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The map label for this gene is pdxA [H]

Identifier: 22127556

GI number: 22127556

Start: 4093820

End: 4094827

Strand: Direct

Name: pdxA [H]

Synonym: y3682

Alternate gene names: 22127556

Gene position: 4093820-4094827 (Clockwise)

Preceding gene: 22127555

Following gene: 22127557

Centisome position: 88.98

GC content: 49.9

Gene sequence:

>1008_bases
TTGATGGTAGTAATGCACAACCACAATAATCGTCTAGTGATCACCCCCGGCGAGCCAGCCGGGGTCGGGCCGGATTTAGC
CATCACTCTGGCTCAACAGGATTGGCCTGTTGAGCTGGTAGTCTGCGCGGATCCGGCCTTGCTACTGGCCCGAGCCAGCC
AACTTAATCTGCCCCTGCAATTGCGTGAGTACCAAGCTGACCAGCCGGCAATAGCACAGCAAGCAGGGTCACTGACTATT
TTACCTGTAAAAACAGCTGTTAATGTTGTCCCTGGCAAGCTTGATGTCGGTAACAGTCACTATGTGGTTGAAACGTTAGC
CAAGGCTTGTGATGGTGCGATCAGTGGTGAATTCGCTGCATTGGTCACGGGCCCGGTACAAAAAAGTATTATCAATGATG
CCGGCATCCCCTTCATTGGGCATACCGAATTCTTTGCTGACCGCAGCCACTGCCAGAGGGTGGTGATGATGCTGGCAACG
GAAGAGTTGCGTGTGGCTTTAGCGACCACCCACTTGCCATTATTGGCGGTGCCAGGTGCCATTACGCAAGCCAGCTTACA
TGAAGTGATCACCATCCTTGATAACGACCTAAAAACCAAGTTTGGTATTACTCAGCCACAAATTTATGTTTGTGGGCTTA
ATCCTCATGCTGGCGAAGGGGGACATATGGGCCATGAAGAGATCGATACAATTATTCCTGCCCTGAATACACTACGCCAG
CAAGGGATAAACCTCATTGGCCCACTACCAGCAGACACCCTGTTTCAGCCGAAATATCTGCAACATGCAGATGCCGTTCT
CGCGATGTATCACGATCAGGGGCTACCAGTATTGAAATATCAAGGGTTTGGCCGAGCAGTCAATATCACTCTCGGTTTGC
CTTTTATCCGCACTTCTGTGGATCACGGTACCGCTTTAGAACTCGCCGCAACCGGTACTGCCGATGTTGGCAGTTTCATT
ACGGCATTAAACTTAGCCATCAAAATGATAAATAACAGCAATGAATAA

Upstream 100 bases:

>100_bases
CAAAAAGAGCGGGCGTACCGTATGCTCTTCAACCGTAAATTTGCTGAAGAAGCACAAACCTGGATGCAAGAGCAGCGTGC
TGCTGCTTATGTAAAAATTC

Downstream 100 bases:

>100_bases
TAGAGTCCACCAAGGGCATTTTGCCCGCAAACGCTTTGGACAAAACTTTTTAAACGATCAGTTTGTCATCGACAGTATTG
TCTCCGCAATCCACCCAGTT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MMVVMHNHNNRLVITPGEPAGVGPDLAITLAQQDWPVELVVCADPALLLARASQLNLPLQLREYQADQPAIAQQAGSLTI
LPVKTAVNVVPGKLDVGNSHYVVETLAKACDGAISGEFAALVTGPVQKSIINDAGIPFIGHTEFFADRSHCQRVVMMLAT
EELRVALATTHLPLLAVPGAITQASLHEVITILDNDLKTKFGITQPQIYVCGLNPHAGEGGHMGHEEIDTIIPALNTLRQ
QGINLIGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAATGTADVGSFI
TALNLAIKMINNSNE

Sequences:

>Translated_335_residues
MMVVMHNHNNRLVITPGEPAGVGPDLAITLAQQDWPVELVVCADPALLLARASQLNLPLQLREYQADQPAIAQQAGSLTI
LPVKTAVNVVPGKLDVGNSHYVVETLAKACDGAISGEFAALVTGPVQKSIINDAGIPFIGHTEFFADRSHCQRVVMMLAT
EELRVALATTHLPLLAVPGAITQASLHEVITILDNDLKTKFGITQPQIYVCGLNPHAGEGGHMGHEEIDTIIPALNTLRQ
QGINLIGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAATGTADVGSFI
TALNLAIKMINNSNE
>Mature_335_residues
MMVVMHNHNNRLVITPGEPAGVGPDLAITLAQQDWPVELVVCADPALLLARASQLNLPLQLREYQADQPAIAQQAGSLTI
LPVKTAVNVVPGKLDVGNSHYVVETLAKACDGAISGEFAALVTGPVQKSIINDAGIPFIGHTEFFADRSHCQRVVMMLAT
EELRVALATTHLPLLAVPGAITQASLHEVITILDNDLKTKFGITQPQIYVCGLNPHAGEGGHMGHEEIDTIIPALNTLRQ
QGINLIGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAATGTADVGSFI
TALNLAIKMINNSNE

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=326, Percent_Identity=74.2331288343558, Blast_Score=491, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35731; Mature: 35731

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVVMHNHNNRLVITPGEPAGVGPDLAITLAQQDWPVELVVCADPALLLARASQLNLPLQ
CEEEEEECCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCHHHHHHHHHCCCCEE
LREYQADQPAIAQQAGSLTILPVKTAVNVVPGKLDVGNSHYVVETLAKACDGAISGEFAA
EHHCCCCCCHHHHHCCCEEEEEEHHHHEECCCEEECCCCCHHHHHHHHHHCCCCCCCEEE
LVTGPVQKSIINDAGIPFIGHTEFFADRSHCQRVVMMLATEELRVALATTHLPLLAVPGA
EEECHHHHHHHHCCCCCEEECHHHHHCHHHHHHHHHHHHHHHHEEEEEECCCCEEECCCC
ITQASLHEVITILDNDLKTKFGITQPQIYVCGLNPHAGEGGHMGHEEIDTIIPALNTLRQ
HHHHHHHHHHHHHCCCHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
QGINLIGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSV
CCCCEECCCCCCCCCCCHHHHHHHHEEEEEECCCCCEEEECCCCCEEEEEEECCHHEECC
DHGTALELAATGTADVGSFITALNLAIKMINNSNE
CCCCEEEEEECCCCHHHHHHHHHHHHHHEECCCCC
>Mature Secondary Structure
MMVVMHNHNNRLVITPGEPAGVGPDLAITLAQQDWPVELVVCADPALLLARASQLNLPLQ
CEEEEEECCCEEEEECCCCCCCCCCEEEEEECCCCCEEEEEECCCHHHHHHHHHCCCCEE
LREYQADQPAIAQQAGSLTILPVKTAVNVVPGKLDVGNSHYVVETLAKACDGAISGEFAA
EHHCCCCCCHHHHHCCCEEEEEEHHHHEECCCEEECCCCCHHHHHHHHHHCCCCCCCEEE
LVTGPVQKSIINDAGIPFIGHTEFFADRSHCQRVVMMLATEELRVALATTHLPLLAVPGA
EEECHHHHHHHHCCCCCEEECHHHHHCHHHHHHHHHHHHHHHHEEEEEECCCCEEECCCC
ITQASLHEVITILDNDLKTKFGITQPQIYVCGLNPHAGEGGHMGHEEIDTIIPALNTLRQ
HHHHHHHHHHHHHCCCHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
QGINLIGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSV
CCCCEECCCCCCCCCCCHHHHHHHHEEEEEECCCCCEEEECCCCCEEEEEEECCHHEECC
DHGTALELAATGTADVGSFITALNLAIKMINNSNE
CCCCEEEEEECCCCHHHHHHHHHHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA