Click here to switch to the map view.

The map label for this gene is pgsA [H]

Identifier: 221232920

GI number: 221232920

Start: 2200806

End: 2201351

Strand: Reverse

Name: pgsA [H]

Synonym: SPN23F_22550

Alternate gene names: 221232920

Gene position: 2201351-2200806 (Counterclockwise)

Preceding gene: 221232921

Following gene: 221232919

Centisome position: 99.1

GC content: 34.98

Gene sequence:

>546_bases
ATGAAAAAAGAACAAATTCCCAATCTCTTAACAATAGGTCGAATTCTCTTTATACCTATTTTTATCTTTATTTTAACGAT
AGGAAATTCGATAGAGAGTCATATAGTTGCAGCTATTATCTTTGCTGTTGCCAGTATTACCGACTATTTAGATGGATATT
TAGCTCGTAAATGGAATGTGGTCAGTAATTTTGGTAAATTTGCAGATCCTATGGCGGATAAGTTACTAGTTATGTCGGCT
TTTATTATGTTGATTGAGTTAGGTATGGCTCCGGCTTGGATTGTTGCAGTGATTATCTGTCGTGAGTTAGCTGTGACAGG
TTTAAGGCTTTTATTGGTTGAAACTGGTGGAACAATTTTAGCAGCAGCAATGCCTGGAAAAATTAAAACTTTTAGTCAGA
TGTTTGCCATTATTTTCTTGCTATTACATTGGACTTTGCTTGGTCAAGTTCTACTTTATGTAGCCTTATTTTTCACTATC
TACTCTGGCTATGACTATTTCAAGGGTAGTGCCTATGTATTTAAAGGGACATTTGGTTCGAAATGA

Upstream 100 bases:

>100_bases
GTTGATTTGACAGTAGATAATCAGACTGTTGATTTATCGAAATTAACAGCTCAGACTGGACAAATCACTGTAACCTTTAC
TAAAAATTAAGGAAAAACGA

Downstream 100 bases:

>100_bases
AATCAATAATTGATGTAAAAAATCTTTCTTTTCGCTATAAAGAAAATCAGAACTACTACGATGTGAAGGATATTACGTTT
CACGTGAAACGTGGAGAATG

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MKKEQIPNLLTIGRILFIPIFIFILTIGNSIESHIVAAIIFAVASITDYLDGYLARKWNVVSNFGKFADPMADKLLVMSA
FIMLIELGMAPAWIVAVIICRELAVTGLRLLLVETGGTILAAAMPGKIKTFSQMFAIIFLLLHWTLLGQVLLYVALFFTI
YSGYDYFKGSAYVFKGTFGSK

Sequences:

>Translated_181_residues
MKKEQIPNLLTIGRILFIPIFIFILTIGNSIESHIVAAIIFAVASITDYLDGYLARKWNVVSNFGKFADPMADKLLVMSA
FIMLIELGMAPAWIVAVIICRELAVTGLRLLLVETGGTILAAAMPGKIKTFSQMFAIIFLLLHWTLLGQVLLYVALFFTI
YSGYDYFKGSAYVFKGTFGSK
>Mature_181_residues
MKKEQIPNLLTIGRILFIPIFIFILTIGNSIESHIVAAIIFAVASITDYLDGYLARKWNVVSNFGKFADPMADKLLVMSA
FIMLIELGMAPAWIVAVIICRELAVTGLRLLLVETGGTILAAAMPGKIKTFSQMFAIIFLLLHWTLLGQVLLYVALFFTI
YSGYDYFKGSAYVFKGTFGSK

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1788220, Length=174, Percent_Identity=36.7816091954023, Blast_Score=103, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6320059, Length=109, Percent_Identity=39.4495412844037, Blast_Score=62, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24650130, Length=131, Percent_Identity=35.8778625954198, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24650126, Length=131, Percent_Identity=35.8778625954198, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24650128, Length=131, Percent_Identity=35.8778625954198, Blast_Score=73, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 20057; Mature: 20057

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKEQIPNLLTIGRILFIPIFIFILTIGNSIESHIVAAIIFAVASITDYLDGYLARKWNV
CCCHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSNFGKFADPMADKLLVMSAFIMLIELGMAPAWIVAVIICRELAVTGLRLLLVETGGTIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEE
AAAMPGKIKTFSQMFAIIFLLLHWTLLGQVLLYVALFFTIYSGYDYFKGSAYVFKGTFGS
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEECCCCC
K
C
>Mature Secondary Structure
MKKEQIPNLLTIGRILFIPIFIFILTIGNSIESHIVAAIIFAVASITDYLDGYLARKWNV
CCCHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSNFGKFADPMADKLLVMSAFIMLIELGMAPAWIVAVIICRELAVTGLRLLLVETGGTIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEE
AAAMPGKIKTFSQMFAIIFLLLHWTLLGQVLLYVALFFTIYSGYDYFKGSAYVFKGTFGS
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEECCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7750561; 9384377 [H]