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The map label for this gene is tesA

Identifier: 221230752

GI number: 221230752

Start: 2824001

End: 2824786

Strand: Reverse

Name: tesA

Synonym: MLBr_02359

Alternate gene names: 221230752

Gene position: 2824786-2824001 (Counterclockwise)

Preceding gene: 221230753

Following gene: 221230751

Centisome position: 86.44

GC content: 51.65

Gene sequence:

>786_bases
ATGCTGCACGTTCTTAGACCAGGGTATGCTGGCGCGGTGAACGGGCACTCGAACAACGGCAACGATGATGAAACATCTAC
CACCCCTACGCTATATATTTTCCCGCATGCAGGTGGAGATGCGACATACTATGTCCCATTTTCCCGGGAGTTTTCAGCGG
ACATAAAGCGGATCGCTGTTCACTACCCAGGGCAGCGCGATGGGTATGGCTTGCCGGCGCTTACTAGTATTCCCGCTCTC
GCTGACGAAATCTTTGCGATCATGAAGCCGTCGGCGCCGCCGGAGGGGGCAGTCGCTTTTTTTGGTCACAGCATGGGCGG
CATGCTGGCTTTCGAAGTTGCGTTGAGATTCCAATCGGCGGGGTATCGTCTTATCGCCCTTTTCGTCTCGGCCTGCTCGG
CTCCGGGGTATATTAGGTACAAGCAGATCAAAGATTTTTCCGATAACGATATGCTGGACTTAGTCGTCCGCATGACCGGC
ATGAATCCGGATTTTTTTGAGGACGAAGAATTCCGTGTTGGAGTGCTTCCTACATTGCGTGCGGCCCGCATCATTGCAGG
TTATAATTGTCCGCCAGAGACGACGGTTTCATGCCCAATTTATACTTACATTGGCGATAAGGATTGGATTGCTACCCAAG
AAGACATGAAGCCATGGCGTGAGCGAACTACGGGAGCGTTCGCGATTCGCGTGTTTCCTGGGGACCATTTCTACCTTAAC
GGAAATTTGTCAGAGCTAGTATGCGATATAGAAGATAAAACCCTCGAATGGTGTGATCGAGCTTAG

Upstream 100 bases:

>100_bases
GTGCCGTGCTGATGTCGCCCAAATCGGTTGCTGTCGAAGGCAAAGTATTCAGTAACGCCGTCAGATAAGACTTCGTCGTC
TCTGTTTGATGCTCGAAGTG

Downstream 100 bases:

>100_bases
CTGGGTCTATCGGTCGCGGATCGGTCGGCGTTCGACGCTAACTGTTGTCCACCCTGTCACGCACCATGACCCATGACCGG
TGCAGTTGGAGTTAGGTGTG

Product: thioesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MLHVLRPGYAGAVNGHSNNGNDDETSTTPTLYIFPHAGGDATYYVPFSREFSADIKRIAVHYPGQRDGYGLPALTSIPAL
ADEIFAIMKPSAPPEGAVAFFGHSMGGMLAFEVALRFQSAGYRLIALFVSACSAPGYIRYKQIKDFSDNDMLDLVVRMTG
MNPDFFEDEEFRVGVLPTLRAARIIAGYNCPPETTVSCPIYTYIGDKDWIATQEDMKPWRERTTGAFAIRVFPGDHFYLN
GNLSELVCDIEDKTLEWCDRA

Sequences:

>Translated_261_residues
MLHVLRPGYAGAVNGHSNNGNDDETSTTPTLYIFPHAGGDATYYVPFSREFSADIKRIAVHYPGQRDGYGLPALTSIPAL
ADEIFAIMKPSAPPEGAVAFFGHSMGGMLAFEVALRFQSAGYRLIALFVSACSAPGYIRYKQIKDFSDNDMLDLVVRMTG
MNPDFFEDEEFRVGVLPTLRAARIIAGYNCPPETTVSCPIYTYIGDKDWIATQEDMKPWRERTTGAFAIRVFPGDHFYLN
GNLSELVCDIEDKTLEWCDRA
>Mature_261_residues
MLHVLRPGYAGAVNGHSNNGNDDETSTTPTLYIFPHAGGDATYYVPFSREFSADIKRIAVHYPGQRDGYGLPALTSIPAL
ADEIFAIMKPSAPPEGAVAFFGHSMGGMLAFEVALRFQSAGYRLIALFVSACSAPGYIRYKQIKDFSDNDMLDLVVRMTG
MNPDFFEDEEFRVGVLPTLRAARIIAGYNCPPETTVSCPIYTYIGDKDWIATQEDMKPWRERTTGAFAIRVFPGDHFYLN
GNLSELVCDIEDKTLEWCDRA

Specific function: Unknown

COG id: COG3208

COG function: function code Q; Predicted thioesterase involved in non-ribosomal peptide biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioesterase family

Homologues:

Organism=Homo sapiens, GI89257335, Length=219, Percent_Identity=26.9406392694064, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI8922871, Length=188, Percent_Identity=27.6595744680851, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TESA_MYCLE (Q9Z5K4)

Other databases:

- EMBL:   AL035480
- EMBL:   AL583925
- PIR:   C87204
- RefSeq:   NP_302538.1
- ProteinModelPortal:   Q9Z5K4
- EnsemblBacteria:   EBMYCT00000028613
- GeneID:   908644
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML2359
- NMPDR:   fig|272631.1.peg.1410
- Leproma:   ML2359
- GeneTree:   EBGT00050000015282
- HOGENOM:   HBG756950
- OMA:   GDDDEIA
- ProtClustDB:   CLSK792167
- BioCyc:   MLEP272631:ML2359-MONOMER
- InterPro:   IPR012223
- InterPro:   IPR001031
- PANTHER:   PTHR11487

Pfam domain/function: PF00975 Thioesterase

EC number: NA

Molecular weight: Translated: 28950; Mature: 28950

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: ACT_SITE 104-104

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHVLRPGYAGAVNGHSNNGNDDETSTTPTLYIFPHAGGDATYYVPFSREFSADIKRIAV
CCEEECCCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCHHCCEEEEEE
HYPGQRDGYGLPALTSIPALADEIFAIMKPSAPPEGAVAFFGHSMGGMLAFEVALRFQSA
ECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHEEHHHHHHHCC
GYRLIALFVSACSAPGYIRYKQIKDFSDNDMLDLVVRMTGMNPDFFEDEEFRVGVLPTLR
CHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEHCCCCCCCCCCCCEEEECCCHHH
AARIIAGYNCPPETTVSCPIYTYIGDKDWIATQEDMKPWRERTTGAFAIRVFPGDHFYLN
HHHEEECCCCCCCCEECCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEEEEC
GNLSELVCDIEDKTLEWCDRA
CCHHHEEECCCHHHHHHHCCC
>Mature Secondary Structure
MLHVLRPGYAGAVNGHSNNGNDDETSTTPTLYIFPHAGGDATYYVPFSREFSADIKRIAV
CCEEECCCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCHHCCEEEEEE
HYPGQRDGYGLPALTSIPALADEIFAIMKPSAPPEGAVAFFGHSMGGMLAFEVALRFQSA
ECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHEEHHHHHHHCC
GYRLIALFVSACSAPGYIRYKQIKDFSDNDMLDLVVRMTGMNPDFFEDEEFRVGVLPTLR
CHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEHCCCCCCCCCCCCEEEECCCHHH
AARIIAGYNCPPETTVSCPIYTYIGDKDWIATQEDMKPWRERTTGAFAIRVFPGDHFYLN
HHHEEECCCCCCCCEECCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEEEEC
GNLSELVCDIEDKTLEWCDRA
CCHHHEEECCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002