPLAVLYDEYGGTAGI
VTLEDILEEIVGEIRDEYDEDEHPPIEHISEGCKIVEGKVLISEVNDLFGIHLIADDVDTIGGWIMVQKQIVAEGDIIEK
HGFSFKVLEKDMHQIKRVEIKKGEE

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=387, Percent_Identity=49.6124031007752, Blast_Score=381, Evalue=1e-106,
Organism=Escherichia coli, GI1790664, Length=427, Percent_Identity=23.1850117096019, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI145693175, Length=416, Percent_Identity=24.0384615384615, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1786879, Length=257, Percent_Identity=30.7392996108949, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI87082033, Length=242, Percent_Identity=24.3801652892562, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788119, Length=238, Percent_Identity=25.2100840336134, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17539402, Length=243, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 48252; Mature: 48252

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVILIALTGFFVAVEFAIIKVRSSRIDQLVSEKRRGALAAKKVTSNLDEYLSACQLGIT
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCE
ITALGLGWLGEPTIKHLLEPLFLKLHLSPAISSTVSFIIAFAVITFLHVVIGELAPKTFA
EEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
IQRAEQVSLLLSKPLIYFYRIMYPFIWALNGSARLVTGLFGLHPASEHEVAHSEEELRLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHCCHHHHHHH
LSESYESGEINQREFKYVNNIFEFDNRVAKEIMVPRTEVVGLYEDEPFETHIKIIAQEKY
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHEEECCCC
TRYPVFGEDKDEIIGMVNVKDLFIRYMDGNRDEDCSIMPYTRPVIEVLENIPIHDLLLQM
CCCCCCCCCHHHEEEEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
QRKHIPLAVLYDEYGGTAGIVTLEDILEEIVGEIRDEYDEDEHPPIEHISEGCKIVEGKV
HHHCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECHH
LISEVNDLFGIHLIADDVDTIGGWIMVQKQIVAEGDIIEKHGFSFKVLEKDMHQIKRVEI
HHHHHHHHHEEEEEECCHHHHCCHHEEHHHHHCCCCEEHHCCCCHHHHHHHHHHHHHHHH
KKGEE
CCCCC
>Mature Secondary Structure
MVVILIALTGFFVAVEFAIIKVRSSRIDQLVSEKRRGALAAKKVTSNLDEYLSACQLGIT
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCE
ITALGLGWLGEPTIKHLLEPLFLKLHLSPAISSTVSFIIAFAVITFLHVVIGELAPKTFA
EEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
IQRAEQVSLLLSKPLIYFYRIMYPFIWALNGSARLVTGLFGLHPASEHEVAHSEEELRLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHCCHHHHHHH
LSESYESGEINQREFKYVNNIFEFDNRVAKEIMVPRTEVVGLYEDEPFETHIKIIAQEKY
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCHHHHHHEEECCCC
TRYPVFGEDKDEIIGMVNVKDLFIRYMDGNRDEDCSIMPYTRPVIEVLENIPIHDLLLQM
CCCCCCCCCHHHEEEEEEHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
QRKHIPLAVLYDEYGGTAGIVTLEDILEEIVGEIRDEYDEDEHPPIEHISEGCKIVEGKV
HHHCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECHH
LISEVNDLFGIHLIADDVDTIGGWIMVQKQIVAEGDIIEKHGFSFKVLEKDMHQIKRVEI
HHHHHHHHHEEEEEECCHHHHCCHHEEHHHHHCCCCEEHHCCCCHHHHHHHHHHHHHHHH
KKGEE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 8969508; 7608059 [H]