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The map label for this gene is coaE

Identifier: 221230198

GI number: 221230198

Start: 1654133

End: 1655365

Strand: Direct

Name: coaE

Synonym: MLBr_01383

Alternate gene names: 221230198

Gene position: 1654133-1655365 (Clockwise)

Preceding gene: 221230197

Following gene: 221230199

Centisome position: 50.61

GC content: 60.18

Gene sequence:

>1233_bases
ATGCTGTGCATCGGGATCACCGGTGGCATCGGCGCCGGGAAGTCTTTGCTGTCTAGTACGTTCTCACAGTGTGGTGGGAT
CGTCGTCGACGGCGATGTGCTGGCACGCGAAGTGGTGCAGCCCGGCACCAAAGGATTGTCATCGCTGGTCGATGCATTTG
GTCAGGACATCCTGCTTCCTGGCGGTGCGTTGGATCGGCGGGCTTTGGCTGTCAAGGCTTTTCGAGACGACGCGGCGCGC
AATGTGCTTAACGGGATTGTGCACCCACTGGTGGCCAACCGCCGCGCGGAGATCATTGCGGCGATATCCGAGGACGCGGT
TGTGGTCGAAGACATTCCTCTGCTGGTGGAATCCGGGATGGCGCACCTGTTCCCGCTGGTCGTTGTGGTGCATGCCGACG
TCGAACTGCGAGTACGCAGGCTGGTTGAGCAACGTGGTGTGGCCGAAACGGATGCGCGTGCCAGGATCGCTGCACAGGCT
AGCGATGAGGAGCGTCGTGCTGTTGCTGATGTCTGGTTAGACAATTCAAGTACACCAGAGGTTTTGGTCCAACGGGCTCG
TGACCTATGGTACCATCGCATATTGCCGTTCGCCTACAACCTGAGTCAGCGTCAGGCGGTCTATGCACCGGCAGGTTTGG
TCACGTCTGATCCGATCTGGCTGGGGCAGGCGAAGCGCATTGTTGCTCGGCTGAAGACCACGTGTGGCCATAAGGCGTTA
CGCGTTGACCACATCGGCTCGACCGCGGTGCCGCATTATCCAGGTTTTCCTGATTTTCAGGCCAAAGACATCATCGACAT
TCAGATCACCGTCGAGTCACTAGCGATGGCTGACGAACTCGCCGACCCTCTGTTGTCTGCCGGGTACCCGCGCCTGGAGC
ACGTCACCGGTGATGCCGCCAAGACCAATGCCCGCAGCACCGTAGATCGCTACGAACACAGTAGCGACCCAAATTTATGG
CACAAGAGGTTTCATGCCTCTGCAGACCCCGGTCGACCGACATACGTGCATATCCGGGTGGCTGGCTGGCCGAATCAGCA
ATTCGGTTTGCTGTTCGTCGACTGGTTGAAAGCTAACCCGGGTGTGCGTGCCGACTACTTGGACGTCAAACGCACGGCGG
ACCGGCTGGCGGCCGGAGACATGGGCCGTTACGCCGACGCGAAGGAACCATGGCTCCTCGACGCCTACCGGCGAGCGTGG
GAGTGGGCCGACTCCACGGGTTGGCGGCTCTAG

Upstream 100 bases:

>100_bases
AGGCCACGGGTGGGTCGCTGGCTAGCGATGCCCAACTAGCAGCTTTACGGGAAAAGCTCGCCGGCAGCGCATAATAACTG
TTCTGGGTCGTATTCGTGTA

Downstream 100 bases:

>100_bases
GTGGGCCCTAAGTAGACATGGACGTGTCGGGGGATCGCGGCAACCGTTTATGGGATTTGGTACTTCCGGGTGTCGGTCTA
AAACTAATTTTGTTTTGGTC

Product: dephospho-CoA kinase/protein folding accessory domain-containing protein

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MLCIGITGGIGAGKSLLSSTFSQCGGIVVDGDVLAREVVQPGTKGLSSLVDAFGQDILLPGGALDRRALAVKAFRDDAAR
NVLNGIVHPLVANRRAEIIAAISEDAVVVEDIPLLVESGMAHLFPLVVVVHADVELRVRRLVEQRGVAETDARARIAAQA
SDEERRAVADVWLDNSSTPEVLVQRARDLWYHRILPFAYNLSQRQAVYAPAGLVTSDPIWLGQAKRIVARLKTTCGHKAL
RVDHIGSTAVPHYPGFPDFQAKDIIDIQITVESLAMADELADPLLSAGYPRLEHVTGDAAKTNARSTVDRYEHSSDPNLW
HKRFHASADPGRPTYVHIRVAGWPNQQFGLLFVDWLKANPGVRADYLDVKRTADRLAAGDMGRYADAKEPWLLDAYRRAW
EWADSTGWRL

Sequences:

>Translated_410_residues
MLCIGITGGIGAGKSLLSSTFSQCGGIVVDGDVLAREVVQPGTKGLSSLVDAFGQDILLPGGALDRRALAVKAFRDDAAR
NVLNGIVHPLVANRRAEIIAAISEDAVVVEDIPLLVESGMAHLFPLVVVVHADVELRVRRLVEQRGVAETDARARIAAQA
SDEERRAVADVWLDNSSTPEVLVQRARDLWYHRILPFAYNLSQRQAVYAPAGLVTSDPIWLGQAKRIVARLKTTCGHKAL
RVDHIGSTAVPHYPGFPDFQAKDIIDIQITVESLAMADELADPLLSAGYPRLEHVTGDAAKTNARSTVDRYEHSSDPNLW
HKRFHASADPGRPTYVHIRVAGWPNQQFGLLFVDWLKANPGVRADYLDVKRTADRLAAGDMGRYADAKEPWLLDAYRRAW
EWADSTGWRL
>Mature_410_residues
MLCIGITGGIGAGKSLLSSTFSQCGGIVVDGDVLAREVVQPGTKGLSSLVDAFGQDILLPGGALDRRALAVKAFRDDAAR
NVLNGIVHPLVANRRAEIIAAISEDAVVVEDIPLLVESGMAHLFPLVVVVHADVELRVRRLVEQRGVAETDARARIAAQA
SDEERRAVADVWLDNSSTPEVLVQRARDLWYHRILPFAYNLSQRQAVYAPAGLVTSDPIWLGQAKRIVARLKTTCGHKAL
RVDHIGSTAVPHYPGFPDFQAKDIIDIQITVESLAMADELADPLLSAGYPRLEHVTGDAAKTNARSTVDRYEHSSDPNLW
HKRFHASADPGRPTYVHIRVAGWPNQQFGLLFVDWLKANPGVRADYLDVKRTADRLAAGDMGRYADAKEPWLLDAYRRAW
EWADSTGWRL

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=182, Percent_Identity=35.7142857142857, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI191252795, Length=182, Percent_Identity=35.7142857142857, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI110227607, Length=192, Percent_Identity=29.6875, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI110227605, Length=193, Percent_Identity=30.5699481865285, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI110227603, Length=193, Percent_Identity=30.5699481865285, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI110227601, Length=193, Percent_Identity=30.5699481865285, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI205277394, Length=193, Percent_Identity=30.5699481865285, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1786292, Length=203, Percent_Identity=32.0197044334975, Blast_Score=109, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17554944, Length=191, Percent_Identity=34.0314136125654, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320402, Length=185, Percent_Identity=35.1351351351351, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24644728, Length=207, Percent_Identity=28.9855072463768, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24658602, Length=191, Percent_Identity=31.413612565445, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_MYCLE (Q50178)

Other databases:

- EMBL:   Z46257
- EMBL:   AL583921
- PIR:   S77661
- RefSeq:   NP_301984.1
- ProteinModelPortal:   Q50178
- EnsemblBacteria:   EBMYCT00000028709
- GeneID:   910513
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1383
- NMPDR:   fig|272631.1.peg.856
- Leproma:   ML1383
- GeneTree:   EBGT00050000016455
- HOGENOM:   HBG650290
- OMA:   RVDGWPG
- ProtClustDB:   PRK03333
- BioCyc:   MLEP272631:ML1383-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- InterPro:   IPR007344
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE; PF04229 UPF0157

EC number: =2.7.1.24

Molecular weight: Translated: 44977; Mature: 44977

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCIGITGGIGAGKSLLSSTFSQCGGIVVDGDVLAREVVQPGTKGLSSLVDAFGQDILLP
CEEEEECCCCCCCHHHHHHHHHHHCCEEEEHHHHHHHHHCCCHHHHHHHHHHCCCCEECC
GGALDRRALAVKAFRDDAARNVLNGIVHPLVANRRAEIIAAISEDAVVVEDIPLLVESGM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCEEEHHHHHHHHCCH
AHLFPLVVVVHADVELRVRRLVEQRGVAETDARARIAAQASDEERRAVADVWLDNSSTPE
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHEECCCCCHHHHHHHHHCCCCCCCHH
VLVQRARDLWYHRILPFAYNLSQRQAVYAPAGLVTSDPIWLGQAKRIVARLKTTCGHKAL
HHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEHHHHHHHHHHHHHHCCCCEE
RVDHIGSTAVPHYPGFPDFQAKDIIDIQITVESLAMADELADPLLSAGYPRLEHVTGDAA
EEECCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHCCCCHH
KTNARSTVDRYEHSSDPNLWHKRFHASADPGRPTYVHIRVAGWPNQQFGLLFVDWLKANP
HCCHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCC
GVRADYLDVKRTADRLAAGDMGRYADAKEPWLLDAYRRAWEWADSTGWRL
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLCIGITGGIGAGKSLLSSTFSQCGGIVVDGDVLAREVVQPGTKGLSSLVDAFGQDILLP
CEEEEECCCCCCCHHHHHHHHHHHCCEEEEHHHHHHHHHCCCHHHHHHHHHHCCCCEECC
GGALDRRALAVKAFRDDAARNVLNGIVHPLVANRRAEIIAAISEDAVVVEDIPLLVESGM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCEEEHHHHHHHHCCH
AHLFPLVVVVHADVELRVRRLVEQRGVAETDARARIAAQASDEERRAVADVWLDNSSTPE
HHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHEECCCCCHHHHHHHHHCCCCCCCHH
VLVQRARDLWYHRILPFAYNLSQRQAVYAPAGLVTSDPIWLGQAKRIVARLKTTCGHKAL
HHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEHHHHHHHHHHHHHHCCCCEE
RVDHIGSTAVPHYPGFPDFQAKDIIDIQITVESLAMADELADPLLSAGYPRLEHVTGDAA
EEECCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHCCCCHH
KTNARSTVDRYEHSSDPNLWHKRFHASADPGRPTYVHIRVAGWPNQQFGLLFVDWLKANP
HCCHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCCC
GVRADYLDVKRTADRLAAGDMGRYADAKEPWLLDAYRRAWEWADSTGWRL
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7476188; 11234002