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The map label for this gene is mvaIM [H]

Identifier: 22127663

GI number: 22127663

Start: 4211816

End: 4213141

Strand: Reverse

Name: mvaIM [H]

Synonym: y3792

Alternate gene names: 22127663

Gene position: 4213141-4211816 (Counterclockwise)

Preceding gene: 22127664

Following gene: 22127662

Centisome position: 91.57

GC content: 32.28

Gene sequence:

>1326_bases
ATGAACGACATAGACAAAGACAATATGCTCTTGAATAAGGTAATTTCAAATTCGAAAGGTGACAAAGCTTATTGGTCATT
TAAGGGGCGAGCAAAAAGACAATACTGTCATGCTTTGATTCAATATCCAGCAATGATGGTTCCAGCTATGCAAGGGGAAC
TTATAGATGCTGTATTAGAAATAGATTCAAACGTAACAAGTATAATAGATCCCTTTGTCGGTTCAGGGACTACTCTTGGT
GAAGCTATGCGCCGAGGGCTTGATTTTGTCGGGATGGATATCAATCCTCTTTCAATTTTAGCATGTGAAGTAAAAAGTGG
CCCATTGTATATTGATTCTTTTAAAGAAAAATTCATTTTTCTATTGGATAAAATACGTGCTGATTTACGAGTAGACATAG
CTGTTCAAATAAAAAATATTGATAAATGGTTTACTAAAGAAGTCCAGTTAGATTTAAGTAAGATATATAGGGCTATTCAG
GACGAAAGTTCTAAGTGGGCTAGGAAGGTTTTTTGGTTGTGCATGAGTAATACTGTTCGTACCGTTTGTAATTCAAGAAG
TTCAACGTTTAAACTTCATATTAAATCGTTCAATCAAATCGAGAATATACCTAATACATTAGAAGTTTTTACAAAAAACA
TTGAAAAAAGTATAGTTGCGTTATGTGAGCAGAAGAACATACTTACTGAAATGGGCAGTTTAAAAAGATCTATTTCTAAG
AGTAAAATTAAAATAATACATGCTGACACTTCTAAGAAGATGAAAAAAAATATCCAATGTGATCTTCTGGTAAGTTCTCC
ACCATACGGAGATAATAATACTACCGTCACTTATGGGCAATTTTCTTATTTATCCTTAAAATGGATTGATGAAAAAGATA
TAGATAATTTGAAAATTAAAGGTTTGCTTGAAACTCAAAACAAAATTGATTCTAGCAGCCTTGGTGGCTCCCTTAAGGGA
GCCAATGAAAAAATGGAACTCTTGAAATATAAGTCTCCTACTTTGCTAAATACTGTAAAAGAAATTTCAAAAGTTAACTC
TGAAAATGTTAAGAAGTTAATTACATTTATTTTTGATCTAGATCTTGCCTTGGATAATGCGTTGTTATATCTGCGGAAAA
ATGCGTATATGATATGGACACTCGGTAACAGAAGAATTTCCAACATTGAAGTCCCATTAGACAGAATAATGAGAGAGATT
CTAGAATATAAAGGTTGTGTTTTTATTCATCAAATAGAAAGGGAAATATTATCCAAGAGAATGGCGATGAAAAATAGCAT
TGCTAATACGATGGATAAAGAATTGATTCTTATAATGAGGAAGTAA

Upstream 100 bases:

>100_bases
ATCGGGGAGTGTTAATCAACGGGGAGCAGGTCAAGGGGGCTGGTATGAAGTTCTCGCATCTGCTAGAGTTTCGTTCAAGG
GAAAATAGAGAAAGCCATAA

Downstream 100 bases:

>100_bases
TGCTATTTTGAATAACGTTATTTAATTTTTTGAGAGGGAGTTTTTATATATGGTGTCTACGTCATTGAAATTTGGTGGGA
AGATAATTGAGGAACTATCT

Product: modification methylase

Products: NA

Alternate protein names: M.MvaI; N-4 cytosine-specific methyltransferase MvaI [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MNDIDKDNMLLNKVISNSKGDKAYWSFKGRAKRQYCHALIQYPAMMVPAMQGELIDAVLEIDSNVTSIIDPFVGSGTTLG
EAMRRGLDFVGMDINPLSILACEVKSGPLYIDSFKEKFIFLLDKIRADLRVDIAVQIKNIDKWFTKEVQLDLSKIYRAIQ
DESSKWARKVFWLCMSNTVRTVCNSRSSTFKLHIKSFNQIENIPNTLEVFTKNIEKSIVALCEQKNILTEMGSLKRSISK
SKIKIIHADTSKKMKKNIQCDLLVSSPPYGDNNTTVTYGQFSYLSLKWIDEKDIDNLKIKGLLETQNKIDSSSLGGSLKG
ANEKMELLKYKSPTLLNTVKEISKVNSENVKKLITFIFDLDLALDNALLYLRKNAYMIWTLGNRRISNIEVPLDRIMREI
LEYKGCVFIHQIEREILSKRMAMKNSIANTMDKELILIMRK

Sequences:

>Translated_441_residues
MNDIDKDNMLLNKVISNSKGDKAYWSFKGRAKRQYCHALIQYPAMMVPAMQGELIDAVLEIDSNVTSIIDPFVGSGTTLG
EAMRRGLDFVGMDINPLSILACEVKSGPLYIDSFKEKFIFLLDKIRADLRVDIAVQIKNIDKWFTKEVQLDLSKIYRAIQ
DESSKWARKVFWLCMSNTVRTVCNSRSSTFKLHIKSFNQIENIPNTLEVFTKNIEKSIVALCEQKNILTEMGSLKRSISK
SKIKIIHADTSKKMKKNIQCDLLVSSPPYGDNNTTVTYGQFSYLSLKWIDEKDIDNLKIKGLLETQNKIDSSSLGGSLKG
ANEKMELLKYKSPTLLNTVKEISKVNSENVKKLITFIFDLDLALDNALLYLRKNAYMIWTLGNRRISNIEVPLDRIMREI
LEYKGCVFIHQIEREILSKRMAMKNSIANTMDKELILIMRK
>Mature_441_residues
MNDIDKDNMLLNKVISNSKGDKAYWSFKGRAKRQYCHALIQYPAMMVPAMQGELIDAVLEIDSNVTSIIDPFVGSGTTLG
EAMRRGLDFVGMDINPLSILACEVKSGPLYIDSFKEKFIFLLDKIRADLRVDIAVQIKNIDKWFTKEVQLDLSKIYRAIQ
DESSKWARKVFWLCMSNTVRTVCNSRSSTFKLHIKSFNQIENIPNTLEVFTKNIEKSIVALCEQKNILTEMGSLKRSISK
SKIKIIHADTSKKMKKNIQCDLLVSSPPYGDNNTTVTYGQFSYLSLKWIDEKDIDNLKIKGLLETQNKIDSSSLGGSLKG
ANEKMELLKYKSPTLLNTVKEISKVNSENVKKLITFIFDLDLALDNALLYLRKNAYMIWTLGNRRISNIEVPLDRIMREI
LEYKGCVFIHQIEREILSKRMAMKNSIANTMDKELILIMRK

Specific function: This methylase recognizes the double-stranded sequence CCWGG, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the MvaI endonuclease [H]

COG id: COG0863

COG function: function code L; DNA modification methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017985
- InterPro:   IPR000241 [H]

Pfam domain/function: PF01170 UPF0020 [H]

EC number: =2.1.1.113 [H]

Molecular weight: Translated: 50459; Mature: 50459

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDIDKDNMLLNKVISNSKGDKAYWSFKGRAKRQYCHALIQYPAMMVPAMQGELIDAVLE
CCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDSNVTSIIDPFVGSGTTLGEAMRRGLDFVGMDINPLSILACEVKSGPLYIDSFKEKFIF
HCCCHHHHHCCCCCCCCHHHHHHHCCCCEECCCCCCEEEEEEEECCCCEEHHHHHHHHHH
LLDKIRADLRVDIAVQIKNIDKWFTKEVQLDLSKIYRAIQDESSKWARKVFWLCMSNTVR
HHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TVCNSRSSTFKLHIKSFNQIENIPNTLEVFTKNIEKSIVALCEQKNILTEMGSLKRSISK
HHHCCCCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SKIKIIHADTSKKMKKNIQCDLLVSSPPYGDNNTTVTYGQFSYLSLKWIDEKDIDNLKIK
CEEEEEECCCHHHHHCCCEEEEEECCCCCCCCCCEEEEECEEEEEEEECCCCCCCCEEEE
GLLETQNKIDSSSLGGSLKGANEKMELLKYKSPTLLNTVKEISKVNSENVKKLITFIFDL
EEEHHHHCCCCHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
DLALDNALLYLRKNAYMIWTLGNRRISNIEVPLDRIMREILEYKGCVFIHQIEREILSKR
HHHHHHHEEEEECCEEEEEEECCCEECCCCCCHHHHHHHHHHHCCEEEHHHHHHHHHHHH
MAMKNSIANTMDKELILIMRK
HHHHHHHHHHCCCEEEEEEEC
>Mature Secondary Structure
MNDIDKDNMLLNKVISNSKGDKAYWSFKGRAKRQYCHALIQYPAMMVPAMQGELIDAVLE
CCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDSNVTSIIDPFVGSGTTLGEAMRRGLDFVGMDINPLSILACEVKSGPLYIDSFKEKFIF
HCCCHHHHHCCCCCCCCHHHHHHHCCCCEECCCCCCEEEEEEEECCCCEEHHHHHHHHHH
LLDKIRADLRVDIAVQIKNIDKWFTKEVQLDLSKIYRAIQDESSKWARKVFWLCMSNTVR
HHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TVCNSRSSTFKLHIKSFNQIENIPNTLEVFTKNIEKSIVALCEQKNILTEMGSLKRSISK
HHHCCCCCEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SKIKIIHADTSKKMKKNIQCDLLVSSPPYGDNNTTVTYGQFSYLSLKWIDEKDIDNLKIK
CEEEEEECCCHHHHHCCCEEEEEECCCCCCCCCCEEEEECEEEEEEEECCCCCCCCEEEE
GLLETQNKIDSSSLGGSLKGANEKMELLKYKSPTLLNTVKEISKVNSENVKKLITFIFDL
EEEHHHHCCCCHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
DLALDNALLYLRKNAYMIWTLGNRRISNIEVPLDRIMREILEYKGCVFIHQIEREILSKR
HHHHHHHEEEEECCEEEEEEECCCEECCCCCCHHHHHHHHHHHCCEEEHHHHHHHHHHHH
MAMKNSIANTMDKELILIMRK
HHHHHHHHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2690010 [H]