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The map label for this gene is yfnA [H]

Identifier: 222094345

GI number: 222094345

Start: 653443

End: 654762

Strand: Direct

Name: yfnA [H]

Synonym: BCQ_0659

Alternate gene names: 222094345

Gene position: 653443-654762 (Clockwise)

Preceding gene: 222094344

Following gene: 222094346

Centisome position: 12.53

GC content: 36.89

Gene sequence:

>1320_bases
ATGCTAGGGATTGGTGCGATAATCGGTACAGGAGTACTAGTATTAACAGGATTAGTAGCAGCAAGAGATGCTGGTCCAGC
AGTTATTTTTTCATTCATGATTGCAGCGATTGTTTGTGGATTTGCAGCATTATGTTATGCAGAAGTTGCATCTACACTTC
CGGTTTCAGGTAGTGTGTACACATATTCATATGCGACAATTGGTGAGTTTATTGCCCACCTAATGGGATGGACATTACTA
TCTGTATATGTCGTAACAACTGCCGCAGTAGCTGGTGGATGGACGGGTTATTTTAATAACTTAGTGAGTGGATTTGGATT
AGAAATTCCAACAGAGCTGTTAAAGATTCCATCACAAGGTGGAATGGTGAATTTACCAGCAGTAGTCATTACATTAGTTT
TAACTTGGTTACTATCAAGAGGTACGAAAGAAAGTAAGCGTGTGAATAACATAATGGTATTAATTAAAATTGGTATTGTT
ATTTTATTCATTGCAGTTGGTGCGTTTTACGTACAACCAGAAAACTGGACACCATTTGCACCATACGGCATTAGCGGAAT
CTTTGCCGGAGGAGCAGCAGTATTCTTCGCTTTCTTAGGATTTGATGCATTAGCAACTTCTGCTGAAGAAGTAAAAAATC
CACAACGTGATTTACCGATTGGTATTATTGCTTCGTTAGTTATTTGTACAATTATTTATGTTGTAGTTTGTCTCGTTATG
ACAGGTATGGTTTCTTATAAAGAATTAGATGTACCAGAAGCTATGGCATATGTATTAGAAGTTGTAGGACAAGATAAAGT
AGCTGGTGTAATCGCAGTTGGAGCTGTAATTGGTATTATGGCTGTAATCTTTGCTTACATTTATGCAACGACACGTGTAT
TCTTCGCGATGAGCCGTGATGGTTTATTACCAAAATCATTTGCGAAAATTAATAAGAAGACAGAAGCACCAGTATTCTCA
ACTTGGTTAACGGGTATTGGTAGTGCATTAATTGCTGGATTTATCGATTTAAAAGAATTGTCGAATTTAGCGAATATTGG
AGCGTTGTTAACATTTGCGATGGTAGGTGTGTCAGTTATTATTCTTCGTAAAACACATCCGAACTTAAAACGTGGCTTTG
TGGTACCACTTGTACCAACGCTACCGATTATTTCAATCGCATGTTGTCTATTCTTAATGTTTAACCTACCATTAACAACA
TGGATCTACTTCGGTATTTGGTTAGCAATTGGAGTAGTTGTATACTTTGTTTATTCGAAAAAACATAGTCATTTAAAAGA
CGATGGAAGTTCGCAGGATAATTTAGAACAAGCTAATTAA

Upstream 100 bases:

>100_bases
CATCGTGGCCAACCTATTTAAAAAGAAATCCGTTACGCAATTGTTAGGGGAAAGTAAAAGTAAAACTTTAACGAAAACGC
TAGGGGCATTTGACCTAACA

Downstream 100 bases:

>100_bases
AAGCTTAATTAAAAGCTTAATTAAAAGCTTAATTAAAAGCTTAATTAAAAGGGATATAAGTATAGTAAGCCTTGTGCGTC
TAGGGAGCGCGCAAGGCTTT

Product: amino acid permease (amino acid transporter)

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MLGIGAIIGTGVLVLTGLVAARDAGPAVIFSFMIAAIVCGFAALCYAEVASTLPVSGSVYTYSYATIGEFIAHLMGWTLL
SVYVVTTAAVAGGWTGYFNNLVSGFGLEIPTELLKIPSQGGMVNLPAVVITLVLTWLLSRGTKESKRVNNIMVLIKIGIV
ILFIAVGAFYVQPENWTPFAPYGISGIFAGGAAVFFAFLGFDALATSAEEVKNPQRDLPIGIIASLVICTIIYVVVCLVM
TGMVSYKELDVPEAMAYVLEVVGQDKVAGVIAVGAVIGIMAVIFAYIYATTRVFFAMSRDGLLPKSFAKINKKTEAPVFS
TWLTGIGSALIAGFIDLKELSNLANIGALLTFAMVGVSVIILRKTHPNLKRGFVVPLVPTLPIISIACCLFLMFNLPLTT
WIYFGIWLAIGVVVYFVYSKKHSHLKDDGSSQDNLEQAN

Sequences:

>Translated_439_residues
MLGIGAIIGTGVLVLTGLVAARDAGPAVIFSFMIAAIVCGFAALCYAEVASTLPVSGSVYTYSYATIGEFIAHLMGWTLL
SVYVVTTAAVAGGWTGYFNNLVSGFGLEIPTELLKIPSQGGMVNLPAVVITLVLTWLLSRGTKESKRVNNIMVLIKIGIV
ILFIAVGAFYVQPENWTPFAPYGISGIFAGGAAVFFAFLGFDALATSAEEVKNPQRDLPIGIIASLVICTIIYVVVCLVM
TGMVSYKELDVPEAMAYVLEVVGQDKVAGVIAVGAVIGIMAVIFAYIYATTRVFFAMSRDGLLPKSFAKINKKTEAPVFS
TWLTGIGSALIAGFIDLKELSNLANIGALLTFAMVGVSVIILRKTHPNLKRGFVVPLVPTLPIISIACCLFLMFNLPLTT
WIYFGIWLAIGVVVYFVYSKKHSHLKDDGSSQDNLEQAN
>Mature_439_residues
MLGIGAIIGTGVLVLTGLVAARDAGPAVIFSFMIAAIVCGFAALCYAEVASTLPVSGSVYTYSYATIGEFIAHLMGWTLL
SVYVVTTAAVAGGWTGYFNNLVSGFGLEIPTELLKIPSQGGMVNLPAVVITLVLTWLLSRGTKESKRVNNIMVLIKIGIV
ILFIAVGAFYVQPENWTPFAPYGISGIFAGGAAVFFAFLGFDALATSAEEVKNPQRDLPIGIIASLVICTIIYVVVCLVM
TGMVSYKELDVPEAMAYVLEVVGQDKVAGVIAVGAVIGIMAVIFAYIYATTRVFFAMSRDGLLPKSFAKINKKTEAPVFS
TWLTGIGSALIAGFIDLKELSNLANIGALLTFAMVGVSVIILRKTHPNLKRGFVVPLVPTLPIISIACCLFLMFNLPLTT
WIYFGIWLAIGVVVYFVYSKKHSHLKDDGSSQDNLEQAN

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of D-Alanine, D-Serine And Glycine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI258614003, Length=394, Percent_Identity=37.5634517766497, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI258614005, Length=394, Percent_Identity=37.5634517766497, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI258645169, Length=394, Percent_Identity=37.0558375634518, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI4507047, Length=401, Percent_Identity=37.1571072319202, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI181337167, Length=381, Percent_Identity=35.4330708661417, Blast_Score=221, Evalue=2e-57,
Organism=Homo sapiens, GI114326544, Length=401, Percent_Identity=34.4139650872818, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI114326550, Length=401, Percent_Identity=34.4139650872818, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI110347453, Length=371, Percent_Identity=35.5795148247978, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI186910308, Length=446, Percent_Identity=26.457399103139, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI186910306, Length=446, Percent_Identity=26.457399103139, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI186910304, Length=446, Percent_Identity=26.457399103139, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI33286428, Length=449, Percent_Identity=27.3942093541203, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI7657683, Length=402, Percent_Identity=26.3681592039801, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI115648063, Length=437, Percent_Identity=26.5446224256293, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI115648022, Length=437, Percent_Identity=26.5446224256293, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71979932, Length=225, Percent_Identity=30.6666666666667, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI187423910, Length=429, Percent_Identity=23.5431235431235, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI7657591, Length=429, Percent_Identity=23.5431235431235, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI33286430, Length=245, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI9790235, Length=312, Percent_Identity=24.0384615384615, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1790653, Length=427, Percent_Identity=25.2927400468384, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081869, Length=387, Percent_Identity=25.5813953488372, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082023, Length=404, Percent_Identity=26.4851485148515, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87081708, Length=476, Percent_Identity=20.1680672268908, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786694, Length=396, Percent_Identity=27.020202020202, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788480, Length=336, Percent_Identity=24.4047619047619, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789017, Length=390, Percent_Identity=24.1025641025641, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786302, Length=411, Percent_Identity=21.654501216545, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082250, Length=451, Percent_Identity=23.5033259423503, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI2367353, Length=317, Percent_Identity=24.9211356466877, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786908, Length=223, Percent_Identity=26.0089686098655, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790584, Length=268, Percent_Identity=25.7462686567164, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=376, Percent_Identity=34.3085106382979, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17533459, Length=379, Percent_Identity=35.3562005277045, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17531343, Length=375, Percent_Identity=32.2666666666667, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17537453, Length=326, Percent_Identity=25.1533742331288, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540018, Length=199, Percent_Identity=29.6482412060301, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32566699, Length=380, Percent_Identity=24.4736842105263, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71982612, Length=396, Percent_Identity=22.2222222222222, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71982608, Length=396, Percent_Identity=22.2222222222222, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17568033, Length=409, Percent_Identity=22.4938875305623, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32566695, Length=334, Percent_Identity=23.6526946107784, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193208714, Length=334, Percent_Identity=23.6526946107784, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221512776, Length=392, Percent_Identity=37.7551020408163, Blast_Score=261, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24666159, Length=392, Percent_Identity=37.7551020408163, Blast_Score=261, Evalue=6e-70,
Organism=Drosophila melanogaster, GI24667468, Length=390, Percent_Identity=34.8717948717949, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24668806, Length=385, Percent_Identity=34.5454545454545, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI21356285, Length=385, Percent_Identity=34.5454545454545, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24668802, Length=385, Percent_Identity=34.5454545454545, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI161077963, Length=370, Percent_Identity=36.2162162162162, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI281366235, Length=380, Percent_Identity=34.2105263157895, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI116007820, Length=380, Percent_Identity=34.2105263157895, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI116007818, Length=383, Percent_Identity=34.2036553524804, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI85725152, Length=383, Percent_Identity=34.2036553524804, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI21357367, Length=407, Percent_Identity=28.2555282555283, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI221331183, Length=453, Percent_Identity=26.9315673289183, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17647653, Length=453, Percent_Identity=26.9315673289183, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24664379, Length=453, Percent_Identity=26.9315673289183, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45550968, Length=453, Percent_Identity=26.7108167770419, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921172, Length=453, Percent_Identity=26.7108167770419, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24651635, Length=410, Percent_Identity=24.8780487804878, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24651633, Length=410, Percent_Identity=24.8780487804878, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46829; Mature: 46829

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]