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The map label for this gene is ilvD

Identifier: 221230884

GI number: 221230884

Start: 3112893

End: 3114587

Strand: Reverse

Name: ilvD

Synonym: MLBr_02608

Alternate gene names: 221230884

Gene position: 3114587-3112893 (Counterclockwise)

Preceding gene: 221230886

Following gene: 221230880

Centisome position: 95.3

GC content: 61.12

Gene sequence:

>1695_bases
ATGATGCCCCCTGACATCAAACCCCGCAGCCGCGACGTTACCGATGGCCTGGAGAAGGCCGCTGCTCGTGGCATGTTGCG
CGCAGTCGGCATGAACGATGACGACTTCGCCAAGGCGCAGATCGGAGTTGCGTCATCATGGAACGAGATCACACCTTGCA
ATCTCTCGCTGGACCGCCTGGCCAAGGCGGTCAAGGAGGGGGTATTCTCGGCCGGCGGTTATCCGCTTGAGTTCGGAACA
ATTTCGGTTTCCGACGGCATCTCGATGGGGCACCAGGGGATGCACTTCTCGCTGGTGTCGCGCGAGGTTATAGCGGACAG
CGTCGAAACCGTAATGCAGGCCGAGCGCCTCGACGGCTCAGTGCTTTTGGCTGGCTGCGATAAATCACTACCCGGAATGC
TGATGGCCGCCGCACGTCTCGACCTCGCGTCGGTATTTCTCTACGCCGGCTCGATCTTGCCCGGACGAACCAAGCTCTCC
GACGGCACCGAACACGAAGTCACGCTCATCGACGCATTCGAAGCGGTCGGCGCGTGTTCTCGCGGATTAATGCCCCGCGC
TGATGTCGACGCCATCGAGCGGGCGATCTGCCCCGGCGAGGGGGCATGCGGTGGCATGTACACTGCCAACACTATGGCCA
GCGCAGCAGAGGCGCTGGGTATGTCCTTGCCGGGCAGCGCTGCGCCGCCGGCAACAGACCGTCGCCGTGATGGCTTCGCG
CGGCGTAGCGGGCAGGCCGTCATCGAACTGCTGCGTCGCGGTATAACCGCTCGCGACATCCTTACCAAGGAAGCGTTTGA
GAACGCGATCGCGGTGGTGATGGCGTTCGGTGGCTCGACCAACGCGATCCTGCATCTACTGGCCATTGCCCATGAGGCCG
ACGTCACCTTGTCGCTCGAGGACTTCAGTCGGATCGGATTTAAGGTGCCGCATATAGCCGACGTTAAGCCGTTCGGCCGG
CACGTGATGTTCGACGTCGACCACATCGGTGGTGTGCCGGTGGTAATGAAAGCACTTCTGGACGCAGGTCTACTGCACGG
TGATTGCCTGACGGTGACCGGTCAGACGATGGCCGAGAACCTAGCCTCCATTGCCCCGCCAGACCCGGATGGCCAGGTGA
TCCGCACGTTGCATAATCCAATTCATCCGACGGGAGGCATTACGATCCTGCGTGGATCGTTGGCACCTGATGGCGCGGTG
GTTAAGACGGCTGGACTCGACTCCGATGTGTTCGAAGGAACTGCAAGGGTTTTCGACGGAGAACGGGCCGCGTTGGACGC
ACTCAAGGACGGCACCATCGCCAAAGGCGATGTTGTGGTTATCCGCTATGAAGGCCCGAAAGGCGGCCCGGGGATGCGCG
AAATGCTAGCCATCACCGGTGCCATCAAAGGTGCCGGGCTAGGCAAAGATGTTCTGCTACTTACTGACGGCAGGTTCTCT
GGCGGAACGACCGGCTTTTGCGTAGGACACATCGCGCCGGAAGCTGTCGAAGCGGGACCAATCGCATTCCTGCGTGACGG
CGACCGGGTCCTGCTAGACGTTGTCGGCTGCTCCCTCGATGTGCTGGTCGATCCAGTCGAATTTTCCTCTCGGAAAAAGG
ATTTCATTCCTCCTGCGCCACGCTACACCACCGGTGTGCTTGCCAAGTACGTCAAGCTCGTCAGTTCGGCGACGGTCGGC
GCGGTCTGCGGTTAG

Upstream 100 bases:

>100_bases
GTTGCCAACTTCGGCGCGATCGCCGATGATCTAGCATACCTCATACCCCAACTGGGTATTACCCGCCGATTTTGGGCACA
CTTACGCCGCGCATACTTAG

Downstream 100 bases:

>100_bases
CCTTCGCCAATACTGACCGCATCCGGCGCCAGCCTTTCACGCCAGGCGAATTGCTACCTGGTTGGACGAACGTCCGACTA
CCCGAGTAGATCGAGGGGTC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MMPPDIKPRSRDVTDGLEKAAARGMLRAVGMNDDDFAKAQIGVASSWNEITPCNLSLDRLAKAVKEGVFSAGGYPLEFGT
ISVSDGISMGHQGMHFSLVSREVIADSVETVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLASVFLYAGSILPGRTKLS
DGTEHEVTLIDAFEAVGACSRGLMPRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAPPATDRRRDGFA
RRSGQAVIELLRRGITARDILTKEAFENAIAVVMAFGGSTNAILHLLAIAHEADVTLSLEDFSRIGFKVPHIADVKPFGR
HVMFDVDHIGGVPVVMKALLDAGLLHGDCLTVTGQTMAENLASIAPPDPDGQVIRTLHNPIHPTGGITILRGSLAPDGAV
VKTAGLDSDVFEGTARVFDGERAALDALKDGTIAKGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFS
GGTTGFCVGHIAPEAVEAGPIAFLRDGDRVLLDVVGCSLDVLVDPVEFSSRKKDFIPPAPRYTTGVLAKYVKLVSSATVG
AVCG

Sequences:

>Translated_564_residues
MMPPDIKPRSRDVTDGLEKAAARGMLRAVGMNDDDFAKAQIGVASSWNEITPCNLSLDRLAKAVKEGVFSAGGYPLEFGT
ISVSDGISMGHQGMHFSLVSREVIADSVETVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLASVFLYAGSILPGRTKLS
DGTEHEVTLIDAFEAVGACSRGLMPRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAPPATDRRRDGFA
RRSGQAVIELLRRGITARDILTKEAFENAIAVVMAFGGSTNAILHLLAIAHEADVTLSLEDFSRIGFKVPHIADVKPFGR
HVMFDVDHIGGVPVVMKALLDAGLLHGDCLTVTGQTMAENLASIAPPDPDGQVIRTLHNPIHPTGGITILRGSLAPDGAV
VKTAGLDSDVFEGTARVFDGERAALDALKDGTIAKGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFS
GGTTGFCVGHIAPEAVEAGPIAFLRDGDRVLLDVVGCSLDVLVDPVEFSSRKKDFIPPAPRYTTGVLAKYVKLVSSATVG
AVCG
>Mature_564_residues
MMPPDIKPRSRDVTDGLEKAAARGMLRAVGMNDDDFAKAQIGVASSWNEITPCNLSLDRLAKAVKEGVFSAGGYPLEFGT
ISVSDGISMGHQGMHFSLVSREVIADSVETVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLASVFLYAGSILPGRTKLS
DGTEHEVTLIDAFEAVGACSRGLMPRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAPPATDRRRDGFA
RRSGQAVIELLRRGITARDILTKEAFENAIAVVMAFGGSTNAILHLLAIAHEADVTLSLEDFSRIGFKVPHIADVKPFGR
HVMFDVDHIGGVPVVMKALLDAGLLHGDCLTVTGQTMAENLASIAPPDPDGQVIRTLHNPIHPTGGITILRGSLAPDGAV
VKTAGLDSDVFEGTARVFDGERAALDALKDGTIAKGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFS
GGTTGFCVGHIAPEAVEAGPIAFLRDGDRVLLDVVGCSLDVLVDPVEFSSRKKDFIPPAPRYTTGVLAKYVKLVSSATVG
AVCG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=38.3606557377049, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1786464, Length=496, Percent_Identity=36.2903225806452, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI2367371, Length=527, Percent_Identity=34.1555977229602, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1788157, Length=578, Percent_Identity=29.4117647058824, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6322476, Length=555, Percent_Identity=48.4684684684685, Blast_Score=516, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_MYCLE (O06069)

Other databases:

- EMBL:   Z95398
- EMBL:   AL583926
- PIR:   F87235
- RefSeq:   NP_302670.1
- ProteinModelPortal:   O06069
- SMR:   O06069
- EnsemblBacteria:   EBMYCT00000028792
- GeneID:   910866
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2608
- NMPDR:   fig|272631.1.peg.1542
- Leproma:   ML2608
- GeneTree:   EBGT00050000016366
- HOGENOM:   HBG671001
- OMA:   NMPGAMI
- ProtClustDB:   PRK00911
- BioCyc:   MLEP272631:ML2608-MONOMER
- BRENDA:   4.2.1.9
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 58783; Mature: 58783

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPPDIKPRSRDVTDGLEKAAARGMLRAVGMNDDDFAKAQIGVASSWNEITPCNLSLDRL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCCCCCCCCCHHHH
AKAVKEGVFSAGGYPLEFGTISVSDGISMGHQGMHFSLVSREVIADSVETVMQAERLDGS
HHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
VLLAGCDKSLPGMLMAAARLDLASVFLYAGSILPGRTKLSDGTEHEVTLIDAFEAVGACS
EEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHH
RGLMPRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAPPATDRRRDGFA
CCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCHH
RRSGQAVIELLRRGITARDILTKEAFENAIAVVMAFGGSTNAILHLLAIAHEADVTLSLE
HHCCHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHCCCEEEEHH
DFSRIGFKVPHIADVKPFGRHVMFDVDHIGGVPVVMKALLDAGLLHGDCLTVTGQTMAEN
HHHHCCCCCCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHH
LASIAPPDPDGQVIRTLHNPIHPTGGITILRGSLAPDGAVVKTAGLDSDVFEGTARVFDG
HHHCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHHHHHHCCC
ERAALDALKDGTIAKGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFS
CHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCC
GGTTGFCVGHIAPEAVEAGPIAFLRDGDRVLLDVVGCSLDVLVDPVEFSSRKKDFIPPAP
CCCCCEEEECCCCHHHCCCCEEEEECCCEEEEEECCCCEEEEECCHHHCCCCCCCCCCCC
RYTTGVLAKYVKLVSSATVGAVCG
CHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MMPPDIKPRSRDVTDGLEKAAARGMLRAVGMNDDDFAKAQIGVASSWNEITPCNLSLDRL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCCCCCCCCCHHHH
AKAVKEGVFSAGGYPLEFGTISVSDGISMGHQGMHFSLVSREVIADSVETVMQAERLDGS
HHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
VLLAGCDKSLPGMLMAAARLDLASVFLYAGSILPGRTKLSDGTEHEVTLIDAFEAVGACS
EEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHH
RGLMPRADVDAIERAICPGEGACGGMYTANTMASAAEALGMSLPGSAAPPATDRRRDGFA
CCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCHH
RRSGQAVIELLRRGITARDILTKEAFENAIAVVMAFGGSTNAILHLLAIAHEADVTLSLE
HHCCHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHHCCCEEEEHH
DFSRIGFKVPHIADVKPFGRHVMFDVDHIGGVPVVMKALLDAGLLHGDCLTVTGQTMAEN
HHHHCCCCCCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHCCCCCCCEEEECCHHHHHH
LASIAPPDPDGQVIRTLHNPIHPTGGITILRGSLAPDGAVVKTAGLDSDVFEGTARVFDG
HHHCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHHHHHHCCC
ERAALDALKDGTIAKGDVVVIRYEGPKGGPGMREMLAITGAIKGAGLGKDVLLLTDGRFS
CHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCC
GGTTGFCVGHIAPEAVEAGPIAFLRDGDRVLLDVVGCSLDVLVDPVEFSSRKKDFIPPAP
CCCCCEEEECCCCHHHCCCCEEEEECCCEEEEEECCCCEEEEECCHHHCCCCCCCCCCCC
RYTTGVLAKYVKLVSSATVGAVCG
CHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002