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The map label for this gene is metC [H]

Identifier: 22127370

GI number: 22127370

Start: 3878312

End: 3879523

Strand: Direct

Name: metC [H]

Synonym: y3496

Alternate gene names: 22127370

Gene position: 3878312-3879523 (Clockwise)

Preceding gene: 22127367

Following gene: 22127371

Centisome position: 84.3

GC content: 48.43

Gene sequence:

>1212_bases
ATGGCAGTGAATAAAGCAATCCCAGAAAAACTGGAAACAGCCTTAGTCAGCGCAGGGCGAAGTAAAAAATTTACTCAAGG
CTCAGTGAATACCGTGATCCAACGAGCATCATCTCTGGTTTTCGAATCTGTAAAAGCGAAAAAACATGCCACGATCAATC
GGGGCAATGGTGAGTTGTTCTATGGCCGCAGGGGGACATTAACCCACTTCTCTTTGCAAGAGGCAATGACGGAGCTGGAG
GGCGGCGCAGGTTGCGTGCTTTATCCTTGTGGCGCTGCCGCCATCAGTAATGCGATTTTATCGTTTGTCGCCACGGGCGA
TCATGTGCTGATGACCGGCTCAGCTTATGAGCCCGCCCAAAGTTTCTGCGATAAGATTTTATCGCGCATGAATATCACGA
CGACCTATTTTGATCCCATGATAGGTGCTGGGATTGCTTCACTGATTACCCCGAAAACCAAGGTGATATTTCTTGAGTCA
CCCGGCTCCATCACCATGGAAGTGCAGGATATTCCTGCGATGGTGGCGGCCATCCGGGCGGTGGCTCCGGATGTCGTTAT
CATGATGGACAACACCTGGGCCGCAGGTGTGTTATTTAAAGCACTGGATTTTGATATCGATATCTCTATTCAATCCGGCA
CTAAATACATTATTGGTCACTCTGATGCCATGCTGGGCATTGCGGTTGCCAATGCCCGCTGCTGGGAACAACTGCGTGAA
GACTCTTATTTGATGGGCCAGATGGTCGATGCTGATACTGCCTATCTTGCCAGCCGGGGCTTACGCACGTTAAGCGTCCG
GTTAAAACAACATGAGAAAAACAGCATTGAAATCGCTAACTGGTTGGCAGAGCGCCCGGAAGTGGCGGTGGTTTATCATC
CCGCACTGCCAGGCTGCAAGGGCCATGAATTCTACAAGCGGGATTTTAATGGCTGCAATGGTTTGTTTTCTTTCGAATTA
AAAGAAGAATTAACCCAGCAACAACTGGAGAATTACCTGGATCACTTTACCCATTTCAGCATGGCGTTTTCATGGGGTGG
TTTTGAATCGCTGATATTAGGTTATCAGCCGAAGGATATTCGTGCGATCCGCAAATATGACGCGGAAGGCATCAAAGGAA
CATTATTCCGTCTGCATATTGGCCTTGAGAATGTGCAAGATTTGCAAGACGATCTGGCCGCAGGATTTGAGCGAATTCAA
GCCGTAAAATAG

Upstream 100 bases:

>100_bases
CCCAGACAACAATCATCATGCTAACGTAGGAATACATCCCCAAAATGAATGCTGGCTGGCGATTGACTAGCTTGGCTTAT
ACGAAGGTGACAACACAATT

Downstream 100 bases:

>100_bases
AGGCCACCACTCCGTTAATGCGCTATCAATTCTTGGCGCATTAACGCTCCCTTACATAAAAGAACCAACGATAGGTTTAT
ATCGCCTGCCAAATTGAGTT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MAVNKAIPEKLETALVSAGRSKKFTQGSVNTVIQRASSLVFESVKAKKHATINRGNGELFYGRRGTLTHFSLQEAMTELE
GGAGCVLYPCGAAAISNAILSFVATGDHVLMTGSAYEPAQSFCDKILSRMNITTTYFDPMIGAGIASLITPKTKVIFLES
PGSITMEVQDIPAMVAAIRAVAPDVVIMMDNTWAAGVLFKALDFDIDISIQSGTKYIIGHSDAMLGIAVANARCWEQLRE
DSYLMGQMVDADTAYLASRGLRTLSVRLKQHEKNSIEIANWLAERPEVAVVYHPALPGCKGHEFYKRDFNGCNGLFSFEL
KEELTQQQLENYLDHFTHFSMAFSWGGFESLILGYQPKDIRAIRKYDAEGIKGTLFRLHIGLENVQDLQDDLAAGFERIQ
AVK

Sequences:

>Translated_403_residues
MAVNKAIPEKLETALVSAGRSKKFTQGSVNTVIQRASSLVFESVKAKKHATINRGNGELFYGRRGTLTHFSLQEAMTELE
GGAGCVLYPCGAAAISNAILSFVATGDHVLMTGSAYEPAQSFCDKILSRMNITTTYFDPMIGAGIASLITPKTKVIFLES
PGSITMEVQDIPAMVAAIRAVAPDVVIMMDNTWAAGVLFKALDFDIDISIQSGTKYIIGHSDAMLGIAVANARCWEQLRE
DSYLMGQMVDADTAYLASRGLRTLSVRLKQHEKNSIEIANWLAERPEVAVVYHPALPGCKGHEFYKRDFNGCNGLFSFEL
KEELTQQQLENYLDHFTHFSMAFSWGGFESLILGYQPKDIRAIRKYDAEGIKGTLFRLHIGLENVQDLQDDLAAGFERIQ
AVK
>Mature_402_residues
AVNKAIPEKLETALVSAGRSKKFTQGSVNTVIQRASSLVFESVKAKKHATINRGNGELFYGRRGTLTHFSLQEAMTELEG
GAGCVLYPCGAAAISNAILSFVATGDHVLMTGSAYEPAQSFCDKILSRMNITTTYFDPMIGAGIASLITPKTKVIFLESP
GSITMEVQDIPAMVAAIRAVAPDVVIMMDNTWAAGVLFKALDFDIDISIQSGTKYIIGHSDAMLGIAVANARCWEQLRED
SYLMGQMVDADTAYLASRGLRTLSVRLKQHEKNSIEIANWLAERPEVAVVYHPALPGCKGHEFYKRDFNGCNGLFSFELK
EELTQQQLENYLDHFTHFSMAFSWGGFESLILGYQPKDIRAIRKYDAEGIKGTLFRLHIGLENVQDLQDDLAAGFERIQA
VK

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=330, Percent_Identity=31.5151515151515, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI299473759, Length=242, Percent_Identity=35.5371900826446, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI25453487, Length=330, Percent_Identity=27.8787878787879, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1789383, Length=391, Percent_Identity=70.3324808184143, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI1790375, Length=346, Percent_Identity=32.9479768786127, Blast_Score=158, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71980708, Length=348, Percent_Identity=29.5977011494253, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17538055, Length=332, Percent_Identity=29.2168674698795, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17560056, Length=332, Percent_Identity=31.3253012048193, Blast_Score=153, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321170, Length=337, Percent_Identity=42.433234421365, Blast_Score=276, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6319307, Length=360, Percent_Identity=29.1666666666667, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321904, Length=253, Percent_Identity=30.0395256916996, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6321254, Length=269, Percent_Identity=26.3940520446097, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323333, Length=454, Percent_Identity=24.0088105726872, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI19922554, Length=343, Percent_Identity=30.9037900874636, Blast_Score=171, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44311; Mature: 44180

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVNKAIPEKLETALVSAGRSKKFTQGSVNTVIQRASSLVFESVKAKKHATINRGNGELF
CCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEE
YGRRGTLTHFSLQEAMTELEGGAGCVLYPCGAAAISNAILSFVATGDHVLMTGSAYEPAQ
ECCCCCEEHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHH
SFCDKILSRMNITTTYFDPMIGAGIASLITPKTKVIFLESPGSITMEVQDIPAMVAAIRA
HHHHHHHHHCCCCHHHHCHHHHHHHHHHCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHH
VAPDVVIMMDNTWAAGVLFKALDFDIDISIQSGTKYIIGHSDAMLGIAVANARCWEQLRE
HCCCEEEEECCCCHHHHHHHHHCCEEEEEEECCCEEEEECCCCEEEEEEHHHHHHHHHHC
DSYLMGQMVDADTAYLASRGLRTLSVRLKQHEKNSIEIANWLAERPEVAVVYHPALPGCK
CCHHHHHHCCCHHHHHHHCCCCEEHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCCCCCC
GHEFYKRDFNGCNGLFSFELKEELTQQQLENYLDHFTHFSMAFSWGGFESLILGYQPKDI
CCHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHCCCCCHHH
RAIRKYDAEGIKGTLFRLHIGLENVQDLQDDLAAGFERIQAVK
HHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVNKAIPEKLETALVSAGRSKKFTQGSVNTVIQRASSLVFESVKAKKHATINRGNGELF
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEE
YGRRGTLTHFSLQEAMTELEGGAGCVLYPCGAAAISNAILSFVATGDHVLMTGSAYEPAQ
ECCCCCEEHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCHHH
SFCDKILSRMNITTTYFDPMIGAGIASLITPKTKVIFLESPGSITMEVQDIPAMVAAIRA
HHHHHHHHHCCCCHHHHCHHHHHHHHHHCCCCEEEEEEECCCCEEEEEHHHHHHHHHHHH
VAPDVVIMMDNTWAAGVLFKALDFDIDISIQSGTKYIIGHSDAMLGIAVANARCWEQLRE
HCCCEEEEECCCCHHHHHHHHHCCEEEEEEECCCEEEEECCCCEEEEEEHHHHHHHHHHC
DSYLMGQMVDADTAYLASRGLRTLSVRLKQHEKNSIEIANWLAERPEVAVVYHPALPGCK
CCHHHHHHCCCHHHHHHHCCCCEEHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCCCCCC
GHEFYKRDFNGCNGLFSFELKEELTQQQLENYLDHFTHFSMAFSWGGFESLILGYQPKDI
CCHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHCCCCCHHH
RAIRKYDAEGIKGTLFRLHIGLENVQDLQDDLAAGFERIQAVK
HHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3513164; 9278503; 3307782; 8831789 [H]