BacMap

Definition	Yersinia pestis KIM 10 chromosome, complete genome.
Accession	NC_004088
Length	4,600,755

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The map label for this gene is angR [H]

Identifier: 22127288

GI number: 22127288

Start: 3782564

End: 3784252

Strand: Direct

Name: angR [H]

Synonym: y3412

Alternate gene names: 22127288

Gene position: 3782564-3784252 (Clockwise)

Preceding gene: 22127287

Following gene: 22127289

Centisome position: 82.22

GC content: 53.46

Gene sequence:

>1689_bases
GTGCAACGGCTTGCACAGTATTTACACGAGCAAGGGGTGAGGGAAAGTGCCCATGTCGGTGTAGCATTACCACGGGGTTG
TGATCAGATCATTGCGGTACTGGCGATTCAGTGGCTCGGTGCGGCTTATGTACCTATCAGTGTGGAATGGCCCGCGTGTC
GCCGATCACAGGTTATCACTTTGGCTGATATCCATTTCCTTATTGGTGATCGCACGCTGGGCTGGCCGGAAGAGGTCGAT
GTGCTTTCGGTGGAGAGTGAACCGGTTTCTGACGAGCGCCCCACGCCACGGGTAGTGAGTGCAGATAGCCTGGCTTATCT
TATTTTCACGTCCGGCAGTACGGGTGTCCCTAAAGGGGTGGCGGTTAGCCATGGCGCGGCGGTCAATACCATTGAGTCGG
TCAATCGTCAGCATCAAATCAACCCACAAGATACGGCCTTGGCATTATCAGCGCTGTATTTTGACCTCTCCGTTTGGGAT
GTTTTTGGTGTGTTGTCTGCCGGCGCGAGGTTAGTCCTTATTCCGCAGCAGGCACAGCGAGAGGCGGCAATATGGTTATC
ACTGGTCCAACAACATCAAGTGACGGTGTGGAACAGTGTGCCAGCGTTATTAGAGATGATGCTGTTATTTAATGAACAGA
TATTTAATGAACAGGATGAACAGCCGCCAGCGTTGCCCTCGCTGCGAGTGGTGATGCTCTCAGGGGATTGGATAGTACCG
GAGTTGCCTCAACGCCTGCGGCGGTTTGCGCCAAATGCTCACTGTGTCGCCATGGGGGGGGCCACGGAAGCGGCTATCTG
GTCCAATTATTGGATAGCAGATACAGCGCTAACCGGGTGGTGCTCGGTGCCTTACGGCGTGCCATTGCCTAATCAGCAAT
TCCGAATTGTGAATGAGCAAGAAGAGGATTGCCCTGACTGGGTGGCGGGTGAGTTGTGGATTGGAGGGCAAGGGGTTGCA
CAGGGCTATTATGGCGATAGCGCCGGCACTGAACAGCAATTTATCCTACGCGATGGGCAACGGTGGTACCGCACAGGGGA
TACTGGCCGCTATCGCCCTGACGCCATCATCGAGTTTCTGGGGCGCAAGGACCAGCAAGTTAAAATCTCGGGTTACCGCG
TAGAACTAGAAGAAATTACGTTAGCCCTAAAAAGCTATCCTTCGATCGAGGATGTGGTCGCTTTTGTTATTCAACACAAT
GACCGCTCTGTTTTAGCGGCTGTTGCTGTTACGCCAACCCCCCTGGATAGGCAGGCGGTGACCGCATTTCTTCGCGAGCG
GCTACCGGAGTATGCCATCCCCTCCCGGTTAGGGCATTGCTGCGCATGGCCACTGACGGATAACGGGAAACGTGACCAGC
ATGCCCTCCGTGCCTTCGTCACACCGTCTTTCGAACCGACCGAAACACCTCAGGTAACCCAGCCCATGACGGCTATGGAG
CAATTACTGTGCGAGCAGCTCCAGTTACTGCTGAATGTGGTGTCGATTCAATCTCATGACAACTTTTTTGCGCTTGGCGG
CGACTCCTTTATTGCCATTCGCCTGACATCCGTATTGCGCCGAAACTATGGGGTTGAACTCCCACTGTGGAAAATTTTCA
GCGTACAGACAATCGCACAAATTGCTTTAGTTATGGAGCCTGCACACCAGAGTGCAGGGCGTATTCAATTTGTGGAAGAC
TCAATTTGA

Upstream 100 bases:

>100_bases
ATGCACTGTCGGGTCGCGCACGCTATGGCGGCATACGCCCAGCAGACCGCGTTAATTTGGGGGGGGCAGCCGCCTCAGCT
ATCAACAACTTGAACACGCT

Downstream 100 bases:

>100_bases
GGAGGAATCATTATGAATATTAATCTAGATTCATCTTCAGCAACACAGGCCACCGATCTACTCGTGAACCTTGAACAACA
GGAGGTTCGTTTCTGGTTAG

Product: hypothetical protein

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MQRLAQYLHEQGVRESAHVGVALPRGCDQIIAVLAIQWLGAAYVPISVEWPACRRSQVITLADIHFLIGDRTLGWPEEVD
VLSVESEPVSDERPTPRVVSADSLAYLIFTSGSTGVPKGVAVSHGAAVNTIESVNRQHQINPQDTALALSALYFDLSVWD
VFGVLSAGARLVLIPQQAQREAAIWLSLVQQHQVTVWNSVPALLEMMLLFNEQIFNEQDEQPPALPSLRVVMLSGDWIVP
ELPQRLRRFAPNAHCVAMGGATEAAIWSNYWIADTALTGWCSVPYGVPLPNQQFRIVNEQEEDCPDWVAGELWIGGQGVA
QGYYGDSAGTEQQFILRDGQRWYRTGDTGRYRPDAIIEFLGRKDQQVKISGYRVELEEITLALKSYPSIEDVVAFVIQHN
DRSVLAAVAVTPTPLDRQAVTAFLRERLPEYAIPSRLGHCCAWPLTDNGKRDQHALRAFVTPSFEPTETPQVTQPMTAME
QLLCEQLQLLLNVVSIQSHDNFFALGGDSFIAIRLTSVLRRNYGVELPLWKIFSVQTIAQIALVMEPAHQSAGRIQFVED
SI

Sequences:

>Translated_562_residues
MQRLAQYLHEQGVRESAHVGVALPRGCDQIIAVLAIQWLGAAYVPISVEWPACRRSQVITLADIHFLIGDRTLGWPEEVD
VLSVESEPVSDERPTPRVVSADSLAYLIFTSGSTGVPKGVAVSHGAAVNTIESVNRQHQINPQDTALALSALYFDLSVWD
VFGVLSAGARLVLIPQQAQREAAIWLSLVQQHQVTVWNSVPALLEMMLLFNEQIFNEQDEQPPALPSLRVVMLSGDWIVP
ELPQRLRRFAPNAHCVAMGGATEAAIWSNYWIADTALTGWCSVPYGVPLPNQQFRIVNEQEEDCPDWVAGELWIGGQGVA
QGYYGDSAGTEQQFILRDGQRWYRTGDTGRYRPDAIIEFLGRKDQQVKISGYRVELEEITLALKSYPSIEDVVAFVIQHN
DRSVLAAVAVTPTPLDRQAVTAFLRERLPEYAIPSRLGHCCAWPLTDNGKRDQHALRAFVTPSFEPTETPQVTQPMTAME
QLLCEQLQLLLNVVSIQSHDNFFALGGDSFIAIRLTSVLRRNYGVELPLWKIFSVQTIAQIALVMEPAHQSAGRIQFVED
SI
>Mature_562_residues
MQRLAQYLHEQGVRESAHVGVALPRGCDQIIAVLAIQWLGAAYVPISVEWPACRRSQVITLADIHFLIGDRTLGWPEEVD
VLSVESEPVSDERPTPRVVSADSLAYLIFTSGSTGVPKGVAVSHGAAVNTIESVNRQHQINPQDTALALSALYFDLSVWD
VFGVLSAGARLVLIPQQAQREAAIWLSLVQQHQVTVWNSVPALLEMMLLFNEQIFNEQDEQPPALPSLRVVMLSGDWIVP
ELPQRLRRFAPNAHCVAMGGATEAAIWSNYWIADTALTGWCSVPYGVPLPNQQFRIVNEQEEDCPDWVAGELWIGGQGVA
QGYYGDSAGTEQQFILRDGQRWYRTGDTGRYRPDAIIEFLGRKDQQVKISGYRVELEEITLALKSYPSIEDVVAFVIQHN
DRSVLAAVAVTPTPLDRQAVTAFLRERLPEYAIPSRLGHCCAWPLTDNGKRDQHALRAFVTPSFEPTETPQVTQPMTAME
QLLCEQLQLLLNVVSIQSHDNFFALGGDSFIAIRLTSVLRRNYGVELPLWKIFSVQTIAQIALVMEPAHQSAGRIQFVED
SI

Specific function: According to Ref.3:an enzyme involved in the biosynthesis of anguibactin; an iron-binding siderophore [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 acyl carrier domain [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=589, Percent_Identity=24.7877758913413, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI12669909, Length=367, Percent_Identity=25.3405994550409, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI4758332, Length=367, Percent_Identity=25.3405994550409, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI42794754, Length=362, Percent_Identity=27.0718232044199, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI42794752, Length=362, Percent_Identity=27.0718232044199, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI187761345, Length=415, Percent_Identity=26.7469879518072, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI187761343, Length=415, Percent_Identity=26.7469879518072, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI156151445, Length=360, Percent_Identity=23.8888888888889, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1786801, Length=575, Percent_Identity=30.7826086956522, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1786810, Length=379, Percent_Identity=25.5936675461741, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693145, Length=489, Percent_Identity=21.6768916155419, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788107, Length=372, Percent_Identity=23.3870967741935, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1790505, Length=518, Percent_Identity=23.1660231660232, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556356, Length=531, Percent_Identity=26.3653483992467, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=550, Percent_Identity=23.4545454545455, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32564422, Length=455, Percent_Identity=22.4175824175824, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32564420, Length=455, Percent_Identity=22.4175824175824, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538037, Length=479, Percent_Identity=22.1294363256785, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=665, Percent_Identity=26.4661654135338, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6319699, Length=363, Percent_Identity=22.5895316804408, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24648676, Length=580, Percent_Identity=25.1724137931034, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI18859661, Length=350, Percent_Identity=24.2857142857143, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI62471689, Length=351, Percent_Identity=24.2165242165242, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI62471679, Length=351, Percent_Identity=24.2165242165242, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI62471683, Length=351, Percent_Identity=24.2165242165242, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI62471685, Length=351, Percent_Identity=24.2165242165242, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24586636, Length=351, Percent_Identity=24.2165242165242, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI62471681, Length=351, Percent_Identity=24.2165242165242, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI62471687, Length=351, Percent_Identity=24.2165242165242, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24586634, Length=351, Percent_Identity=24.2165242165242, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI22026970, Length=351, Percent_Identity=24.2165242165242, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648253, Length=486, Percent_Identity=21.3991769547325, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648255, Length=454, Percent_Identity=22.2466960352423, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24653035, Length=484, Percent_Identity=20.8677685950413, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356947, Length=366, Percent_Identity=23.7704918032787, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR006163 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 62464; Mature: 62464

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRLAQYLHEQGVRESAHVGVALPRGCDQIIAVLAIQWLGAAYVPISVEWPACRRSQVIT
CHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCEEE
LADIHFLIGDRTLGWPEEVDVLSVESEPVSDERPTPRVVSADSLAYLIFTSGSTGVPKGV
EEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCEEEEEEECCCCCCCCCC
AVSHGAAVNTIESVNRQHQINPQDTALALSALYFDLSVWDVFGVLSAGARLVLIPQQAQR
EECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHH
EAAIWLSLVQQHQVTVWNSVPALLEMMLLFNEQIFNEQDEQPPALPSLRVVMLSGDWIVP
HHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCH
ELPQRLRRFAPNAHCVAMGGATEAAIWSNYWIADTALTGWCSVPYGVPLPNQQFRIVNEQ
HHHHHHHHHCCCCEEEEECCCCCHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEECCC
EEDCPDWVAGELWIGGQGVAQGYYGDSAGTEQQFILRDGQRWYRTGDTGRYRPDAIIEFL
CCCCCCHHCCEEEECCCCCCCCCCCCCCCCCCHHEECCCCHHEECCCCCCCCHHHHHHHH
GRKDQQVKISGYRVELEEITLALKSYPSIEDVVAFVIQHNDRSVLAAVAVTPTPLDRQAV
CCCCCEEEEEEEEEEHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHH
TAFLRERLPEYAIPSRLGHCCAWPLTDNGKRDQHALRAFVTPSFEPTETPQVTQPMTAME
HHHHHHHCCCCCCHHHHCCEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
QLLCEQLQLLLNVVSIQSHDNFFALGGDSFIAIRLTSVLRRNYGVELPLWKIFSVQTIAQ
HHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHH
IALVMEPAHQSAGRIQFVEDSI
HHHHHCCCCCCCCCEEEECCCC
>Mature Secondary Structure
MQRLAQYLHEQGVRESAHVGVALPRGCDQIIAVLAIQWLGAAYVPISVEWPACRRSQVIT
CHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCEEE
LADIHFLIGDRTLGWPEEVDVLSVESEPVSDERPTPRVVSADSLAYLIFTSGSTGVPKGV
EEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCEEECCCEEEEEEECCCCCCCCCC
AVSHGAAVNTIESVNRQHQINPQDTALALSALYFDLSVWDVFGVLSAGARLVLIPQQAQR
EECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHH
EAAIWLSLVQQHQVTVWNSVPALLEMMLLFNEQIFNEQDEQPPALPSLRVVMLSGDWIVP
HHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCH
ELPQRLRRFAPNAHCVAMGGATEAAIWSNYWIADTALTGWCSVPYGVPLPNQQFRIVNEQ
HHHHHHHHHCCCCEEEEECCCCCHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEECCC
EEDCPDWVAGELWIGGQGVAQGYYGDSAGTEQQFILRDGQRWYRTGDTGRYRPDAIIEFL
CCCCCCHHCCEEEECCCCCCCCCCCCCCCCCCHHEECCCCHHEECCCCCCCCHHHHHHHH
GRKDQQVKISGYRVELEEITLALKSYPSIEDVVAFVIQHNDRSVLAAVAVTPTPLDRQAV
CCCCCEEEEEEEEEEHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHH
TAFLRERLPEYAIPSRLGHCCAWPLTDNGKRDQHALRAFVTPSFEPTETPQVTQPMTAME
HHHHHHHCCCCCCHHHHCCEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
QLLCEQLQLLLNVVSIQSHDNFFALGGDSFIAIRLTSVLRRNYGVELPLWKIFSVQTIAQ
HHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHH
IALVMEPAHQSAGRIQFVEDSI
HHHHHCCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2311935; 8335354 [H]