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The map label for this gene is ilvD [H]

Identifier: 221232838

GI number: 221232838

Start: 2097248

End: 2098951

Strand: Reverse

Name: ilvD [H]

Synonym: SPN23F_21580

Alternate gene names: 221232838

Gene position: 2098951-2097248 (Counterclockwise)

Preceding gene: 221232839

Following gene: 221232836

Centisome position: 94.49

GC content: 47.48

Gene sequence:

>1704_bases
ATGACTGAATTAGATAAACGTCACCGCAGTAGCATCTATGACAGCATGGTTAAATCACCTAACCGTGCTATGCTTCGTGC
GACTGGTATGACAGATAAGGACTTTGAAACATCGATTGTGGGAGTGATTTCGACTTGGGCGGAAAATACACCATGTAACA
TTCACTTGCATGATTTCGGGAAACTGGCTAAAGAAGGTGTCAAATCTGCAGGCGCTTGGCCTGTACAGTTTGGAACCATT
ACCGTAGCGGACGGGATCGCTATGGGAACGCCTGGTATGCGTTTCTCTCTAACATCTCGTGACATCATCGCGGACTCCAT
CGAGGCGGCTATGAGTGGTCACAACGTGGATGCCTTCGTCGCTATCGGTGGCTGTGACAAGAACATGCCTGGATCTATGA
TTGCTATTGCTAATATGGATATCCCAGCTATTTTCGCCTATGGTGGAACTATTGCACCGGGAAATCTTGATGGTAAAGAT
ATCGACTTGGTTTCTGTCTTTGAAGGTATCGGAAAATGGAACCACGGTGACATGACAGCTGAGGACGTGAAACGTCTTGA
ATGTAATGCCTGCCCTGGCCCTGGTGGTTGTGGTGGTATGTATACTGCTAATACCATGGCAACTGCTATCGAAGTTCTAG
GGATGAGTTTGCCAGGGTCATCCTCTCACCCAGCTGAATCAGCTGATAAGAAAGAAGATATCGAAGCAGCAGGACGTGCT
GTTGTTAAGATGTTGGAACTTGGTCTCAAACCATCAGATATCTTGACTCGTGAAGCCTTTGAAGATGCTATTACTGTAAC
GATGGCTCTCGGTGGTTCTACAAACGCCACTCTTCACTTGCTCGCCATTGCCCATGCCGCAAATGTTGACTTGTCACTTG
AGGACTTCAATACGATTCAAGAACGTGTGCCTCACTTGGCCGACTTGAAACCATCTGGTCAGTATGTCTTCCAAGACCTC
TACGAAGTCGGTGGTGTCCCTGCGGTTATGAAGTACTTGTTGGCAAATGGTTTCCTTCACGGAGATCGCATCACATGTAC
TGGTAAGACTGTAGCTGAAAACTTGGCTGACTTTGCAGACTTGACTCCAGGCCAAAAAGTTATCATGCCACTTGAAAATC
CAAAACGTGCGGATGGTCCGCTTATCATCTTGAACGGGAACCTTGCTCCTGACGGTGCAGTTGCCAAGGTATCAGGTGTT
AAAGTGCGTCGTCACGTTGGGCCAGCTAAGGTCTTTGACTCAGAAGAAGATGCGATTCAGGCCGTTCTGACAGATGAAAT
CGTTGATGGCGATGTAGTCGTTGTTCGTTTTGTTGGACCTAAAGGTGGTCCTGGTATGCCTGAGATGCTGTCACTTTCTT
CAATGATTGTTGGTAAAGGTCAGGGAGATAAGGTGGCCCTCTTGACGGACGGACGTTTCTCTGGTGGTACTTATGGTCTG
GTTGTTGGACATATCGCTCCTGAAGCTCAGGATGGTGGACCAATTGCCTATCTCCGTACCGGCGATATCGTTACGGTTGA
CCAAGATACCAAAGAAATTTCCATGGCCGTATCCGAAGAAGAACTTGAAAAACGCAAGGCAGAAACAACCTTGCCACCAC
TTTACAGCCGTGGTGTCCTCGGTAAATATGCCCATATCGTATCATCTGCTTCACGCGGAGCCGTGACAGACTTCTGGAAT
ATGGACAAGTCAGGTAAAAAATAA

Upstream 100 bases:

>100_bases
TTCACATGCGTATAGAATTTTCTGAAAATTCAAGAATTTTATTCTGTTCATTGCCTTTAAATTGTGCTATAATAGTAAAA
ACTGAAATGGGAGGGATAAG

Downstream 100 bases:

>100_bases
ACTCATACTTGAAAATCTCTTCAAATCACGTCAACGTCGCCTTGCCGTAGGTATGGTTACTGACTTCGTCAGTTCTATCC
ACAACCTCAAAACAGTGTTT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 567; Mature: 566

Protein sequence:

>567_residues
MTELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETSIVGVISTWAENTPCNIHLHDFGKLAKEGVKSAGAWPVQFGTI
TVADGIAMGTPGMRFSLTSRDIIADSIEAAMSGHNVDAFVAIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKD
IDLVSVFEGIGKWNHGDMTAEDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLPGSSSHPAESADKKEDIEAAGRA
VVKMLELGLKPSDILTREAFEDAITVTMALGGSTNATLHLLAIAHAANVDLSLEDFNTIQERVPHLADLKPSGQYVFQDL
YEVGGVPAVMKYLLANGFLHGDRITCTGKTVAENLADFADLTPGQKVIMPLENPKRADGPLIILNGNLAPDGAVAKVSGV
KVRRHVGPAKVFDSEEDAIQAVLTDEIVDGDVVVVRFVGPKGGPGMPEMLSLSSMIVGKGQGDKVALLTDGRFSGGTYGL
VVGHIAPEAQDGGPIAYLRTGDIVTVDQDTKEISMAVSEEELEKRKAETTLPPLYSRGVLGKYAHIVSSASRGAVTDFWN
MDKSGKK

Sequences:

>Translated_567_residues
MTELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETSIVGVISTWAENTPCNIHLHDFGKLAKEGVKSAGAWPVQFGTI
TVADGIAMGTPGMRFSLTSRDIIADSIEAAMSGHNVDAFVAIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKD
IDLVSVFEGIGKWNHGDMTAEDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLPGSSSHPAESADKKEDIEAAGRA
VVKMLELGLKPSDILTREAFEDAITVTMALGGSTNATLHLLAIAHAANVDLSLEDFNTIQERVPHLADLKPSGQYVFQDL
YEVGGVPAVMKYLLANGFLHGDRITCTGKTVAENLADFADLTPGQKVIMPLENPKRADGPLIILNGNLAPDGAVAKVSGV
KVRRHVGPAKVFDSEEDAIQAVLTDEIVDGDVVVVRFVGPKGGPGMPEMLSLSSMIVGKGQGDKVALLTDGRFSGGTYGL
VVGHIAPEAQDGGPIAYLRTGDIVTVDQDTKEISMAVSEEELEKRKAETTLPPLYSRGVLGKYAHIVSSASRGAVTDFWN
MDKSGKK
>Mature_566_residues
TELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETSIVGVISTWAENTPCNIHLHDFGKLAKEGVKSAGAWPVQFGTIT
VADGIAMGTPGMRFSLTSRDIIADSIEAAMSGHNVDAFVAIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKDI
DLVSVFEGIGKWNHGDMTAEDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLPGSSSHPAESADKKEDIEAAGRAV
VKMLELGLKPSDILTREAFEDAITVTMALGGSTNATLHLLAIAHAANVDLSLEDFNTIQERVPHLADLKPSGQYVFQDLY
EVGGVPAVMKYLLANGFLHGDRITCTGKTVAENLADFADLTPGQKVIMPLENPKRADGPLIILNGNLAPDGAVAKVSGVK
VRRHVGPAKVFDSEEDAIQAVLTDEIVDGDVVVVRFVGPKGGPGMPEMLSLSSMIVGKGQGDKVALLTDGRFSGGTYGLV
VGHIAPEAQDGGPIAYLRTGDIVTVDQDTKEISMAVSEEELEKRKAETTLPPLYSRGVLGKYAHIVSSASRGAVTDFWNM
DKSGKK

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=595, Percent_Identity=37.3109243697479, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI2367371, Length=508, Percent_Identity=32.4803149606299, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1786464, Length=467, Percent_Identity=35.9743040685225, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1788157, Length=509, Percent_Identity=31.434184675835, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6322476, Length=559, Percent_Identity=48.8372093023256, Blast_Score=525, Evalue=1e-150,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59860; Mature: 59729

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETSIVGVISTWAENTPCNIHLHDFG
CCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHH
KLAKEGVKSAGAWPVQFGTITVADGIAMGTPGMRFSLTSRDIIADSIEAAMSGHNVDAFV
HHHHHHHHCCCCCEEEECEEEEECCEEECCCCCEEEECCCHHHHHHHHHHHCCCCCEEEE
AIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKDIDLVSVFEGIGKWNHGDMTA
EEECCCCCCCCCEEEEECCCCCEEEECCCEECCCCCCCCCCHHHHHHHHHCCCCCCCCCH
EDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLPGSSSHPAESADKKEDIEAAGRA
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
VVKMLELGLKPSDILTREAFEDAITVTMALGGSTNATLHLLAIAHAANVDLSLEDFNTIQ
HHHHHHHCCCCHHHHHHHHHHCEEEEEEEECCCCCCEEEEEEEEHHCCCCEEHHHHHHHH
ERVPHLADLKPSGQYVFQDLYEVGGVPAVMKYLLANGFLHGDRITCTGKTVAENLADFAD
HHCCHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHH
LTPGQKVIMPLENPKRADGPLIILNGNLAPDGAVAKVSGVKVRRHVGPAKVFDSEEDAIQ
CCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEEEECCEEEECCCCCHHHCCCHHHHHH
AVLTDEIVDGDVVVVRFVGPKGGPGMPEMLSLSSMIVGKGQGDKVALLTDGRFSGGTYGL
HHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHEECCCCCEEEEEECCCCCCCEEEE
VVGHIAPEAQDGGPIAYLRTGDIVTVDQDTKEISMAVSEEELEKRKAETTLPPLYSRGVL
EEEEECCCCCCCCCEEEEECCCEEEECCCCHHHHHHHCHHHHHHHHHHCCCCCHHHCCCH
GKYAHIVSSASRGAVTDFWNMDKSGKK
HHHHHHHHCCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure 
TELDKRHRSSIYDSMVKSPNRAMLRATGMTDKDFETSIVGVISTWAENTPCNIHLHDFG
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHH
KLAKEGVKSAGAWPVQFGTITVADGIAMGTPGMRFSLTSRDIIADSIEAAMSGHNVDAFV
HHHHHHHHCCCCCEEEECEEEEECCEEECCCCCEEEECCCHHHHHHHHHHHCCCCCEEEE
AIGGCDKNMPGSMIAIANMDIPAIFAYGGTIAPGNLDGKDIDLVSVFEGIGKWNHGDMTA
EEECCCCCCCCCEEEEECCCCCEEEECCCEECCCCCCCCCCHHHHHHHHHCCCCCCCCCH
EDVKRLECNACPGPGGCGGMYTANTMATAIEVLGMSLPGSSSHPAESADKKEDIEAAGRA
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
VVKMLELGLKPSDILTREAFEDAITVTMALGGSTNATLHLLAIAHAANVDLSLEDFNTIQ
HHHHHHHCCCCHHHHHHHHHHCEEEEEEEECCCCCCEEEEEEEEHHCCCCEEHHHHHHHH
ERVPHLADLKPSGQYVFQDLYEVGGVPAVMKYLLANGFLHGDRITCTGKTVAENLADFAD
HHCCHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHH
LTPGQKVIMPLENPKRADGPLIILNGNLAPDGAVAKVSGVKVRRHVGPAKVFDSEEDAIQ
CCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEEEECCEEEECCCCCHHHCCCHHHHHH
AVLTDEIVDGDVVVVRFVGPKGGPGMPEMLSLSSMIVGKGQGDKVALLTDGRFSGGTYGL
HHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHEECCCCCEEEEEECCCCCCCEEEE
VVGHIAPEAQDGGPIAYLRTGDIVTVDQDTKEISMAVSEEELEKRKAETTLPPLYSRGVL
EEEEECCCCCCCCCEEEEECCCEEEECCCCHHHHHHHCHHHHHHHHHHCCCCCHHHCCCH
GKYAHIVSSASRGAVTDFWNMDKSGKK
HHHHHHHHCCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA