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The map label for this gene is lspA

Identifier: 221230087

GI number: 221230087

Start: 1417056

End: 1417661

Strand: Direct

Name: lspA

Synonym: MLBr_01199

Alternate gene names: 221230087

Gene position: 1417056-1417661 (Clockwise)

Preceding gene: 221230085

Following gene: 221230088

Centisome position: 43.36

GC content: 58.25

Gene sequence:

>606_bases
ATGATGGGTAGAGTGCCTGACGGACCAACAGGATTGGCTGCGTTGGTGCCTTCAGTTGAGGAAGCTCAAGCTATGCTGCC
TCCGCGGCGGCTGCGTCTGCTGTTGTCGATCGCGGCGGTTGTGCTGACGCTGGACATTGTCACGAAGGTGCTCGCCGTCA
AGTTTTTGCTTCCTGGGAAGTCGGTGTCGATCATCGGTGACACGGTGACCTGGACTTTGGTGCGAAATTCGGGAGCAGCC
TTCTCGATGGCGACCGGATACACTTGGGTGTTGACGCTGATCGCGACGGGTGTGGTGATTGGGATCTTCTGGATGGGGCG
GCGGCTGGTGTCGTCTTGGTGGGCGTTGGGTCTTGGTATGATCCTTGGTGGTGCGATGGGTAACTTGGTCGATCGCTTCT
TCCGCGCGCCCGCGCCGCTTCGGGGACATGTCGTCGATTTTTTGTCGATCGGCTGGTGGCCAGTGTTCAATGTTGCCGAT
CCATCGGTGGTGGTCGGTGCCATCCTGCTGGTCGTCCTGTCAATCTTTGGCTTTGACTTCGACACTGTAGGTCGGCGTAA
AGCCGAGTTCGACATTGCAGGTCAGCGGAAGGCTGAACAGCGTTGA

Upstream 100 bases:

>100_bases
GTGGCGATGACGGTGAGGCGGCTCATGGTGGGATCATCCTGCACGATTGGTCGGTCCGTATCGATCGCGGGGGTCGGTAG
GACAGTATTACCCTTGGGGG

Downstream 100 bases:

>100_bases
TGGCCGGAAGCGACGATGAAGAGGGCAGAAATGCGGTGGGGAGGTGCCCCCCACAGGTGGGTGTGGGCGCCCCACTTTGG
GGGCGTGCCTCAATTGTTTG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MMGRVPDGPTGLAALVPSVEEAQAMLPPRRLRLLLSIAAVVLTLDIVTKVLAVKFLLPGKSVSIIGDTVTWTLVRNSGAA
FSMATGYTWVLTLIATGVVIGIFWMGRRLVSSWWALGLGMILGGAMGNLVDRFFRAPAPLRGHVVDFLSIGWWPVFNVAD
PSVVVGAILLVVLSIFGFDFDTVGRRKAEFDIAGQRKAEQR

Sequences:

>Translated_201_residues
MMGRVPDGPTGLAALVPSVEEAQAMLPPRRLRLLLSIAAVVLTLDIVTKVLAVKFLLPGKSVSIIGDTVTWTLVRNSGAA
FSMATGYTWVLTLIATGVVIGIFWMGRRLVSSWWALGLGMILGGAMGNLVDRFFRAPAPLRGHVVDFLSIGWWPVFNVAD
PSVVVGAILLVVLSIFGFDFDTVGRRKAEFDIAGQRKAEQR
>Mature_201_residues
MMGRVPDGPTGLAALVPSVEEAQAMLPPRRLRLLLSIAAVVLTLDIVTKVLAVKFLLPGKSVSIIGDTVTWTLVRNSGAA
FSMATGYTWVLTLIATGVVIGIFWMGRRLVSSWWALGLGMILGGAMGNLVDRFFRAPAPLRGHVVDFLSIGWWPVFNVAD
PSVVVGAILLVVLSIFGFDFDTVGRRKAEFDIAGQRKAEQR

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_MYCLB (B8ZR76)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503503.1
- EnsemblBacteria:   EBMYCT00000087478
- GeneID:   7327210
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000017480
- HOGENOM:   HBG724422
- OMA:   MATRNNG
- ProtClustDB:   PRK14764
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 21691; Mature: 21691

Theoretical pI: Translated: 11.16; Mature: 11.16

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 131-131 ACT_SITE 160-160

Signals:

None

Transmembrane regions:

HASH(0x2990b4ac)-; HASH(0x296ed118)-; HASH(0x29f1c1ec)-; HASH(0x29eb0a08)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGRVPDGPTGLAALVPSVEEAQAMLPPRRLRLLLSIAAVVLTLDIVTKVLAVKFLLPGK
CCCCCCCCCCCHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVIGIFWMGRRLVSSWWALGLGM
CEEEEECCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILGGAMGNLVDRFFRAPAPLRGHVVDFLSIGWWPVFNVADPSVVVGAILLVVLSIFGFDF
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCH
DTVGRRKAEFDIAGQRKAEQR
HHHCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure
MMGRVPDGPTGLAALVPSVEEAQAMLPPRRLRLLLSIAAVVLTLDIVTKVLAVKFLLPGK
CCCCCCCCCCCHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVIGIFWMGRRLVSSWWALGLGM
CEEEEECCEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILGGAMGNLVDRFFRAPAPLRGHVVDFLSIGWWPVFNVADPSVVVGAILLVVLSIFGFDF
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCH
DTVGRRKAEFDIAGQRKAEQR
HHHCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA