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The map label for this gene is prcB

Identifier: 221230164

GI number: 221230164

Start: 1575704

End: 1576579

Strand: Direct

Name: prcB

Synonym: MLBr_01322

Alternate gene names: 221230164

Gene position: 1575704-1576579 (Clockwise)

Preceding gene: 221230163

Following gene: 221230165

Centisome position: 48.22

GC content: 59.59

Gene sequence:

>876_bases
GTGACCCGGTCGTTTCCTGATCGTCTGCCTACAAACTTGGCATTTCCCGGAATTTCAGTGATAAATCAGTCCTCGTTCGT
CGACCTGCTGCGTCGCCAAGCGCCAGAATTGCTACCGGTGAGTCTTGGCGGCGGCCAATCTGGCGGTGGTCAACAACTGT
CGCACGGGACCACGATCGTCGTGCTGAAATACCCAGGCGGCGTCGTCATCGCGGGTGATCGCCGTTCTACTCAGGGCAAT
ATGATCGCCGGCCGCGATGTGCGCAAAGTCTACATCACCGATGACTACACCGCCACCGGTATCGCCGGCATTGCTGCCGT
AGCGGTCGAGTTCGCCCGCCTCTACGCGGTCGAACTCGAGCACTATGAGAAGCTCGAAGGCGTGCCGCTTACGTTTGCTG
GCAAGGTAAACCGGCTTGCGATCATGGTCCGTAGCAATTTAACGGCCGCGATGCAGGGGCTGTTGGCGCTGCCACTGCTG
GCGGGCTACGACATTCATGCACCTGACCCGCAGAGCGCGGGGCGCATCGTCTCTTTCGATGCCGCCGGCGGCTGGAACAT
CGAGGAAGAGGGCTACCAGTCGGTAGGGTCGGGGTCGATTTTCGCTAAGTCGTCGATAAAGAAATTGTACTCGCAGGTCT
CCGATGCTGATTCTGCCTTGAGGGTAGCCATCGAGGCGCTCTATGACGCAGCCGACGACGATTCCGCTACCGGAGGGCCG
GATTTGGTCCGTGGCATCTACCCTACGGCGGTCACTATCGGCGCTGAGGGAGCGGCCGAGGTAACAGAAAGCCGGATCGC
CGAACTTGCCCGCGAGATTATCGAAAGCCGTTCACGTGCGTACACTCTTGGCTCCTTTGGCGGGAGTGAGAAATGA

Upstream 100 bases:

>100_bases
AGCTGACTGAGGAGACCGATGATTTGCTCGACGAAATTGACGATGTCCTTGAGGAGAATGCGGAAGACTTTGTTCGCGCG
TACGTACAAAAGGGCGGACA

Downstream 100 bases:

>100_bases
GTTTTCCGTACTTCATCTCACCTGAACAGGCTATGCGCGAGCGCAGCGAGCTCGCTCGCAAGGGTATTGCTCGGGGCCGC
AGCGTGGTAGCGCTAGCCTA

Product: proteasome beta-type subunit 2

Products: NA

Alternate protein names: 20S proteasome beta subunit; Proteasome core protein PrcB

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MTRSFPDRLPTNLAFPGISVINQSSFVDLLRRQAPELLPVSLGGGQSGGGQQLSHGTTIVVLKYPGGVVIAGDRRSTQGN
MIAGRDVRKVYITDDYTATGIAGIAAVAVEFARLYAVELEHYEKLEGVPLTFAGKVNRLAIMVRSNLTAAMQGLLALPLL
AGYDIHAPDPQSAGRIVSFDAAGGWNIEEEGYQSVGSGSIFAKSSIKKLYSQVSDADSALRVAIEALYDAADDDSATGGP
DLVRGIYPTAVTIGAEGAAEVTESRIAELAREIIESRSRAYTLGSFGGSEK

Sequences:

>Translated_291_residues
MTRSFPDRLPTNLAFPGISVINQSSFVDLLRRQAPELLPVSLGGGQSGGGQQLSHGTTIVVLKYPGGVVIAGDRRSTQGN
MIAGRDVRKVYITDDYTATGIAGIAAVAVEFARLYAVELEHYEKLEGVPLTFAGKVNRLAIMVRSNLTAAMQGLLALPLL
AGYDIHAPDPQSAGRIVSFDAAGGWNIEEEGYQSVGSGSIFAKSSIKKLYSQVSDADSALRVAIEALYDAADDDSATGGP
DLVRGIYPTAVTIGAEGAAEVTESRIAELAREIIESRSRAYTLGSFGGSEK
>Mature_290_residues
TRSFPDRLPTNLAFPGISVINQSSFVDLLRRQAPELLPVSLGGGQSGGGQQLSHGTTIVVLKYPGGVVIAGDRRSTQGNM
IAGRDVRKVYITDDYTATGIAGIAAVAVEFARLYAVELEHYEKLEGVPLTFAGKVNRLAIMVRSNLTAAMQGLLALPLLA
GYDIHAPDPQSAGRIVSFDAAGGWNIEEEGYQSVGSGSIFAKSSIKKLYSQVSDADSALRVAIEALYDAADDDSATGGPD
LVRGIYPTAVTIGAEGAAEVTESRIAELAREIIESRSRAYTLGSFGGSEK

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

Organism=Homo sapiens, GI4506201, Length=196, Percent_Identity=29.5918367346939, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130281, Length=238, Percent_Identity=27.7310924369748, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB_MYCLB (B8ZRF3)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503580.1
- ProteinModelPortal:   B8ZRF3
- SMR:   B8ZRF3
- MEROPS:   T01.005
- EnsemblBacteria:   EBMYCT00000085394
- GeneID:   7326469
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016799
- HOGENOM:   HBG322409
- OMA:   FQVELEH
- ProtClustDB:   CLSK872008
- GO:   GO:0005737
- HAMAP:   MF_02113_B
- InterPro:   IPR022483
- InterPro:   IPR001353
- TIGRFAMs:   TIGR03690

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 30639; Mature: 30508

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 57-57

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSFPDRLPTNLAFPGISVINQSSFVDLLRRQAPELLPVSLGGGQSGGGQQLSHGTTIV
CCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCEEE
VLKYPGGVVIAGDRRSTQGNMIAGRDVRKVYITDDYTATGIAGIAAVAVEFARLYAVELE
EEECCCCEEEECCCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
HYEKLEGVPLTFAGKVNRLAIMVRSNLTAAMQGLLALPLLAGYDIHAPDPQSAGRIVSFD
HHHHHCCCCEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
AAGGWNIEEEGYQSVGSGSIFAKSSIKKLYSQVSDADSALRVAIEALYDAADDDSATGGP
CCCCCCCCHHHHHCCCCCCEEHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCH
DLVRGIYPTAVTIGAEGAAEVTESRIAELAREIIESRSRAYTLGSFGGSEK
HHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCC
>Mature Secondary Structure 
TRSFPDRLPTNLAFPGISVINQSSFVDLLRRQAPELLPVSLGGGQSGGGQQLSHGTTIV
CCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHCCCCEEEEEECCCCCCCCCEECCCCEEE
VLKYPGGVVIAGDRRSTQGNMIAGRDVRKVYITDDYTATGIAGIAAVAVEFARLYAVELE
EEECCCCEEEECCCCCCCCCEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
HYEKLEGVPLTFAGKVNRLAIMVRSNLTAAMQGLLALPLLAGYDIHAPDPQSAGRIVSFD
HHHHHCCCCEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
AAGGWNIEEEGYQSVGSGSIFAKSSIKKLYSQVSDADSALRVAIEALYDAADDDSATGGP
CCCCCCCCHHHHHCCCCCCEEHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCH
DLVRGIYPTAVTIGAEGAAEVTESRIAELAREIIESRSRAYTLGSFGGSEK
HHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA